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compositionComposition:LACTULOSE-3.335GM
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Duphalac Enema Solution is a laxative used in the treatment of constipation and hepatic encephalopathy. It contains lactulose, which works by absorbing water from the body and into the bowel, and thus makes it easier to pass. Common side effects include diarrhoea, flatulence (wind), abdominal pain, nausea, and vomiting. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

LACTULOSE-3.335GM

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Rectal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Duphalac Enema Solution

Duphalac Enema Solution is a prescription liquid medication used rectally to treat and manage hepatic encephalopathy, which is a serious brain complication caused by severe liver damage. It helps lower the levels of toxic substances, particularly ammonia, in the blood when the liver is unable to filter them properly. This rectal form is typically used in urgent situations or when a patient is unable to take medicine by mouth due to confusion or severe illness.

This medicine must be used consistently according to a strict schedule set by your doctor, often multiple times a day during an acute episode. Because it is given rectally, it does not matter if you have eaten food, as it does not pass through your stomach. Along with using this medicine, your doctor may suggest dietary changes, such as managing your protein intake and drinking plenty of fluids, to help support your liver and bowel health.

While using Duphalac Enema Solution , you may experience mild side effects such as abdominal gas, bloating, or temporary cramping. However, you must contact your doctor immediately if you experience severe diarrhoea, extreme muscle weakness, or worsening confusion, as these can be signs of dehydration or electrolyte imbalance.

Before starting Duphalac Enema Solution , talk to your doctor if you have diabetes, severe dehydration, or if you require a low-galactose diet. Do not take this if you have a blocked bowel or if you are unable to tolerate galactose.

This medicine can interact with other laxatives or certain antacids, which can prevent it from working correctly in your bowel. If you are pregnant, breastfeeding, or caring for an elderly patient, consult your healthcare provider before using this medicine to ensure it is safe and appropriate.

Uses of Duphalac Enema Solution

Duphalac Enema Solution is used to treat and manage hepatic encephalopathy. The detailed uses of Duphalac Enema Solution are as follows:

  • Hepatic encephalopathy: Duphalac Enema Solution helps lower elevated ammonia levels in the blood, which reduces brain-related symptoms like confusion, tremors, and sleep issues caused by severe liver damage.
  • Severe constipation: In cases where a patient cannot take laxatives by mouth, this rectal solution helps soften stool and stimulate bowel movements to relieve severe blockages.

Key Benefits

Duphalac Enema Solution helps reduce high ammonia levels in patients with liver-related brain complications by acting directly in the colon. When used as prescribed, it helps improve mental alertness, supports safe bowel clearance, and provides an effective treatment option when oral medicines cannot be taken.

  • Improves Mental Clarity: By helping remove excess ammonia from the body, this medicine helps improve confusion, drowsiness, and reduced alertness associated with liver-related brain complications.
  • Provides Effective Rectal Treatment: Given rectally, this medicine is a suitable option for patients who are unable to swallow oral medications due to nausea, weakness, or altered consciousness.
  • Supports Gentle Bowel Clearance: This medicine helps empty the bowels effectively, reducing ammonia absorption from the colon while promoting digestive comfort and supporting recovery.
Side effects of Duphalac Enema Solution 300 ml
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Shake the bottle well and remove the protective shield from the tip.
  • Lie down on your left side and raise your right knee to your chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly.

How Duphalac Enema Solution Works

Duphalac Enema Solution contains lactulose. When Duphalac Enema Solution is inserted rectally, it reaches the colon, where natural gut bacteria break it down into mild acids. These acids make the colon environment more acidic, which draws toxic ammonia from the bloodstream into the colon. Once in the colon, the ammonia is converted into a form that cannot be reabsorbed by the body, allowing it to be safely flushed out through bowel movements. Additionally, this process draws water into the stool, which softens the stool and stimulates a bowel movement. This dual action helps lower harmful toxin levels in the body while relieving severe bowel blockages.
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Alcohol

Caution

It is not known if alcohol consumption affects Duphalac Enema Solution . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor before using Duphalac Enema Solution if you are pregnant; your doctor will prescribe Duphalac Enema Solution if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor before using Duphalac Enema Solution if you are breastfeeding; your doctor will prescribe Duphalac Enema Solution if the benefits outweigh the risks.

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Driving

Safe if prescribed

Duphalac Enema Solution usually does not affect your ability to drive.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Duphalac Enema Solution in children.

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Heart

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Duphalac Enema Solution in patients with heart problems.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Duphalac Enema Solution in elderly patients.

What if I have taken an overdose of Duphalac Enema Solution

If you or someone else accidentally receives too much of this medicine, seek immediate medical attention. An overdose can cause severe diarrhoea, stomach pain, and dangerous fluid loss.

Diet & Lifestyle Advise

  • Manage protein intake: Work closely with a dietitian or doctor to consume the right amount and type of protein, as excess protein can increase ammonia levels in the blood.
  • Stay hydrated: Drink plenty of fluids, such as water, to prevent dehydration, which is a common risk when using rectal laxative solutions.
  • Track bowel movements: Keep a daily log of bowel movements and share this with your healthcare provider, as this helps monitor the medication's effectiveness.
  • Monitor mental clarity: Have a family member or caregiver monitor you for subtle signs of confusion, forgetfulness, or changes in sleep patterns, which may indicate a need for treatment adjustments.

Health Queries

What is constipation treatment?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Treatment of Constipation mainly involves lifestyle changes and, if needed, medicines. Drink plenty of water, eat a high-fiber diet (fruits, vegetables, whole grains), and stay physically active with regular toilet timing. For relief, you can use fiber supplements like Isabgol or osmotic laxatives like Lactulose to soften stools. Avoid frequent use of strong stimulant laxatives, and consult a doctor if constipation is persistent or associated with pain or bleeding.

I'm going to have constipation today, but it's not finished because it's cuming in a really hard and solid condition. I'm concerned because I've had piles in the past. Could you kindly recommend a medication for constipation that goes softly and likwidify?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Hard stools with a history of piles (Hemorrhoids) should be softened to avoid straining. Drink plenty of water and take a gentle stool-softening laxative like Lactulose or a fiber supplement like Isabgol at night to make stools soft and easy to pass. Avoid frequent use of strong stimulant laxatives, and include fruits, vegetables, and warm fluids in your diet. If pain, bleeding, or constipation persists, consult a doctor.

I have a constipation issue because of IVF. Tell me about any medications since I'm in my sixth month of pregnancy.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Constipation is common in the 6th month of pregnancy after IVF due to hormonal changes and iron tablets. Along with plenty of water, fiber-rich diet, and light activity, you can safely use gentle options like Isabgol or Lactulose; a stool softener like Docusate may also help. Avoid frequent use of strong stimulant laxatives, and always check with your gynecologist before starting any medicine.

I am a fourth-year MBBS student with lower abdominal pain in both the hypogastrium and the lower abdomen. I also have low-grade fever, constipation, and trouble starting and emptying my bladder. My KFT, urine microscopy, culture, and sensitivity tests all came back normal. I also went to get a PSA (Total), and the result was I am really concerned. My exams are coming up, and I can't focus.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Lower abdominal pain with low-grade fever and urinary difficulty despite normal tests may suggest conditions like Prostatitis or Chronic pelvic pain syndrome, and sometimes bowel issues like Irritable bowel syndrome can overlap. Since PSA and basic tests are normal, it?s less likely something serious, but your symptoms still need evaluation. Stay hydrated, avoid holding urine, manage constipation with fiber or Lactulose, and use Paracetamol for pain if needed. Please consult a urologist soon for proper examination and guidance, especially as symptoms are affecting your studies.

I've had constipation for the past fifteen days.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Constipation for 15 days suggests a persistent issue and needs proper care. Increase water intake, eat a high-fiber diet (fruits, vegetables, whole grains), and maintain regular toilet timing. For relief, you can use gentle options like Isabgol or Lactulose daily; avoid frequent use of strong stimulant laxatives. If it continues or is associated with pain, bloating, or blood in stool, consult a doctor to rule out causes like Irritable bowel syndrome or other conditions.
health query

Have a query?

How Soon It Starts Working

The time required for Duphalac Enema Solution to start to work: The onset time of Duphalac Enema Solution has not been clinically established.

The time for which the effects of Duphalac Enema Solution last: The duration of Duphalac Enema Solution ’s effect is clinically not established.

Storage

• Store Duphalac Enema Solution at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

What if you forget to take Duphalac Enema Solution

If you miss a dose, use it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not use a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure what to do.

Drug Warnings

  • Always check the appearance of the solution before use; a slight darkening of the liquid is normal, but do not use it if it contains visible particles or looks cloudy.
  • Do not use other laxatives while using Duphalac Enema Solution unless your doctor specifically tells you to, as this can make it difficult to evaluate the success of your treatment.
  • Make sure to use clean, sanitised equipment for every rectal application to prevent infection.
  • Try your best to hold the solution in the colon for the full recommended time (usually 30 to 60 minutes) to allow the medicine to work effectively.
  • Have your blood checked regularly as recommended by your doctor to monitor your electrolyte and fluid levels during long-term use.

Drug-Drug Interactions

verifiedApollotooltip
  • Antacids: Taking antacids alongside this medication may prevent the colon from becoming acidic enough, reducing the effectiveness of Duphalac Enema Solution .
  • Antibiotics: Certain oral antibiotics may kill the beneficial gut bacteria required to break down this medicine, making it less effective.
  • Other laxatives: Using other bowel-clearing medications can cause severe diarrhea, leading to dehydration and making it difficult to find the correct dose of Duphalac Enema Solution .
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Duphalac Enema Solution when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[LAXATIVES]

FAQs

Duphalac Enema Solution belongs to the group of medicines called laxatives, used to treat constipation. Duphalac Enema Solution is also used to treat hepatic encephalopathy.
Duphalac Enema Solution works by drawing water into the bowel and makes the stool softer and easier to pass, thereby providing relief from constipation.
Duphalac Enema Solution is used to treat hepatic encephalopathy in adults. Hepatic encephalopathy is a liver disease in which the liver does not remove toxins from the body, which leads to loss of brain function.
Diarrhoea might occur if Duphalac Enema Solution is taken in larger doses. Drink lots of fluids if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Do not use Duphalac Enema Solution for longer durations unless prescribed by the doctor. Using Duphalac Enema Solution for longer durations might cause dehydration, an imbalance of electrolytes in the body, which can affect the tightness of muscles in the intestine. If your bowel movement is irregular even after using Duphalac Enema Solution for a week, consult your doctor.
Try to lie still on your left side to help retain the liquid. If you cannot hold it for the recommended time, hold it for as long as possible, and then inform your healthcare provider, as they may need to adjust your treatment plan. Talk to your doctor.
Yes. Duphalac Enema Solution contains lactulose, a synthetic sugar. In the recommended doses, it is generally not expected to significantly affect blood glucose levels. If you have diabetes, use Duphalac Enema Solution with caution and monitor your blood sugar as advised by your doctor, particularly if using high doses or rectal treatment. Consult your doctor before using this medicine.
This medicine is typically reserved for severe constipation or liver-related brain issues when oral medications cannot be taken. It is not generally recommended for everyday constipation. Talk to your doctor.
Yes, a slight darkening of the solution is normal and does not mean the medicine has lost its effectiveness. However, if the liquid becomes very dark, cloudy, or contains visible floating particles, do not use it. Talk to your pharmacist.
You should avoid using other laxatives unless your doctor specifically instructs you to do so, as combining them can cause severe diarrhoea and make it hard to tell if your treatment is working. Talk to your doctor.
Signs of success include improved mental clarity, reduced confusion, better sleep patterns, and improved muscle control or reduced shaking. If you do not see these changes, talk to your doctor.
Rectal use of this medicine during pregnancy should only be done under direct medical supervision, as fluid and electrolyte balances are critical during this time. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Solvate Laboratories Pvt.Ltd., C-57, IIIrd Floor, Vikas Marg, Preet Vihar, Delhi-110092
Other Info - DUP0027

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