How can I safely treat my long-term constipation, which has not been cured despite normal colon CT scans, thyroid, and calcium tests, and still requires me to take high daily doses of laxatives even though I stopped drinking alcohol and get some relief from Escitalopram, Melanxit, and Prothiaden?
Dealing with chronic constipation is incredibly frustrating, especially when tests are normal. Since structural issues are ruled out, this may relate to gut motility. Interestingly, medications like escitalopram, Melanxit, and Prothiaden (dosulepin) affect gut-brain signaling. While they can offer relief, some, like dosulepin, can actually worsen constipation. Please be reassured that this is manageable. I highly recommend discussing a tailored plan with your doctor to safely adjust your daily laxatives, review your current medications, and focus on high-fiber foods and optimal hydration.