Tranesma 3% Gel (Tranexamic acid) is typically used for a few weeks to a few months, depending on the severity of your hyperpigmentation and skin tolerance. Most people begin to notice improvement within 8 to 12 weeks of regular application. It should be continued only for the duration advised by your dermatologist, even if you notice early improvement, and should not be used long-term without medical review. If there is no improvement after a few weeks or if any irritation develops, consult your doctor for reassessment and possible adjustment of treatment.