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Cisatracurium

About Cisatracurium

Cisatracurium is a prescription injection used to relax the body's muscles during surgery, certain medical procedures, or while you are receiving breathing support with a ventilator in an intensive care unit (ICU). It works by temporarily blocking the signals between your nerves and muscles, allowing your healthcare team to safely place a breathing tube, perform surgery, or provide mechanical ventilation.

This medicine is commonly used to provide muscle relaxation during surgery, make tracheal intubation (placement of a breathing tube) easier, and help patients breathe comfortably with a mechanical ventilator in the ICU. It relaxes only the muscles and does not provide pain relief or make you unconscious, so it is always used together with appropriate anaesthesia or sedation.

Because this medicine is given as an injection in a hospital, it is not used as a regular treatment at home. It is administered as a single injection or a continuous intravenous infusion by trained healthcare professionals only when needed for your procedure. Before surgery, you will usually be asked to avoid eating or drinking for a certain period as instructed by your anaesthesia team.

Some people may develop temporary side effects such as a slow heart rate, low blood pressure, flushing, or mild breathing changes while the medicine is wearing off. Your medical team will monitor you closely throughout treatment. Tell your healthcare provider immediately if you experience severe difficulty breathing, prolonged muscle weakness, or signs of a severe allergic reaction after your procedure.

Do not receive this medicine if you have previously had a severe allergic reaction to cisatracurium or similar muscle relaxants. Before treatment, tell your doctor if you have myasthenia gravis, other nerve-muscle disorders, severe electrolyte imbalances, or a history of major burn injuries. Certain medicines, including some antibiotics, lithium, and medicines for seizures or heart conditions, may affect how this medicine works. If you are pregnant, breastfeeding, elderly, or have kidney or liver disease, your doctor will monitor your treatment carefully.

Uses of Cisatracurium

Cisatracurium is used for Muscle relaxation during surgery or mechanical ventilation. The detailed uses of Cisatracurium are as follows: • Muscle Relaxation in Surgery: Cisatracurium used as an adjunct to general anesthesia to prevent involuntary muscle movements. • Mechanical Ventilation Support: Cisatracurium is used in ICUs for patients on prolonged ventilation, promoting muscle relaxation to ensure safe and effective ventilation support. • Endotracheal intubation: Cisatracurium helps to facilitate tracheal intubation when a person requires assistance with breathing.

Medicinal Benefits

This medicine provides reliable muscle relaxation during surgery and critical care.

  • Provides controlled muscle relaxation: Keeps the muscles relaxed throughout surgery, helping surgeons perform delicate procedures with greater precision and reducing unwanted movement.
  • Supports safe airway management: Makes inserting a breathing tube smoother and helps reduce strain on the airway during medical procedures.
  • Supports mechanical ventilation: Helps patients breathe comfortably with a ventilator by allowing the breathing machine to work effectively without muscle resistance.
  • Suitable for patients with kidney or liver disease: This medicine is broken down naturally in the body and does not depend mainly on the kidneys or liver for elimination, making its effects more predictable in many patients with kidney or liver impairment.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Cisatracurium will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cisatracurium

Common Side Effects (Usually mild)

  • Temporary slow heart rate
  • Temporary low blood pressure
  • Flushing or redness of the skin
  • Mild wheezing or temporary breathing changes as the medicine wears off
     

Serious Side Effects (Consult your doctor right away)

  • Signs of a severe allergic reaction, such as hives, swelling of the face, lips, tongue, or throat, severe itching, or difficulty breathing
  • Severe difficulty breathing or shortness of breath after your procedure
  • Prolonged muscle weakness or inability to move your muscles long after surgery
  • Extremely fast, slow, or irregular heartbeat

Drug Warnings

  • Receive this medicine only in a hospital: It should only be administered in a fully equipped healthcare facility where emergency breathing equipment and medicines to reverse its effects are immediately available.
  • Check the medicine before use: Your healthcare provider will inspect the vial to ensure the solution is clear, colourless to pale yellow, and free from visible particles before administration.
  • Tell your doctor about previous burns: A history of severe burn injuries can change how your body responds to this medicine and may affect the dose you need.
  • Inform your doctor about nerve-muscle disorders: Conditions such as myasthenia gravis or Eaton-Lambert syndrome can make you much more sensitive to this medicine and require careful dose adjustments.
  • Discuss pregnancy and breastfeeding: Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding before receiving this medicine so the benefits and risks can be carefully assessed.

Drug Interactions

  • Aminoglycoside, polymyxin, and tetracycline antibiotics (i.e. gentamicin, amikacin, polymyxin B, tetracycline): May increase the muscle-relaxing effects of Cisatracurium, causing muscle weakness to last longer than expected.
  • Mood stabilisers and calcium channel blockers (i.e. lithium, amlodipine, diltiazem, verapamil): May prolong the effects of this medicine, requiring careful monitoring and dose adjustment.
  • Antiseizure medicines (i.e. phenytoin, carbamazepine): May reduce the duration of muscle relaxation, meaning additional doses may be needed during prolonged procedures.

Drug-Drug Interactions Checker List:

  • PROCAINAMIDE
  • QUINIDINE
  • PHENYTOIN
  • CARBAMAZEPINE
  • SUCCINYLCHOLINE
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      It is unknown if alcohol interacts with Cisatracurium. Please consult a doctor if you have any concerns.

    • Safety Warning

      Pregnancy

      caution

      If you are pregnant or planning a pregnancy, inform the doctor before receiving Cisatracurium. Your doctor may prescribe this medicine if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      There is limited data on the use of Cisatracurium during breastfeeding. Consult your healthcare provider to assess risks and benefits.

    • Safety Warning

      Driving

      consult your doctor

      There is limited data on the use of Cisatracurium during driving. Consult your healthcare provider to assess risks and benefits.

    • Safety Warning

      Liver

      consult your doctor

      Please consult the doctor if you have any concerns regarding the usage of Cisatracurium in patients with liver problems.

    • Safety Warning

      Kidney

      consult your doctor

      Please consult the doctor if you have any concerns regarding the usage of Cisatracurium in patients with kidney problems.

    • Safety Warning

      Children

      safe if prescribed

      Cisatracurium is safe for children over 1 month of age if prescribed by the doctor. Please consult your doctor if you have any concerns regarding its usage in children.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Follow fasting instructions carefully: Do not eat or drink before your procedure unless your anaesthesia team tells you it is safe to do so. This helps reduce the risk of stomach contents entering your lungs during anaesthesia.
    • Rest after your procedure: Give your body enough time to recover and allow your muscles to regain their normal strength and coordination.
    • Stay well hydrated: Drink plenty of water after your procedure once your healthcare provider confirms that it is safe to do so.
    • Avoid driving or operating machinery: Do not drive, operate heavy machinery, or make important decisions for at least 24 hours after your procedure because the effects of anaesthesia and other medicines may temporarily affect your alertness and coordination.
       

    Patients Concern

    Disease/Condition Glossary

    Skeletal muscle relaxation: Skeletal muscle relaxation during surgery aids in smooth surgical procedures, assists with intubation, and ensures effective mechanical ventilation while supporting recovery and minimizing potential complications.

    FAQs

    Cisatracurium is a neuromuscular blocking agent used to relax muscles during surgery, assist with tracheal intubation, and support muscle relaxation in intensive care settings.

    Cisatracurium contains Cisatracurium, which works by inhibiting acetylcholine from binding to the nicotinic receptors at the neuromuscular junction. This prevents muscle cell depolarization and causes muscular relaxation.

    Yes, Cisatracurium is safe for children over 1 month of age if prescribed by the doctor. However, it should only be administered under medical supervision.

    Some people may experience reactions at the injection site, such as pain, redness, or swelling, but these typically resolve on their own. Seek medical advice if the reactions persist or worsen.

    It is advised to consult a doctor before taking other medicines with Cisatracurium to prevent any interactions. Let the doctor know if you are on treatment with other medicines, including herbal products.

    The side effects of Cisatracurium include flushing, slow heartbeat, low blood pressure, and bronchospasm. Seek medical care if any of the side effects bother you.

    No. Cisatracurium only relaxes your muscles. It does not make you sleep or relieve pain. It is always used together with anaesthetic and pain-relieving medicines during surgery so that you remain comfortable throughout the procedure. Your anaesthetist can explain your anaesthesia plan in more detail.

    Yes. This medicine is often preferred for people with kidney or liver disease because it is mainly broken down naturally in the body rather than relying on these organs. However, your medical team will still monitor you closely throughout treatment.

    No. You will usually receive a general anaesthetic or appropriate sedation before or at the same time as this medicine, so you should not be aware of the muscle relaxation during the procedure. Speak with your anaesthetist if you have concerns about what to expect.

    Because this medicine is only administered in hospitals, trained healthcare professionals can recognise and treat allergic reactions immediately using emergency medicines and supportive care. Tell your doctor if you have previously had an allergic reaction to a muscle relaxant.

    This medicine is used during pregnancy only when your doctor believes the expected benefits outweigh the possible risks to the unborn baby. Your healthcare team will carefully assess your condition before making this decision.

    If necessary, your anaesthetist can give a medicine that reverses the muscle-relaxing effects, helping your muscles recover normal strength more quickly after surgery. If you have questions about your recovery, your healthcare team will be happy to explain the process.

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