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  3. Xone Ceff 0.25 gm Injection 5 ml

Xone Ceff 0.25 gm Injection 5 ml, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xone Ceff 0.25 gm Injection 5 ml is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, Lyme disease (caused by tick bites), and gonorrhoea (sexually transmitted disease). It contains Ceftriaxone, which kills the bacteria and helps in treating bacterial infection. In some cases, it may cause side effects such as diarrhoea, rashes, changes in results of blood and liver tests, and abnormalities (increase/decrease) in the number of white blood cells and platelets. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

CEFTRIAXONE-250MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Xone Ceff 0.25 gm Injection 5 ml

Xone Ceff 0.25 gm Injection 5 ml is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body.

Xone Ceff 0.25 gm Injection 5 ml contains 'Ceftriaxone', which works by interfering with the formation of bacterial cell walls, thereby killing the bacteria. Thus, Xone Ceff 0.25 gm Injection 5 ml helps in treating bacterial infection.

In some cases, Xone Ceff 0.25 gm Injection 5 ml may cause side effects such as diarrhoea, rashes, changes in results of blood and liver tests, and abnormalities (increase/decrease) in the number of white blood cells and platelets. Although not everybody experiences these side effects, if they occur, consult your doctor.

Talk to your doctor before taking Xone Ceff 0.25 gm Injection 5 ml if you have/had received calcium-containing products recently, had diarrhoea after taking antibiotics, inflammation of the bowel, kidney stones, or any other illness. Do not take antacids along with Xone Ceff 0.25 gm Injection 5 ml; maintain a gap of 2-3 hours between both. Consult your doctor if you are pregnant or breastfeeding. Xone Ceff 0.25 gm Injection 5 ml may cause dizziness, so be cautious while driving. Avoid alcohol consumption to prevent unpleasant side effects.

Uses of Xone Ceff 0.25 gm Injection 5 ml

Xone Ceff 0.25 gm Injection 5 ml is used in the treatment of bacterial infections. The detailed uses of Xone Ceff 0.25 gm Injection 5 ml are as follows:

  • Treatment of bacterial infections: Xone Ceff 0.25 gm Injection 5 ml is commonly used to treat various types of bacterial infections, including brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease).
  • Surgical prophylaxis: Xone Ceff 0.25 gm Injection 5 ml may be administered before surgical procedures to prevent potential infections in patients undergoing surgery.
  • Treatment of meningitis: Xone Ceff 0.25 gm Injection 5 ml treats bacterial meningitis by targeting susceptible bacteria and reducing inflammation in the central nervous system.
  • Lyme disease treatment: Xone Ceff 0.25 gm Injection 5 ml can be used to treat Lyme disease, especially when there's neurological involvement, helping manage symptoms.
  • Treatment of sepsis: Xone Ceff 0.25 gm Injection 5 ml helps to treat sepsis by targeting the underlying bacterial infection, aiming to reduce the severity of the condition.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety. • Xone Ceff 0.25 gm Injection 5 ml will be administered by the doctor or healthcare professional. • Do not self-administer.

Medicinal Benefits

Xone Ceff 0.25 gm Injection 5 ml belongs to the group of antibiotic medicines called cephalosporins used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease). Xone Ceff 0.25 gm Injection 5 ml is a broad-spectrum antibiotic that is effective against gram-positive and gram-negative bacteria, aerobic and some anaerobic bacteria. Xone Ceff 0.25 gm Injection 5 ml works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helps in treating and preventing the spread of infections.

How Xone Ceff 0.25 gm Injection 5 ml Works

Xone Ceff 0.25 gm Injection 5 ml contains 'Ceftriaxone', which works by interfering with the formation of bacterial cell walls, thereby killing the bacteria. Thus, Xone Ceff 0.25 gm Injection 5 ml helps in treating bacterial infection.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Xone Ceff 0.25 gm Injection 5 ml
  • Drink plenty of water to stay hydrated.
  • Avoid foods that can cause black stools, such as liquorice, blueberries, and iron-rich foods.
  • Practice stress-reducing techniques like meditation, deep breathing, or yoga to help minimize stress-related digestive issues.
  • Avoid taking medications that can cause black stools, such as iron supplements or bismuth subsalicylate.
  • Monitor your stool colour, consistency, and frequency to identify any changes or patterns.
  • Seek medical attention if you experience persistent or severe black stools, abdominal pain, or other symptoms.
  • Get tested if your doctor suspects an underlying condition, such as gastrointestinal bleeding or ulcers.
  • Make lifestyle changes, such as getting regular exercise and quitting smoking, to help improve overall digestive health.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • Follow your doctor's advice to manage underlying conditions causing swollen glands.
  • Apply a warm compress to reduce swelling and ease discomfort.
  • Gargle with warm salt water to soothe swelling in your neck or throat.
  • Wash your hands frequently, especially after contact with sick individuals.
  • Exercise regularly, like walking or yoga, to boost your immune system.
  • Monitor symptoms and consult your doctor if swelling lasts, increases, or is accompanied by fever, weight loss, or night sweats.

What if I have taken an overdose of Xone Ceff 0.25 gm Injection 5 ml

The overdose of Xone Ceff 0.25 gm Injection 5 ml is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Xone Ceff 0.25 gm Injection 5 ml, please inform your doctor immediately.

Drug Warnings

Before starting Xone Ceff 0.25 gm Injection 5 ml, please inform your doctor if you are allergic to any of the components in Xone Ceff 0.25 gm Injection 5 ml or against any antibiotic. Talk to your doctor if you have/had received calcium-containing products recently, had diarrhoea after taking antibiotics, inflammation of the bowel, kidney stones, or any other illness. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Xone Ceff 0.25 gm Injection 5 ml to prevent unpleasant side effects. Xone Ceff 0.25 gm Injection 5 ml may cause dizziness, so be cautious while driving. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

Drug-Drug Interactions

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CeftriaxoneCalcium chloride
Critical
CeftriaxoneCalcium gluconate
Critical

Drug-Drug Interactions

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CeftriaxoneCalcium chloride
Critical
How does the drug interact with Xone Ceff 0.25 gm Injection 5 ml:
Co-administration of Calcium chloride with Xone Ceff 0.25 gm Injection 5 ml can increase the risk of side effects.

How to manage the interaction:
Taking Xone Ceff 0.25 gm Injection 5 ml with Calcium chloride is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CeftriaxoneCalcium gluconate
Critical
How does the drug interact with Xone Ceff 0.25 gm Injection 5 ml:
Co-administration of Calcium gluconate with Xone Ceff 0.25 gm Injection 5 ml can increase the risk of adverse effects.

How to manage the interaction:
Taking Xone Ceff 0.25 gm Injection 5 ml with Calcium gluconate is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CeftriaxoneCholera, live attenuated
Severe
How does the drug interact with Xone Ceff 0.25 gm Injection 5 ml:
Taking the cholera vaccine after or along with Xone Ceff 0.25 gm Injection 5 ml may reduce the activity of the vaccine.

How to manage the interaction:
Although taking Xone Ceff 0.25 gm Injection 5 ml and Cholera, live attenuated together can evidently cause an interaction, it can be taken if your doctor has suggested it. To ensure adequate vaccine response, you should not receive cholera vaccine, live until at least 14 days after you complete your antibiotic therapy. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.

  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.

  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.

  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Xone Ceff 0.25 gm Injection 5 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid consuming alcohol while taking Xone Ceff 0.25 gm Injection 5 ml to prevent unpleasant side-effects.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Xone Ceff 0.25 gm Injection 5 ml only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding; your doctor will prescribe Xone Ceff 0.25 gm Injection 5 ml only if the benefits outweigh the risks.

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Driving

Caution

Xone Ceff 0.25 gm Injection 5 ml may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Safe if prescribed

Xone Ceff 0.25 gm Injection 5 ml is safe for children if prescribed by a doctor. Xone Ceff 0.25 gm Injection 5 ml is not recommended for a premature baby, or a newborn baby who has jaundice (yellowing of the skin or eyes).

Have a query?

FAQs

Xone Ceff 0.25 gm Injection 5 ml is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease).

Xone Ceff 0.25 gm Injection 5 ml works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helps in treating and preventing the spread of infections.

Xone Ceff 0.25 gm Injection 5 ml may cause dizziness, so drive only if you are alert and omit driving and operating machinery if you experience dizziness.

Diarrhoea might be a side-effect of Xone Ceff 0.25 gm Injection 5 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Xone Ceff 0.25 gm Injection 5 ml may affect the results of urine tests for sugar and blood test known as coomb’s test (antiglobulin test). Inform the person performing the tests that you are taking Xone Ceff 0.25 gm Injection 5 ml.

Do not take antacids along with Xone Ceff 0.25 gm Injection 5 ml; maintain a gap of 2-3 hours between both. However, consult your doctor before taking other medicines while on treatment with Xone Ceff 0.25 gm Injection 5 ml.

Yes, Xone Ceff 0.25 gm Injection 5 ml is generally considered safe when taken in the recommended dose and duration as directed by your doctor. However, sometimes it may cause side effects or allergic reactions in some individuals. Please let your doctor know if any of the side effects bother you.

Xone Ceff 0.25 gm Injection 5 ml usually starts working within a few hours after administration. However, Xone Ceff 0.25 gm Injection 5 ml may take a few days to show its full effect, depending on the infection being treated. If your symptoms do not improve or get worse, please consult your doctor.

Xone Ceff 0.25 gm Injection 5 ml should not be used by individuals who are allergic to its components or other cephalosporin antibiotics. It is also not recommended for use in newborns, especially those with jaundice (yellowing of the skin or eyes).

If you do not feel better after using Xone Ceff 0.25 gm Injection 5 ml, it could mean that the infection isn't responding to the antibiotic, or you might have a different type of infection that needs a different treatment. Please consult your doctor for further evaluation and to discuss possible changes to your treatment plan.

Xone Ceff 0.25 gm Injection 5 ml is usually eliminated from the body within 5 to 9 hours in healthy individuals. However, Xone Ceff 0.25 gm Injection 5 ml may stay in the body for longer depending on the individual's medical condition.

Yes, Xone Ceff 0.25 gm Injection 5 ml is effective against a wide range of bacterial infections, including respiratory, urinary tract, skin, and bloodstream infections.

Xone Ceff 0.25 gm Injection 5 ml will be administered either intravenously (IV) or intramuscularly (IM), depending on the condition being treated, by your healthcare provider. Please do not self-administer.

No, you should complete the full course of treatment with Xone Ceff 0.25 gm Injection 5 ml as prescribed by your doctor, even if you feel better. Please consult your doctor before stopping the medication early, as your infection may not be completely treated and the bacteria may become resistant to the antibiotics.

If you are allergic to Cefuroxime, there is a possible risk of an allergic reaction to Xone Ceff 0.25 gm Injection 5 ml, since both are in the same group of antibiotics (cephalosporins). Please consult your healthcare provider before taking Xone Ceff 0.25 gm Injection 5 ml or any other cephalosporin antibiotics to ensure safety.

Before starting Xone Ceff 0.25 gm Injection 5 ml, you should inform your doctor if you have recently received calcium-containing products, have had diarrhoea after taking antibiotics, or have a history of colitis (inflammation of the large intestine), malnutrition (inability to consume or digest essential nutrients), problems with vitamin K levels, or kidney or liver disease.

No, Xone Ceff 0.25 gm Injection 5 ml should only be administered by a healthcare professional, as it requires proper injection technique and monitoring for potential side effects. Please do not administer Xone Ceff 0.25 gm Injection 5 ml at home.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Other Info - XON0046

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 9:02 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/0550585s063lbl.pdf
  2. https://www.npra.gov.my/images/reg-and-noti/PI/scheduled-poison/CEFTRIAXONE_Powder_for_Solution_for_Injection_or_Infusion.pdf
  3. https://www.drugs.com/cdi/ceftriaxone.html
  4. https://pubmed.ncbi.nlm.nih.gov/3875430/

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