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compositionComposition:APREPITANT-150MG
prescription
Prescription Medicine
info
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Apriset Iv Inj is used to manage Chemotherapy-induced nausea and vomiting. It contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

APREPITANT-150MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Apriset Iv Inj

Apriset Iv Inj is the parenteral (injectable) form of aprepitant, a prescription anti-nausea medicine used to prevent nausea and vomiting associated with certain chemotherapy treatments or surgery. It works by blocking a natural chemical involved in triggering nausea and vomiting. When used with chemotherapy, it is usually given as part of a treatment plan that includes other anti-nausea medicines.

Apriset Iv Inj is given into a vein by a trained healthcare professional in a clinic or hospital. The dose and treatment schedule depend on why you are receiving it and the other medicines included in your treatment plan. Because it is given directly into a vein, you do not need to take it with food.

Common side effects may include tiredness, headache, constipation, diarrhoea, or reactions at the injection site. Serious allergic reactions can also occur. Consult your doctor right away if you develop difficulty breathing, swelling of the face, lips, tongue, or throat, hives, severe dizziness, or fainting during or after treatment.

Before receiving Apriset Iv Inj, tell your doctor if you have liver problems, particularly severe liver impairment, or if you have previously had an allergic reaction to aprepitant or any ingredient in the formulation. Kidney impairment generally does not require a dose adjustment, but your doctor should still know about any kidney problems and other health conditions before planning your treatment.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, and supplements you take, as aprepitant can interact with several medicines. Also tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if the medicine is intended for a child. In children, suitability and dosing depend on factors such as age, body weight, reason for treatment, and the specific parenteral formulation.

Uses of Apriset Iv Inj

Your doctor may prescribe Apriset Iv Inj to help manage the following conditions:

  • Chemotherapy-induced nausea and vomiting: It may be used with other anti-nausea medicines to help prevent nausea and vomiting caused by certain chemotherapy treatments.
  • Postoperative nausea and vomiting: It may be used to help prevent nausea and vomiting associated with surgery and anaesthesia when considered appropriate by your doctor.
     

Key Benefits

When used as prescribed, Apriset Iv Inj may provide the following benefits:

  • Helps you stay more comfortable during treatment: Preventing nausea and vomiting can make chemotherapy or recovery from surgery easier to tolerate.
  • Helps you maintain food and fluid intake: Better control of nausea and vomiting may make it easier to eat and drink as tolerated, helping reduce problems related to poor intake.
  • Provides protection against delayed vomiting after chemotherapy: When used as part of an appropriate anti-nausea regimen, it can help control vomiting that may occur after the day chemotherapy is given.
  • Supports recovery after surgery: Preventing postoperative nausea and vomiting can reduce discomfort and make the period after anaesthesia more manageable.
Side effects of Apriset Iv Inj
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Apriset Iv Inj will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Apriset Iv Inj Works

Apriset Iv Inj contains aprepitant, an antiemetic medicine that belongs to a group called neurokinin-1 (NK1) receptor antagonists. A natural chemical in the body (called substance P) activates NK1 receptors in areas of the brain involved in nausea and vomiting. Aprepitant blocks these receptors and prevents substance P from activating them. By blocking this pathway, aprepitant helps prevent signals that contribute to nausea and vomiting. During chemotherapy, it is usually combined with other anti-nausea medicines that act through different pathways to provide broader protection.
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Alcohol

Consult your doctor

The interaction of alcohol with Apriset Iv Inj is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Apriset Iv Inj. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Apriset Iv Inj.

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Driving

Caution

Drive only if you are alert after receiving Apriset Iv Inj.

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Liver

Caution

If you have liver disease, inform your doctor before taking Apriset Iv Inj.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before taking Apriset Iv Inj.

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Children

Caution

Apriset Iv Inj is not recommended for children below six months of age as the safety and effectiveness are unknown.

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Heart

Consult your doctor

Please consult your doctor before receiving Apriset Iv Inj if you have pre-existing heart problems. Your doctor will prescribe Apriset Iv Inj if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Apriset Iv Inj is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Apriset Iv Inj

Because this medicine is prepared and given by trained medical professionals in a controlled environment, an overdose is highly improbable. If you suspect an error has occurred or you experience severe side effects during or after the injection, notify the medical staff right away.

Diet & Lifestyle Advise

  • Eat smaller meals: Small, frequent meals may be easier to tolerate than large meals when you are prone to nausea.
  • Choose foods you tolerate well: Bland or lightly prepared foods may be easier to eat when your stomach feels unsettled. Avoid foods or smells that make your nausea worse.
  • Stay hydrated: Take regular sips of water or other suitable fluids throughout the day, particularly if chemotherapy or surgery affects your appetite or fluid intake.
  • Eat slowly: Take your time with meals and avoid lying down immediately after eating if this makes nausea or indigestion worse.
  • Follow your treatment team's dietary advice: Chemotherapy, surgery, or other health conditions may affect your nutritional needs, so follow any individual recommendations provided by your healthcare team.
health query

Have a query?

How Soon It Starts Working

The time required for Apriset Iv Inj to start to work: Apriset Iv Inj ideally shows its action within 5 minutes after administration. The time for which the effects of Apriset Iv Inj last: The effect of Apriset Iv Inj lasts for 40 hours.

What if you forget to take Apriset Iv Inj

Since this medicine is given by a healthcare professional in a clinic, it is unlikely that you will miss a dose. However, if you miss an appointment for your injection, contact your doctor or clinic immediately to reschedule.

Storage

• Store unopened vials of Apriset Iv Inj in a refrigerator between 2°C and 8°C.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Remember that Apriset Iv Inj prevents nausea and vomiting: It is generally given before chemotherapy or surgery rather than used to treat nausea or vomiting that has already started.
  • Tell your doctor about all your medicines: Aprepitant can interact with several prescription and over-the-counter medicines. Keep your healthcare team informed about everything you take.
  • Use additional contraceptive protection when advised: Aprepitant can reduce the effectiveness of hormonal contraceptives. Follow your doctor's advice about using an effective non-hormonal or additional method of contraception for the recommended period after treatment.
  • Watch for allergic reactions: Consult your doctor right away if you develop hives, swelling of the face or throat, difficulty breathing, severe dizziness, or other signs of a serious allergic reaction.
  • Keep all treatment appointments: Apriset Iv Inj is often one part of a planned anti-nausea regimen. Receiving it and your other prescribed medicines at the recommended times is important for effective prevention.
  • Severe liver problems: Tell your doctor before receiving Apriset Iv Inj if you have severe liver disease or severely reduced liver function. Aprepitant has not been well studied in people with severe liver impairment, so your doctor will determine whether it is appropriate for you. 

Drug-Drug Interactions

verifiedApollotooltip
  • Pimozide: Do not use pimozide with Apriset Iv Inj, as the combination can cause serious heart rhythm problems.
  • Warfarin: Apriset Iv Inj may change the blood-thinning effect of warfarin. Your doctor may monitor your blood clotting more closely.
  • Certain sedatives (e.g. midazolam, triazolam, or alprazolam): Apriset Iv Inj may increase their effects and cause more drowsiness or other side effects.
  • Certain antibiotics, antifungals, HIV medicines, and seizure medicines (e.g. clarithromycin, ketoconazole, ritonavir, rifampicin, carbamazepine, or phenytoin): These medicines may change how much aprepitant is in your body, which can increase side effects or make Apriset Iv Inj less effective.
  • Hormonal contraceptives: Apriset Iv Inj may make hormonal contraceptives less effective. Your doctor may recommend an additional or alternative non-hormonal method of contraception.
AprepitantCisapride
Critical
AprepitantFlibanserin
Critical

Drug-Drug Interactions

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AprepitantCisapride
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Apriset Iv Inj and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Apriset Iv Inj:
Using flibanserin together with Apriset Iv Inj can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Apriset Iv Inj together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Apriset Iv Inj:
Apriset Iv Inj combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Apriset Iv Inj and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Apriset Iv Inj and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Apriset Iv Inj:
Lomitapide blood levels can be significantly increased by combining it with Apriset Iv Inj.

How to manage the interaction:
Although using Lomitapide and Apriset Iv Inj together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Apriset Iv Inj:
Using pimozide together with Apriset Iv Inj may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Apriset Iv Inj and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Apriset Iv Inj and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantBromocriptine
Severe
How does the drug interact with Apriset Iv Inj:
When used with bromocriptine, Apriset Iv Inj may raise blood levels of bromocriptine.

How to manage the interaction:
Although co-administration of Apriset Iv Inj and bromocriptine may result in an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any of the following symptoms: nausea, headache, dizziness, drowsiness, lightheadedness, or compulsive behaviors (e.g., gambling or sexual urges; uncontrolled spending). Do not discontinue any medications without consulting a doctor.
AprepitantAcalabrutinib
Severe
How does the drug interact with Apriset Iv Inj:
Coadministration of Apriset Iv Inj can significantly increase the blood levels of Acalabrutinib.

How to manage the interaction:
Although there is an interaction between Apriset Iv Inj and acalabrutinib, it can be taken if prescribed by a doctor. A doctor should be consulted if you experience any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in the phlegm, red or irritated skin, body sores, and discomfort when urinating. Without consulting a doctor, never stop taking medicines.
AprepitantVenetoclax
Severe
How does the drug interact with Apriset Iv Inj:
Using venetoclax in conjunction with Apriset Iv Inj may drastically increase venetoclax blood levels and effects.

How to manage the interaction:
Although using Venetoclax and Apriset Iv Inj together may cause an interaction, it can be used if advised by a doctor. Consult a doctor if you have any of the following symptoms: nausea, vomiting, diarrhea, weakness, paleness, or unusual bleeding. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Apriset Iv Inj when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Apriset Iv Inj is used to treat Chemotherapy-induced nausea and vomiting.
Apriset Iv Inj works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines.
Yes, Apriset Iv Inj is an anti-emetic drug, that helps to treat nausea and vomiting which may occur after receiving cancer chemotherapy treatment.
Apriset Iv Inj rarely causes serious side effects, which may include allergic reactions, breathing difficulties, and severe stomach pain in some individuals.
Apriset Iv Inj does not reduce the effectiveness of all types of contraceptives. It may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, and injections). It is advised to use another method of contraception (like condoms, diaphragm) to prevent pregnancy while taking Apriset Iv Inj. Talk to your doctor about other ways to prevent pregnancy while taking this medication.
Apriset Iv Inj is given before chemotherapy treatment to prevent nausea and vomiting caused by chemotherapy treatment.
Yes, there are some dietary restrictions while taking Apriset Iv Inj. It is recommended to avoid alcohol, heavy meals, and fatty foods. Instead, you should follow a healthy, low-fat diet that includes fruits, vegetables, lean meats, and whole grains.
During chemotherapy, avoid raw/undercooked foods, processed (packaged) foods, fried foods, unpasteurized dairy, sugar, probiotics, alcohol, smoking, excessive UV exposure, and new medications/supplements.
Apriset Iv Inj may cause common side effects in some individuals such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen.
Apriset Iv Inj is given as an injection or infusion into a vein by a trained healthcare professional in a clinic or hospital. Talk to your doctor if you have questions about your scheduled doses.
The safety of Apriset Iv Inj during pregnancy is not fully established. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the potential benefits against the risks.
Yes, this medicine can make hormonal birth control methods less effective. You should use a reliable barrier method of contraception during your treatment and for 30 days after your dose. Talk to your doctor for advice on suitable birth control options.
It is best to avoid alcohol, as it can worsen side effects like dizziness and sleepiness, and can trigger stomach upset. Talk to your doctor for more specific guidance.
While mild soreness can occur, you must tell your medical team immediately if you feel severe pain, burning, or see swelling at the injection site during or after the infusion. Talk to your doctor if the pain persists after you go home.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - APR0085

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