Hydralazine
About Hydralazine
Hydralazine is an injectable medicine used to quickly lower dangerously high blood pressure in emergency situations. It helps protect critical organs by reducing the pressure on your heart and blood vessels when blood pressure spikes to unsafe levels. This fast-acting treatment is typically used in clinical settings when oral medications cannot be taken or are not working quickly enough.
Because this medication is usually injected in urgent situations, it is used on a short-term basis as directed by your healthcare team rather than as a daily routine. For long-term blood pressure control, your doctor will likely recommend a combination of regular oral medications and key lifestyle habits. Adopting a low-salt diet, staying physically active, and managing stress are essential steps to keep your heart healthy over time.
While receiving this medicine, you might experience mild side effects like a headache, a fast heartbeat, or mild nausea. These symptoms are common as your body adjusts to the rapid lowering of your blood pressure, but you must tell your medical team immediately if they become severe or if you experience chest pain. Your doctor will closely monitor your vital signs to ensure your safety throughout the process.
Before you receive Hydralazine, tell your doctor if you have a history of heart disease, stroke, or kidney problems. Do not take this if you have coronary artery disease or rheumatic heart disease, as this medicine can worsen these conditions. It is also important to tell your medical team if you have ever had lupus or similar autoimmune conditions.
This medicine can interact with other blood pressure drugs, alcohol, and certain pain relievers, which can cause your blood pressure to drop too low. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits of this treatment in your specific situation.
Uses of Hydralazine
Medicinal Benefits
Using Hydralazine as prescribed helps rapidly lower dangerously high blood pressure during medical emergencies. Here are the key benefits you can expect:
- Rapid blood pressure control: Hydralazine quickly lowers blood pressure to a safer range, helping reduce the immediate risk of serious complications such as stroke, heart attack, or kidney failure.
- Reduces strain on the heart: By widening the blood vessels, it helps your heart pump blood more efficiently with less effort.
- Provides fast symptom relief: It can quickly relieve symptoms associated with severe high blood pressure, such as severe headache, chest tightness, and blurred vision, helping you feel more comfortable.
- Supports emergency stabilisation: By bringing blood pressure under control, Hydralazine gives your body time to stabilise while further medical treatment is provided.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
- Hydralazine will be administered by the doctor or healthcare professional.
- Do not self-administer.
Storage
Side Effects of Hydralazine
Common Side Effects (Usually mild):
- Headache
- Rapid or pounding heartbeat (palpitations)
- Loss of appetite, nausea, or vomiting
- Diarrhea or upset stomach
Serious Side Effects (Consult your doctor right away):
- Chest pain or pressure
- Joint pain, fever, or a skin rash
- Numbness, tingling, or weakness in your hands or feet
- Severe allergic reactions, such as swelling of the face, lips, or throat, or difficulty breathing
Medicines Containing this Salt
View AllDrug Warnings
- Inspect Before Use: Always check the injection vial before use. The solution should be clear and colourless. Do not use it if you notice any discolouration or visible particles.
- Stand Up Slowly: Rise slowly from a sitting or lying position to help prevent dizziness, light-headedness, or fainting caused by a sudden drop in blood pressure.
- Use a New Needle and Syringe: If you are injecting this medicine at home, use a new sterile needle and syringe for every injection and dispose of them safely in a puncture-resistant sharps container.
- Monitor Blood Pressure and Heart Rate: Check your blood pressure and heart rate regularly as directed by your healthcare team to ensure the medicine is working safely.
- Inform Healthcare Providers: Tell your dentist, surgeon, or any other healthcare professional that you are receiving Hydralazine before undergoing any medical or dental procedure.
Drug Interactions
- Other blood pressure-lowering medicines: May cause an excessive drop in blood pressure.
- Diuretics (water tablets): Can increase the blood pressure-lowering effect, raising the risk of dizziness or fainting.
- Non-steroidal anti-inflammatory drugs (NSAIDs): May reduce the effectiveness of Hydralazine in lowering blood pressure.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption with Hydralazine as it may increase the risk of low blood pressure and cause dizziness, or light-headedness.
Pregnancy
consult your doctorIf you are pregnant or planning pregnancy, inform your doctor before receiving Hydralazine. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
consult your doctorHydralazine may be excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Hydralazine. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
cautionHydralazine may cause dizziness or light-headedness in some people. Therefore, avoid driving if you feel dizzy or light-headed after receiving Hydralazine.
Liver
consult your doctorIf you have a pre-existing history of liver disease, inform your doctor before receiving Hydralazine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
consult your doctorIf you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Hydralazine. Your doctor may adjust the dose of this medicine based on your condition.
Children
unsafeHydralazine is not recommended for children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Reduce Salt Intake: Limit your sodium (salt) intake, as excess salt can cause your body to retain water and increase your blood pressure.
- Limit Alcohol: Avoid or limit alcohol consumption, as it may interact with Hydralazine and cause a sudden drop in blood pressure, leading to dizziness or fainting.
- Stay Hydrated: Drink enough fluids, but follow your doctor's advice on your daily fluid intake, especially if you have heart or kidney disease.
- Stay Physically Active: Include light, low-impact activities such as walking in your daily routine, but only after your doctor confirms it is safe for you.
Special Advise
- If you notice symptoms such as joint pain, skin rash, fever, and change in blood count, stop receiving Hydralazine and contact your doctor immediately as these might be symptoms of Systemic lupus erythematosus (an autoimmune disease).
Patients Concern
Disease/Condition Glossary
Hypertension: Blood pressure is the measurement of the heart's force to pump blood to all parts of the body. Hypertension is a chronic condition in which blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. Normal blood pressure lies between 90/60 mm of Hg and 120/80 mm of Hg. If the blood pressure is 140/90 mmHg or greater, it is considered high blood pressure.
FAQs
Hydralazine is used to treat Very high blood pressure.
Hydralazine contains Hydralazine, a vasodilator that works by relaxing and widening the walls of blood vessels. Thus, it increases blood and oxygen supply to the heart and reduces blood pressure.
Hydralazine is usually used only briefly to quickly bring down very high blood pressure. After that, your doctor may recommend you take blood pressure tablets.
Hydralazine may cause diarrhoea as a common side effect. However, if the condition persists or worsens, please inform your doctor.
Yes, Hydralazine is often used in hospital settings to treat dangerously high blood pressure during pregnancy, particularly for conditions like preeclampsia. If you are pregnant or planning to become pregnant, talk to your doctor to discuss the benefits and risks of this treatment.
In most cases, Hydralazine is injected by healthcare professionals in a hospital or clinic because it requires close monitoring of your blood pressure and heart rate. If home use is prescribed, you will receive specialised training. Talk to your doctor if you have questions about where you will receive your doses.
Feeling dizzy or lightheaded can happen if your blood pressure drops quickly. Sit or lie down immediately to prevent fainting or falling, and inform your nurse or doctor right away. Talk to your doctor or pharmacist for advice on how to manage these symptoms.
You should avoid alcohol while receiving Hydralazine. Alcohol can widen your blood vessels further, which may cause your blood pressure to drop dangerously low, resulting in severe dizziness or fainting. Talk to your doctor or pharmacist if you have questions about lifestyle restrictions.
Yes, especially with high doses or long-term use, Hydralazine can cause symptoms that mimic lupus, such as joint pain, fever, or a skin rash. These symptoms usually go away after the medication is stopped, but you must report them immediately. Talk to your doctor if you experience any unusual joint pain or rashes.
Hydralazine relaxes blood vessels, which can sometimes trigger a natural reflex in your body that makes your heart beat faster to maintain blood flow. Your medical team will closely monitor your heart rate to ensure it stays within a safe range. Talk to your doctor if you feel your heart racing or pounding.
You should never use the injection if it is discoloured, cloudy, or contains any visible particles. Using a compromised injection can be dangerous. Talk to your doctor or pharmacist immediately to get a replacement vial.
