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Thiotroy Injection contains Sodium Thiosulfate, an antidote used to treat cyanide poisoning, works by helping the body convert cyanide to a less dangerous chemical called thiocyanate. You may experience common side effects like headache, disorientation, diarrhoea, increased urge to urinate, dizziness, nausea and vomiting, muscle cramps or joint pain, blurred vision, strange or disturbing thoughts or behaviour, buzzing, hissing, whistling, ringing or another persistent noise in the ears. Before taking Thiotroy Injection, inform your doctor about any allergies or pre-existing medical conditions.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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More about the Product

Manufacturer/Marketer :

Troikaa Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Thiotroy Injection

Thiotroy Injection is an injection used as a protective medical treatment in emergencies and specific clinical therapies. It is primarily prescribed as an antidote for acute cyanide poisoning and to help prevent permanent hearing loss in patients undergoing certain chemotherapy treatments. In some clinical cases, it is also used to treat rare conditions involving calcium buildup in the blood vessels.

Because this medicine is given as an injection directly into a vein, it is typically given by a healthcare professional in a hospital or clinical setting. Your doctor will determine how often you need this treatment based on your specific medical condition and therapy schedule. Drinking plenty of water is a simple lifestyle change that can support your kidneys as they process the medicine, though no specific food restrictions are required before your injection.

While this medicine is highly effective, some people may experience mild side effects like nausea, vomiting, or a warm, flushed feeling during the injection. These symptoms are usually temporary, but you should alert your healthcare provider immediately if you experience severe dizziness, rapid breathing, or signs of an allergic reaction.

Before starting this medicine, talk to your doctor if you have kidney disease, congestive heart failure, high blood pressure, or a history of swelling and fluid retention. Do not take this if you have had a severe allergic reaction to this medicine or any of its ingredients in the past. Because this medicine contains sodium, your doctor will also assess whether it is suitable if you have significantly high sodium levels in your blood (hypernatraemia), low potassium levels (hypokalaemia), or medical conditions that require careful control of your body's fluid and electrolyte balance.

It is important to discuss all other medications, vitamins, or supplements you are taking with your doctor, as some substances may interact with this injection or stop it from working properly. You should also consult your healthcare provider if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, to ensure this treatment is safe for your specific needs.

Uses of Thiotroy Injection

Your doctor may prescribe Thiotroy Injection to help manage the following conditions:

  • Cyanide poisoning: It acts as an emergency antidote that helps your body convert toxic cyanide into a harmless compound that can be safely filtered out by your kidneys and passed in your urine.
  • Hearing loss caused by cisplatin chemotherapy: It helps protect the delicate cells in the inner ear from damage caused by certain chemotherapy drugs, reducing the risk of long-term hearing loss.This use has been studied most extensively and is primarily approved for certain paediatric patients receiving cisplatin chemotherapy. Your doctor will determine whether it is appropriate for your individual situation.
  • Calcium deposits in blood vessels (calciphylaxis): It helps dissolve painful calcium buildups in the blood vessels of people with severe kidney disease, improving blood flow and supporting wound healing. It is usually used as part of a broader treatment plan that may also include specialised wound care, dialysis adjustments, and management of underlying mineral imbalances. 

Key Benefits

Thiotroy Injection provides critical, targeted benefits that help protect your vital functions and improve your recovery during complex medical treatments.

  • Protects your hearing: For patients undergoing chemotherapy, this injection preserves quality of life by safeguarding your ability to hear without interfering with your cancer treatment.
  • Lifesaving protection: In emergency situations involving cyanide exposure, it works rapidly to neutralise toxins and protect your organs from severe damage.
  • Relieves painful skin wounds: By dissolving calcium deposits in blood vessels, it helps reduce pain, restore healthy circulation, and speed up the healing of serious skin ulcers.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Thiotroy Injection should be administered by a nurse or doctor to ensure proper dosage, technique, and monitoring for any potential side effects or complications.
  • Do not self-administer.

How Thiotroy Injection Works

Thiotroy Injection contains sodium thiosulphate, which works by supplying the body with a specific compound that neutralises toxins and unwanted mineral buildups. When used for poisoning, it provides a source of sulfur that helps a natural enzyme in your liver convert toxic cyanide into a safe chemical called thiocyanate, which your kidneys can easily flush out.
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Alcohol

Caution

The interaction of alcohol with Thiotroy Injection is unknown. Please consult a doctor before consuming alcohol with Thiotroy Injection.

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Pregnancy

Caution

Thiotroy Injection is given to pregnant women only if the doctor thinks the benefits outweigh the risks to the foetus.

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Breast Feeding

Consult your doctor

It is unknown whether Thiotroy Injection passes into breast milk, so consult your doctor before using it while breastfeeding.

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Driving

Caution

There is no data available; it is unknown whether Thiotroy Injection affects your driving ability.

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Liver

Caution

Thiotroy Injection should be used with caution if you have a history of liver diseases/conditions. Your doctor will decide to administer Thiotroy Injection if the benefits are greater than the risks.

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Kidney

Caution

Thiotroy Injection should be used with caution if you have a history of kidney diseases/conditions. Your doctor will decide to administer Thiotroy Injection if the benefits are greater than the risks.

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Children

Caution

Thiotroy Injection is given to children in doses advised by a doctor based on the child’s age and weight.

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Heart

Caution

Thiotroy Injection should be used with caution if you have a history of heart diseases/conditions. Your doctor will decide to administer Thiotroy Injection if the benefits are greater than the risks.

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Geriatrics

Caution

Thiotroy Injection should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Thiotroy Injection

Because this medicine is prepared and given by trained medical professionals, an overdose is highly unlikely. In the rare event that an overdose occurs, your clinical team will monitor you closely and provide immediate supportive care. If you suspect an overdose or experience severe side effects after leaving the clinic, seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water before and after your infusion, unless your doctor has advised you to limit your fluid intake. This helps your kidneys filter and remove the medicine safely.
  • Monitor your sodium intake: Since this injection contains sodium, your doctor may recommend cutting back on salt in your daily diet to prevent fluid retention or high blood pressure.
  • Care for your skin: If you are receiving this treatment for painful calcium skin wounds, keep the affected skin clean and dry. Follow your healthcare team's precise wound-care guide to support healing and prevent infections.
  • Get plenty of rest: Allow your body time to recover after receiving an infusion, especially if you experience mild side effects like dizziness or fatigue.
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How Soon It Starts Working

The time required for Thiotroy Injection to start to work: Thiotroy Injection ideally shows its effects within a few minutes of administration. The time for which the effects of Thiotroy Injection last: The effect of Thiotroy Injection usually lasts approximately for a few hours.

What if you forget to take Thiotroy Injection

Since this injection is typically given by a healthcare professional in a medical setting, missing a dose is uncommon. However, if you miss a scheduled appointment for your infusion, contact your doctor or clinic immediately to reschedule your treatment.

Storage

•Keep the medicine in its original packaging to protect it from excessive heat and direct light.

Drug Warnings

  • Inspect the Vial Before Use: Always inspect the liquid inside the vial before it is used. The solution should be completely clear and colourless; do not allow it to be injected if it is cloudy, discoloured, or contains any visible particles.
  • Report Injection Site Discomfort Immediately: Tell your doctor or nurse immediately if you feel any burning, stinging, pain, or swelling around the needle or catheter during your infusion.
  • Attend All Monitoring Tests: Keep all appointments for your scheduled blood or urine tests. Your doctor may monitor your kidney function, mineral and electrolyte levels (including sodium), and your overall response to treatment to help ensure the medicine remains safe and effective.
  • Avoid Driving if You Feel Unwell: Do not drive or operate heavy machinery immediately after your injection if you feel dizzy, lightheaded, or unusually tired.
  • Inform All Healthcare Providers About Your Treatment: Inform all your healthcare providers, including your dentist, that you are receiving Thiotroy Injection before starting any new treatments or surgeries.

Drug-Drug Interactions

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  • Other intravenous medications: This injection should not be mixed in the same tubing or infusion bag with certain other emergency medications, such as hydroxocobalamin, as they can deactivate each other. Always use separate infusion lines if multiple treatments are needed.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Thiotroy Injection when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDOTES]

FAQs

Thiotroy Injection is used to treat cyanide poisoning and prevent poisoning caused by sodium nitroprusside.
Thiotroy Injection contains sodium thiosulphate, which works by helping the body convert cyanide to a less dangerous chemical called thiocyanate.
Thiotroy Injection should be stored at temperatures from 20°C to 25°C. Do not freeze. Keep it protected from light and out of reach of children. Thiotroy Injection should be disposed of after using it once by following local guidelines or asking your pharmacist how to dispose of unused medicine properly.
Thiotroy Injection is safe when used in the dose and duration advised by a doctor. Avoid exceeding the recommended doses of Thiotroy Injection.
Thiotroy Injection is a parenteral therapy, administered by a healthcare professional. The appropriate dose is carefully determined and given based on individual patient needs. Using more than the recommended dose is not recommended, as it can increase the risk of serious side effects.
It is given as a slow injection directly into a vein (intravenous infusion) by a trained healthcare professional in a hospital or medical clinic. Talk to your doctor for more details about the infusion process.
Generally, this medicine is administered in a controlled clinical environment like a hospital. In some rare cases of long-term therapy, home treatment may be arranged, but only under the strict supervision of a healthcare provider. Talk to your doctor or pharmacist to learn more.
You should tell your doctor if you have a history of kidney problems, heart failure, high blood pressure, fluid retention, or if you are pregnant or breastfeeding. Talk to your doctor to discuss your complete health history before starting treatment.
The most common side effects include nausea, vomiting, headache, dizziness, and a feeling of warmth or flushing during the injection. These are usually mild and temporary. Talk to your doctor or pharmacist if these symptoms persist.
Yes, it can interact with certain other intravenous drugs if they are mixed together in the same line. Always provide your clinical team with a complete list of all medications you are currently taking. Talk to your doctor or pharmacist for a full list of potential interactions.
The safety of this medicine during pregnancy or breastfeeding depends on the clinical situation, especially in life-threatening emergencies. Talk to your doctor or pharmacist to weigh the benefits and potential risks for your specific situation.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.
Other Info - THI0422
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