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Nise Gel is used to treat musculoskeletal pain. It works by blocking the release of certain chemicals that cause pain and inflammation and inhibiting the transmission of pain signals to the brain. In some cases, this medicine may cause side effects such as redness, itching, irritation or a burning sensation at the site of application. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nise Gel

Nise Gel is a topical pain-relieving gel used to treat localised muscle aches, joint discomfort, sprains, strains, and arthritic pain. It is formulated to target pain directly at the source, reducing swelling and improving comfort in the affected area. Because it is applied directly to the skin, it delivers targeted relief where you need it most.

For the best results, this medication is typically applied to the affected area three to four times a day. Consistency is important, especially for chronic conditions like joint wear-and-tear, to maintain continuous pain relief. Because this is a topical skin gel, it does not need to be timed with meals. Incorporating gentle daily stretching and staying hydrated can further support your recovery.

Most people tolerate this topical gel well, though you may experience mild skin reactions at the application site, such as redness, warmth, or temporary itching. If you experience severe burning, blistering, or a widespread skin rash, stop using the gel and consult your doctor immediately.

Talk to your doctor or pharmacist before starting Nise Gel if you have a history of skin allergies, sensitive skin, or asthma. Do not use this medicine on open wounds, broken or infected skin, or if you have a known allergy to pain-relieving medicines like aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).

While topical absorption is low, it is still wise to discuss using this gel with your healthcare provider if you are taking oral blood thinners or pain medications. Pregnant or breastfeeding women, as well as elderly individuals, should consult their doctor before using this medicine to ensure it is safe for their specific situation.

Uses of Nise Gel

Nise Gel is used to treat localized muscle aches, joint discomfort, sprains, strains, and arthritic pain.The detailed uses of Nise Gel are as follows:

  • Osteoarthritis and Joint Pain: Helps relieve local pain, stiffness, and swelling in joints affected by wear-and-tear.
  • Muscle Sprains and Strains: Helps reduce pain, inflammation, and discomfort associated with muscle sprains, strains, and sore muscles.
  • Backache: Provides targeted, fast-acting relief for lower and upper back pain.
  • Rheumatoid Arthritis Discomfort: Eases localized joint aches and inflammation during symptom flare-ups.

Key Benefits

Nise Gel provides targeted relief directly at the site of pain, helping you move more comfortably and continue with your daily routine.This targeted approach offers several key benefits:

  • Targeted Pain Relief: Delivers pain-relieving action directly to the affected area, helping reduce discomfort in muscles, joints, and soft tissues without exposing the whole body to medication.
  • Improved Mobility and Flexibility: Helps ease muscle tension and joint stiffness, making everyday movements, physical activity, and rehabilitation exercises more comfortable.
  • Reduced Need for Pain Medicines: Localized treatment may reduce dependence on  pain medications, thereby minimizing the risk of common systemic side effects such as stomach irritation.
  • Fast-Acting Comfort: Begins working soon after application to provide quick relief, allowing you to resume work, physical therapy, and daily activities with greater ease.
Side effects of Nise Gel 30 gm
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Take a small amount of Nise Gel on the fingertip and apply it as a thin layer on the clean and dry affected area as advised by your doctor.
  • Nise Gel is only for external use.
  • Avoid contact of the Nise Gel with the nose, mouth, or eyes. In case of accidental contact with these areas, rinse with water thoroughly.

How Nise Gel Works

Nise Gel combines four active ingredients that work together to relieve pain and reduce inflammation at the application site: Nimesulide: A nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins responsible for pain and inflammation. Methyl Salicylate: Acts as a counter-irritant, producing a warming sensation on the skin that helps temporarily relieve muscle and joint pain by reducing the perception of deeper pain. Menthol: Activates cold-sensitive TRPM8 receptors in the skin, producing a cooling sensation that temporarily reduces the perception of pain. This cooling effect is its primary mechanism of action and complements the pain-relieving effects of the other ingredients. Menthol may also produce a mild counter-irritant effect, contributing to temporary relief of minor muscle and joint pain. Capsaicin: With repeated application, capsaicin desensitises TRPV1 (transient receptor potential vanilloid 1) receptors on pain-sensing nerves, leading to reversible defunctionalisation of these nerve endings. This process reduces the release of pain mediators, including Substance P, resulting in long-term pain relief. A temporary burning or stinging sensation is common during the first few applications and usually decreases with continued use. For chronic pain, the full desensitising effect typically develops after consistent daily use for 1–2 weeks, although the exact timeframe may vary between individuals.
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Alcohol

Unsafe

Avoid consumption of alcohol with Nise Gel as it may increase the risk of stomach bleeding.

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Pregnancy

Caution

The safety of Nise Gel in pregnancy is unknown. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Caution

It is unknown whether Nise Gel is excreted in human milk. Please consult a doctor before using Nise Gel while breastfeeding.

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Driving

Safe if prescribed

Nise Gel usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Use Nise Gel with caution, especially if you have a history of liver disease. Please consult a doctor for appropriate dose adjustments.

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Kidney

Caution

Use Nise Gel with caution, especially if you have a history of Kidney diseases/conditions. Please consult a doctor for appropriate dose adjustments.

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Children

Caution

The safety of Nise Gel in children is unknown. Please consult your doctor.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Nise Gel. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Nise Gel in elderly patients. Please consult your doctor.

What if I have taken an overdose of Nise Gel

If you apply too much gel, wipe away the excess with a clean tissue. If Nise Gel is accidentally swallowed, or if it gets into the eyes or mouth causing severe irritation, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat an anti-inflammatory diet: Support your joint health by consuming foods rich in omega-3 fatty acids (like fish or flaxseeds), berries, and leafy green vegetables.
  • Stay hydrated: Drinking plenty of water helps keep your joint cartilage lubricated and supports muscle recovery.
  • Engage in low-impact exercise: Activities like swimming, cycling, or walking help keep your joints flexible without placing excess strain on them.
  • Maintain a healthy weight: Managing your weight reduces the physical load on weight-bearing joints like your knees and hips.
  • Warm up properly: Always stretch gently before physical activity to prevent muscle strains and sprains.
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Have a query?

How Soon It Starts Working

The time required for Nise Gel to start to work: Nise Gel starts to show its action within 30 minutes of application. The time for which the effects of Nise Gel last: Nise Gel effect lasts for 6 to 8 hours.

Storage

•Store Nise Gel at room temperature below 25°C in a cool, dry place away from direct sunlight and moisture.

What if you forget to take Nise Gel

If you forget to apply the gel, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and return to your regular routine. Do not apply double the amount to make up for a missed application.

Drug Warnings

  • Avoid Contact with Sensitive Areas: Avoid getting the gel in your eyes, nose, mouth, or other sensitive mucous membranes. If contact occurs, rinse thoroughly with cool water.
  • Do Not Apply to Damaged Skin: Do not apply this medication to scraped, sunburned, infected, or open wounds.
  • Avoid Hot Baths or Showers Around Application: Do not take a hot bath or shower immediately before or after applying this gel, as this can increase the burning sensation.
  • Do Not Use External Heat: Avoid applying external heat, such as heating pads or hot water bottles, to the treated area.
  • Inspect the Product Before Use: Always inspect the tube before use to ensure the seal is intact and the gel has not changed colour or consistency.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any prescription medicines, over-the-counter products, or topical preparations before starting Nise Gel, as some medicines may affect its safety or increase the risk of side effects.

  • Other topical skin products: Avoid applying other creams, ointments, or lotions to the same skin area, as they can interfere with how Nise Gel is absorbed or increase skin irritation.
  • NSAIDs or blood thinners: If used over large areas for long periods, there is a small risk of interaction. Talk to your doctor if you take aspirin, warfarin, or pain relievers.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Nise Gel when used as directed.

No clinically significant drug interactions are known with Nise Gel when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Nise Gel is used to relieve joint pain, low back pain, muscle sprain and sports injuries. Besides this, it also reduces pain and swelling in conditions like osteoarthritis and rheumatoid arthritis.
Nise Gel is a combination of four painkillers/analgesics: Nimesulide, Capsaicin, Methyl salicylate and one cooling agent (Menthol). Nimesulide and Methyl salicylate works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. Cooling and warming up distracts from the pain and helps improve blood circulation.
You are recommended to avoid using Nise Gel if you have had any recent bypass heart surgery, heart attack, stroke, gastrointestinal bleeding (bloody stool), or ulcer of the stomach or intestine. Elderly (more than 65 years of age) or smokers are at greater risk of having gastrointestinal bleeding, so they should use Nise Gel with caution.
Yes, Nise Gel may cause skin irritation at the site of application as a common side effect. It is not necessary for everyone using Nise Gel to experience this side effect. However, if the irritation persists or worsens, please consult a doctor.
Patients with heart failure are not advised to take Nise Gel because painkillers may alter blood substance levels and make blood clots more likely. These blood clots have the potential to block and constrict your heart's artery, leading to a heart attack.
You are recommended to take a shower, bathe or wash the treated area of skin after 1 hour of applying Nise Gel for effective results.
No, Nise Gel does not cure arthritis. Nise Gel is only used to relieve symptoms of arthritis-like joint pain, swelling and stiffness.
Nise Gel is for external use only. Take a small amount of Nise Gel on the finger and apply as a thin layer on the clean and dry affected area and surrounding skin. Avoid contact with the eyes, mouth, or nose. If accidental contact occurs, rinse thoroughly with water. Be sure to wash your hands before and after application.
No, Nise Gel, is not a steroid. It belongs to the class of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
While using Nise Gel, you are recommended to tell your doctor if you are allergic to the active substances of Nise Gel and if you have kidney, liver, or heart disease, diabetes, asthma, high blood pressure, bleeding in the stomach or intestines, stomach ulcers, and edema. Avoid using Nise Gel on cuts, wounds, or damaged skin. Avoid consuming alcohol while using it to reduce the risk of stomach bleeding. Do not apply heat or tightly wrap the treated area. Use only as directed, and avoid excessive or prolonged application to prevent adverse effects.
If you forget to use Nise Gel, then apply as soon as you remember. Avoid applying more to make up for the missed one. If you have any concerns, contact your doctor.
You are not recommended to stop using Nise Gel without consulting your doctor, even if you feel better as stopping early might affect the treatment's effectiveness. Always follow your doctor’s instructions.
Nise Gel is generally safe for most patients when used as per the dose and duration advised by a doctor. Follow the instructions given by your doctor. Do not self-medicate.
No, Nise Gel is not an antibiotic. It contains capsaicin, menthol methyl salicylate, and nimesulide as its active substances, used to relieve pain and inflammation associated with conditions like muscle aches, joint pain, and sprains.
Both Nise Gel and paracetamol are pain-relieving medications. Using them together is generally not advised, as it may raise the risk of gastric ulcers and bleeding. It is essential to consult your doctor before taking Nise Gel with paracetamol or other medicines.
No, Nise Gel does not contain aspirin.
Nise Gel may be used for headaches, but only when prescribed by a doctor. It has been shown to help with mild migraines and can be effective for headaches when used as directed. However, it is not recommended for long-term use in cases of recurring headaches. If you experience frequent headaches, consult your doctor for proper treatment.
Nise Gel does not cause drowsiness as it works locally and applied to the skin. Nise Gel active ingredients work directly on the area to relieve pain. Inform your doctor if your symptoms worsen while using Nise Gel.
You are recommended to consult your doctor before using Nise Gel with other medicines.
Nise Gel may be taken with aspirin as no interactions have been observed. However, please consult a doctor before using Nise Gel with aspirin or other medicines to avoid potential interactions.
No, Nise Gel is not banned in India.
It is unknown if Nise Gel passes into breast milk and if it can harm the baby. Therefore, consult a doctor before using Nise Gel if you are breastfeeding.
Nise Gel may be safe for asthma patients. However, it's advisable to inform your doctor if you have a history of asthma. Do not self-medicate.
Nise Gel causes side effects such as irritated skin, burning sensation, stinging sensation, red skin or rashes, erythema (redness of skin or mucous membranes), and desquamation (peeling skin). Consult your doctor if these side effects persist or worsen.
No. Do not apply Nise Gel to open wounds, cuts, burns, scrapes, rashes, infected areas, peeling skin, or other damaged skin. Applying it to broken skin may cause severe irritation and increase absorption into the bloodstream. If accidental application occurs or you have skin damage, consult your doctor.
If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using Nise Gel. Your doctor will assess whether the benefits outweigh any potential risks and advise you on the safest treatment option.
The warming sensation is normal and is caused by ingredients like methyl salicylate and capsaicin, which stimulate local blood flow and distract your brain from deeper pain. If the heat becomes painful, wash the area gently with cool water and soap.
No, do not use heating pads or hot compresses on the treated area. Doing so can cause severe skin irritation, burns, or increase the risk of side effects. Talk to your pharmacist if you have questions about heat therapy.
Immediately flush your eyes with large amounts of cool, clean water for several minutes. If burning, redness, or vision changes persist, seek medical attention right away.
Do not use this product if you have a known severe allergy to aspirin or other NSAIDs, as cross-reactions can occur. Talk to your doctor or pharmacist about safer alternative pain relievers.
It is typically applied three to four times a day, but you should always follow the specific dosing frequency prescribed by your doctor. Talk to your doctor if your symptoms persist.

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Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - NIS0003
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