Zexipag 200 Tablet 10's

Prescription drug

MRP ₹840

(Inclusive of all Taxes)

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Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zexipag 200 Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs), slow down the worsening of symptoms, and reduce the chance of hospitalisation. It contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries, lowering the pressure in them.

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About Zexipag 200 Tablet

Zexipag 200 Tablet belongs to the group of medicines called selective non-prostanoid IP prostacyclin receptor agonists used to treat pulmonary arterial hypertension (high blood pressure in the lungs), to slow down the worsening of symptoms and to reduce the chance of hospitalisation.

Zexipag 200 Tablet contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries. Thereby, it lowers the pressure in the pulmonary arteries.

In some cases, Zexipag 200 Tablet may cause side effects such as headache, nausea, vomiting, diarrhoea, and stuffy nose. Most of these side effects may not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult the doctor.

Do not take Zexipag 200 Tablet if you are pregnant or breastfeeding. Zexipag 200 Tablet is not recommended for use in children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Zexipag 200 Tablet

Zexipag 200 Tablet is used in the treatment of Pulmonary arterial hypertension (PAH). The detailed uses of Zexipag 200 Tablet are as follows:

Treat pulmonary arterial hypertension (PAH): Zexipag 200 Tablet helps lower high blood pressure in the arteries of the lungs by relaxing and widening blood vessels, improving blood flow and reducing strain on the heart.
Improve exercise capacity: Zexipag 200 Tablet enhances physical endurance in patients with PAH by reducing symptoms such as breathlessness and fatigue during activity.
Delay disease progression: Zexipag 200 Tablet slows the worsening of PAH symptoms and reduces the risk of hospitalization by targeting prostacyclin receptors to prevent abnormal blood vessel growth.

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Directions for Use

Take Zexipag 200 Tablet with food to reduce stomach upset.
Recommended to take twice a day or as advised by your doctor.
Swallow the medicine as a whole with a glass of water.
Do not crush, break, or chew it.

Medicinal Benefits

Zexipag 200 Tablet belongs to the group of medicines called selective non-prostanoid IP prostacyclin receptor agonists used to treat pulmonary arterial hypertension (high blood pressure in the lungs), delay disease progression and lower the risk of hospitalisation for pulmonary arterial hypertension. Zexipag 200 Tablet contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries. Thereby, Zexipag 200 Tablet lowers the pressure in the pulmonary arteries, relieves symptoms of pulmonary arterial hypertension and slows down its progression.

How Zexipag 200 Tablet Works

Zexipag 200 Tablet contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries. Thereby, it lowers the pressure in the pulmonary arteries.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zexipag 200 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Zexipag 200 Tablet

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Jaw Pain

Consult your doctor to discuss which medicine could be contributing to your jaw pain and whether you need to change the dose or switch to a different medicine.
Try taking pain relievers like paracetamol, ibuprofen or naproxen.
Apply cold or warm compresses to your jaw for pain relief.
Do gentle jaw stretching exercises to enhance muscle flexibility and reduce pain.
Eat soft foods that need little jaw movement to reduce strain.
Avoid habits like nail biting, clenching your jaw, and gum chewing.
Maintain good posture of your jaw to reduce strain.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Muscle Pain

Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:

Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Pain In Arm Or Leg

Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
Rest and take a break from usual activities.
Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
Avoid strenuous activities and rest the affected area.
Try light stretching with gentle exercises to maintain flexibility.
Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.

What if I have taken an overdose of Zexipag 200 Tablet

Do not take more than prescribed dose. Using more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you may have overdosed of Zexipag 200 Tablet , please go to the emergency department of the closest hospital or nursing home.

Drug Warnings

Do not take Zexipag 200 Tablet if you are allergic to any of its components, if you have/had heart problems such as unstable angina, severe coronary heart disease, heart attack within last six months, weak heart, severe irregular heartbeat, defect of heart valves, or if you had a stroke within the last three months, reduced blood supply to the brain, or if you are taking gemfibrozil. Inform the doctor if you have low blood pressure associated with dizziness, severe diarrhoea or vomiting, thyroid problems, severe kidney problems, undergoing dialysis, severe liver problems, or if you are taking medicines for high blood pressure. Do not take Zexipag 200 Tablet if you are pregnant or breastfeeding. Zexipag 200 Tablet is not recommended for children. Let the doctor know if you are taking any other medicines, including supplements or herbal products.

Drug-Drug Interactions

SelexipagClopidogrel

Critical

SelexipagGemfibrozil

Critical

Drug-Drug Interactions

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SelexipagClopidogrel

Critical

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet and Clopidogrel are taken together, the body's ability to break down Zexipag 200 Tablet may be reduced.

How to manage the interaction:
Taking Clopidogrel with Zexipag 200 Tablet is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.

SelexipagGemfibrozil

Critical

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet is taken with Gemfibrozil, the amount of Zexipag 200 Tablet in the blood can go up. This can increase the risk or severity of side effects like anemia, muscle and joint pain, or electrolyte imbalance.

How to manage the interaction:
Taking Zexipag 200 Tablet with Gemfibrozil can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle and joint pain, diarrhea, sudden dizziness, lightheadedness, fainting, shortness of breath, nausea, vomiting, flushing, and decreased appetite, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

SelexipagEfavirenz

Severe

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet is taken with Efavirenz, the levels and efficacy of Zexipag 200 Tablet increases. This results in an increased risk of side effects.

How to manage the interaction:
Taking Zexipag 200 Tablet with Efavirenz together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.

SelexipagCarbamazepine

Severe

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet is taken with Carbamazepine, it can decrease the levels of Zexipag 200 Tablet which may lead to reduced action.

How to manage the interaction:
Co-administration of Zexipag 200 Tablet with Carbamazepine can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

SelexipagCelecoxib

Severe

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet is taken with Celecoxib, therapeutic efficacy of Zexipag 200 Tablet can be decreased.

How to manage the interaction:
Taking Zexipag 200 Tablet with Celecoxib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience any unusual symptoms. Do not stop using any medications without a doctor's advice.

SelexipagDeferasirox

Severe

How does the drug interact with Zexipag 200 Tablet:
When Zexipag 200 Tablet and Deferasirox are taken together Deferasirox may significantly increase the blood levels of Zexipag 200 Tablet.

How to manage the interaction:
Although taking Zexipag 200 Tablet and Deferasirox together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience any sife effects like anemia (paleness), reduced hunger, diarrhea, nausea, and vomiting, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Lower your intake of salt. This helps in reducing the risk of developing oedema.
Include vegetables, fruits, whole grains, lean meats, poultry, fish, and fat-free/low-fat dairy products in your diet.
Avoid canned foods, processed foods, pickled, and frozen foods. Instead, consume fresh foods.
Limit consumption of caffeine and alcohol as they can alter blood pressure.
Monitor fluid intake to prevent swelling/fluid retention.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

All Substitutes & Brand Comparisons

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Alcohol

Consult your doctor

It is not known whether Zexipag 200 Tablet interacts with alcohol. Please consult your doctor.

Pregnancy

Unsafe

Zexipag 200 Tablet is not recommended during pregnancy. Consult the doctor if you become pregnant during treatment with Zexipag 200 Tablet .

Breast Feeding

Unsafe

It is not known if Selexipag passes into breast milk. Zexipag 200 Tablet is not recommended during lactation.

Driving

Caution

Zexipag 200 Tablet may cause headaches and low blood pressure, affecting your ability to drive. Drive or operate machinery only if you are alert.

Liver

Caution

Zexipag 200 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in people with moderate hepatic impairment. Consult the doctor if you have liver problems.

Kidney

Caution

Please consult the doctor if you have any concerns regarding the usage of Zexipag 200 Tablet in patients with kidney impairment.

Children

Unsafe

Zexipag 200 Tablet is not recommended for use in children below 18 years as the safety and effectiveness have not been established.

Heart

Zexipag 200 Tablet is often used in heart-related conditions like PAH and may benefit certain cardiac patients. However, it must be taken under medical supervision to manage potential side effects and drug interactions.

Geriatrics

Caution

Zexipag 200 Tablet may be used in geriatric patients, but with caution due to increased sensitivity to its effects. While studies haven’t shown major age-related issues, doctors monitor elderly patients closely and may adjust the dose to ensure safe and effective treatment.

FAQs

What is the use of Zexipag 200 Tablet ?

Zexipag 200 Tablet is used to treat Pulmonary arterial hypertension (PAH).

How does Zexipag 200 Tablet work?

Zexipag 200 Tablet relaxes the blood vessels in the lungs and allows the blood to flow easily. Thereby, it relieves the symptoms of pulmonary arterial hypertension and slows down its progression.

Can I stop taking Zexipag 200 Tablet if I feel well?

Do not stop taking Zexipag 200 Tablet on your own. Zexipag 200 Tablet helps control the symptoms of PAH but does not cure it. Therefore, continue taking Zexipag 200 Tablet for as long as it has been prescribed by the doctor.

Is Zexipag 200 Tablet safe for use in the elderly?

Zexipag 200 Tablet should be used with caution in patients older than 75 years as there is limited experience in this age group. Consult the doctor if you have any concerns.

Can I take Zexipag 200 Tablet with gemfibrozil?

Let the doctor know if you are taking gemfibrozil, a medicine used to lower fat levels in the blood. If you are taking gemfibrozil, your doctor may tell you not to take Zexipag 200 Tablet .

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Other Info - ZEX0023

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:50 AM IST

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