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compositionComposition:ZIDOVUDINE-300MG
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Prescription Medicine
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Zidine-300 mg Tablet 60's (Emcure) is used in the treatment of HIV. It contains Zidovudine, which belongs to the class of protease nucleoside reverse transcriptase inhibitor (NRTI). It works by inhibiting the nucleoside reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This inhibits viral replication and thereby prevents the further spread of infection. Common side effects of this medication may include nausea, headache, stomach pain, loss of appetite, vomiting, nausea, cough, diarrhoea, nasal congestion, fever, tiredness, muscle pain, dizziness, and allergic reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ZIDOVUDINE-300MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Zidine-300 mg Tablet 60's (Emcure)

Zidine-300 mg Tablet 60's (Emcure) is an antiretroviral medicine used in the treatment of HIV. Human Immunodeficiency Virus (HIV) is a retroviral infection that attacks and damages the cells of the immune system. This weakens the ability to fight against infections and diseases. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Syndrome (AIDS). Symptoms of HIV include fever, chills, night sweats, muscle aches, etc. This medicine is also used for the prevention of maternal-fetal HIV transmission.

Zidine-300 mg Tablet 60's (Emcure) contains Zidovudine, which belongs to the class of protease nucleoside reverse transcriptase inhibitor (NRTI). It works by inhibiting the nucleoside reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of viral replication and thereby prevents further spread of infection.

Zidine-300 mg Tablet 60's (Emcure) may cause certain side effects such as nausea, headache, stomach pain, loss of appetite, vomiting, nausea, cough, diarrhea, nasal congestion, fever, tiredness, muscle pain, dizziness, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Zidine-300 mg Tablet 60's (Emcure) should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on your health condition. Do not take more than the recommended dose.

Zidine-300 mg Tablet 60's (Emcure) should be avoided if you are allergic to it. Before taking this medicine, inform your doctor if you have heart problems, liver/kidney diseases, haematological toxicity, severe anemia, hepatomegaly with steatosis, lactic acidosis, or peripheral nephropathy. If you are pregnant and breastfeeding, let your doctor know before taking Zidine-300 mg Tablet 60's (Emcure). Zidine-300 mg Tablet 60's (Emcure) can be used in children only if recommended by the doctor. If prescribed, the child should be carefully monitored for any changes. Zidine-300 mg Tablet 60's (Emcure) is used to treat the infection but does not cure or prevent it. Inform your doctor about your medical history and the medicines you take to prevent possible interactions.

Uses of Zidine-300 mg Tablet 60's (Emcure)

Zidine-300 mg Tablet 60's (Emcure) is used in the treatment and prevention of HIV (Human Immunodeficiency Virus) infection. The detailed uses of Zidine-300 mg Tablet 60's (Emcure) are as follows:

  • Treatment of HIV infection: Zidine-300 mg Tablet 60's (Emcure), in combination with other antiretroviral medications, helps reduce HIV levels in the blood and slows disease progression.
  • Prevention of mother-to-child transmission: Zidine-300 mg Tablet 60's (Emcure) is used in HIV-positive pregnant women to lower the risk of passing the infection to their babies.
  • Delay progression to AIDS: Zidine-300 mg Tablet 60's (Emcure) reduces the risk of developing AIDS and associated complications like infections and certain cancers.
  • Part of comprehensive HIV management: Zidine-300 mg Tablet 60's (Emcure) is an nucleoside reverse transcriptase inhibitor (NRTI) that forms a key component of combination antiretroviral therapy (cART), supporting viral suppression and improved quality of life.

Key Benefits

Zidine-300 mg Tablet 60's (Emcure) contains Zidovudine, which belongs to the class of protease nucleoside reverse transcriptase inhibitor (NRTI). It works by inhibiting the nucleoside reverse transcriptase enzymes that are necessary for the virus's DNA reproduction. This causes inhibition of viral replication and thereby prevents further spread of infection. Zidine-300 mg Tablet 60's (Emcure) is used in combination with other antiretroviral medicines to help reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV. 

Directions for Use

  • Zidine-300 mg Tablet 60's (Emcure) can be taken with or without food as prescribed by your doctor.
  • It is usually taken twice daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not open, chew, or break the medicine.

How Zidine-300 mg Tablet 60's (Emcure) Works

Zidine-300 mg Tablet 60's (Emcure) contains zidovudine, a nucleoside reverse transcriptase inhibitor (NRTI) that helps treat HIV-1 infection. Once inside the body, it is converted into its active form, which mimics the natural building blocks of viral DNA. When HIV tries to copy its genetic material, it mistakenly uses Zidine-300 mg Tablet 60's (Emcure) instead of the natural building block, stopping the viral DNA chain from being completed. This prevents the virus from multiplying and spreading to new cells, helping the immune system better control the infection.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while taking Zidine-300 mg Tablet 60's (Emcure).

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Pregnancy

Consult your doctor

If you are pregnant or suspect you may be pregnant, inform your doctor before taking Zidine-300 mg Tablet 60's (Emcure). Your doctor will prescribe a suitable dose of this medicine to prevent maternal-fetal HIV transmission.

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Breast Feeding

Unsafe

Zidine-300 mg Tablet 60's (Emcure) is excreted in milk. You should not nurse your child if you are taking this medicine because of the risk of HIV-1 transmission and serious adverse reactions in breastfeeding infants.

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Driving

Unsafe

Avoid driving vehicles after taking Zidine-300 mg Tablet 60's (Emcure) as it may cause dizziness and affect your ability to drive.

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Liver

Caution

Zidine-300 mg Tablet 60's (Emcure) should be used with caution in patients with mild to moderate liver impairment. In case of severe liver problems, it may increase the risk of hematologic toxicity. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Zidine-300 mg Tablet 60's (Emcure) should be used with caution in patients with kidney impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

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Heart

Caution

Inform your doctor before receiving Zidine-300 mg Tablet 60's (Emcure) if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available about the use of Zidine-300 mg Tablet 60's (Emcure) in geriatric patients. Please consult your physician.

What if I have taken an overdose of Zidine-300 mg Tablet 60's (Emcure)

If you think you have taken more than the prescribed dose of Zidine-300 mg Tablet 60's (Emcure), seek immediate medical attention straight away. Symptoms of an overdose may include extreme tiredness, severe nausea, vomiting, or difficulty breathing. Take the medicine pack with you so healthcare professionals know exactly what was taken.

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin-rich and nutrient-rich food such as vegetables and fruit as it helps to boost your immune system. Try to take lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injection or drug equipment.
  • Get tested for other sexually transmitted infections, such as gonorrhoea or syphilis.
  • Try to reduce emotional and physical stress by spending time with your family or doing whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration.
health query

Have a query?

How Soon It Starts Working

The time required for Zidine-300 mg Tablet 60's (Emcure) to start to work: The exact onset time of Zidine-300 mg Tablet 60's (Emcure) has not been clinically established. The time for which the effects of Zidine-300 mg Tablet 60's (Emcure) last: The duration of Zidine-300 mg Tablet 60's (Emcure)’s effect is clinically not established.

What if you forget to take Zidine-300 mg Tablet 60's (Emcure)

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep Zidine-300 mg Tablet 60's (Emcure) out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor your blood counts regularly: Your doctor will perform routine blood tests to check for anemia (low red blood cells) or neutropenia (low white blood cells), which are common serious risks with this medicine.
  • Watch for liver warning signs: Seek immediate medical care if you experience persistent nausea, upper abdominal pain, dark urine, or yellowing of the skin or eyes.
  • Avoid self-medication: Never start any new over-the-counter medicines, herbal supplements, or vitamins without asking your pharmacist or doctor first, as they could block Zidine-300 mg Tablet 60's (Emcure) or cause harmful side effects.
  • Do not share your medication: This prescription is specific to your medical condition and viral profile; sharing it can lead to treatment failure or dangerous drug resistance in others.
  • Check your pills: Inspect your capsules or tablets before taking them; do not use them if they are discoloured, cracked, or showing signs of dampness.
  • Do not replace or stop Zidine-300 mg Tablet 60's (Emcure) on your own: Never substitute Zidine-300 mg Tablet 60's (Emcure) with another HIV medicine or stop treatment without consulting your doctor, as this may reduce treatment effectiveness and increase the risk of drug resistance.

Drug-Drug Interactions

verifiedApollotooltip
  • Bone marrow-suppressing medicines: Medicines such as ganciclovir or certain chemotherapy drugs may increase the risk of severe anaemia and low white blood cell counts when taken with Zidine-300 mg Tablet 60's (Emcure).
  • Other antiviral medicines: Taking Zidine-300 mg Tablet 60's (Emcure) with antivirals such as ribavirin may reduce its effectiveness or increase the risk of liver damage.
  • Phenytoin or methadone: Zidine-300 mg Tablet 60's (Emcure) may alter the levels of phenytoin or methadone in your body, so your doctor may need to monitor you closely or adjust your treatment.

Drug-Drug Interactions

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How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
Combining Zidine-300 mg Tablet 60's (Emcure) with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Zidine-300 mg Tablet 60's (Emcure), but it can be taken if prescribed by a doctor. If you notice any of these symptoms - such as a severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating - it is important to contact your doctor right away." Do not stop using any medications without a doctor's advice.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
Combining Cladribine with Zidine-300 mg Tablet 60's (Emcure) can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Zidine-300 mg Tablet 60's (Emcure) together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
Taking Zidine-300 mg Tablet 60's (Emcure) with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Zidine-300 mg Tablet 60's (Emcure), you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
coadministration of baricitinib and Zidine-300 mg Tablet 60's (Emcure) can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Zidine-300 mg Tablet 60's (Emcure) if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
When Zidine-300 mg Tablet 60's (Emcure) and Infliximab are taken together, the body breaks down Zidine-300 mg Tablet 60's (Emcure) faster. This can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Zidine-300 mg Tablet 60's (Emcure) together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
When Etanercept is used with Zidine-300 mg Tablet 60's (Emcure), the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Etanercept with Zidine-300 mg Tablet 60's (Emcure) together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
Combining Valganciclovir with Zidine-300 mg Tablet 60's (Emcure) can increase the risk of side effects.

How to manage the interaction:
Although taking Valganciclovir and Zidine-300 mg Tablet 60's (Emcure) together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Zidine-300 mg Tablet 60's (Emcure):
Using Zidine-300 mg Tablet 60's (Emcure) together with ganciclovir may increase the risk of side effects affecting the blood leading to decreased levels of blood cells.

How to manage the interaction:
Taking ganciclovir with Zidine-300 mg Tablet 60's (Emcure) together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, sore throat, rashes, tiredness, headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Zidine-300 mg Tablet 60's (Emcure) when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

No, Zidine-300 mg Tablet 60's (Emcure) is not a cure for HIV. It is an antiviral medication that helps control and manage the virus so that your immune system can stay healthy. You must continue taking your medication as prescribed. Talk to your doctor if you have questions about your long-term treatment plan.
It is highly recommended to avoid or severely limit alcohol while taking Zidine-300 mg Tablet 60's (Emcure). Alcohol can increase the risk of liver damage and worsen side effects like dizziness or stomach upset. Talk to your doctor or pharmacist about safe lifestyle choices.
Unexplained or severe muscle pain, weakness, or tenderness can be a sign of a serious side effect, such as muscle tissue breakdown or lactic acidosis. If you experience these symptoms, contact your healthcare provider immediately. Talk to your doctor.
Yes, you can take Zidine-300 mg Tablet 60's (Emcure) with or without food. If the medicine causes an upset stomach or nausea, taking it with a meal can help reduce these symptoms. Talk to your doctor or pharmacist if stomach issues persist.
While Zidine-300 mg Tablet 60's (Emcure) lowers your viral load and reduces the risk of transmitting HIV, it does not completely eliminate the risk of passing the virus to others through sexual contact or blood sharing. Continue using safe protection methods. Talk to your doctor for guidance.
Yes, Zidine-300 mg Tablet 60's (Emcure) is commonly prescribed during pregnancy to help prevent the transmission of HIV from the mother to the baby. Your healthcare provider will guide you on how to take it safely during this time. Talk to your doctor for personalised advice.
Early signs of liver problems include persistent nausea, loss of appetite, dark-coloured urine, light-coloured stools, and yellowing of the skin or the whites of your eyes. If you notice any of these signs, seek medical help immediately. Talk to your doctor.
HIV can sometimes become resistant to Zidine-300 mg Tablet 60's (Emcure), especially if medicines are not taken exactly as prescribed. If this happens, your doctor may perform tests to check for drug resistance and recommend a different combination of HIV medicines. Do not stop or replace Zidine-300 mg Tablet 60's (Emcure) with another HIV medicine without your doctor's advice.

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Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - ZID0056
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