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compositionComposition:ENZALUTAMIDE-40MG
prescription
Prescription Medicine
info
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Xtandi 40Mg Capsule is used to treat prostate cancer. It contains Enzalutamide, an androgen receptor blocker (inhibitor) that blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow; this can slow the growth of the cancer and may shrink it. Enzalutamide is only for use in men. Men using this medication must use effective birth control whenever they have sex during their treatment and for three months after their final dose.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ENZALUTAMIDE-40MG

Manufacturer/Marketer :

Astellas Pharma India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Xtandi 40Mg Capsule

Xtandi 40Mg Capsule is a prescription medicine primarily used to treat advanced types of prostate cancer. It is designed for prostate cancer that has spread to other parts of the body or no longer responds to medical or surgical treatments that lower testosterone. This medicine works by stopping hormone signals that would otherwise allow cancer cells to grow and multiply.

To get the best results, you must take Xtandi 40Mg Capsule consistently every single day at the same time as prescribed. You can take this medicine with or without food, making it easy to fit into your daily routine. Making small adjustments to your daily life, such as incorporating gentle physical activity and eating a balanced diet, can help your body handle the therapy more effectively.

While taking this medicine, you may experience common side effects like hot flashes, fatigue, and joint discomfort. However, you must contact your doctor immediately if you experience severe symptoms such as sudden confusion, severe dizziness, chest pain, or seizures.

Before starting Xtandi 40Mg Capsule , you must talk to your doctor if you have a history of seizures, brain injury, stroke, heart disease, or high blood pressure. Do not take this if you are allergic to Xtandi 40Mg Capsule or any of the inactive ingredients contained in the tablet.

This medicine can interact with other drugs like blood thinners and certain heart medicines, which may change how well they work or increase side effects. It is not approved for use in women, and pregnant or breastfeeding individuals must not handle or touch the tablets. Elderly patients should talk to their doctor to closely monitor their physical strength and heart health, taking extra precautions against falls due to the combined risk of dizziness, fatigue, and bone weakening.

Uses of Xtandi 40Mg Capsule

Xtandi 40Mg Capsule is used to treat advanced prostate cancer. The detailed uses of Xtandi 40Mg Capsule are as follows:

  • Non-metastatic castration-resistant prostate cancer (nmCRPC): Xtandi 40Mg Capsule treats prostate cancer that is 'castration-resistant' (meaning it continues to grow despite very low testosterone levels) and has not yet spread to other body parts on scans.
  • Metastatic castration-sensitive prostate cancer (mCSPC): Treats prostate cancer that has spread to other body parts (such as bones or lymph nodes) but still responds to medical or surgical treatments that lower testosterone.
  • Metastatic castration-resistant prostate cancer (mCRPC): Treats advanced prostate cancer that has spread to other parts of the body and no longer responds to initial testosterone-lowering treatments.

Key Benefits

Xtandi 40Mg Capsule helps slow the progression of advanced prostate cancer and supports long-term disease management. The key benefits of Xtandi 40Mg Capsule are as follows:

  • Slows Cancer Progression: By blocking the hormones that fuel tumour growth, Xtandi 40Mg Capsule helps slow the progression of advanced prostate cancer, reduces cancer-related pain, and helps prevent the disease from spreading further.
  • Prolongs Survival and Delays Intensive Treatment: Clinical studies have shown that Xtandi 40Mg Capsule helps prolong survival and may delay the need for more intensive treatments, such as chemotherapy, allowing many patients to maintain their independence and daily routine for longer.
Side effects of Xtandi 40 mg Soft Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.

Directions for Use

  • Xtandi 40Mg Capsule can be taken with or without food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Xtandi 40Mg Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Xtandi 40Mg Capsule Works

Xtandi 40Mg Capsule contains enzalutamide, which belongs to a group of medicines called androgen receptor inhibitors. Male hormones, such as testosterone, act as fuel for prostate cancer cells by attaching to specific receptors on the cancer cells and stimulating their growth. Xtandi 40Mg Capsule blocks these androgen receptors, preventing testosterone and other male hormones from attaching to them. This interrupts the growth signals that cancer cells rely on, helping slow the spread of prostate cancer, shrink tumours, and reduce prostate-specific antigen (PSA) levels.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Xtandi 40Mg Capsule .

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Pregnancy

Not applicable

Enzalutamide is only for use in men. Women should not take this medication.

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Breast Feeding

Not applicable

Enzalutamide is only for use in men. Women should not take this medication.

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Driving

Unsafe

Xtandi 40Mg Capsule may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Unsafe

The safety and effectiveness of Xtandi 40Mg Capsule in pediatric patients have not been established.

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Heart

Caution

Xtandi 40Mg Capsule may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Xtandi 40Mg Capsule .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Xtandi 40Mg Capsule to geriatric patients. Your doctor will prescribe Xtandi 40Mg Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Xtandi 40Mg Capsule

If you accidentally take more than your prescribed dose, seek emergency medical care immediately. An overdose can increase your risk of severe side effects, especially seizures.

Diet & Lifestyle Advise

  • Protect your bones: Since hormone therapies can weaken bones, talk to your doctor about taking calcium and vitamin D supplements to lower your risk of bone loss and fractures.
  • Discuss fertility options early: Because Xtandi 40Mg Capsule can significantly impair sperm production and male fertility, speak with your oncologist before starting therapy if family planning is important to you, and consider options like sperm banking.
  • Stay active safely: Regular, low-impact exercise like daily walking can help reduce treatment-related fatigue and maintain your muscle strength.
  • Manage hot flashes: Wear loose, layered clothing made from natural fibres like cotton, and limit triggers like hot beverages, spicy foods, alcohol, and caffeine.
  • Monitor your blood pressure: Keep a regular home log of your blood pressure readings, as this medicine can cause your numbers to rise. Share these readings with your healthcare team.
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How Soon It Starts Working

The time required for Xtandi 40Mg Capsule to start to work: Xtandi 40Mg Capsule ideally shows its action within 1 hour after administration. The time for which the effects of Xtandi 40Mg Capsule last: The duration of action for Xtandi 40Mg Capsule is unknown.

What if you forget to take Xtandi 40Mg Capsule

If you forget to take your dose of Xtandi 40Mg Capsule , take it as soon as you remember on that same day. If you do not remember until the next day, skip the missed dose entirely and take your regular dose at your usual time. Do not take two doses at once to make up for a missed one. If you miss doses for multiple days, talk to your doctor or pharmacist for advice.

Storage

• Store Xtandi 40Mg Capsule at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Be aware of seizure and fall risks: This medicine can increase your risk of seizures, severe dizziness, and fatigue. Take extra precautions to prevent falls, and avoid activities like driving, climbing, or operating heavy machinery if you feel lightheaded.
  • Handle with care: Pregnant women, those planning a pregnancy, or breastfeeding individuals should not touch or handle broken, cracked, or damaged tablets of Xtandi 40Mg Capsule to prevent the drug from absorbing through the skin.
  • Use reliable birth control and consider fertility: If you are sexually active with a female partner who could become pregnant, you must use a highly effective birth control method (such as a condom) during treatment and for 3 months after your last dose. Because Xtandi 40Mg Capsule can impair male fertility, discuss sperm banking options with your doctor before starting treatment if desired.
  • Inspect your tablets: Always check your pills before taking them. Do not take any tablets that look damaged, broken, or moist.

Drug-Drug Interactions

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  • Blood thinners: Taking Xtandi 40Mg Capsule with medicines like warfarin can alter how your blood clots, increasing your risk of bleeding or reducing the drug's effectiveness.
  • Seizure medicines: Combining this medicine with certain anticonvulsants can lower the seizure threshold or affect how both medicines work.
  • Certain heart, cholesterol, and daily medicines: Xtandi 40Mg Capsule is a strong liver enzyme inducer, meaning it speeds up how your liver processes many other medicines, making them less effective. Your doctor will regularly monitor your liver function and review all your medicines.
EnzalutamideRanolazine
Critical
EnzalutamideRegorafenib
Critical

Drug-Drug Interactions

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EnzalutamideRanolazine
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Xtandi 40 mg Soft Capsule may decrease the blood levels of Ranolazine, which may make Ranolazine less effective.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule with Ranolazine is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideRegorafenib
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Xtandi 40 mg Soft Capsule with Regorafenib may decrease the blood levels of Regorafenib, which may make Regorafenib less effective in treating your condition.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule with Regorafenib is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideLurasidone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule:
Co-administration of Lurasidone with Xtandi 40 mg Soft Capsule may result in significantly lower blood levels of Lurasidone, making the medication less effective.

How to manage the interaction:
Taking Lurasidone with Xtandi 40 mg Soft Capsule is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EnzalutamideDronedarone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule:
Co-administration of Xtandi 40 mg Soft Capsule and Dronedarone together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule and Dronedarone together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EnzalutamideZiprasidone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Xtandi 40 mg Soft Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule with Ziprasidone is not recommended, as it may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
EnzalutamideNimodipine
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule:
Co-administration of Nimodipine with Xtandi 40 mg Soft Capsule may make the medication less effective.

How to manage the interaction:
Although taking Nimodipine and Xtandi 40 mg Soft Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EnzalutamideMacitentan
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Xtandi 40 mg Soft Capsule with Macitentan may decrease the blood levels of Macitentan, which may make Macitentan less effective in treating your condition.

How to manage the interaction:
Although taking Xtandi 40 mg Soft Capsule and Macitentan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms like- watery eyes, a runny nose, sneezing, yawning, sweating heavily, fever, chills, flushing, restlessness, irritability, anxiety, eye problems, shaking, rapid heartbeat, body aches, involuntary twitching and kicking, stomach pain, diarrhea, consult the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideGatifloxacin
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Xtandi 40 mg Soft Capsule and Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule and Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EnzalutamideEscitalopram
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule:
Using escitalopram together with Xtandi 40 mg Soft Capsule can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule and Escitalopram together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
EnzalutamideImatinib
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule:
Taking Imatinib and Xtandi 40 mg Soft Capsule together may possibly reduce the blood levels of Imatinib, which could reduce its capacity to treat cancer.

How to manage the interaction:
Although there is a possible interaction between Xtandi 40 mg Soft Capsule and Imatinib, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Limit high amounts of caffeine, as it can worsen hot flashes, raise your blood pressure, or interfere with your sleep patterns during treatment.
ENZALUTAMIDE-40MGHerbal products/medicines
Moderate

Drug-Food Interactions

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ENZALUTAMIDE-40MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Taking St. John's Wort products during Xtandi 40 mg Soft Capsule treatment may lead to decrease in the effectiveness of Xtandi 40 mg Soft Capsule. Avoid St. John's Wort products during Xtandi 40 mg Soft Capsule treatment

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Xtandi 40Mg Capsule is used to treat prostate cancer in men.
Most prostate cancers require testosterone to grow. Xtandi 40Mg Capsule contains Enzalutamide, which blocks testosterone, a hormone, from reaching prostate cancer cells. Thus, Xtandi 40Mg Capsule can slow the cancer's growth and cause it to shrink.
Xtandi 40Mg Capsule is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.
In some cases, Xtandi 40Mg Capsule may cause decreased fertility in men. However, you should not assume that your female partner cannot become pregnant. Please discuss with your doctor if you have any concerns.
Seizures may occur in patients receiving Xtandi 40Mg Capsule . So, patients who have had a seizure, please inform your doctor about your condition. Your doctor may monitor your condition closely.
Yes, you can take Xtandi 40Mg Capsule with or without food. Taking it at the same time every morning or evening is the best way to help you remember your dose. Talk to your doctor or pharmacist if you need help planning your schedule.
Xtandi 40Mg Capsule does not cure prostate cancer, but it is highly effective at slowing down the growth and spread of the disease. This helps control your symptoms and prolongs survival. Talk to your doctor to understand your specific treatment goals.
Dizziness is a known side effect of this medicine. If you feel dizzy, sit or lie down immediately, and avoid driving or operating tools until you feel completely clear-headed. Talk to your doctor if the dizziness does not go away.
If your partner is pregnant, planning to become pregnant, or breastfeeding, they must not handle or touch Xtandi 40Mg Capsule tablets, especially if they are broken or damaged, as the medicine can be absorbed through the skin. Talk to your doctor or pharmacist if you have concerns about safe handling.
Your doctor will keep you on Xtandi 40Mg Capsule as long as it continues to effectively control your cancer and you tolerate the medicine well. Your progress will be tracked through regular blood tests (including PSA and liver function checks), blood pressure monitoring, and periodic imaging. If the cancer eventually progresses, your doctor will guide you through subsequent options—such as chemotherapy or other targeted therapies—noting that cross-resistance can occur with similar hormone therapies like abiraterone. Talk to your doctor about what to expect during your follow-up visits.
This medicine works by lowering the effects of male hormones, which can naturally lead to weaker bones and joint pain. Talk to your doctor about safe over-the-counter pain relievers or if you need calcium and vitamin D supplements to protect your bones.
Yes, if your partner can become pregnant, you must use highly effective birth control, such as condoms, during your treatment and for 3 months after you take your final dose. Talk to your doctor if you have questions about family planning.
It is highly recommended to limit or avoid alcohol while taking Xtandi 40Mg Capsule , as alcohol can worsen side effects like dizziness, hot flashes, and liver strain. Talk to your doctor or pharmacist for personalised guidance regarding alcohol use.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A612033 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 203415Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Enzalutamide Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. CiplaMed: Enzalutamide [Prescribing Information]. 2022. [Accessed on 20 Feb. 2024]Check here
  5. Enzalutamide [Prescribing Information]. 2018. [Accessed on 14 Mar. 2026]Check here
  6. DailyMed - XTANDI- enzalutamide capsuleXTANDI- enzalutamide tablet [Internet]. Dailymed.nlm.nih.gov. 2025 [Accessed on 19 February 2025]Check here
  7. Enzalutamide Astellas 40 mg film coated tablets (previously named Xtandi) - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 12 Jan 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Astellas Pharma India Pvt Ltd, 301, 3rd Floor, C and B Square, 127 Andheri Kurla Road, Chakala, Andheri East, Mumbai 400 069.
Other Info - XTA0010
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