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compositionComposition:PROMETHAZINE-25MG
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Phenergan Injection 2 ml is used to manage and treat allergic conditions, nausea and vomiting, motion sickness, and sedation. It contains Promethazine, which blocks the effects of histamine in your brain and reduces symptoms. Common side effects of Phenergan Injection 2 ml are drowsiness, dizziness, tiredness, incoordination, lack of energy, increased blood pressure or occasional low blood pressure.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PROMETHAZINE-25MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Phenergan Injection 2 ml

Phenergan Injection 2 ml is an injectable medication used to treat severe allergic reactions, control nausea and vomiting after surgery, and provide sedation before or after medical procedures. It belongs to a group of medicines that block histamine, a natural substance your body makes during an allergic reaction. This medicine is also used to help prevent motion sickness when other forms of treatment are not possible.

Because this medicine is given as an injection, a healthcare professional will usually inject it in a hospital or clinic setting on an as-needed basis. It can be injected deep into a muscle or given slowly through a vein, and it does not require any specific food restrictions beforehand. Avoiding alcohol and staying well-hydrated can help support your body's recovery during treatment.

While using Phenergan Injection 2 ml, you may experience common side effects such as drowsiness, dizziness, or a dry mouth. However, you must seek immediate medical help if you notice severe pain at the injection site, breathing difficulties, or involuntary muscle movements.

Talk to your doctor before starting this medicine if you have asthma, glaucoma, heart disease, or liver problems. Do not take this if you are treating a child under two years of age, or if you have severe breathing difficulties or a history of allergic reactions to similar medicines.

This medicine can interact with alcohol, sleeping pills, and certain pain relievers, which can cause extreme sleepiness and dangerous slow breathing. If you are pregnant, breastfeeding, or over the age of 65, consult your doctor to ensure this injection is safe for your specific situation.

Uses of Phenergan Injection 2 ml

Phenergan Injection 2 ml is used to treat severe allergic reactions, control nausea and vomiting after surgery, and provide sedation before or after medical procedures. The detailed uses of Phenergan Injection 2 ml are as follows:

  • Severe allergic reactions: It helps relieve symptoms of severe allergies by blocking histamine, reducing swelling, hives, and itching.
  • Nausea and vomiting: It helps control and prevent severe nausea and vomiting, especially after surgery or anaesthesia, by acting on the part of the brain that triggers vomiting.
  • Sedation and relaxation: It is used to help patients feel calm and relaxed before or after surgery, or during childbirth, by reducing anxiety and producing a sleepy effect.
  • Motion sickness: It helps prevent and treat motion sickness by calming the inner ear mechanisms that control balance.

Key Benefits

Phenergan Injection 2 ml provides fast and effective relief from severe nausea, vomiting, allergic reactions, and other conditions requiring rapid treatment through injectable administration. By delivering the medicine directly into the bloodstream or muscle, it helps control symptoms quickly and supports a smoother recovery.

  • Provides Rapid Symptom Relief: Because this medicine is administered by injection, it begins working quickly to relieve severe nausea, vomiting, allergic itching, and other distressing symptoms, especially when oral medicines are not suitable.
  • Supports Comfort During Medical Procedures: This medicine helps reduce anxiety before surgery and supports a smoother anaesthesia process, promoting greater comfort during and after medical procedures.
  • Prevents Dehydration and Aids Recovery: By effectively controlling nausea and vomiting, this medicine helps patients retain fluids, reduces the risk of dehydration, and supports a faster and more comfortable recovery after surgery or illness.

Directions for Use

  • Phenergan Injection 2 ml is given by a healthcare professional in a hospital or clinic. It is usually injected into a vein (IV) or muscle (IM). The healthcare provider will decide the correct dose and administer it slowly to avoid side effects.
  • Do not self-administer.
  • Your doctor will administer a few doses of this medication until your condition improves, at which point you will be switched to an oral medication that functions similarly.

How Phenergan Injection 2 ml Works

Phenergan Injection 2 ml contains promethazine, which helps to look at how certain chemicals behave in your body. When you have an allergic reaction or feel nauseous, your body releases specific chemicals, such as histamine and acetylcholine. This medicine works by blocking the action of these natural chemicals. By blocking histamine, it stops allergic symptoms like swelling, redness, and itching. At the same time, its ability to interfere with acetylcholine helps block signals to the vomiting centre in your brain and calms the parts of your brain responsible for wakefulness. This dual action is what makes it so effective at both stopping nausea and helping you feel calm and sleepy.
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Alcohol

Unsafe

Avoid consumption of alcohol while using Phenergan Injection 2 ml as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before receiving Phenergan Injection 2 ml. It is not recommended for use during the last two weeks before delivery as it may cause excitement and irritability in the newborn baby.

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Breast Feeding

Caution

The amount of Promethazine excreted in breast milk is unknown. Phenergan Injection 2 ml should be used with caution in breastfeeding mothers. Hence, if you are a nursing mother, inform your doctor before receiving Phenergan Injection 2 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Phenergan Injection 2 ml may cause drowsiness or affect concentration in some people. Therefore, avoid driving if you experience any side effects that impair your physical or mental abilities after receiving Phenergan Injection 2 ml.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Phenergan Injection 2 ml. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Phenergan Injection 2 ml. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Phenergan Injection 2 ml is not recommended for children below two years due to the risk of fatal respiratory depression. Phenergan Injection 2 ml should be avoided in dehydrated or acutely ill children. Also, it is not recommended for adolescents and children with signs and symptoms of Reye’s syndrome.

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Heart

Consult your doctor

Inform your doctor before receiving Phenergan Injection 2 ml if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Phenergan Injection 2 ml should be used with caution in elderly patients. Therefore, please consult your doctor before use.

What if I have taken an overdose of Phenergan Injection 2 ml

In case of an accidental overdose, seek immediate medical attention. Symptoms of an overdose may include extreme drowsiness, severe dizziness, dry mouth, flushed skin, large pupils, slow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Stay hydrated: If you are receiving this medicine for nausea and vomiting, sip small amounts of clear fluids (like water or broth) once you are able to keep liquids down to prevent dehydration.
  • Avoid alcohol: Do not drink alcohol while being treated with this medicine, as it can dangerously increase drowsiness and slow your breathing.
  • Stand up slowly: Since this medicine can cause dizziness and a drop in blood pressure, take your time when moving from a lying or sitting position to standing.
  • Manage dry mouth: Chew sugarless gum, suck on ice chips, or drink water frequently to help relieve dry mouth symptoms.
  • Avoid driving: Do not drive, operate heavy machinery, or perform tasks requiring mental alertness until you know how this medicine affects you.
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How Soon It Starts Working

The time required for Phenergan Injection 2 ml to start to work: Phenergan Injection 2 ml can show its effects within 3 to 5 minutes for IV and 20 minutes for IM administration. The time for which the effects of Phenergan Injection 2 ml last: Phenergan Injection 2 ml effect lasts for about 12 hours.

What if you forget to take Phenergan Injection 2 ml

Since this medicine is often given in a hospital or clinic as needed, you are unlikely to miss a dose. If you are on a regular injection schedule at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not double the dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store the injection at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).•Keep the medicine in its original carton or packaging to protect it from light.

Drug Warnings

  • Check the solution: Before injecting, always inspect the liquid. It should be clear and colourless to pale yellow. Do not use it if it is cloudy, discoloured, or contains visible particles.
  • Monitor the injection site: Pay close attention to where the medicine was injected. If you feel burning, extreme pain, or notice redness, blistering, or dark skin changes, tell a healthcare professional immediately.
  • Rotate injection sites: If you receive multiple intramuscular injections, rotate the injection site each time to help prevent muscle damage or irritation.
  • Practice needle safety: Always use sterile needles and syringes for each injection. Dispose of them immediately in a puncture-proof 'sharps' container; never reuse needles.
  • Watch for breathing issues: Monitor for slow or shallow breathing, especially when this medicine is given to children over the age of two or the elderly.

Drug-Drug Interactions

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  • Central nervous system depressants: Combining this medicine with sleeping pills, anxiety medications, muscle relaxants, or narcotic pain relievers can lead to severe sleepiness, shallow breathing, and dangerous drops in blood pressure.
  • Anticholinergic medications: Taking this with other drugs that cause dryness (like certain allergy or bladder control medicines) may increase the risk of dry mouth, blurred vision, heat stroke, and constipation.
  • Monoamine oxidase inhibitors (MAOIs): Avoid using this medicine with or within 14 days of taking MAOIs (used for depression), as this can cause severe side effects, including sudden high blood pressure.
PromethazineHalofantrine
Critical

Drug-Drug Interactions

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How does the drug interact with Phenergan Injection 2 ml:
Co-administration of Phenergan Injection 2 ml with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Ziprasidone together can possibly result in an interaction, they can be taken if a doctor has advised it. However, consult a doctor immediately if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
PromethazineHalofantrine
Critical
How does the drug interact with Phenergan Injection 2 ml:
Using Halofantrine together with Phenergan Injection 2 ml may raise the chance of an irregular heart rhythm.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Halofantrine is not recommended, please consult your doctor before taking it. They can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
PromethazineMesoridazine
Critical
How does the drug interact with Phenergan Injection 2 ml:
Using Mesoridazine together with Phenergan Injection 2 ml may raise the chance of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Phenergan Injection 2 ml is not recommended, please consult your doctor before taking it. They can be taken if your doctor prescribes them. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Phenergan Injection 2 ml:
Taking Phenergan Injection 2 ml with Thioridazine can increases the risk and severity of side effects such as extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, seizure (fits).

How to manage the interaction:
Taking Phenergan Injection 2 ml with Thioridazine is not recommended. Please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs, fever, muscle rigidity, irregular pulse, or fast or irregular heartbeats. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Phenergan Injection 2 ml:
Coadministration of Phenergan Injection 2 ml and dronedarone can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Phenergan Injection 2 ml:
When Ropinirole is taken with Phenergan Injection 2 ml, it may reduce the effectiveness of ropinirole.

How to manage the interaction:
Taking Ropinirole with Phenergan Injection 2 ml is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, dizziness, and lightheadedness. Do not stop using any medications without consulting a doctor.
How does the drug interact with Phenergan Injection 2 ml:
Phenergan Injection 2 ml can increase the blood levels of Cisapride, which increases the risk of side effects.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Cisapride is not recommended. Please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PromethazineSaquinavir
Critical
How does the drug interact with Phenergan Injection 2 ml:
Phenergan Injection 2 ml can make Saquinavir more potent and increase the risk of side effects.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Saquinavir is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Phenergan Injection 2 ml:
Coadministration of Metoclopramide with Phenergan Injection 2 ml can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Metoclopramide is generally avoided as it can possibly result in an interaction. They can be taken together However, consult a doctor if you experience puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Phenergan Injection 2 ml:
Taking Phenergan Injection 2 ml with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Phenergan Injection 2 ml with Potassium chloride is not recommended, as it can lead to an interaction, they can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately.

Drug-Food Interactions

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  • Alcohol: Avoid alcohol entirely. Combining alcohol with this medicine can cause severe drowsiness, dizziness, and life-threatening breathing problems.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[ANTIHISTAMINE]

FAQs

Phenergan Injection 2 ml is used to treat Allergic symptoms, nausea and vomiting.
Phenergan Injection 2 ml contains Promethazine, an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.
Yes, Phenergan Injection 2 ml may be used to prevent nausea and vomiting after surgery. Phenergan Injection 2 ml blocks histamine from binding to its receptors in the vomiting centre located in the brain and prevents nausea and vomiting.
Phenergan Injection 2 ml may interact with diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG and may increase glucose intolerance. Therefore, inform your doctor that you are on treatment with Phenergan Injection 2 ml before undergoing any tests.
In most cases, Phenergan Injection 2 ml is given by a healthcare professional in a clinic or hospital. If your doctor prescribes it for home use, they will provide detailed training on how to prepare and inject it safely. Do not attempt to inject it yourself unless you are fully trained. Talk to your doctor for guidance.
Injecting this medicine under the skin (subcutaneously) can cause severe tissue irritation, chemical damage, and even tissue death (gangrene). It must only be injected deep into a large muscle or given slowly into a vein. Talk to your doctor or nurse if you feel any pain during the injection.
This medicine should only be used during pregnancy if the potential benefits outweigh the risks to the unborn baby. It is sometimes used during labour to help with relaxation and nausea, but using it close to delivery can affect the newborn's breathing. Talk to your doctor about safe alternatives.
Yes, drowsiness is one of the most common effects of this medicine. It is often used specifically for its calming and sedative properties before or after medical procedures. Avoid driving or operating machinery after receiving this injection. Talk to your doctor if you are concerned about sleepiness.
Do not give this medicine to children under two years of age because it can cause severe, life-threatening breathing difficulties. For children over two, it must be used with extreme caution and only under a doctor's close supervision. Talk to your doctor to understand the risks.
While there is no direct, dangerous interaction, caffeine is a stimulant that can interfere with the sedative and calming effects of this medicine. If you are taking it to rest or recover, it is best to avoid caffeine. Talk to your doctor or pharmacist for personalised advice.
Some mild soreness at the injection site can occur. However, if you experience severe pain, burning, redness, warmth, or swelling, contact your healthcare provider immediately, as this could indicate tissue damage or infection. Talk to your doctor for proper evaluation.

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Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - PHE0003
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