Erythropoietin
About Erythropoietin
Erythropoietin is a prescription injection used to treat anaemia, a condition where your body does not have enough healthy red blood cells. It is commonly prescribed for individuals living with long-term kidney disease, cancer patients undergoing chemotherapy, or patients scheduled for major surgeries to reduce the need for blood transfusions.
This medicine is injected either under the skin or directly into a vein, typically one to three times a week or every few weeks as prescribed. Because it is given as an injection, food does not affect how it works. Incorporating iron-rich foods like dark leafy greens and lean meats into your daily diet is a vital lifestyle habit that supports your treatment, as your body requires iron to build new blood cells.
While using it, you may experience mild side effects such as high blood pressure, headaches, or mild pain at the injection site. However, you must contact your doctor immediately if you experience serious side effects, such as sudden weakness, severe chest pain, shortness of breath, or a sudden, severe headache.
Before starting this treatment, talk to your doctor if you have a history of high blood pressure, heart disease, or blood clots. Do not take this if you have high blood pressure that is not controlled, or if you have ever had a severe allergic reaction to this medicine or similar red-blood-cell-stimulating treatments.
This medicine may interact with other therapies, so it is important to avoid alcohol and smoking, which can worsen blood pressure or circulation issues during your treatment. If you are pregnant, breastfeeding, or an older adult, you should consult your healthcare provider to discuss safe usage. This medicine should only be used in children under the care of a specialist. The dose and monitoring schedule are different from those used in adults.
Uses of Erythropoietin
Medicinal Benefits
When taken consistently as directed, this injection may provide the following physiological benefits:
- Helps improve energy levels: By increasing your red blood cell count, this medicine helps your body deliver more oxygen to its tissues. This may reduce fatigue and improve your energy, making everyday activities easier
- May reduce the need for blood transfusions: By stimulating your body to produce more red blood cells, this medicine may help reduce the need for blood transfusions and the risks associated with repeated transfusions.
Directions for Use
- Follow your doctor's instructions on the dosage and timing of this medication.
- Administer Erythropoietin subcutaneously as instructed by the doctor. Pinch a fold of skin using your finger and thumb and inject the prescribed dose into the fold.
- Do not inject into red or bruised areas.
Storage
Side Effects of Erythropoietin
Common Side Effects (Usually mild):
- High blood pressure
- Headache
- Pain, redness, or swelling around the injection site
- Mild joint or muscle pain
- Nausea or mild stomach upset
Serious Side Effects (Consult your doctor right away):
- Signs of a blood clot, such as sudden swelling, warmth, redness, or pain in one leg
- Signs of a heart issue, such as chest pain, shortness of breath, or sudden dizziness
- Severe allergic reactions, including a widespread skin rash, hives, or swelling of the face, lips, or throat
- Sudden, severe headache, confusion, or vision changes, which could indicate a dangerous spike in blood pressure
- Worsening tiredness, unusual weakness, or symptoms of severe anaemia after previously responding well to treatment (sign of pure red cell aplasia)
Medicines Containing this Salt
View AllDrug Warnings
- Check the medicine before use: Always check the expiration date on the package before using the injection.
- Handle the injection carefully: Do not shake the vial or pre-filled syringe, as this may damage the medicine.
- Rotate injection sites: Change your injection site each time between the thighs, abdomen, or upper arms to help reduce skin irritation or thickening.
- Use a new needle each time: Never reuse needles or syringes. Dispose of them safely in a designated sharps container after use.
- Attend follow-up tests: Keep all scheduled blood test appointments so your doctor can monitor your red blood cell levels and adjust your treatment if needed.
- Choose a healthy injection site: Do not inject into skin that is tender, bruised, red, hard, scarred, or has stretch marks.
- Seek emergency medical help: if you develop a severe allergic reaction, stroke, hypertensive crisis, or signs of pure red cell aplasia (PRCA) while receiving this medicine.
Drug Interactions
- Cyclosporine: It may affect how cyclosporine (an immune-system-suppressing drug) works in your body. Your doctor may need to monitor your blood levels of this drug more closely.
- Other blood-stimulating medicines: Combining it with other medicines that boost red blood cell production can raise your blood counts too high, increasing your risk of stroke or heart attack.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorPlease consult a doctor, as it is unknown whether it is safe to consume alcohol with Erythropoietin.
Pregnancy
consult your doctorLimited data is available on the effect of Erythropoietin in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Erythropoietin. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
consult your doctorLimited data is available on the effect of Erythropoietin on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Erythropoietin. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
consult your doctorIt is not known if Erythropoietin affects your ability to drive. Drive or operate machinery only if you are alert.
Liver
consult your doctorIf you have a history of liver disease, inform your doctor before receiving Erythropoietin. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
consult your doctorIf you have a history of kidney disease, inform your doctor before receiving Erythropoietin.
Children
consult your doctorThe safety of Erythropoietin in children is not known. Please consult the doctor.
Habit Forming
Diet & Lifestyle Advise
- Eat iron-rich foods: Your body needs iron to build red blood cells. Include foods like lean meats, poultry, beans, spinach, and iron-fortified cereals in your meals as advised by your doctor or dietitian.
- Monitor your blood pressure daily: Since this medicine can raise your blood pressure, keep a daily log of your readings and share them with your healthcare team.
- Stay well-hydrated: Drink plenty of fluids throughout the day, unless your doctor has placed you on a fluid restriction due to kidney issues.
- Take prescribed vitamin supplements: Your doctor may recommend that you take iron, vitamin B12, or folic acid supplements to support the production of red blood cells. Do not start any new supplements without consulting your doctor first.
Patients Concern
Disease/Condition Glossary
Anaemia: It occurs when the body has a lower amount of red blood cells or haemoglobin (the iron-rich protein responsible for allowing red blood cells to carry more oxygen from the lungs to the rest of the body). In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia. Symptoms of anaemia in chronic kidney disease include fatigue or tiredness, shortness of breath, ashen skin, weakness, body aches, chest pain, dizziness, fainting, fast or irregular heartbeat, headache, sleep problems, and trouble concentrating.
FAQs
Erythropoietin is used in the treatment of anaemia (lower red blood cell count) associated with renal disease, anaemia related to cancer chemotherapy, and drug-induced anaemia.
Erythropoietin contains erythropoietin, a glycoprotein which stimulates the bone marrow to increase the production of red blood cells.
Erythropoietin may cause side effects such as vomiting, headache, body aches, diarrhoea, stomach upset, and injection site reactions. If these side effects persist or worsen, seek medical attention.
Store Erythropoietin at temperatures between 2°C and 8°C. Do not freeze or shake it excessively. Protect from light. Keep it out of reach of children.
Before using Erythropoietin, inform your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding. Also, inform your doctor about your health condition and if you are taking other medicines, vitamins, or supplements.
Yes, you can inject it at home once your healthcare provider has trained you on how to prepare and inject it safely. Do not attempt to inject it yourself until you feel completely comfortable with the process. Talk to your doctor or pharmacist if you have any doubts.
This medicine signals your bone marrow to produce more red blood cells, which requires a large amount of iron. If your iron stores are low, the medicine will not work effectively. Talk to your doctor about whether you need an iron supplement.
If it was left at room temperature, check the package insert or contact your pharmacist immediately to see if it is still safe to use. Never freeze the medicine or use it if it has been exposed to extreme heat.
Yes, this medicine can increase the risk of serious blood clots, heart attacks, or strokes, especially if your red blood cell count rises too quickly or too high. Your doctor will monitor your blood closely to keep your levels in a safe range. Talk to your doctor if you experience sudden pain or swelling.
You should only use it during pregnancy if your doctor decides that the benefits clearly outweigh the potential risks to the baby. Always inform your healthcare provider if you are pregnant or planning to become pregnant. Talk to your doctor for personalised advice.
Shaking the vial can break down the delicate protein molecules in the medicine, making it completely inactive and ineffective. Always handle the vial gently and roll it between your hands if it needs mixing. Talk to your pharmacist if you suspect a vial has been shaken.
Your doctor will likely order blood tests once or twice a week when you first start treatment, and then less frequently once your red blood cell levels stabilise. These tests are critical to ensure your dose is safe and effective. Talk to your doctor to understand your test schedule.
