Sodium Thiosulphate
About Sodium Thiosulphate
Sodium Thiosulphate is an injection used as a protective medical treatment in emergencies and specific clinical therapies. It is primarily prescribed as an antidote for acute cyanide poisoning and to help prevent permanent hearing loss in patients undergoing certain chemotherapy treatments. In some clinical cases, it is also used to treat rare conditions involving calcium buildup in the blood vessels.
Because this medicine is given as an injection directly into a vein, it is typically given by a healthcare professional in a hospital or clinical setting. Your doctor will determine how often you need this treatment based on your specific medical condition and therapy schedule. Drinking plenty of water is a simple lifestyle change that can support your kidneys as they process the medicine, though no specific food restrictions are required before your injection.
While this medicine is highly effective, some people may experience mild side effects like nausea, vomiting, or a warm, flushed feeling during the injection. These symptoms are usually temporary, but you should alert your healthcare provider immediately if you experience severe dizziness, rapid breathing, or signs of an allergic reaction.
Before starting this medicine, talk to your doctor if you have kidney disease, congestive heart failure, high blood pressure, or a history of swelling and fluid retention. Do not take this if you have had a severe allergic reaction to this medicine or any of its ingredients in the past. Because this medicine contains sodium, your doctor will also assess whether it is suitable if you have significantly high sodium levels in your blood (hypernatraemia), low potassium levels (hypokalaemia), or medical conditions that require careful control of your body's fluid and electrolyte balance.
It is important to discuss all other medications, vitamins, or supplements you are taking with your doctor, as some substances may interact with this injection or stop it from working properly. You should also consult your healthcare provider if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, to ensure this treatment is safe for your specific needs.
Uses of Sodium Thiosulphate
Medicinal Benefits
Sodium Thiosulphate provides critical, targeted benefits that help protect your vital functions and improve your recovery during complex medical treatments.
- Protects your hearing: For patients undergoing chemotherapy, this injection preserves quality of life by safeguarding your ability to hear without interfering with your cancer treatment.
- Lifesaving protection: In emergency situations involving cyanide exposure, it works rapidly to neutralise toxins and protect your organs from severe damage.
- Relieves painful skin wounds: By dissolving calcium deposits in blood vessels, it helps reduce pain, restore healthy circulation, and speed up the healing of serious skin ulcers.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
- Sodium Thiosulphate should be administered by a nurse or doctor to ensure proper dosage, technique, and monitoring for any potential side effects or complications.
- Do not self-administer.
Storage
Side Effects of Sodium Thiosulphate
Common Side Effects (Usually mild):
- Nausea and vomiting
- Headache or mild dizziness
- A warm, flushed feeling or sweating during the injection
- Mild irritation, redness, or swelling at the injection site
Serious Side Effects (Consult your doctor right away):
- Signs of a severe allergic reaction, such as hives, itching, trouble breathing, or swelling of your face, lips, tongue, or throat
- Severe muscle cramping, spasms, or weakness
- Rapid, shallow breathing or extreme drowsiness
- Sudden, severe changes in blood pressure
Medicines Containing this Salt
View AllDrug Warnings
- Inspect the Vial Before Use: Always inspect the liquid inside the vial before it is used. The solution should be completely clear and colourless; do not allow it to be injected if it is cloudy, discoloured, or contains any visible particles.
- Report Injection Site Discomfort Immediately: Tell your doctor or nurse immediately if you feel any burning, stinging, pain, or swelling around the needle or catheter during your infusion.
- Attend All Monitoring Tests: Keep all appointments for your scheduled blood or urine tests. Your doctor may monitor your kidney function, mineral and electrolyte levels (including sodium), and your overall response to treatment to help ensure the medicine remains safe and effective.
- Avoid Driving if You Feel Unwell: Do not drive or operate heavy machinery immediately after your injection if you feel dizzy, lightheaded, or unusually tired.
- Inform All Healthcare Providers About Your Treatment: Inform all your healthcare providers, including your dentist, that you are receiving Sodium Thiosulphate before starting any new treatments or surgeries.
Drug Interactions
- Other intravenous medications: This injection should not be mixed in the same tubing or infusion bag with certain other emergency medications, such as hydroxocobalamin, as they can deactivate each other. Always use separate infusion lines if multiple treatments are needed.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionThe interaction of alcohol with Sodium Thiosulphate is unknown. Please consult a doctor before consuming alcohol with Sodium Thiosulphate.
Pregnancy
cautionSodium Thiosulphate is given to pregnant women only if the doctor thinks the benefits outweigh the risks to the foetus.
Breast Feeding
consult your doctorIt is unknown whether Sodium Thiosulphate passes into breast milk, so consult your doctor before using it while breastfeeding.
Driving
cautionThere is no data available; it is unknown whether Sodium Thiosulphate affects your driving ability.
Liver
cautionSodium Thiosulphate should be used with caution if you have a history of liver diseases/conditions. Your doctor will decide to administer Sodium Thiosulphate if the benefits are greater than the risks.
Kidney
cautionSodium Thiosulphate should be used with caution if you have a history of kidney diseases/conditions. Your doctor will decide to administer Sodium Thiosulphate if the benefits are greater than the risks.
Children
cautionSodium Thiosulphate is given to children in doses advised by a doctor based on the child’s age and weight.
Habit Forming
Diet & Lifestyle Advise
- Stay well-hydrated: Drink plenty of water before and after your infusion, unless your doctor has advised you to limit your fluid intake. This helps your kidneys filter and remove the medicine safely.
- Monitor your sodium intake: Since this injection contains sodium, your doctor may recommend cutting back on salt in your daily diet to prevent fluid retention or high blood pressure.
- Care for your skin: If you are receiving this treatment for painful calcium skin wounds, keep the affected skin clean and dry. Follow your healthcare team's precise wound-care guide to support healing and prevent infections.
- Get plenty of rest: Allow your body time to recover after receiving an infusion, especially if you experience mild side effects like dizziness or fatigue.
Patients Concern
Disease/Condition Glossary
Cyanide poisoning: It is a condition caused by exposure to cyanide, a toxic substance that interferes with the body’s ability to use oxygen. This leads to symptoms such as headache, dizziness, shortness of breath, and confusion, and can progress to unconsciousness or death. Cyanide poisoning can result from inhalation, ingestion, or absorption of cyanide. Immediate treatment with antidotes like sodium nitrite is crucial for survival.
FAQs
Sodium Thiosulphate is used to treat cyanide poisoning and prevent poisoning caused by sodium nitroprusside.
Sodium Thiosulphate contains sodium thiosulphate, which works by helping the body convert cyanide to a less dangerous chemical called thiocyanate.
Sodium Thiosulphate should be stored at temperatures from 20°C to 25°C. Do not freeze. Keep it protected from light and out of reach of children. Sodium Thiosulphate should be disposed of after using it once by following local guidelines or asking your pharmacist how to dispose of unused medicine properly.
Sodium Thiosulphate is safe when used in the dose and duration advised by a doctor. Avoid exceeding the recommended doses of Sodium Thiosulphate.
Sodium Thiosulphate is a parenteral therapy, administered by a healthcare professional. The appropriate dose is carefully determined and given based on individual patient needs. Using more than the recommended dose is not recommended, as it can increase the risk of serious side effects.
It is given as a slow injection directly into a vein (intravenous infusion) by a trained healthcare professional in a hospital or medical clinic. Talk to your doctor for more details about the infusion process.
Generally, this medicine is administered in a controlled clinical environment like a hospital. In some rare cases of long-term therapy, home treatment may be arranged, but only under the strict supervision of a healthcare provider. Talk to your doctor or pharmacist to learn more.
You should tell your doctor if you have a history of kidney problems, heart failure, high blood pressure, fluid retention, or if you are pregnant or breastfeeding. Talk to your doctor to discuss your complete health history before starting treatment.
The most common side effects include nausea, vomiting, headache, dizziness, and a feeling of warmth or flushing during the injection. These are usually mild and temporary. Talk to your doctor or pharmacist if these symptoms persist.
Yes, it can interact with certain other intravenous drugs if they are mixed together in the same line. Always provide your clinical team with a complete list of all medications you are currently taking. Talk to your doctor or pharmacist for a full list of potential interactions.
The safety of this medicine during pregnancy or breastfeeding depends on the clinical situation, especially in life-threatening emergencies. Talk to your doctor or pharmacist to weigh the benefits and potential risks for your specific situation.
