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  3. Renargan 25 mg Injection 2 ml

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Renargan 25 mg Injection 2 ml, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Renargan 25 mg Injection 2 ml is used to manage and treat allergic conditions, nausea and vomiting, motion sickness, and sedation. It contains Promethazine, which blocks the effects of histamine in your brain and reduces symptoms. Common side effects of Renargan 25 mg Injection 2 ml are drowsiness, dizziness, tiredness, incoordination, lack of energy, increased blood pressure or occasional low blood pressure.

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Composition :

PROMETHAZINE-25MG

Manufacturer/Marketer :

Regaine Laboratories

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Renargan 25 mg Injection 2 ml

Renargan 25 mg Injection 2 ml belongs to the class of drugs called antihistamines used to prevent or treat symptoms of allergic conditions such as hay fever (seasonal allergies), allergic skin reactions such as itching or hives (itchy, raised bumps on the skin), allergic conjunctivitis (redness and irritation in the membrane that covers the eye) and other types of allergy. Also, it is used to prevent and treat nausea and vomiting after surgery due to certain types of anaesthesia and motion sickness. Additionally, Renargan 25 mg Injection 2 ml is used for postoperative, preoperative, and obstetric (during labour) sedation. An allergy occurs when foreign elements, known as allergens, attack and invade our body, thereby causing the release of histamine (a chemical messenger) that causes swelling, inflammation, redness, itchiness, and watery nose and eyes.

Renargan 25 mg Injection 2 ml contains Promethazine, an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Also, it blocks the histamine receptors in the vomiting centre in the brain and prevents nausea and vomiting. Additionally, Promethazine possesses sedative effects and helps you feel relaxed before and after surgery. 

Renargan 25 mg Injection 2 ml will be administered by a healthcare professional; do not self-administer. Renargan 25 mg Injection 2 ml may cause common side effects such as drowsiness, dizziness, tiredness, incoordination, lack of energy, increased blood pressure or occasional low blood pressure. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Promethazine or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, inform your doctor before receiving Renargan 25 mg Injection 2 ml. Renargan 25 mg Injection 2 ml is not recommended for use in children below two years of age and in dehydrated children. Avoid alcohol consumption while receiving Renargan 25 mg Injection 2 ml as it may increase drowsiness and decrease mental alertness. Avoid driving if you experience any side effects that impair your physical or mental abilities after receiving Renargan 25 mg Injection 2 ml. 

Uses of Renargan 25 mg Injection 2 ml

Renargan 25 mg Injection 2 ml is used in the treatment of Allergic symptoms, nausea, and vomiting. The detailed uses of Renargan 25 mg Injection 2 ml are as follows:<br/>• Allergic Reactions: Renargan 25 mg Injection 2 ml treats allergic reactions to blood or plasma, reducing symptoms like itching, redness, and swelling, as well as other uncomplicated allergic conditions when oral therapy is impossible or contraindicated.<br/>• Anaphylaxis Adjunct: Renargan 25 mg Injection 2 ml serves as an adjunct to epinephrine in anaphylaxis after acute symptoms are controlled.<br/>• Sedation and Pain Management: Renargan 25 mg Injection 2 ml induces sedation for preoperative, postoperative, and obstetric care, and enhances pain control when used with analgesics.<br/>• Motion Sickness: Renargan 25 mg Injection 2 ml alleviates motion sickness.<br/>• Nausea and Vomiting: Renargan 25 mg Injection 2 ml prevents and controls nausea and vomiting associated with anesthesia and surgery.<br/>

Directions for Use

• Renargan 25 mg Injection 2 ml is given by a healthcare professional in a hospital or clinic. It is usually injected into a vein (IV) or muscle (IM). The healthcare provider will decide the correct dose and administer it slowly to avoid side effects.• Do not self-administer. • Your doctor will administer a few doses of this medication until your condition improves, at which point you will be switched to an oral medication that functions similarly.

Medicinal Benefits

Renargan 25 mg Injection 2 ml contains Promethazine, an antihistamine (anti-allergic drug) used to prevent or treat symptoms of allergic conditions such as hay fever (seasonal allergies), allergic skin reactions such as itching or hives (itchy, raised bumps on the skin), allergic conjunctivitis (redness and irritation in the membrane covering the eye) and other types of allergy. It blocks the action of histamine, a substance responsible for causing allergic reactions. Therefore, it helps relieve symptoms of allergy. Also, it blocks the histamine receptors in the vomiting centre in the brain and prevents nausea and vomiting after surgery due to certain types of anaesthesia and motion sickness. Additionally, Promethazine possesses sedative effects and helps you feel relaxed before and after surgery. Thus, it is used in postoperative, preoperative and obstetric (during labour) sedation. Renargan 25 mg Injection 2 ml may be used to treat a symptom of Parkinson’s disease known as oculogyric crises (uncontrolled rolling of eyeballs).

How Renargan 25 mg Injection 2 ml Works

Renargan 25 mg Injection 2 ml contains Promethazine, an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Also, it blocks the histamine receptors in the vomiting centre in the brain and prevents nausea and vomiting. Additionally, Promethazine possesses sedative effects and helps you feel relaxed before and after surgery.

Storage

• Store in a cool and dry place away from sunlight.• Keep Renargan 25 mg Injection 2 ml out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Renargan 25 mg Injection 2 ml

As Renargan 25 mg Injection 2 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Renargan 25 mg Injection 2 ml may cause dilated pupils, fainting, overactive reflexes, loss of coordination, severe drowsiness or weakness, seizure (convulsions), and weak or shallow breathing.

Drug Warnings

If you are known to be allergic to Promethazine or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before receiving Renargan 25 mg Injection 2 ml. Renargan 25 mg Injection 2 ml is not recommended for children below two years of age and in dehydrated children. Avoid alcohol consumption while receiving Renargan 25 mg Injection 2 ml as it may increase drowsiness and decrease mental alertness. Avoid driving if you experience any side effects that impair your physical or mental abilities after receiving Renargan 25 mg Injection 2 ml. You may be advised to postpone skin allergy tests as Renargan 25 mg Injection 2 ml may suppress the reaction to the test allergens. Renargan 25 mg Injection 2 ml may give false positive or false negative results on pregnancy tests. Also, it may interact with blood sugar tests and not yield accurate results. Therefore, before undergoing any tests, please inform your doctor or lab technician that you are on treatment with Renargan 25 mg Injection 2 ml.

Diet & Lifestyle Advise

Allergies:

  • Regularly wash your hands with soap and water to prevent the spread of germs.
  • Eat plenty of foods rich in good bacteria, like yoghurt, to improve overall health.
  • Drink plenty of fluids to avoid dehydration.
  • Gargle with salt water for relief from sore throat.
  • Avoid consumption of alcohol with Renargan 25 mg Injection 2 ml as it may cause tiredness, drowsiness or lack of concentration.

Nausea and vomiting:

  • Eat a healthy low-fat diet, especially in small portions, as it will be easy to digest. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Drink any other liquid at least 30 minutes after eating food. 
  • If the smell of the food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

Yes

Therapeutic Class

ANTIHISTAMINE

Renargan 25 mg Injection 2 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while using Renargan 25 mg Injection 2 ml as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before receiving Renargan 25 mg Injection 2 ml. It is not recommended for use during the last two weeks before delivery as it may cause excitement and irritability in the newborn baby.

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Breast Feeding

Caution

The amount of Promethazine excreted in breast milk is unknown. Renargan 25 mg Injection 2 ml should be used with caution in breastfeeding mothers. Hence, if you are a nursing mother, inform your doctor before receiving Renargan 25 mg Injection 2 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Renargan 25 mg Injection 2 ml may cause drowsiness or affect concentration in some people. Therefore, avoid driving if you experience any side effects that impair your physical or mental abilities after receiving Renargan 25 mg Injection 2 ml.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Renargan 25 mg Injection 2 ml. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Renargan 25 mg Injection 2 ml. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Renargan 25 mg Injection 2 ml is not recommended for children below two years due to the risk of fatal respiratory depression. Renargan 25 mg Injection 2 ml should be avoided in dehydrated or acutely ill children. Also, it is not recommended for adolescents and children with signs and symptoms of Reye’s syndrome.

Have a query?

FAQs

Renargan 25 mg Injection 2 ml is used to treat Allergic symptoms, nausea and vomiting.

Renargan 25 mg Injection 2 ml contains Promethazine, an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

Yes, Renargan 25 mg Injection 2 ml may be used to prevent nausea and vomiting after surgery. Renargan 25 mg Injection 2 ml blocks histamine from binding to its receptors in the vomiting centre located in the brain and prevents nausea and vomiting.

Renargan 25 mg Injection 2 ml may interact with diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG and may increase glucose intolerance. Therefore, inform your doctor that you are on treatment with Renargan 25 mg Injection 2 ml before undergoing any tests.

Country of origin

India
Other Info - REN0318

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:21 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medsafe.govt.nz/profs/datasheet/d/dblpromethazinehydrochlorideinj.pdf
  2. https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2022/05/Promethazine-HCl-Approved-PIL-22-Apr-2022.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/040454_s006_promethazine_hydrochloride_injection.pdf

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