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  3. Fosapine 150mg Injection

Fosapine 150mg Injection, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Fosapine 150mg Injection is used to manage Chemotherapy-induced nausea and vomiting. It contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

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Composition :

APREPITANT-150MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Fosapine 150mg Injection

Fosapine 150mg Injection belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in patients six months of age and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Fosapine 150mg Injection contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking neurokinin-1 receptors (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Fosapine 150mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Fosapine 150mg Injection may cause common side effects such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen. 

If you are allergic to Fosapine 150mg Injection or any other medicines, please tell your doctor. Fosapine 150mg Injection is not recommended for children below six months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Fosapine 150mg Injection. Drive only if you are alert after receiving Fosapine 150mg Injection. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Fosapine 150mg Injection. 

Uses of Fosapine 150mg Injection

Fosapine 150mg Injection is used in the prevention of nausea and vomiting caused by cancer chemotherapy. The detailed uses of Fosapine 150mg Injection are as follows:<br/>• Chemotherapy-induced nausea and vomiting (CINV): Fosapine 150mg Injection helps prevent both acute and delayed nausea and vomiting associated with cancer chemotherapy.<br/>• Supportive care in cancer treatment: Fosapine 150mg Injection is commonly used as part of antiemetic regimens to improve patient comfort and treatment adherence during chemotherapy.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Fosapine 150mg Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Fosapine 150mg Injection contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

How Fosapine 150mg Injection Works

Fosapine 150mg Injection contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking neurokinin-1 receptors (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting.

Storage

• Store in a cool and dry place away from sunlight.• Keep Fosapine 150mg Injection out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Fosapine 150mg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Tell your doctor about any pain or discomfort at the infusion site.
  • Apply a warm compress to reduce swelling and ease pain.
  • Switch infusion sites to avoid irritating the same spot.
  • Practice calming techniques like deep breathing, meditation, or yoga to manage pain and anxiety.

What if I have taken an overdose of Fosapine 150mg Injection

Since Fosapine 150mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Fosapine 150mg Injection or any other medicines, please tell your doctor. Fosapine 150mg Injection is not recommended for children below 6 months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Fosapine 150mg Injection. Drive only if you are alert after receiving Fosapine 150mg Injection. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Fosapine 150mg Injection. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Fosapine 150mg Injection to check your blood clotting.

Drug-Drug Interactions

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AprepitantAstemizole
Critical
AprepitantCisapride
Critical

Drug-Drug Interactions

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AprepitantAstemizole
Critical
How does the drug interact with Fosapine 150mg Injection:
Co-administration with Fosapine 150mg Injection and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Fosapine 150mg Injection and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantCisapride
Critical
How does the drug interact with Fosapine 150mg Injection:
Co-administration with Fosapine 150mg Injection and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Fosapine 150mg Injection and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Fosapine 150mg Injection:
Fosapine 150mg Injection combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Fosapine 150mg Injection and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Fosapine 150mg Injection:
Using pimozide together with Fosapine 150mg Injection may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosapine 150mg Injection and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Fosapine 150mg Injection:
Using flibanserin together with Fosapine 150mg Injection can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Fosapine 150mg Injection together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Fosapine 150mg Injection:
Lomitapide blood levels can be significantly increased by combining it with Fosapine 150mg Injection.

How to manage the interaction:
Although using Lomitapide and Fosapine 150mg Injection together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Fosapine 150mg Injection:
Co-administration with Fosapine 150mg Injection and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Fosapine 150mg Injection and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantLurasidone
Severe
How does the drug interact with Fosapine 150mg Injection:
Using Lurasidone together with Fosapine 150mg Injection may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Fosapine 150mg Injection may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantIvabradine
Severe
How does the drug interact with Fosapine 150mg Injection:
Co-administartion of Fosapine 150mg Injection and Ivabradine may significantly increase the blood levels of Ivabradine which can result in excessive slowing of heart rate or other side effects.

How to manage the interaction:
Although there is an interaction between Fosapine 150mg Injection and Ivabradine, it can be taken if prescribed by a doctor. If you have dizziness, tiredness, low blood pressure, heart palpitations, chest pain, or worsening shortness of breath, you should see a doctor. Without consulting a doctor, never stop taking medicines.
AprepitantIvacaftor
Severe
How does the drug interact with Fosapine 150mg Injection:
Ivacaftor blood levels may be significantly raised by Fosapine 150mg Injection, which may also enhance the possibility of adverse effects such liver damage.

How to manage the interaction:
Even though there is an interaction between Fosapine 150mg Injection and Ivacaftor, it is still possible to take it if a doctor prescribes it. In case you happen to have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, pale stools, or yellowing of the skin or eyes, get medical attention. Without consulting a doctor, never stop taking medicines.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Fosapine 150mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of alcohol with Fosapine 150mg Injection is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Fosapine 150mg Injection. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Fosapine 150mg Injection.

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Driving

Caution

Drive only if you are alert after receiving Fosapine 150mg Injection.

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Liver

Caution

If you have liver disease, inform your doctor before taking Fosapine 150mg Injection.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before taking Fosapine 150mg Injection.

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Children

Caution

Fosapine 150mg Injection is not recommended for children below six months of age as the safety and effectiveness are unknown.

Have a query?

FAQs

Fosapine 150mg Injection is used to treat Chemotherapy-induced nausea and vomiting.

Fosapine 150mg Injection works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines.

Fosapine 150mg Injection may cause weakness as a common side effect. However, if the weakness persists or worsens, consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Fosapine 150mg Injection. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Fosapine 150mg Injection and for up to 1 month after using Fosapine 150mg Injection.

Yes, Fosapine 150mg Injection is an anti-emetic drug, that helps to treat nausea and vomiting which may occur after receiving cancer chemotherapy treatment.

Fosapine 150mg Injection rarely causes serious side effects, which may include allergic reactions, breathing difficulties, and severe stomach pain in some individuals.

Fosapine 150mg Injection does not reduce the effectiveness of all types of contraceptives. It may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, and injections). It is advised to use another method of contraception (like condoms, diaphragm) to prevent pregnancy while taking Fosapine 150mg Injection. Talk to your doctor about other ways to prevent pregnancy while taking this medication.

Fosapine 150mg Injection is given before chemotherapy treatment to prevent nausea and vomiting caused by chemotherapy treatment.

Yes, there are some dietary restrictions while taking Fosapine 150mg Injection. It is recommended to avoid alcohol, heavy meals, and fatty foods. Instead, you should follow a healthy, low-fat diet that includes fruits, vegetables, lean meats, and whole grains.

During chemotherapy, avoid raw/undercooked foods, processed (packaged) foods, fried foods, unpasteurized dairy, sugar, probiotics, alcohol, smoking, excessive UV exposure, and new medications/supplements.

Fosapine 150mg Injection may cause common side effects in some individuals such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen.

Country of origin

India
Other Info - FO10751

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:05 AM IST

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Reference

  1. https://www.merck.com/product/usa/pi_circulars/e/emend_iv/emend_iv_ppi.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209296s003lbl.pdf
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