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compositionComposition:CLOBETASOL-0.05%W/W+NEOMYCIN-0.5%W/W
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Propygenta NF Cream is used to treat bacterial skin infections. It contains Clobetasol and Neomycin, which stops the growth of bacteria and blocks the production of prostaglandins (chemical messengers) that make the skin red, swollen and itchy. Some may experience side effects like burning, irritation, itching, redness, and thinning of skin at the application site. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Ms. Santoshini Reddy , M Pharmacy
Reviewed By Dr. Lalit Kanodia , MBBS, MD, MBA Healthcare Adminiatration
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More about the Product

Composition :

CLOBETASOL-0.05%W/W+NEOMYCIN-0.5%W/W

Manufacturer/Marketer :

Hegde & Hegde Pharmaceutica Llp

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Propygenta NF Cream

Propygenta NF Cream is a topical prescription medication used to treat various inflammatory skin conditions that have become complicated by a bacterial infection. It helps relieve the redness, swelling, intense itching, and discomfort associated with skin issues like eczema, psoriasis, and dermatitis. By addressing both the underlying skin inflammation and the bacterial infection at the same time, this medication helps your skin heal faster.

You should apply this medication exactly as directed by your healthcare provider, usually once or twice daily. Consistency is key to clearing the infection completely, so make sure not to skip applications even if your skin begins to look better. Alongside using this topical treatment, keeping your skin clean, dry, and well-hydrated with a gentle, fragrance-free moisturiser can significantly support your skin's healing process.

While Propygenta NF Cream is highly effective, it can occasionally cause local side effects such as temporary burning, stinging, or dryness where it is applied. If you notice severe skin thinning, stretch marks, or signs that the medicine is being absorbed into your bloodstream, such as rapid weight gain or extreme fatigue, you should contact your doctor immediately.

Do not use this medicine if you have untreated viral skin infections (like shingles, chickenpox, or cold sores), fungal infections (like athlete's foot or ringworm), or tuberculosis of the skin. It is also important to talk to your doctor before starting Propygenta NF Cream if you have a history of skin allergies, a weakened immune system, or poor blood circulation.

Before applying Propygenta NF Cream, let your doctor know if you are using other topical steroid creams or taking oral medicines, as combining them can increase the risk of side effects. If you are pregnant, planning to become pregnant, breastfeeding, or treating an elderly family member, consult your doctor first to ensure this medication is safe for use.

Uses of Propygenta NF Cream

Propygenta NF Cream is used to treat various inflammatory skin conditions. The detailed uses of Propygenta NF Cream are as follows:

  • Infected Eczema: This medicine reduces severe itching, swelling, and redness while clearing up the complicating bacterial infection.
  • Infected Dermatitis: It soothes inflamed, irritated skin and targets the bacteria causing the local skin infection.
  • Psoriasis with Secondary Infection: It may be used when psoriasis lesions have developed a confirmed secondary bacterial infection. The clobetasol component helps reduce inflammation, while neomycin targets susceptible bacteria. A doctor should confirm that a bacterial infection is present and that this combination is appropriate before use in psoriasis. 
     

Key Benefits

Propygenta NF Cream provides targeted treatment for skin conditions involving both inflammation and bacterial infection. By addressing multiple causes of skin symptoms at the same time, it helps relieve discomfort, control infection, and support healthier skin recovery. This medicine offers several key benefits:

  • Helps Relieve Itching, Redness, and Swelling: By reducing inflammation at the affected site, Propygenta NF Cream helps relieve symptoms such as itching, redness, irritation, and swelling. This can improve comfort and reduce the urge to scratch the skin.
  • Helps Control Bacterial Infection: The antibacterial component of Propygenta NF Cream works to eliminate susceptible bacteria that may be contributing to the skin condition. Controlling the infection can help prevent worsening of symptoms and reduce the risk of the infection spreading to nearby areas.
  • Supports Faster Skin Healing: By managing both inflammation and bacterial growth, Propygenta NF Cream creates a more favourable environment for the skin to recover. This helps support restoration of the skin's natural protective barrier and promotes healthier healing.
     
Side effects of Propygenta NF Cream 20 gm
  • Avoid extreme heat or cold, like hot showers or cold winds, to prevent worsening skin discomfort.
  • Cool compresses: To reduce itch, redness, and swelling.
  • Avoid irritants like harsh chemicals or allergens to prevent worsening skin discomfort.
  • If you have severe itching, burning, or blistering seek medical attention.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
  • Mild hair follicle inflammation often heals on its own without needing treatment.
  • You can apply a warm saltwater or vinegar solution to the affected area with a washcloth, or use over-the-counter antibiotics, oatmeal lotion, or hydrocortisone cream for relief.
  • Avoid making the affected area worse by not shaving, scratching, or wearing tight clothes.
  • Apply a warm compress to the area 3-4 times a day for 15-20 minutes to help speed up healing.
  • Do not scratch, squeeze, or pop any bumps, as this may lead to infection or other problems.
  • If self-care methods fail, consult a doctor for further treatment and advice.
  • Shield your skin from the sun by using sunscreen, seeking shade, and wearing protective clothing.
  • Please don't smoke, as it damages the skin and reduces blood flow.
  • Treat your skin gently by limiting bath time, using mild cleansers, and shaving carefully.
  • Eat a healthy diet of fruits, vegetables, whole grains, and lean proteins.
  • Stay hydrated by drinking plenty of water.
  • Manage stress through sleep, exercise, meditation, and enjoyable activities.
  • Additionally, use moisturizers to coat your skin with a protective barrier, and consider wearing sun-protective clothing.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

Please follow your doctor's exact instructions when using Propygenta NF Cream. Below is a step-by-step guide on how to apply it safely:

  • Wash your hands thoroughly with mild soap and water before applying the medicine.
  • Gently clean and dry the affected skin area.
  • Apply a thin layer of the cream or ointment to the affected area and rub it in gently.
  • Wash your hands immediately after application, unless you are using the medicine to treat an infection on your hands.
  • Do not cover the treated area with bandages, dressings, or tight clothing unless your doctor specifically tells you to do so.
     

How Propygenta NF Cream Works

Propygenta NF Cream works through the combined action of two active medicines that target different aspects of your skin condition: Clobetasol: This is a highly potent corticosteroid. It binds to glucocorticoid receptors within skin cells and alters the expression of multiple genes involved in inflammation. This suppresses the production and activity of inflammatory mediators, helping to reduce redness, swelling, itching, and other signs of skin inflammation. Neomycin: This is an aminoglycoside antibiotic. It binds to the 30S ribosomal subunit within susceptible bacteria and disrupts normal protein synthesis. This interferes with the production of essential bacterial proteins, helping to control the infection and allowing the body's immune system to eliminate the bacteria.
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Alcohol

Safe if prescribed

No interaction found of Propygenta NF Cream with alcohol.

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Pregnancy

Caution

There is limited data on how the Propygenta NF Cream affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Propygenta NF Cream.

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Breast Feeding

Safe if prescribed

Please consult your doctor before using Propygenta NF Cream if you are breastfeeding.

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Driving

Caution

There have been no studies to investigate the effect of Propygenta NF Cream on driving performance or the ability to operate machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before using Propygenta NF Cream.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before using Propygenta NF Cream.

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Children

Caution

Propygenta NF Cream is not recommended for children less than two years of age. However, it can be given to the children above two years of age if prescribed by the doctor.

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Heart

Consult your doctor

Please consult your doctor before using Propygenta NF Cream if you have pre-existing heart problems. Your doctor will prescribe Propygenta NF Cream if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Propygenta NF Cream to geriatric patients. Your doctor will prescribe Propygenta NF Cream if the benefits outweigh the risks.

What if I have taken an overdose of Propygenta NF Cream

Do not apply Propygenta NF Cream in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects.

Diet & Lifestyle Advise

  • Keep skin hydrated: Use a gentle, fragrance-free emollient daily to support your skin's moisture barrier, applying it at least 30 minutes apart from Propygenta NF Cream.
  • Avoid known skin triggers: Stay away from harsh soaps, detergents, synthetic fabrics, and allergens that can aggravate eczema or psoriasis.
  • Wear loose clothing: Wear loose-fitting, breathable cotton clothing over treated areas to prevent skin friction and sweat build-up.
  • Practice gentle hygiene: Take short, lukewarm showers instead of hot baths to avoid drying out your skin further.
     
health query

Have a query?

How Soon It Starts Working

The time required for Propygenta NF Cream to start to work: The time required for Propygenta NF Cream to show its action is unknown. The time for which the effects of Propygenta NF Cream last: The duration of action for Propygenta NF Cream is unknown.

What if you forget to take Propygenta NF Cream

Apply the missed dose as soon as you remember. If it is almost time for next dose, skip the missed dose and follow your regular schedule.

Storage

•Store Propygenta NF Cream at room temperature, ideally below 25°C (77°F). •Keep the tube tightly closed when not in use to protect the medicine from moisture and air.

Drug Warnings

  • Do not use on the face, groin, or underarms: These areas have very thin skin and are highly susceptible to side effects like skin thinning unless specifically monitored by your doctor.
  • Avoid airtight dressings: Do not wrap, bandage, or cover the treated area with waterproof dressings unless your doctor explicitly guides you to, as this can drastically increase drug absorption and cause systemic side effects.
  • Limit the duration of use: Avoid using this high-potency topical treatment for longer than 1 to 2 consecutive weeks without a clinical re-evaluation by your doctor.
  • Watch for new infections: If your skin condition does not improve after a few days, or if it suddenly gets worse, stop using the cream and consult your doctor, as a fungal or viral infection may have developed.
  • Avoid contact with your eyes: If the medicine accidentally gets into your eyes, rinse them thoroughly with cool water immediately.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Other topical corticosteroids: Using other steroid creams alongside Propygenta NF Cream may increase the risk of skin thinning and adrenal suppression.
  • Oral corticosteroids: Combining topical steroids with oral steroid tablets can raise the level of steroids in your body, increasing the risk of systemic side effects.
  • Aminoglycoside antibiotics: Using other medications containing neomycin or related antibiotics simultaneously may increase the risk of toxicity, especially if applied over large areas of broken skin.

Drug-Disease Interactions

  • Viral or fungal skin infections: Using Propygenta NF Cream on viral infections (like herpes) or fungal infections (like ringworm) can worsen the infection because steroids suppress the local immune response.
  • Tuberculosis of the skin: This medicine should not be applied to skin lesions caused by tuberculosis, as it can worsen the condition.
  • Kidney or hearing impairment: If neomycin is absorbed through large open wounds, it may worsen pre-existing kidney problems or hearing issues.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBACTERIAL AND CORTICOSTEROID]

FAQs

Propygenta NF Cream belongs to the class of dermatological medication primarily used to treat bacterial skin infections.
Propygenta NF Cream contains Clobetasol and Neomycin. Clobetasol is a steroid medicine that blocks the production of prostaglandins (chemical messengers), which make the skin red, swollen and itchy. Neomycin is an antibiotic used in treating bacterial and fungal infections of the skin. It prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Thus, Propygenta NF Cream treats bacterial infections.
No, it is not advised to stop using Propygenta NF Cream even after your symptoms are relieved. You should complete the full course of treatment. You might see improvement in your symptoms, but the disease might not be cured completely.
Propygenta NF Cream is only for external use. Take a small amount on the fingertip and apply it as a thin layer on the clean and dry affected area as prescribed by your doctor.
Propygenta NF Cream should not be used by anyone who is allergic to its ingredients. It should also not be used on fungal infections such as ringworm, athlete's foot, or yeast infections, or on viral infections such as herpes or chickenpox, unless specifically advised by a doctor. Consult your doctor if you have psoriasis, rosacea, acne, or other chronic skin conditions before using this medicine.
Propygenta NF Cream should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of reach of children.
Do not use Propygenta NF Cream on an open wound or broken skin unless advised otherwise by the doctor. Always consult your doctor before applying Propygenta NF Cream to an open wound.
The common side effects of Propygenta NF Cream include burning, irritation, itching, redness, and thinning of skin at the application site. If these side effects persist longer, please consult your doctor.
No, Propygenta NF Cream does not interact with other medications because it is a topical treatment. However, systemic absorption may occur if used for prolonged periods, which may lead to interactions with other drugs. Always consult your doctor if you are using other medicines during treatment with Propygenta NF Cream.
You should avoid using Propygenta NF Cream on your face unless your doctor specifically instructs you to do so. The skin on your face is very thin and highly sensitive, making it prone to side effects like permanent skin thinning and acne. Talk to your doctor for advice on facial skin concerns.
Most patients notice an improvement in itching, redness, and swelling within a few days of starting treatment. However, you should complete the full course prescribed by your healthcare provider. If your symptoms do not improve after one week, talk to your doctor.
No, Propygenta NF Cream is not designed to treat acne or common pimples. Using potent steroids on acne can actually make the breakouts worse or trigger a specific type of steroid-induced acne. Talk to your doctor or a dermatologist for appropriate acne treatments.
Propygenta NF Cream should only be used during pregnancy if the potential benefits outweigh the risks to the developing baby. High-potency topical steroids should not be used in large amounts or for long periods by pregnant women. Talk to your doctor before using this medicine.
You should not cover the treated area with a bandage, wrap, or plastic dressing unless specifically told to do so by your doctor. Covering the area increases how much medicine is absorbed into your body, which raises the risk of serious side effects. Talk to your doctor for clarification.
Using Propygenta NF Cream for longer than prescribed or in larger amounts than recommended can cause skin thinning, stretch marks, changes in skin colour, visible blood vessels, and increased absorption of the medicine into the bloodstream. This may increase the risk of serious side effects. Always use the medicine exactly as directed by your doctor.
No, Propygenta NF Cream is not effective against fungal infections like ringworm, athlete's foot, or yeast infections. It contains an antibacterial agent and a steroid, which can actually make fungal infections worse by lowering your skin's natural defences. Talk to your doctor for an accurate diagnosis.
Yes, you can use moisturisers, but you should wait at least 30 minutes after applying Propygenta NF Cream before applying any other product to the same area. This ensures Propygenta NF Cream is fully absorbed and prevents diluting the medication. Talk to your doctor or pharmacist if you have questions about specific skincare products.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Neomycin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Clobetasol propionate [EMC Label]. 2017. [Accessed on 04 Apr. 2019]Check here
  5. Clobetasol propionate [Prescribing Information]. 2012. [Accessed on 04 Apr. 2019]Check here
  6. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022]Check here
  7. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Office No. 11A ? 15, 1st Floor, Free Press House, 215, Nariman Point, Mumbai ? 400 021
Other Info - PRO0230

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