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compositionComposition:EVOGLIPTIN-5MG+METFORMIN-500MG
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Prescription Medicine
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₹290 with coupons & bank offers*

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Valera M 500 Tablet is used to treat type 2 diabetes mellitus as an adjunct to diet and exercise. It works by decreasing glucose production in the liver and glucose uptake in the intestine. Besides this, it increases insulin release from the pancreas and decreases the hormones that raise blood sugar levels. In some cases, this medicine may cause side effects like nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, and indigestion.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

EVOGLIPTIN-5MG+METFORMIN-500MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Valera M 500 Tablet

Valera M 500 Tablet is an oral prescription medication used to manage blood sugar levels in adults with type 2 diabetes. It is prescribed when diet and exercise alone do not provide enough control over blood glucose levels. By combining two distinct blood sugar-lowering medicines, it helps keep your diabetes under control.

To get the best results, you must take Valera M 500 Tablet regularly and consistently as prescribed by your doctor. This oral tablet is typically taken with meals to minimise the chance of experiencing an upset stomach. Combining this medication with a balanced diet and regular physical activity will significantly improve your blood sugar management.

While taking Valera M 500 Tablet , some people may experience mild side effects like nausea, diarrhoea, or a runny nose. However, you must seek immediate medical attention and consult your doctor if you experience rare but serious symptoms, such as severe stomach pain or signs of an allergic reaction.

Before starting this medicine, talk to your doctor if you have a history of liver damage, heart failure, or kidney problems. Do not take this if you have severe kidney disease, diabetic ketoacidosis, or a known allergy to any of its components.

This medicine can interact with certain other drugs, smoking, and alcohol, which can increase the risk of a dangerous buildup of acid in your blood. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you should consult your doctor before starting this treatment.

Uses of Valera M 500 Tablet

Valera M 500 Tablet is used to treat Type 2 diabetes mellitus. The detailed uses of Valera M 500 Tablet are as follows:

  • Type 2 diabetes mellitus: Valera M 500 Tablet helps lower high blood sugar levels in adults. It works alongside dietary improvements and regular physical activity to keep glucose levels within a safe target range and help prevent long-term health complications.

Key Benefits

Managing type 2 diabetes effectively with Valera M 500 Tablet offers several important health benefits:

  • Steady blood sugar control: By targeting different pathways in the body, it helps prevent sharp rises in blood sugar after meals and maintains stable glucose levels throughout the day.
  • Prevention of long-term complications: Keeping your blood sugar in check reduces your risk of developing severe diabetes-related problems, such as kidney damage, nerve damage, vision loss, and cardiovascular issues.
  • Convenience of combination therapy: Taking two active therapies in a single tablet makes it easier to follow your treatment plan compared to taking multiple separate pills.

Directions for Use

  • Valera M 500 Tablet can be taken with or without food, as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the whole Valera M 500 Tablet with a glass of water.
  • Do not crush, chew, or break it.

How Valera M 500 Tablet Works

Valera M 500 Tablet contains two active components that work together in complementary ways to manage blood sugar levels. The first active component, evogliptin, works by blocking an enzyme in the body called DPP-4. By doing this, it extends the action of natural hormones that stimulate the pancreas to release more insulin when blood sugar levels are high. It also helps reduce the amount of sugar produced by your liver. The second active component, metformin, belongs to a class of medicines called biguanides. It works by making your muscles and tissues more sensitive to insulin, allowing them to absorb sugar from the blood more effectively. It also delays the absorption of sugar from the food you eat and decreases the amount of glucose your liver produces. Together, these actions provide comprehensive, dual-action control over your blood sugar levels throughout the day and night.
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Alcohol

Caution

It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

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Pregnancy

Caution

Limited information is available on the use of Valera M 500 Tablet in pregnant women. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

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Breast Feeding

Caution

Limited information on the use of Valera M 500 Tablet in breastfeeding mothers is available. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

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Driving

Caution

If your blood sugar is too low or too high, your driving ability may be affected. Do not drive if these symptoms appear.

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Liver

Caution

There is limited information available on the use of Valera M 500 Tablet in patients with liver disease. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.

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Kidney

Caution

Limited information is available on using Valera M 500 Tablet in patients with kidney disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

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Children

Unsafe

Valera M 500 Tablet is not recommended for people younger than 18 years of age.

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Heart

Caution

Limited information was available regarding the use of Valera M 500 Tablet in patients with heart problems. Please consult your doctor before using Valera M 500 Tablet .

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Geriatrics

Caution

Valera M 500 Tablet should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Valera M 500 Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Valera M 500 Tablet

In case of an accidental overdose, seek immediate medical attention. An overdose can lead to dangerously low blood sugar or a serious condition caused by acid buildup in the blood.

Diet & Lifestyle Advise

  • Eat a balanced diet: Focus on whole grains, lean proteins, and plenty of non-starchy vegetables. Limit foods high in refined sugars and simple carbohydrates to avoid blood sugar spikes.
  • Stay active: Aim for at least 150 minutes of moderate physical activity, like brisk walking or cycling, per week. Regular exercise helps your body use insulin more efficiently.
  • Monitor your blood sugar: Keep a regular log of your blood glucose levels as advised by your doctor to track how your treatment is working.
  • Do not skip meals: Eating your meals at consistent times helps prevent your blood sugar from dropping too low, especially when taking diabetes medications.
  • Stay hydrated: Drink plenty of water throughout the day to support your kidney function and help your body process the medication safely.
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How Soon It Starts Working

The time required for Valera M 500 Tablet to start to work: The effect of Valera M 500 Tablet is seen within 1 to 2 hours of administration. The time for which the effects of Valera M 500 Tablet last: Valera M 500 Tablet effect lasts for 24 hours.

What if you forget to take Valera M 500 Tablet

If you miss a dose, take it with food as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular timing. Do not take a double dose to make up for a missed one.

Storage

•Store Valera M 500 Tablet tablets in their original packaging at room temperature, ideally below 30°C (86°F). •Keep the medication in a dry place away from direct sunlight, high heat, and moisture.

Drug Warnings

  • Monitor kidney function: Your doctor should check how well your kidneys are working before you start taking this medicine and at least once a year during treatment.
  • Watch out for low blood sugar: While Valera M 500 Tablet alone rarely causes low blood sugar, it can happen when combined with other diabetes medicines. Keep a fast-acting sugar source, like fruit juice or glucose tablets, with you.
  • Avoid heavy alcohol use: Drinking excessive alcohol while taking this medicine can increase the risk of a dangerous buildup of acid in your blood.
  • Pause before certain medical tests: Tell your doctor you are taking Valera M 500 Tablet if you need to have an X-ray or scan that involves injecting a contrast dye, as you may need to stop taking the medicine temporarily.
  • Stop before surgery: If you are planning to have a surgical procedure under anaesthesia, discuss with your doctor when to stop taking this medicine and when to restart it.

Drug-Drug Interactions

verifiedApollotooltip
  • Water pills (diuretics) and steroids: These medicines can increase blood sugar levels, potentially reducing the effectiveness of Valera M 500 Tablet .
  • Other blood sugar lowering medicines: Combining this medicine with insulin or certain oral diabetes drugs may increase the risk of low blood sugar.
  • Certain heart and blood pressure medicines: Some blood pressure drugs may hide the warning signs of low blood sugar, such as a fast heart rate.
Evogliptin + MetforminIopamidol
Critical
Evogliptin + MetforminIodamide
Critical

Drug-Drug Interactions

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Evogliptin + MetforminIopamidol
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Iopamidol can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Iopamidol but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminIodamide
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Iodamide can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Iodamide but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminIodixanol
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Iodixanol can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Iodixanol but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminIopromide
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Iopromide can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Iopromide but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminMetrizamide
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Metrizamide can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Metrizamide but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminGatifloxacin
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Gatifloxacin can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Gatifloxacin but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like excess sweating, fainting, excessive hunger, tiredness, shaking of hands or legs, increased thirst or a dry mouth, urinating frequently, or blurred vision. Do not discontinue without consulting a doctor.
Evogliptin + MetforminIomeprol
Critical
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Iomeprol can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Iomeprol but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminZonisamide
Severe
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with zonisamide can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and zonisamide but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, loss of hunger, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminMethazolamide
Severe
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Methazolamide can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Methazolamide but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, loss of hunger, excessive muscle or body pains. Do not discontinue without consulting a doctor.
Evogliptin + MetforminEthanol
Severe
How does the drug interact with Valera M 500 Tablet:
Co-administration of Evogliptin,Metformin with Ethanol can increase the risk of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Metformin, Evogliptin and Ethanol but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like nausea, vomiting, tiredness, sweating, rapid breathing, loss of hunger, excessive muscle or body pains. Do not discontinue without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid excessive alcohol consumption, as it significantly increases the risk of a rare but life-threatening buildup of acid (lactic acidosis) in your system.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Valera M 500 Tablet is used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than usual.
Valera M 500 Tablet contains Metformin and Evogliptin. Metformin works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. Altogether Valera M 500 Tablet reduces sugar levels in the body.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. Always carry glucose tablets or sugar candies with you.
Do not discontinue taking Valera M 500 Tablet without consulting your doctor. Take Valera M 500 Tablet for as long as it has been advised by the doctor. If you experience any difficulty while taking Valera M 500 Tablet , consult a doctor.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
The side effects of Valera M 500 Tablet include nausea, vomiting, headache, stomach pain, diarrhoea, and indigestion. If these side effects persist or worsen, please consult your doctor.
Medicines used to secrete insulin or insulin injections raise the risk of hypoglycemia (low blood sugar levels) when taken with metformin. Therefore, inform your doctor if you are on insulin injections before starting Valera M 500 Tablet .
There are no human studies conducted to see the effects of Valera M 500 Tablet on fertility. However, studies on animals do not show the harmful effects of high doses of evogliptin and metformin on the fertility in both the genders in rats and mice. If you have any concerns regarding this, please discuss with your doctor.
There is no information on role of Valera M 500 Tablet in causing cancer as no human studies have been performed. However, animal studies results do not show cancer.
It is generally not recommended to take Valera M 500 Tablet during pregnancy. Your doctor will likely switch you to a different treatment to manage your blood sugar levels while pregnant. Talk to your doctor if you are pregnant or planning to become pregnant.
No, Valera M 500 Tablet is typically weight-neutral and is not associated with significant weight gain. In some cases, it may even support modest weight management when combined with a healthy diet and regular physical activity. Talk to your doctor if you have concerns about your weight.
You should avoid heavy or excessive alcohol intake while taking Valera M 500 Tablet . Alcohol increases the risk of a rare but very serious condition called lactic acidosis, which is a dangerous buildup of acid in the blood. Talk to your doctor or pharmacist about safe alcohol consumption limits.
Mild diarrhea and stomach upset are common when first starting Valera M 500 Tablet , and they usually improve over a few weeks. Taking your medicine with meals can help reduce these symptoms. However, if your diarrhea is severe, persistent, or accompanied by dehydration, talk to your doctor.
You may need to stop taking Valera M 500 Tablet temporarily before undergoing surgery involving general anaesthesia. Your medical team will instruct you on when to stop the medication and when it is safe to restart. Talk to your doctor before any scheduled surgical procedure.
Although Valera M 500 Tablet alone has a low risk of causing hypoglycemia (low blood sugar), the risk increases if you take it with insulin or other diabetes medicines, skip or delay meals, drink excessive alcohol, or perform intense physical activity. Symptoms may include sweating, shakiness, dizziness, hunger, or confusion. If you think your blood sugar is low, consume glucose tablets, sugar candies, or another fast-acting source of sugar immediately, and monitor your blood sugar if possible. Talk to your doctor about how to recognise and manage hypoglycemia.
The best time to take Valera M 500 Tablet is usually with your morning or evening meal, as directed by your doctor. Taking it with a meal helps protect your stomach from irritation. To get the best results, try to take it at the same time every day, and talk to your doctor if you need to adjust your schedule.

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Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - VAL0418
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