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compositionComposition:DIATRIZOIC ACID-66%W/V
prescription
Prescription Medicine
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U-Grafin 76% Injection 20 ml is a diagnostic agent used to refine diagnostic precision in various body areas that may have been satisfactorily visualized. It contains Diatrizoic Acid, an iodine-containing X-ray contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during specific medical procedures, such as X-ray, magnetic resonance imaging (MRI) scans and CT scan examinations.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DIATRIZOIC ACID-66%W/V

Manufacturer/Marketer :

Copi Medicare

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About U-Grafin 76% Injection 20 ml

U-Grafin 76% Injection 20 ml is a diagnostic contrast medium used during certain imaging tests to make internal body structures easier for doctors to see. It contains iodine, which helps areas such as blood vessels, the urinary tract, digestive tract, and other organs appear more clearly on X-rays and computed tomography (CT) scans. It is used to help doctors identify abnormalities and make an accurate diagnosis.

U-Grafin 76% Injection 20 ml works by blocking X-rays as they pass through the area containing the contrast medium. This makes the area appear more clearly on the resulting image. Depending on the diagnostic procedure, diatrizoic acid may be injected into a vein or artery, placed into a body cavity, swallowed, or given through the rectum.

U-Grafin 76% Injection 20 ml is given as part of a diagnostic procedure rather than taken on a regular daily schedule. The route and amount used depend on the type of imaging test and the area being examined. Follow the preparation instructions provided by your healthcare team, including any advice about eating, drinking, or taking your usual medicines before the procedure.

Some people may experience temporary warmth, flushing, nausea, or an unusual taste, particularly when U-Grafin 76% Injection 20 ml is injected. Tell your healthcare team immediately if you develop difficulty breathing, severe itching, swelling, severe dizziness, or a noticeable decrease in urination during or after the procedure.

Before receiving U-Grafin 76% Injection 20 ml, tell your doctor if you have kidney disease, thyroid problems, asthma, heart disease, dehydration, or a previous reaction to iodinated contrast media. Also tell your doctor about all medicines you take, particularly metformin. If kidney function becomes significantly impaired around the time iodinated contrast is given, metformin can build up in the body and increase the risk of a rare but serious condition called lactic acidosis. If you are pregnant or breastfeeding, tell your healthcare team before the procedure.

Uses of U-Grafin 76% Injection 20 ml

U-Grafin 76% Injection 20 ml is used during diagnostic procedures to make certain organs and body structures easier to see on imaging tests.

  • Angiography: Helps blood vessels appear clearly on X-rays so doctors can look for narrowing, blockages, or other abnormalities.
  • Urography: Helps the kidneys, ureters, and bladder appear more clearly so doctors can check for stones, tumours, or structural problems.
  • Computed tomography (CT) scans: Improve the visibility of certain tissues, organs, and body structures to help doctors identify abnormalities.
  • Hysterosalpingography: Helps show the uterus and fallopian tubes so doctors can look for blockages or structural problems.
  • Digestive tract imaging: When given by mouth or through the rectum, it can help outline parts of the digestive tract during certain imaging procedures.

Key Benefits

U-Grafin 76% Injection 20 ml helps doctors obtain clearer images of internal body structures during diagnostic procedures.

  • Improves image clarity: Makes certain organs, blood vessels, body cavities, and tissues easier to distinguish from surrounding structures.
  • Supports accurate diagnosis: Clearer images can help doctors identify blockages, stones, structural abnormalities, and other medical problems.
  • Guides further care: The information obtained from imaging can help your healthcare team decide whether further tests or treatment are needed.
Side effects of U-Grafin 76% Injection 20 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • U-Grafin 76% Injection 20 ml will be administered by a trained anesthesiologist.
  • Do not self-administer.

How U-Grafin 76% Injection 20 ml Works

U-Grafin 76% Injection 20 ml, or Diatrizoic acid, is an iodine-containing contrast agent, which absorbs X-rays more strongly than many surrounding body tissues. When U-Grafin 76% Injection 20 ml reaches the area being examined, less X-ray radiation passes through that area. As a result, structures containing the contrast medium appear brighter on the image. This contrast helps doctors see the shape and outline of blood vessels, organs, body cavities, or parts of the digestive tract more clearly.
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Alcohol

Caution

It is unknown whether U-Grafin 76% Injection 20 ml interacts with alcohol. However, as a precautionary measure, it is advisable not to consume alcohol.

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Pregnancy

Caution

Limited data is available. If you are pregnant or planning pregnancy, inform your doctor before receiving U-Grafin 76% Injection 20 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available. Let your doctor know if you are a nursing mother before taking U-Grafin 76% Injection 20 ml; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Caution

Some side effects of U-Grafin 76% Injection 20 ml may last for some time after your diagnostic procedure. Avoid driving until you are alert.

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Liver

Caution

Limited information was available about using U-Grafin 76% Injection 20 ml in patients with liver disease. Inform your doctor before receiving U-Grafin 76% Injection 20 ml if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available about using U-Grafin 76% Injection 20 ml in patients with kidney disease. Inform your doctor before receiving U-Grafin 76% Injection 20 ml if you have a history of kidney diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

U-Grafin 76% Injection 20 ml is safe for use in children if prescribed by the paediatrician. If administered, the child should be monitored carefully for any undesirable effects.

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Heart

Caution

U-Grafin 76% Injection 20 ml should be used with caution in patients with heart problems. Therefore, please consult your doctor before using U-Grafin 76% Injection 20 ml.

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Geriatrics

Consult your doctor

Please consult a doctor before administering U-Grafin 76% Injection 20 ml to geriatric patients. Your doctor will prescribe U-Grafin 76% Injection 20 ml if the benefits outweigh the risks.

What if I have taken an overdose of U-Grafin 76% Injection 20 ml

An overdose of U-Grafin 76% Injection 20 ml is uncommon because it is usually given under medical supervision. If too much is given, your healthcare team will monitor you and provide treatment as needed. If you feel unwell after the procedure, seek medical attention and tell the doctor that you recently received U-Grafin 76% Injection 20 ml.

Diet & Lifestyle Advise

  • Stay hydrated: Drink fluids as advised by your healthcare team before and after the procedure. Adequate hydration may be particularly important for people at risk of kidney problems.
  • Follow preparation instructions: Eat or fast only as instructed for your particular imaging procedure. Fasting is not required for every contrast examination.
  • Tell your doctor about medicines: Make sure your healthcare team knows about all prescription medicines, non-prescription medicines, and supplements you take.
  • Follow aftercare advice: Follow any instructions given after the procedure, particularly if U-Grafin 76% Injection 20 ml was given into the digestive tract or if you have kidney problems.
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Have a query?

How Soon It Starts Working

The time required for U-Grafin 76% Injection 20 ml to start to work: U-Grafin 76% Injection 20 ml ideally starts working immediately upon administration, allowing for rapid visualization of internal structures. The time for which the effects of U-Grafin 76% Injection 20 ml last: The duration of action for U-Grafin 76% Injection 20 ml is unknown.

What if you forget to take U-Grafin 76% Injection 20 ml

U-Grafin 76% Injection 20 ml is normally given as part of a planned diagnostic procedure, so a missed dose is not usually an issue. If you miss or need to postpone your imaging appointment, contact your healthcare provider to arrange another appointment.

Storage

•Store U-Grafin 76% Injection 20 ml according to the temperature and storage instructions provided with your product label, typically between 20°C and 25°C.

Drug Warnings

  • Previous contrast reactions: Tell your healthcare team if you have previously had an allergic-like reaction to iodinated contrast media, as additional precautions may be needed.
  • Kidney health: Tell your doctor if you have kidney disease or severe dehydration. Your kidney function may need to be checked before certain procedures.
  • Metformin use: Tell your healthcare team if you take metformin. Whether it needs to be temporarily stopped depends on your kidney function and the type of contrast procedure.
  • Thyroid problems: Tell your doctor if you have a thyroid disorder because iodine-containing contrast can affect thyroid function in some people.
  • Pregnancy: Tell your healthcare team if you are pregnant or think you may be pregnant so they can consider whether the imaging procedure is appropriate.
  • Breastfeeding: Breastfeeding generally does not need to be interrupted after iodinated contrast is given because only a very small amount reaches breast milk and even less is absorbed by the baby.
  • Seek immediate medical care: Get medical help right away if you develop difficulty breathing, swelling of the face or throat, fainting, severe weakness, or a marked decrease in urination after receiving U-Grafin 76% Injection 20 ml.

Drug-Drug Interactions

verifiedApollotooltip
  • Biguanide antidiabetics (e.g., metformin): If iodinated contrast is associated with acute kidney injury, metformin may build up in the body and increase the risk of lactic acidosis, a rare but serious build-up of acid in the blood. Metformin does not need to be stopped for everyone. Your doctor will decide based on your kidney function and the procedure.
  • Beta-blockers (e.g., metoprolol, propranolol): These medicines may make some severe allergic-like reactions more difficult to treat. Tell your healthcare team if you take a beta-blocker.
  • Interleukin-2 therapy: Recent treatment with interleukin-2 may increase the chance of delayed reactions, such as rash, fever, or flu-like symptoms, after iodinated contrast.
Diatrizoic acidVancomycin
Severe
Diatrizoic acidCelecoxib
Severe

Drug-Drug Interactions

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Diatrizoic acidVancomycin
Severe
How does the drug interact with U-Grafin 76% Injection 20 ml:
Coadministration of Vancomycin with U-Grafin 76% Injection 20 ml can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Vancomycin with U-Grafin 76% Injection 20 ml may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
Diatrizoic acidCelecoxib
Severe
How does the drug interact with U-Grafin 76% Injection 20 ml:
Coadministration of celecoxib with diatrizoate can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Celecoxib and U-Grafin 76% Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, swelling in hands and legs, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[DIAGNOSTIC AGENTS]

FAQs

U-Grafin 76% Injection 20 ml contains Diatrizoic Acid, which aids physicians in diagnosing and treating various pathological processes, such as MRI scans, by improving the visualization of specific organs, tissues, and blood vessels.
Diatrizoate salts significantly hinder coagulation at all stages. Factors V, VII, and VIII and fibrinogen are reduced. Prothrombin and thromboplastin times are prolonged.
U-Grafin 76% Injection 20 ml is a contrast medium used during certain imaging tests to make internal structures easier to see. Depending on the procedure, it can help show blood vessels, the urinary tract, the digestive tract, body cavities, and other structures.
When U-Grafin 76% Injection 20 ml is given into the bloodstream, it is mainly removed through the kidneys. In people with normal kidney function, much of it is cleared relatively quickly. Clearance may take longer if kidney function is reduced.
Not always. Preparation depends on the imaging procedure. Some tests may require changes to food or fluid intake, while others do not. Follow the instructions given by your healthcare team.
Iodinated contrast can increase the risk of acute kidney injury in some people, particularly those with severely reduced kidney function or other risk factors. Your doctor may check your kidney function and take appropriate precautions before the procedure.
Breastfeeding generally does not need to be interrupted after receiving iodinated contrast such as U-Grafin 76% Injection 20 ml. Only a very small amount passes into breast milk, and very little of that amount is absorbed by the baby. Discuss any concerns with your doctor.
U-Grafin 76% Injection 20 ml does not usually cause drowsiness. However, do not drive if you feel dizzy, weak, nauseated, or otherwise unwell after the procedure. Follow any additional advice given by your healthcare team.
Yes. Diatrizoic acid can be swallowed or given through the rectum for certain imaging tests of the digestive tract. It can also be given by injection or placed into certain body cavities depending on the procedure. Your healthcare team will choose the appropriate route.
Tell your healthcare team that you take metformin. You do not need to stop metformin for every contrast procedure. Your doctor will consider your kidney function and the type of procedure and tell you whether you need to temporarily stop it and when to restart it.
A seafood allergy does not by itself mean that you are allergic to iodinated contrast. However, tell your healthcare team about all allergies and especially any previous reaction to contrast media so they can assess your risk and take appropriate precautions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Shed No. C10 (A), Ground Floor, R.S. No. 411, Sagar Industrial Society, Vasta Devdi Road, Near Community Hall, Katargam, Surat, Gujarat, India, 395004
Other Info - UGR0003

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