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compositionComposition:CEFTRIAXONE-250MG
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Prescription Medicine
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Cefox 250Mg Inj is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, Lyme disease (caused by tick bites), and gonorrhoea (sexually transmitted disease). It contains Ceftriaxone, which kills the bacteria and helps in treating bacterial infection. In some cases, it may cause side effects such as diarrhoea, rashes, changes in results of blood and liver tests, and abnormalities (increase/decrease) in the number of white blood cells and platelets. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CEFTRIAXONE-250MG

Manufacturer/Marketer :

ARP Pharma

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Cefox 250Mg Inj

Cefox 250Mg Inj is a prescription injection antibiotic used to treat a wide variety of severe bacterial infections. It is commonly prescribed for serious conditions such as lung infections, meningitis, and infections of the skin, bones, or blood. This medication works by targeting and destroying the bacteria responsible for your illness, helping your body recover.

For this medication to work effectively, it must be injected consistently at the exact times prescribed by your healthcare provider. Because it is given as an injection, food intake does not affect how well it works, meaning it can be injected on an empty or full stomach. Incorporating plenty of rest and staying well-hydrated during your treatment course will significantly support your recovery.

While using Cefox 250Mg Inj, you may experience mild side effects such as temporary pain at the injection site, mild nausea, or loose stools. However, you should contact your doctor immediately if you develop severe watery diarrhoea, a widespread skin rash, or yellowing of your skin and eyes.

Before starting treatment, it is vital to discuss your medical history with your doctor, especially if you have liver disease, kidney problems, or gallbladder issues. This medication must not be used in premature infants, newborns who require calcium-containing fluids through an intravenous line, or anyone with a known severe allergy to cephalosporin antibiotics.

Inform your healthcare provider about all medications you take, as this injection can interact with blood thinners and certain intravenous fluids. It is also wise to avoid alcohol during treatment, and special care should be taken if you are pregnant, breastfeeding, or an elderly patient. Talk to your doctor or pharmacist for personalised advice.

Uses of Cefox 250Mg Inj

Cefox 250Mg Inj is a broad-spectrum antibiotic used to treat a variety of serious bacterial infections and to prevent infections in certain surgical procedures.

  • Severe bacterial infections: Cefox 250Mg Inj is used to treat serious infections affecting the bloodstream, bones, joints, abdomen, and other parts of the body by eliminating susceptible bacteria.
  • Bacterial meningitis: It helps treat infections of the membranes surrounding the brain and spinal cord by reaching effective concentrations within the central nervous system.
  • Community-acquired pneumonia: Cefox 250Mg Inj is used to treat bacterial lung infections, helping clear the infection and improve breathing.
  • Urinary tract infections (UTIs): It is effective against many bacteria responsible for complicated infections of the bladder, urinary tract, and kidneys.
  • Surgical infection prevention: The medication may be given before certain surgical procedures to reduce the risk of postoperative bacterial infections.
  • Gonorrhoea: Cefox 250Mg Inj is commonly used as an effective treatment for uncomplicated gonorrhoea caused by susceptible strains of bacteria.

Key Benefits

Cefox 250Mg Inj provides effective treatment for serious bacterial infections and helps promote faster recovery when used as prescribed.

  • Provides rapid antibacterial action: Because it is administered by injection, Cefox 250Mg Inj enters the bloodstream directly and begins fighting susceptible bacteria quickly.
  • Helps treat severe infections effectively: It is often used when infections are serious, widespread, or unlikely to respond adequately to oral antibiotics.
  • Offers convenient once-daily dosing for many infections: Its long duration of action often allows treatment with a single daily dose, improving convenience and treatment adherence.
  • Provides broad-spectrum bacterial coverage: Cefox 250Mg Inj is active against a wide range of bacteria, making it useful for treating various types of infections.
  • Supports recovery and symptom relief: By eliminating the bacteria causing the infection, it helps reduce symptoms such as fever, pain, inflammation, and discomfort.
  • Helps prevent surgical site infections: When used before surgery, it can reduce the likelihood of bacterial infections developing after the procedure.
  • Remains effective against many resistant bacteria: Cefox 250Mg Inj is stable against certain bacterial resistance mechanisms, making it a reliable treatment option for many difficult-to-treat infections.
Side effects of Cefox 250Mg Inj
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
  • Manage the symptoms with medications as prescribed, and consult your doctor if symptoms persist.
  • Stay away from painkillers like NSAIDs (nonsteroidal anti-inflammatory drugs) and some antibiotics, as they can worsen the symptoms.
  • Make sure to have regular check-ups with your doctor, especially during flare-ups, and get immediate help if you have serious symptoms like dehydration or blood in your stool.
  • Avoid eating fried foods and foods high in fibre, as they can make your symptoms worse.
  • Practice stress-reduction techniques, like meditation or exercise.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

To ensure the best treatment outcomes, Cefox 250Mg Inj should be administered exactly as prescribed by your healthcare provider.

  • Cefox 250Mg Inj is given as an injection, either into a muscle (intramuscularly) or into a vein (intravenously), usually by a trained healthcare professional.
  • The medication may be administered in a hospital, clinic, or home-care setting, depending on your treatment plan.
  • If you have been instructed to administer Cefox 250Mg Inj at home, ensure you receive proper training on preparation, handling, and injection techniques before use.
  • Check the prepared solution before administration. It should generally appear clear and free from visible particles. Do not use the medication if it appears cloudy, discoloured, or contains particles.
  • Administer the medication at the times recommended by your doctor to maintain effective levels in the body.
  • Complete the full course of treatment exactly as prescribed, even if you start feeling better before the treatment is finished.
  • Do not skip doses or stop treatment early unless instructed by your healthcare provider, as this may reduce treatment effectiveness and increase the risk of antibiotic resistance.

How Cefox 250Mg Inj Works

Cefox 250Mg Inj belongs to a group of medicines known as cephalosporin antibiotics. It works by interfering with the formation of the bacterial cell wall. Bacteria require a strong, fully formed cell wall to protect themselves from their environment and to survive. By blocking the chemical processes needed to build these walls, the medication causes the bacterial cells to develop leaks and rupture. This directly kills the bacteria causing the illness, allowing your body's natural immune system to easily clear the remaining infection.
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Alcohol

Caution

Avoid consuming alcohol while taking Cefox 250Mg Inj to prevent unpleasant side-effects.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Cefox 250Mg Inj only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding; your doctor will prescribe Cefox 250Mg Inj only if the benefits outweigh the risks.

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Driving

Caution

Cefox 250Mg Inj may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Safe if prescribed

Cefox 250Mg Inj is safe for children if prescribed by a doctor. Cefox 250Mg Inj is not recommended for a premature baby, or a newborn baby who has jaundice (yellowing of the skin or eyes).

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Heart

Consult your doctor

Please consult your doctor before receiving Cefox 250Mg Inj if you have pre-existing heart problems. Your doctor will administer Cefox 250Mg Inj if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Cefox 250Mg Inj to geriatric patients. Your doctor will prescribe Cefox 250Mg Inj if the benefits outweigh the risks.

What if I have taken an overdose of Cefox 250Mg Inj

Because this medication is typically prepared and administered under professional medical supervision, an overdose is highly unlikely. However, if you suspect an overdose or experience severe symptoms like muscle twitches or seizures, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of water throughout the day to help your kidneys process and safely eliminate the medication from your body.
  • Support Gut Health: Eat probiotic-rich foods (such as yoghurt or kefir) or take a probiotic supplement a few hours after your injection to help maintain healthy gut bacteria and minimise stomach upset.
  • Get Adequate Rest: Prioritise rest and avoid strenuous physical activities to give your immune system the energy it needs to fight off the infection.
  • Avoid Alcohol: Avoid drinking alcohol during your treatment, as it can strain your digestive system and liver while your body is recovering.
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Have a query?

How Soon It Starts Working

The time required for Cefox 250Mg Inj to start to work: Cefox 250Mg Inj ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Cefox 250Mg Inj last: The effect of Cefox 250Mg Inj lasts for 48 hours.

What if you forget to take Cefox 250Mg Inj

If you miss a dose, contact your doctor or home-care provider immediately for instructions on when to receive your next injection. Do not double the dose to make up for a missed one.

Storage

• Store unmixed (dry powder) Cefox 250Mg Inj vials at room temperature, typically between 20°C and 25°C (68°F and 77°F). • Keep the vials in their original packaging to protect them from light and moisture.

Drug Warnings

  • Inspect the Solution Before Use: Always check the liquid solution before injecting. Do not use it if it appears cloudy, contains floating particles, or has changed to a dark colour.
  • Avoid Mixing With Calcium-Containing Fluids: Never mix Cefox 250Mg Inj with any fluids containing calcium in the same intravenous line, as this can cause dangerous solid particles to form.
  • Rotate Injection Sites: If you are receiving intramuscular injections, rotate your injection sites regularly to help prevent muscle soreness and tissue hardening.
  • Monitor for Injection Site Reactions: Watch the injection site closely and contact your doctor if you notice worsening redness, warmth, throbbing pain, swelling, or pus.
  • Inform Healthcare Providers: Tell all of your healthcare providers, including your dentist, that you are being treated with Cefox 250Mg Inj before undergoing any medical tests, procedures, or surgeries.

Drug-Drug Interactions

verifiedApollotooltip

Cefox 250Mg Inj may interact with certain medications, requiring additional monitoring or precautions during treatment.

  • Calcium-containing intravenous solutions: Cefox 250Mg Inj should not be mixed or administered simultaneously with calcium-containing intravenous products through the same infusion line, particularly in newborns, as this can result in the formation of precipitates that may cause serious complications.
  • Blood thinners (such as warfarin): Using Cefox 250Mg Inj together with anticoagulants may increase the risk of bleeding and may require monitoring of blood clotting parameters.
  • Aminoglycosides and certain other antibiotics: Concurrent use may increase the risk of kidney-related side effects, particularly in patients with existing kidney impairment.
CefotaximeCholera, live attenuated
Severe

Drug-Drug Interactions

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CefotaximeCholera, live attenuated
Severe
How does the drug interact with Cefox 250Mg Inj:
Taking the cholera vaccine after or along with Cefox 250Mg Inj may reduce the activity of the vaccine.

How to manage the interaction:
Although taking Cefox 250Mg Inj and Cholera, live attenuated together can evidently cause an interaction, it can be taken if your doctor has suggested it. Make sure to inform the doctor if you are on Cholera vaccine dose or you have already taken it. You should wait at least 14 days after finishing your antibiotic treatment before receiving the cholera vaccine in order to ensure an appropriate immune response. In case of any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Cefox 250Mg Inj when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Cefox 250Mg Inj is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease).
Cefox 250Mg Inj works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helps in treating and preventing the spread of infections.
Cefox 250Mg Inj may cause dizziness, so drive only if you are alert and omit driving and operating machinery if you experience dizziness.
Cefox 250Mg Inj may affect the results of urine tests for sugar and blood test known as coomb’s test (antiglobulin test). Inform the person performing the tests that you are taking Cefox 250Mg Inj.
Do not take antacids along with Cefox 250Mg Inj; maintain a gap of 2-3 hours between both. However, consult your doctor before taking other medicines while on treatment with Cefox 250Mg Inj.
Yes, Cefox 250Mg Inj is generally considered safe when taken in the recommended dose and duration as directed by your doctor. However, sometimes it may cause side effects or allergic reactions in some individuals. Please let your doctor know if any of the side effects bother you.
Cefox 250Mg Inj usually starts working within a few hours after administration. However, Cefox 250Mg Inj may take a few days to show its full effect, depending on the infection being treated. If your symptoms do not improve or get worse, please consult your doctor.
Cefox 250Mg Inj should not be used by individuals who are allergic to its components or other cephalosporin antibiotics. It is also not recommended for use in newborns, especially those with jaundice (yellowing of the skin or eyes).
If you do not feel better after using Cefox 250Mg Inj, it could mean that the infection isn't responding to the antibiotic, or you might have a different type of infection that needs a different treatment. Please consult your doctor for further evaluation and to discuss possible changes to your treatment plan.
Yes, Cefox 250Mg Inj is effective against a wide range of bacterial infections, including respiratory, urinary tract, skin, and bloodstream infections.
Cefox 250Mg Inj will be administered either intravenously (IV) or intramuscularly (IM), depending on the condition being treated, by your healthcare provider. Please do not self-administer.
No, you should complete the full course of treatment with Cefox 250Mg Inj as prescribed by your doctor, even if you feel better. Please consult your doctor before stopping the medication early, as your infection may not be completely treated and the bacteria may become resistant to the antibiotics.
If you are allergic to Cefuroxime, there is a possible risk of an allergic reaction to Cefox 250Mg Inj, since both are in the same group of antibiotics (cephalosporins). Please consult your healthcare provider before taking Cefox 250Mg Inj or any other cephalosporin antibiotics to ensure safety.
Before starting Cefox 250Mg Inj, you should inform your doctor if you have recently received calcium-containing products, have had diarrhoea after taking antibiotics, or have a history of colitis (inflammation of the large intestine), malnutrition (inability to consume or digest essential nutrients), problems with vitamin K levels, or kidney or liver disease.
No, Cefox 250Mg Inj should only be administered by a healthcare professional, as it requires proper injection technique and monitoring for potential side effects. Please do not administer Cefox 250Mg Inj at home.
No, Cefox 250Mg Inj belongs to the cephalosporin class of antibiotics. However, because they are chemically related to penicillins, you must tell your doctor if you have ever had a severe allergic reaction to penicillin. Talk to your doctor or pharmacist.
Intramuscular injections can cause temporary stinging or aching because of the volume of the medicine entering the muscle. Healthcare providers often mix the powder with a local numbing medicine (like lidocaine) to make the injection much more comfortable. Talk to your doctor or pharmacist.
Yes, for certain infections like uncomplicated gonorrhoea, a single intramuscular injection of Cefox 250Mg Inj is often highly effective and sufficient to cure the infection. For other severe infections, a multi-day course is required. Talk to your doctor or pharmacist.
This medicine is long-acting, which is why it is usually given only once a day. It can take several days after your last dose for the active medication to be completely cleared from your body. Talk to your doctor or pharmacist.
No, Cefox 250Mg Inj is an antibiotic that only kills bacteria. It will not work against viral infections like the common cold, flu, or COVID-19. Talk to your doctor or pharmacist.
Contact your healthcare provider immediately to reschedule your dose. Keeping steady levels of the medication in your body is critical to successfully curing the bacterial infection. Talk to your doctor or pharmacist.
Yes, diarrhoea is a possible side effect of Cefox 250Mg Inj. Drink plenty of fluids and eat simple, non-spicy foods. If the diarrhoea becomes severe, watery, or bloody, do not take anti-diarrhoeal medicines without medical advice and contact your doctor immediately, as this may indicate a serious bowel infection.

Disclaimer

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Reference

  1. U.S. Food and Drug Administration (FDA). 0550585S063Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Ceftriaxone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Ceftriaxone Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Ceftriaxone Ceftriaxone. 2013. [Accessed on 07 Feb. 2019]Check here
  5. Ceftriaxone Ceftriaxone. [Accessed on 19 Mar. 2025]Check here
  6. Rocephin 1g Powder for Solution for Injection or Infusion [Internet]. Accessdata.fda.gov. 2021 [Accessed on 18 November 2025]Check here
  7. CEFBACT Injection [Internet]. CiplaMed. 2021 [Accessed on 18 November 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Door No. 10-5-787/A, Sai Nagar, Tukaram Gate, Secunderabad, Near To RIO Point,, Secunderabad, Telangana-500017, India
Other Info - CEF1449
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