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  3. Valparin Oral Solution 100 ml

Valparin Oral Solution 100 ml, Pack of 1 Oral Solution
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Valparin Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, changes in appetite, weight changes, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SODIUM VALPROATE-200MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Valparin Oral Solution

Valparin Oral Solution is used to treat epilepsy/seizures/fits. Additionally, Valparin Oral Solution is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

Valparin Oral Solution contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby, it helps in controlling seizures. Valparin Oral Solution increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder.

You are advised to take Valparin Oral Solution for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, diarrhoea, and changes in weight/appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Valparin Oral Solution without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Valparin Oral Solution . Do not take Valparin Oral Solution if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Valparin Oral Solution . Consult your doctor before taking Valparin Oral Solution if you are breastfeeding. Do not drive or operate machinery as Valparin Oral Solution may cause drowsiness and dizziness. Avoid consuming alcohol along with Valparin Oral Solution as it could lead to increased dizziness and sleepiness.

Uses of Valparin Oral Solution

Valparin Oral Solution is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Valparin Oral Solution are as follows:<br/>• Seizure Management: Valparin Oral Solution is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.<br/>• Bipolar Disorder Treatment: Valparin Oral Solution can be used in the treatment of bipolar disorder, aiding in mood stabilization and reducing the frequency of mood swings.<br/>• Migraine Prevention: Valparin Oral Solution may also be prescribed to prevent migraines, providing relief from recurrent headaches.<br/>

Directions for Use

  • Valparin Oral Solution can be taken with food to prevent stomach upset or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Take the prescribed dose by mouth using the measuring cup, dosing syringe, or dropper.
  • Shake the bottle well before use.

Medicinal Benefits

Valparin Oral Solution belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valparin Oral Solution is also used to treat bipolar disorder and prevent migraine headaches. Valparin Oral Solution decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valparin Oral Solution is used to treat both localised (seizures which affect only a part of the brain) and generalised seizures (seizures which affect the entire brain).

How Valparin Oral Solution Works

Valparin Oral Solution contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby, it helps in controlling seizures. Valparin Oral Solution increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight.• Keep Valparin Oral Solution out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Valparin Oral Solution 100 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Avoid tobacco products, as smoking can worsen gum problems.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Consult your dentist if gums bleed consistently.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

What if I have taken an overdose of Valparin Oral Solution

Do not take more than the prescribed dose of Valparin Oral Solution as it may cause an overdose. The symptoms of overdose include headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Valparin Oral Solution if you are allergic to any of its contents; if you have liver problems, severe hepatitis, urea cycle disorders, porphyria, or an inborn deficiency of carnitine. Consult your doctor immediately if you experience suicidal tendencies while taking Valparin Oral Solution . Contact your doctor if your child gets her first period during the treatment with Valparin Oral Solution . Do not take Valparin Oral Solution if you are pregnant unless prescribed by the doctor, as it is a pregnancy category D medicine and can cause serious congenital disabilities. Consult your doctor before taking Valparin Oral Solution if you are breastfeeding. Valparin Oral Solution may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valparin Oral Solution as it could lead to increased dizziness and sleepiness.

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateBuprenorphine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Valparin Oral Solution 100 ml:
Combining Sodium phenylbutyrate and Valparin Oral Solution 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Valparin Oral Solution 100 ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Using buprenorphine together with Valparin Oral Solution 100 ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Valparin Oral Solution 100 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Valparin Oral Solution 100 ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Meropenam and Valparin Oral Solution 100 ml together can reduce the effect of Valparin Oral Solution 100 ml.

How to manage the interaction:
Co-administration of Meropenam and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Ketamine and Valparin Oral Solution 100 ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Lithium with Valparin Oral Solution 100 ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
The combined use of Ertapenem and Valparin Oral Solution 100 ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Vorinostat with Valparin Oral Solution 100 ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Teriflunomide and Valparin Oral Solution 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Leflunomide and Valparin Oral Solution 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Valparin Oral Solution 100 ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health.
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Valparin Oral Solution Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valparin Oral Solution as it may cause increased dizziness and sleepiness.

bannner image

Pregnancy

Unsafe

Valparin Oral Solution belongs to pregnancy category D. Avoid taking Valparin Oral Solution if you are pregnant, as it could lead to serious birth defects.

bannner image

Breast Feeding

Caution

Valparin Oral Solution may pass into breastmilk. Consult your doctor before taking Valparin Oral Solution if you are breastfeeding.

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Driving

Unsafe

Valparin Oral Solution causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Valparin Oral Solution should not be used if you have liver disease or severe hepatitis. Please consult your doctor if you have any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Valparin Oral Solution can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

bannner image

Heart

If you have heart problems, please inform your doctor before taking Valparin Oral Solution , as it may cause fluid retention, interact with cardiac medications, and affect blood pressure regulation.

bannner image

Geriatrics

Caution

Valparin Oral Solution should be used with caution in elderly patients and only when prescribed by a doctor. Dose adjustment and careful monitoring of side effects are necessary in elderly patients.

Have a query?

FAQs

Valparin Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).

Valparin Oral Solution decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messengers and prevents overactivity of the brain, thereby controlling seizure episodes.

Valparin Oral Solution limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Do not discontinue Valparin Oral Solution without consulting your doctor. To treat your condition effectually, continue taking Valparin Oral Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valparin Oral Solution ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Valparin Oral Solution works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Valparin Oral Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Valparin Oral Solution may cause side effects like stomach pain, nausea, vomiting, diarrhoea, and changes in weight/appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Yes, Valparin Oral Solution causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

Valparin Oral Solution may change levels of liver enzymes, blood clotting factors, salts or sugars shown up on blood and urine tests. Hence, if you are undergoing any tests, inform the doctor that you are taking Valparin Oral Solution .

Country of origin

India

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.
Other Info - VAL0014

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Aug 10, 2025 | 12:09 PM IST

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Reference

  1. https://www.kabirlifescience.com/product/ap-chronohttp://mri.cts-mrp.eu/download/DE_H_0642_002_FinalPI_2of4.pdf
  2. https://www.drugs.com/cons/valproate-sodium-intravenous.html
  3. https://www.medsafe.govt.nz/consumers/cmi/e/Epilim.pdf
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