Yes, Systane Hydration PF Eye Drops are preservative-free, making them suitable for frequent use, especially for those with sensitive eyes or who wear contact lenses. Once opened, the drops should be used within 30 days. Always check the packaging for the exact expiry date, and avoid using them if the solution changes in colour or clarity. Stop use and consult an eye doctor if you notice persistent irritation, worsening symptoms, or signs of infection.