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compositionComposition:ENDOXIFEN-8MG
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ZONALTA 8 TABLETS is an antipsychotic medicine used to treat acute manic episodes in adults associated with bipolar disorder. This medicine inhibits protein kinase C activity, thereby helping to regulate certain brain chemicals that control mood. You may experience side effects like headache, vomiting, Inability to sleep, sleeping more than usual, abdominal discomfort, and diarrhoea. Before starting ZONALTA 8 TABLETS, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ENDOXIFEN-8MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ZONALTA 8 TABLETS

ZONALTA 8 TABLETS is an oral suggested medicine used to treat hormone receptor-positive (estrogen receptor-positive) breast cancer. It works by blocking the effects of estrogen on breast cancer cells, helping slow or stop their growth. Depending on your treatment plan, your doctor may prescribe this medicine after surgery or as part of ongoing therapy to reduce the risk of cancer recurrence and improve long-term treatment outcomes.

For the best results, take ZONALTA 8 TABLETS exactly as suggested by your healthcare provider and at the same time every day. This medicine can be taken with or without food. Maintaining a balanced diet, staying physically active, and attending all scheduled follow-up appointments can help support your overall health during treatment.

While taking ZONALTA 8 TABLETS, you may experience mild side effects such as hot flashes, nausea, tiredness, or joint pain. These side effects are usually manageable and may improve as your body adjusts to the treatment. However, seek immediate medical attention if you develop sudden chest pain, difficulty breathing, swelling or pain in one leg, unusual vaginal bleeding, severe vision changes, or signs of liver problems such as yellowing of the skin or eyes.

Before starting this medicine, tell your doctor if you have a history of blood clots, stroke, liver disease, abnormal vaginal bleeding, or cataracts. Do not take this medicine if you are allergic to endoxifen or any of its ingredients. This medicine should not be used during pregnancy because it may harm the unborn baby.

Certain medicines, including some antidepressants, hormone therapies, and blood thinners, may interact with ZONALTA 8 TABLETS. Avoid smoking and limit alcohol consumption, as these may increase the risk of treatment-related complications. If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before starting this medicine.

Uses of ZONALTA 8 TABLETS

Your doctor may prescribe ZONALTA 8 TABLETS for the following condition:

  • Hormone Receptor-Positive Breast Cancer: Helps block the effects of estrogen on breast cancer cells, slowing or preventing their growth.
  • Reducing the Risk of Breast Cancer Recurrence: May be used as part of long-term treatment to lower the chance of breast cancer returning after primary treatment.
  • Adjuvant Hormonal Therapy: Used alongside surgery, radiation therapy, or other cancer treatments to improve overall treatment outcomes.

Key Benefits

Taking ZONALTA 8 TABLETS helps slow the growth of hormone-sensitive breast cancer by blocking estrogen signals that cancer cells need to survive and multiply. Regular treatment, as suggested by your doctor, plays an important role in reducing disease progression and improving long-term outcomes.


Key benefits of this medicine include:

  • Slows Cancer Growth: Blocks estrogen from stimulating hormone receptor-positive breast cancer cells, helping prevent tumour growth and spread.
  • Reduces the Risk of Cancer Recurrence: Supports long-term treatment by lowering the likelihood of breast cancer returning after surgery or other therapies.
  • Supports Long-Term Breast Cancer Management: Provides sustained hormone-blocking activity that helps improve treatment success when used as part of a comprehensive cancer care plan.
Side effects of Zonalta 8 mg Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.

Directions for Use

  • ZONALTA 8 TABLETS can be taken with or without food, as food intake does not significantly influence its effectiveness.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow ZONALTA 8 TABLETS as a whole with a glass of water.
  • Do not crush, chew, or break it.

How ZONALTA 8 TABLETS Works

ZONALTA 8 TABLETS contains Endoxifen, an active metabolite of tamoxifen that belongs to a group of medicines known as selective estrogen receptor modulators (SERMs). Endoxifen works by attaching to estrogen receptors on breast cancer cells and blocking the action of estrogen. Since many breast cancers depend on estrogen to grow and multiply, preventing estrogen from binding to these receptors slows or stops the growth of hormone-sensitive cancer cells. By reducing estrogen stimulation, this medicine helps control the progression of hormone receptor-positive breast cancer and lowers the risk of the disease returning after treatment.
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Alcohol

Caution

Avoid alcohol consumption while taking ZONALTA 8 TABLETS as it may increase dizziness and sleepiness.

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Pregnancy

Unsafe

ZONALTA 8 TABLETS should not be administered to pregnant women as ZONALTA 8 TABLETS falls under pregnancy category D.

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Breast Feeding

Unsafe

Women should be advised not to breastfeed throughout therapy and for three months following the final dosage of ZONALTA 8 TABLETS.

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Driving

Unsafe

ZONALTA 8 TABLETS causes sleepiness and tiredness or restlessness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

If you have a history or evidence of any Liver-related diseases, inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing ZONALTA 8 TABLETS.

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Kidney

Caution

If you have a history or evidence of any Kidney-related diseases, inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing ZONALTA 8 TABLETS.

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Children

Unsafe

The ZONALTA 8 TABLETS is not recommended for use on children under 18 because of insufficient data on efficacy and safety.

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Heart

Caution

ZONALTA 8 TABLETS should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using ZONALTA 8 TABLETS.

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Geriatrics

Caution

The use of ZONALTA 8 TABLETS is not recommended in elderly patients due to insufficient data on its safety and efficacy.

What if I have taken an overdose of ZONALTA 8 TABLETS

If you or someone else takes more than the suggested dose, seek immediate medical attention or contact your local poison control centre immediately. Symptoms of overdose may include severe dizziness, nausea, vomiting, hot flashes, or other unusual symptoms requiring medical evaluation.

Diet & Lifestyle Advise

  • Eat a balanced diet: Include plenty of fruits, vegetables, whole grains, lean proteins, and calcium-rich foods to support your overall health during breast cancer treatment.
  • Stay physically active: Gentle exercises such as walking, yoga, or swimming may help reduce fatigue, improve joint stiffness, and support bone health.
  • Maintain a healthy weight: Achieving and maintaining a healthy body weight may help improve overall treatment outcomes and reduce the risk of cancer recurrence.
  • Support bone health: Ensure adequate calcium and vitamin D intake through your diet or supplements if recommended by your doctor, as long-term hormone therapy may affect bone strength.
  • Avoid smoking and limit alcohol: Smoking and excessive alcohol consumption may increase the risk of treatment-related complications and negatively affect your overall health during cancer therapy.
health query

Have a query?

How Soon It Starts Working

The time required for ZONALTA 8 TABLETS to start to work: The time required for ZONALTA 8 TABLETS to show its action is unknown.

The time for which the effects of ZONALTA 8 TABLETS last: The duration of action for ZONALTA 8 TABLETS is clinically unknown.

What if you forget to take ZONALTA 8 TABLETS

Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed one.

Storage

• Store ZONALTA 8 TABLETS at room temperature, ideally between 15°C and 30°C (59°F to 86°F).• Keep the medicine in its original container, tightly closed, to protect it from direct light, heat, and moisture.

Drug Warnings

  • Use effective non-hormonal contraception: This medicine may harm an unborn baby. Use effective non-hormonal birth control during treatment and for the period recommended by your doctor after stopping the medicine.
  • Attend regular follow-up appointments: Your doctor may recommend routine blood tests, liver function tests, gynaecological examinations, and eye examinations to monitor your health during long-term treatment.
  • Watch for signs of blood clots: Seek immediate medical attention if you develop sudden chest pain, shortness of breath, swelling or pain in one leg, or sudden vision changes, as these may indicate a serious blood clot.
  • Inform your healthcare providers: Tell your doctor, surgeon, or dentist that you are taking ZONALTA 8 TABLETS before any surgery or invasive procedure, as temporary interruption of treatment may be necessary to reduce the risk of blood clots.

Drug-Drug Interactions

verifiedApollotooltip

ZONALTA 8 TABLETS may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.
Anticoagulants (blood thinners): Medicines such as warfarin may increase the risk of bleeding when taken with ZONALTA 8 TABLETS. Your doctor may recommend closer monitoring.

  • Hormonal therapies containing estrogen: Estrogen-containing medicines, including some hormone replacement therapies and hormonal contraceptives, may reduce the effectiveness of endoxifen and should generally be avoided unless specifically advised by your doctor.
  • Strong CYP enzyme inhibitors or inducers: Certain medicines that affect liver enzymes responsible for drug metabolism may alter endoxifen levels in the body. Inform your doctor about all suggested medicines, over-the-counter medicines, and herbal supplements you are taking.
  • Other anticancer medicines: When used with other cancer treatments, your doctor may adjust your treatment plan and monitor you closely for side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Excessive alcohol consumption may increase the risk of liver problems and should be limited during treatment.
  • Food: ZONALTA 8 TABLETS can be taken with or without food. Taking it consistently in the same way each day may help maintain predictable absorption.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

ZONALTA 8 TABLETS is used to treat or reduce the symptoms of manic episodes in bipolar I illness, with or without mixed characteristics (both highs and lows at the same time).
ZONALTA 8 TABLETS contains Endoxifen, which acts in the neurological system by suppressing protein kinase C activity and so aids in the management of various brain chemicals that affect your moods, such as serotonin, norepinephrine, and dopamine.
ZONALTA 8 TABLETS is indicated in adults for the acute treatment of manic episodes with or without mixed features (both highs and lows simultaneously) that happen with bipolar disorder.
You are not recommended to stop taking ZONALTA 8 TABLETS even if you begin to feel better as it may cause recurring symptoms. Therefore, continue taking ZONALTA 8 TABLETS for as long as it is suggested by a doctor.
ZONALTA 8 TABLETS may cause stomach upset or diarrhoea. Do not take any medication to treat this condition without a doctor's notice. It does not require medical attention and will resolve gradually over time in most cases. However, you are advised to talk to your doctor if you experience these side effects persistently.
The side effects of ZONALTA 8 TABLETS include headache, vomiting, insomnia (inability to sleep), diarrhoea, restlessness, or stomach upset. If these side effects persist or worsen, please consult your doctor.
Bipolar disorder also called as manic depression is a mental illness that causes unusual shifts in a person's mood, energy, concentration, and activity levels. It is marked by episodes of mood swings ranging from depressive lows to manic highs.
ZONALTA 8 TABLETS is not recommended for use during pregnancy and breastfeeding. Therefore, if you are pregnant, planning pregnancy or are breastfeeding, inform your doctor before taking ZONALTA 8 TABLETS.
Some hormone-regulating medicines can affect bone strength over time. Your doctor may monitor your bone density during treatment. Talk to your doctor or pharmacist about lifestyle changes or supplements to protect your bones.
You can take ZONALTA 8 TABLETS at any time of day, as long as you take it consistently at the same time each day. Choose a time that is easy for you to remember. Talk to your doctor or pharmacist if you need help planning your schedule.
It is best to avoid or strictly limit alcohol consumption while taking ZONALTA 8 TABLETS. Alcohol can increase the risk of liver strain and make certain side effects, like hot flashes, more severe. Talk to your doctor for specific advice.
Mild joint pain is a common side effect. However, if the pain becomes severe, affects your daily activities, or is accompanied by swelling, do not ignore it. Talk to your doctor or pharmacist to discuss safe options for relief.
In rare cases, hormone-regulating treatments can cause changes in vision. If you notice any blurriness, double vision, or other eye discomfort while taking this medicine, seek medical advice right away. Talk to your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZON0106

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