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compositionComposition:TRABECTEDIN-1MG
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Prescription Medicine
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TRABEC 1MG INJECTION is used to treat various cancers, including ovarian cancer and soft tissue sarcoma. It contains Trabectedin, which works by sticking to the DNA in cells and damaging it; this stops the cancer cells from growing and multiplying. This medication may cause fetal harm, so it should not be used in pregnant women. Both women and men using this medication should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRABECTEDIN-1MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TRABEC 1MG INJECTION

TRABEC 1MG INJECTION is a prescription chemotherapy medicine given as an infusion into a vein. It is medically used to treat advanced soft tissue cancers, such as liposarcoma and leiomyosarcoma, that have spread or cannot be removed by surgery. It is also used in combination with other medicines to treat advanced ovarian cancer that has returned after previous treatments.

Because this medicine is given as an intravenous infusion by a healthcare professional, the treatment is carefully scheduled in cycles, typically every 3 weeks. You do not need to worry about taking it with food, but staying well-hydrated and eating small, frequent meals can help manage treatment-related nausea and support your body during therapy.

Common side effects of this treatment include extreme tiredness, nausea, headache, and temporary changes in liver blood tests. However, you must contact your healthcare team immediately if you experience signs of infection (such as a fever), unusual bruising, severe muscle pain, or yellowing of your skin or eyes, as these could indicate more serious complications.

Do not take this if you have a severe active infection, severe liver disease, or if you are currently breastfeeding. Before starting this medicine, tell your doctor if you have a history of heart disease, kidney issues, or liver problems so they can determine if this treatment is safe for you.

This medicine can interact with several other drugs, including certain antibiotics, antifungals, and herbal supplements like St. John's Wort, which can alter how your body processes the treatment. Avoid drinking alcohol during your treatment cycle to prevent putting extra strain on your liver, and talk to your doctor if you are pregnant, planning to become pregnant, or are an older adult.

Uses of TRABEC 1MG INJECTION

TRABEC 1MG INJECTION is used to treat certain advanced cancers. The detailed uses of TRABEC 1MG INJECTION are as follows:

  • Soft tissue sarcoma: Helps slow down or stop the growth of advanced cancerous tumours in the body's supportive tissues, such as fat or muscle, especially after other standard chemotherapy treatments have been tried.
  • Ovarian cancer: Works in combination with other chemotherapy drugs to target and destroy recurrent cancer cells in the ovaries, helping to manage the disease when first-line treatments are no longer effective.

Key Benefits

TRABEC 1MG INJECTION helps slow down the growth and spread of cancer cells, supporting disease management and helping to improve quality of life. The benefits of TRABEC 1MG INJECTION are as follows:

  • Helps Shrink or Stabilise Tumours: By directly interfering with the genetic material of rapidly dividing cancer cells, TRABEC 1MG INJECTION helps shrink or stabilise tumours. This provides valuable time and manages cancer-related symptoms like pain or localised discomfort, helping you feel more comfortable during your treatment course.
  • Supports Disease Control: For patients with advanced soft tissue cancers who have already undergone standard chemotherapy, this treatment provides a clinically proven option to keep the disease under control. It offers a vital path forward when other standard treatments have stopped working.
  • Enhances Combination Therapy: When used in combination with other cancer medicines, it works synergistically to enhance the overall effectiveness of the treatment. This collaborative action helps prolong the period during which the cancer does not progress, offering a supportive approach to managing advanced stages of the disease.
Side effects of Trabec 1mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.

Directions for Use

  • Typically, TRABEC 1MG INJECTION is administered once every 3 weeks for as long as your doctor recommends continuing the treatment. However, follow your doctor's instructions on the dosage and timing of this medication.
  • TRABEC 1MG INJECTION will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How TRABEC 1MG INJECTION Works

TRABEC 1MG INJECTION contains trabectedin, which belongs to a class of medicines known as antitumor agents. It works by binding directly to the DNA inside cancer cells. This binding action bends the DNA structure, which prevents the cell from reading its genetic instructions properly. By disrupting this vital process, the medicine stops the cancer cells from multiplying and repairing themselves. Over time, this causes the abnormal cells to self-destruct, helping to slow down or halt the spread of the tumour in the body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with TRABEC 1MG INJECTION.

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Pregnancy

Unsafe

TRABEC 1MG INJECTION should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

TRABEC 1MG INJECTION may cause side effects such as tiredness and dizziness. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

Caution should be exercised. Hepatotoxicity may occur. Monitor and delay and/or reduce dose if needed.

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Kidney

Caution

No dose adjustment is recommended in patients with mild [creatinine clearance (CLcr) 60-89 mL/min] or moderate (CLcr of 30-59 mL/min) renal impairment. There is no information available on patients with severe kidney impairment.

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

TRABEC 1MG INJECTION may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using TRABEC 1MG INJECTION.

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Geriatrics

Safe if prescribed

TRABEC 1MG INJECTION is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of TRABEC 1MG INJECTION

Because a trained healthcare professional prepares and administers this medicine, an overdose is extremely rare. However, if an accidental overdose is suspected, medical staff will monitor you closely and provide supportive treatment as needed.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids (like water or clear broths) to help support your kidneys and flush the medicine through your system, especially on treatment days.
  • Protect your liver: Avoid drinking alcohol and check with your pharmacist before taking any over-the-counter pain relievers to minimise strain on your liver.
  • Eat small, nutrient-dense meals: To combat nausea and loss of appetite, focus on eating smaller meals throughout the day rather than three large ones. Include protein-rich foods to help maintain muscle strength.
  • Practice strict infection prevention: Since this treatment temporarily lowers your white blood cell count, wash your hands frequently, avoid crowded places, and stay away from people who are sick.
  • Prioritise rest: Fatigue is very common during this therapy. Listen to your body and schedule regular rest periods throughout the day.
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How Soon It Starts Working

The time required for TRABEC 1MG INJECTION to start to work: The time required for TRABEC 1MG INJECTION to show its action is not clinically established. The time for which the effects of TRABEC 1MG INJECTION last: The duration of action for TRABEC 1MG INJECTION is not clinically established.

What if you forget to take TRABEC 1MG INJECTION

Since this medicine is given under close medical supervision at a clinic or hospital, it is highly unlikely that you will miss a dose. However, if you miss an appointment or need to delay your treatment, call your healthcare team immediately to reschedule.

Storage

• Store unopened vials of TRABEC 1MG INJECTION in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Monitor the injection site: Tell your nurse immediately if you feel pain, burning, swelling, or redness at the injection site during the infusion, as this medicine can be harsh on veins if it leaks.
  • Get routine blood tests: You will need frequent blood tests to check your liver enzymes, kidney function, and blood cell counts before starting each treatment cycle.
  • Use reliable birth control and consider fertility: Both men and women should use highly effective birth control during treatment and for several months after the final dose. Because TRABEC 1MG INJECTION can impair fertility, discuss fertility preservation options with your oncologist before starting treatment.
  • Take your pre-medicines: Always take the steroid medicines prescribed by your doctor exactly as directed before your infusion to help protect your liver and manage side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 Inhibitors: May interact with strong CYP3A4 inhibitors (such as certain ketoconazole or clarithromycin), which can increase the level of TRABEC 1MG INJECTION in your body and raise the risk of side effects.
  • Strong CYP3A4 Inducers: May interact with strong CYP3A4 inducers (such as rifampin or phenytoin), which can lower the amount of TRABEC 1MG INJECTION in your body, making it less effective.
TrabectedinCladribine
Severe

Drug-Drug Interactions

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TrabectedinCladribine
Severe
How does the drug interact with Trabec 1mg Injection:
Combining Cladribine with Trabec 1mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Cladribine with Trabec 1mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Avoid eating grapefruit or drinking grapefruit juice during your treatment, as it can interfere with how your body breaks down this medicine, potentially increasing side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

TRABEC 1MG INJECTION is used to treat Ovarian Cancer and Soft Tissue Sarcoma (Liposarcoma).
TRABEC 1MG INJECTION contains Trabectedin, which works by sticking to the DNA in cells and damaging it. This stops the cancer cells from growing and multiplying.
It is recommended not to be used in the population who are allergic to Trabectedin or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, TRABEC 1MG INJECTION can cause low neutrophils levels, a type of white blood cells that help fight infections. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
TRABEC 1MG INJECTION may cause permanent fertility problems in men if they take it. Please discuss this with their doctor before starting treatment.
This medicine is given as a slow intravenous infusion through a central line in a vein, administered by a trained healthcare professional in a hospital or clinic. Talk to your doctor for more details about your infusion plan.
Hair thinning or hair loss is possible but is less common with this medicine compared to some other chemotherapies. Talk to your doctor or nurse if you are concerned about hair loss.
Steroid injections (such as dexamethasone) are given before your treatment to help protect your liver from damage and to prevent severe nausea and vomiting. Talk to your doctor about your pre-medicine routine.
This medicine can cause extreme tiredness, dizziness, or weakness. Avoid driving or operating machinery until you know how the treatment affects you. Talk to your doctor if you feel too fatigued to drive.
A fever can be a sign of a serious infection, which can be dangerous when your white blood cell count is low. Contact your healthcare team or go to the nearest emergency room immediately. Talk to your doctor about infection safety.
Your doctor may delay a cycle or lower your dose if your routine blood tests show significantly low white blood cell or platelet counts, elevated liver enzymes, or reduced kidney function. These adjustments ensure your body has enough time to recover safely before your next dose.
The infusion itself can take anywhere from 3 to 24 hours, depending on the specific condition being treated, and is typically repeated every 3 weeks. Talk to your doctor to understand your specific schedule.
You should avoid receiving live vaccines during your treatment, as your immune system may be weakened. Always check with your healthcare provider before getting any vaccine. Talk to your doctor or pharmacist.
No, this medicine can cause severe harm to an unborn baby. You must use effective birth control during treatment and for a specified time after your last dose. Talk to your doctor about safe family planning options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A615059 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 207953S005Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Trabectedin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Nakamura T, Sudo A. The Role of Trabectedin in Soft Tissue Sarcoma. Front Pharmacol. 2022. [Accessed on 6th September 2024]Check here
  5. Pharma Mar, S.A. Electronic Medicines Compendium (EMC). [Revised in April 2024] [Accessed on 6th September 2024]Check here
  6. Trabectedin (Yondelis). [Accessed on 02 Jun. 2026]Check here
  7. Trabectedin. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - TRA0660
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