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  3. Xadomet-GP2 Tablet 10's

Xadomet-GP2 Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xadomet-Gp2 Tab is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

GLIMEPIRIDE-2MG + METFORMIN-500MG + PIOGLITAZONE-15MG

Manufacturer/Marketer :

DR CURE PHARMACEUTICALS INDIA PVT LTD

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Xadomet-Gp2 Tab

Xadomet-Gp2 Tab belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose.

Xadomet-Gp2 Tab contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache, a metallic taste, or low blood sugar. Most of these side effects of Xadomet-Gp2 Tab do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Xadomet-Gp2 Tab or any other medicines, please tell your doctor. Xadomet-Gp2 Tab is not recommended for children. Consult your doctor if you are breastfeeding, pregnant or planning for pregnancy. Avoid alcohol consumption with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Xadomet-Gp2 Tab

Xadomet-Gp2 Tab is used in the treatment of type 2 diabetes mellitus. The detailed uses of Xadomet-Gp2 Tab are as follows:

  • Manages Type 2 Diabetes Mellitus: Xadomet-Gp2 Tab to treat type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
  • Reduces Risk of Diabetes-Related Complications: By effectively controlling blood sugar levels, Xadomet-Gp2 Tab helps reduce the risk of long-term complications such as neuropathy and cardiovascular disease.

Directions for Use

  • Xadomet-Gp2 Tab can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Xadomet-Gp2 Tab as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

  • Xadomet-Gp2 Tab is effective in controlling blood sugar levels in people with Type 2 Diabetes.
  • It combines three complementary antidiabetic agents to provide comprehensive glycemic control when diet, exercise, or monotherapy is insufficient.
  • Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
  • Metformin works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
  • Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enabling them to remove glucose from the blood more effectively.
  • This medicine ensures long-lasting glycaemic control, reducing the frequency of dosage. It also prevents unnecessary sugar spikes.
  • Xadomet-Gp2 Tab manages blood glucose levels, thereby lowering the risk of complications such as nerve problems, kidney problems, eye problems, and cardiovascular disease.

How Xadomet-Gp2 Tab Works

Xadomet-Gp2 Tab contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

Storage

• Store in a cool and dry place away from sunlight.• Keep Xadomet-Gp2 Tab out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Xadomet-Gp2 Tab

Take Xadomet-Gp2 Tab only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include loss of consciousness, lactic acidosis (buildup of lactic acid in the blood), and pancreatitis (inflammation of the pancreas). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • If you are allergic to Xadomet-Gp2 Tab or any other medicines, please tell your doctor.
  • Xadomet-Gp2 Tab is not recommended for children.
  • Avoid breastfeeding while taking Xadomet-Gp2 Tab as it may be excreted in human milk.
  • If you are pregnant or planning for pregnancy, please inform your doctor before taking Xadomet-Gp2 Tab as it may harm the unborn baby.
  • Xadomet-Gp2 Tab should be used with caution in elderly patients.
  • Avoid alcohol consumption with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Drive only if you are alert after taking Xadomet-Gp2 Tab .
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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MetforminIobenzamic acid
Critical
MetforminIopydol
Critical

Drug-Drug Interactions

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MetforminIobenzamic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopydol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopydol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iohexol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.
MetforminMetrizamide
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIodixanol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iodixanol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopromide with Xadomet-GP2 Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Xadomet-GP2 Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIoxitalamic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Xadomet-Gp2 Tab Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

bannner image

Pregnancy

Unsafe

Xadomet-Gp2 Tab is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Xadomet-Gp2 Tab as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Xadomet-Gp2 Tab if you are breastfeeding.

bannner image

Driving

Caution

Xadomet-Gp2 Tab may decrease alertness in some people. Therefore, drive only if you are alert after taking Xadomet-Gp2 Tab .

bannner image

Liver

Caution

Take Xadomet-Gp2 Tab with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Xadomet-Gp2 Tab with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Unsafe

Xadomet-Gp2 Tab is not recommended for children as the safety and effectiveness were not established.

Have a query?

FAQs

Xadomet-Gp2 Tab is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Xadomet-Gp2 Tab contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

Xadomet-Gp2 Tab may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to take Xadomet-Gp2 Tab with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Xadomet-Gp2 Tab with other medicines.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Xadomet-Gp2 Tab on your own, as discontinuing Xadomet-Gp2 Tab suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Xadomet-Gp2 Tab , please consult your doctor so that alternative medicine may be prescribed.

Yes, Xadomet-Gp2 Tab may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.

You are recommended to avoid consumption of alcohol with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.

Yes, Xadomet-Gp2 Tab may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.

Store Xadomet-Gp2 Tab at room temperature, in a dry place. Keep out of sight and reach of children.

Xadomet-Gp2 Tab may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

No.248/13, 2Nd Floor, 67Th Cross, 5Th Block, Rajajinagar, Bangalore - 560010
Other Info - XAD0003

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 4, 2025 | 11:40 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Amaryl-MP-API-Aug-2018.pdf?la=en
  2. https://www.drugs.com/mtm/glimepiride.html#interactions
  3. https://www.drugs.com/metformin.html#interactions
  4. https://www.drugs.com/mtm/pioglitazone.html#interactions

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