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compositionComposition:TRABECTEDIN-1MG
prescription
Prescription Medicine
info
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Yondelis Injection is used to treat various cancers, including ovarian cancer and soft tissue sarcoma. It contains Trabectedin, which works by sticking to the DNA in cells and damaging it; this stops the cancer cells from growing and multiplying. This medication may cause fetal harm, so it should not be used in pregnant women. Both women and men using this medication should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRABECTEDIN-1MG

Manufacturer/Marketer :

Janssen Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Yondelis Injection

Yondelis Injection is a prescription chemotherapy medicine given as an infusion into a vein. It is medically used to treat advanced soft tissue cancers, such as liposarcoma and leiomyosarcoma, that have spread or cannot be removed by surgery. It is also used in combination with other medicines to treat advanced ovarian cancer that has returned after previous treatments.

Because this medicine is given as an intravenous infusion by a healthcare professional, the treatment is carefully scheduled in cycles, typically every 3 weeks. You do not need to worry about taking it with food, but staying well-hydrated and eating small, frequent meals can help manage treatment-related nausea and support your body during therapy.

Common side effects of this treatment include extreme tiredness, nausea, headache, and temporary changes in liver blood tests. However, you must contact your healthcare team immediately if you experience signs of infection (such as a fever), unusual bruising, severe muscle pain, or yellowing of your skin or eyes, as these could indicate more serious complications.

Do not take this if you have a severe active infection, severe liver disease, or if you are currently breastfeeding. Before starting this medicine, tell your doctor if you have a history of heart disease, kidney issues, or liver problems so they can determine if this treatment is safe for you.

This medicine can interact with several other drugs, including certain antibiotics, antifungals, and herbal supplements like St. John's Wort, which can alter how your body processes the treatment. Avoid drinking alcohol during your treatment cycle to prevent putting extra strain on your liver, and talk to your doctor if you are pregnant, planning to become pregnant, or are an older adult.

Uses of Yondelis Injection

Yondelis Injection is used to treat certain advanced cancers. The detailed uses of Yondelis Injection are as follows:

  • Soft tissue sarcoma: Helps slow down or stop the growth of advanced cancerous tumours in the body's supportive tissues, such as fat or muscle, especially after other standard chemotherapy treatments have been tried.
  • Ovarian cancer: Works in combination with other chemotherapy drugs to target and destroy recurrent cancer cells in the ovaries, helping to manage the disease when first-line treatments are no longer effective.

Key Benefits

Yondelis Injection helps slow down the growth and spread of cancer cells, supporting disease management and helping to improve quality of life. The benefits of Yondelis Injection are as follows:

  • Helps Shrink or Stabilise Tumours: By directly interfering with the genetic material of rapidly dividing cancer cells, Yondelis Injection helps shrink or stabilise tumours. This provides valuable time and manages cancer-related symptoms like pain or localised discomfort, helping you feel more comfortable during your treatment course.
  • Supports Disease Control: For patients with advanced soft tissue cancers who have already undergone standard chemotherapy, this treatment provides a clinically proven option to keep the disease under control. It offers a vital path forward when other standard treatments have stopped working.
  • Enhances Combination Therapy: When used in combination with other cancer medicines, it works synergistically to enhance the overall effectiveness of the treatment. This collaborative action helps prolong the period during which the cancer does not progress, offering a supportive approach to managing advanced stages of the disease.
Side effects of Yondelis Injection
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Typically, Yondelis Injection is administered once every 3 weeks for as long as your doctor recommends continuing the treatment. However, follow your doctor's instructions on the dosage and timing of this medication.
  • Yondelis Injection will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Yondelis Injection Works

Yondelis Injection contains trabectedin, which belongs to a class of medicines known as antitumor agents. It works by binding directly to the DNA inside cancer cells. This binding action bends the DNA structure, which prevents the cell from reading its genetic instructions properly. By disrupting this vital process, the medicine stops the cancer cells from multiplying and repairing themselves. Over time, this causes the abnormal cells to self-destruct, helping to slow down or halt the spread of the tumour in the body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Yondelis Injection.

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Pregnancy

Unsafe

Yondelis Injection should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

Yondelis Injection may cause side effects such as tiredness and dizziness. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

Caution should be exercised. Hepatotoxicity may occur. Monitor and delay and/or reduce dose if needed.

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Kidney

Caution

No dose adjustment is recommended in patients with mild [creatinine clearance (CLcr) 60-89 mL/min] or moderate (CLcr of 30-59 mL/min) renal impairment. There is no information available on patients with severe kidney impairment.

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

Yondelis Injection may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Yondelis Injection.

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Geriatrics

Safe if prescribed

Yondelis Injection is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Yondelis Injection

Because a trained healthcare professional prepares and administers this medicine, an overdose is extremely rare. However, if an accidental overdose is suspected, medical staff will monitor you closely and provide supportive treatment as needed.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids (like water or clear broths) to help support your kidneys and flush the medicine through your system, especially on treatment days.
  • Protect your liver: Avoid drinking alcohol and check with your pharmacist before taking any over-the-counter pain relievers to minimise strain on your liver.
  • Eat small, nutrient-dense meals: To combat nausea and loss of appetite, focus on eating smaller meals throughout the day rather than three large ones. Include protein-rich foods to help maintain muscle strength.
  • Practice strict infection prevention: Since this treatment temporarily lowers your white blood cell count, wash your hands frequently, avoid crowded places, and stay away from people who are sick.
  • Prioritise rest: Fatigue is very common during this therapy. Listen to your body and schedule regular rest periods throughout the day.
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Have a query?

How Soon It Starts Working

The time required for Yondelis Injection to start to work: The time required for Yondelis Injection to show its action is not clinically established. The time for which the effects of Yondelis Injection last: The duration of action for Yondelis Injection is not clinically established.

What if you forget to take Yondelis Injection

Since this medicine is given under close medical supervision at a clinic or hospital, it is highly unlikely that you will miss a dose. However, if you miss an appointment or need to delay your treatment, call your healthcare team immediately to reschedule.

Storage

• Store unopened vials of Yondelis Injection in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Monitor the injection site: Tell your nurse immediately if you feel pain, burning, swelling, or redness at the injection site during the infusion, as this medicine can be harsh on veins if it leaks.
  • Get routine blood tests: You will need frequent blood tests to check your liver enzymes, kidney function, and blood cell counts before starting each treatment cycle.
  • Use reliable birth control and consider fertility: Both men and women should use highly effective birth control during treatment and for several months after the final dose. Because Yondelis Injection can impair fertility, discuss fertility preservation options with your oncologist before starting treatment.
  • Take your pre-medicines: Always take the steroid medicines prescribed by your doctor exactly as directed before your infusion to help protect your liver and manage side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 Inhibitors: May interact with strong CYP3A4 inhibitors (such as certain ketoconazole or clarithromycin), which can increase the level of Yondelis Injection in your body and raise the risk of side effects.
  • Strong CYP3A4 Inducers: May interact with strong CYP3A4 inducers (such as rifampin or phenytoin), which can lower the amount of Yondelis Injection in your body, making it less effective.
TrabectedinCladribine
Severe

Drug-Drug Interactions

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TrabectedinCladribine
Severe
How does the drug interact with Yondelis Injection:
Combining Cladribine with Yondelis Injection can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Cladribine with Yondelis Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Avoid eating grapefruit or drinking grapefruit juice during your treatment, as it can interfere with how your body breaks down this medicine, potentially increasing side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Yondelis Injection is used to treat Ovarian Cancer and Soft Tissue Sarcoma (Liposarcoma).
Yondelis Injection contains Trabectedin, which works by sticking to the DNA in cells and damaging it. This stops the cancer cells from growing and multiplying.
It is recommended not to be used in the population who are allergic to Trabectedin or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, Yondelis Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
Yondelis Injection may cause permanent fertility problems in men if they take it. Please discuss this with their doctor before starting treatment.
This medicine is given as a slow intravenous infusion through a central line in a vein, administered by a trained healthcare professional in a hospital or clinic. Talk to your doctor for more details about your infusion plan.
Hair thinning or hair loss is possible but is less common with this medicine compared to some other chemotherapies. Talk to your doctor or nurse if you are concerned about hair loss.
Steroid injections (such as dexamethasone) are given before your treatment to help protect your liver from damage and to prevent severe nausea and vomiting. Talk to your doctor about your pre-medicine routine.
This medicine can cause extreme tiredness, dizziness, or weakness. Avoid driving or operating machinery until you know how the treatment affects you. Talk to your doctor if you feel too fatigued to drive.
A fever can be a sign of a serious infection, which can be dangerous when your white blood cell count is low. Contact your healthcare team or go to the nearest emergency room immediately. Talk to your doctor about infection safety.
Your doctor may delay a cycle or lower your dose if your routine blood tests show significantly low white blood cell or platelet counts, elevated liver enzymes, or reduced kidney function. These adjustments ensure your body has enough time to recover safely before your next dose.
The infusion itself can take anywhere from 3 to 24 hours, depending on the specific condition being treated, and is typically repeated every 3 weeks. Talk to your doctor to understand your specific schedule.
You should avoid receiving live vaccines during your treatment, as your immune system may be weakened. Always check with your healthcare provider before getting any vaccine. Talk to your doctor or pharmacist.
No, this medicine can cause severe harm to an unborn baby. You must use effective birth control during treatment and for a specified time after your last dose. Talk to your doctor about safe family planning options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A615059 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 207953S005Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Trabectedin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Nakamura T, Sudo A. The Role of Trabectedin in Soft Tissue Sarcoma. Front Pharmacol. 2022. [Accessed on 6th September 2024]Check here
  5. Pharma Mar, S.A. Electronic Medicines Compendium (EMC). [Revised in April 2024] [Accessed on 6th September 2024]Check here
  6. Trabectedin (Yondelis). [Accessed on 02 Jun. 2026]Check here
  7. Trabectedin. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - YON0001
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