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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Trespin Respules 5 ml is an aminoglycoside antibiotic used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis. It helps by inhibiting the protein synthesis of the bacterial cell and therby helps fight infection in the lungs. Sometimes, you may experience certain common side effects, such as discolouration of the substance you cough up (sputum), worsening of lung function test results, runny or stuffy nose, sneezing, hoarseness,feeling unwell, muscle pain, etc
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Whats That

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Composition :

TOBRAMYCIN-300MG

Manufacturer/Marketer :

Fusion Health Care Pvt Ltd

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

About Trespin Respules 5 ml

Trespin Respules 5 ml belongs to the class of aminoglycoside antibiotics. Trespin Respules 5 ml is used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis patients aged six years and older. Pseudomonas aeruginosa is a type of bacteria that can cause lung or chest infections, especially in people who already have a lung disease (cystic fibrosis) or an issue with their immune system.

Trespin Respules 5 ml contains Tobramycin, an aminoglycoside antibiotic that fights the infection in your lungs by interfering with protein synthesis in Pseudomonas bacterial cell and helps you breathe better.

Use the Trespin Respules 5 ml as prescribed by your doctor. Sometimes, you may experience certain common side effects, such as runny or stuffy nose, sneezing, voice alteration (hoarseness), discolouration of the substance you cough up (sputum), worsening of lung function test results, feeling unwell, muscle pain and voice alteration with sore throat and difficulty swallowing (laryngitis). Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not use Trespin Respules 5 ml if you are allergic to any of its components or other aminoglycoside antibiotics. Do not use the Trespin Respules 5 ml without consulting your doctor if you are pregnant or breastfeeding. Tell your doctor before prescribing Trespin Respules 5 ml if you have hearing problems, kidney problems, unusual difficulty breathing with wheezing or coughing, chest tightness, blood in the sputum, muscle weakness, and Parkinson's disease. Trespin Respules 5 ml is not recommended to be used in children under the age of six.

Uses of Trespin Respules 5 ml

Treatment of Chest infections (Pseudomonas aeruginosa infection)

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Check the label for directions before using it. Twist off the top of the respule (a small plastic container containing a solution) and pour the solution into the nebuliser chamber. This solution is made into a fine mist to breathe in. Inhale the medicine slowly and deeply through the nebuliser's mouthpiece.• Clean the nebulizer pieces (cup, mouthpiece, mask, and tubing) after each use.

Medicinal Benefits

Trespin Respules 5 ml contains Tobramycin, an aminoglycoside antibiotic that fights pulmonary infection by interfering with protein synthesis in Pseudomonas bacterial cells and allows you to breathe easier.

How Trespin Respules 5 ml Works

Trespin Respules 5 ml contains Tobramycin, an aminoglycoside antibiotic that fights the infection in your lungs by interfering with protein synthesis in Pseudomonas bacterial cell and helps you breathe better.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Trespin Respules 5 ml
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink plenty of water to promote filtration and elimination.
  • Eat protein-rich foods like seeds, nuts, beans, and lean meats.
  • Include fruits, vegetables and whole foods into your diet.
  • Limit salt, sugar, and saturated fats.
  • Choose healthy fats and oils like olive oil and flaxseed oil.
  • Exercise regularly to promote circulation and lymph vessel activity.
  • Practice compression therapy and wear compression garments.
  • Massage therapy can help move fluid through the lymphatic system.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Trespin Respules 5 ml

Overdose of Trespin Respules 5 ml may cause black, tarry stools, chest pain or tightness, continuing ringing or buzzing or other unexplained noise in the ears, feeling of fullness in the ears. If an overdose is suspected, seek immediate medical help.

Drug Warnings

Do not use Trespin Respules 5 ml if you are allergic to any of the components or other aminoglycoside antibiotics (neomycin, paromomycin, kanamycin). Do not use the Trespin Respules 5 ml without consulting your doctor if you are pregnant or breastfeeding. Tell your doctor before prescribing Trespin Respules 5 ml if you have hearing problems, kidney problems, unusual difficulty breathing with wheezing or coughing, chest tightness, blood in the sputum, muscle weakness, and Parkinson's disease. Children and adolescents aged six and up are eligible to use Trespin Respules 5 ml. Trespin Respules 5 ml should not be given to children under the age of six. Before taking the Trespin Respules 5 ml, notify your doctor about your medical history and other medications you are now taking to rule out any potential adverse effects or interactions.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Trespin Respules 5 ml:
Coadministration of cidofovir with Trespin Respules 5 ml can cause kidney problems.

How to manage the interaction:
Taking Trespin Respules 5 ml with Cidofovir is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Trespin Respules 5 ml:
Coadministration of Trespin Respules 5 ml with Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Trespin Respules 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Trespin Respules 5 ml:
Taking tenofovir alafenamide with Trespin Respules 5 ml can increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Trespin Respules 5 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TobramycinTubocurarine
Severe
How does the drug interact with Trespin Respules 5 ml:
Using Trespin Respules 5 ml with tubocurarine can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
There may be a possibility of interaction between Trespin Respules 5 ml and Tubocurarine, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
TobramycinDoxacurium chloride
Severe
How does the drug interact with Trespin Respules 5 ml:
Taking Trespin Respules 5 ml with doxacurium chloride can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
Although there is a possible interaction between Trespin Respules 5 ml and Doxacurium chloride, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
TobramycinFoscarnet
Severe
How does the drug interact with Trespin Respules 5 ml:
Combining Trespin Respules 5 ml with Foscarnet can increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Trespin Respules 5 ml and foscarnet, but it can be taken if prescribed by a doctor. However, if you experience nausea, swelling, sudden weight gain or weight loss, severe pain in your upper stomach spreading to your back, seizures, pounding heart beats, dizziness or chest pain contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Trespin Respules 5 ml:
Taking tacrolimus with Trespin Respules 5 ml may increase risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Trespin Respules 5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trespin Respules 5 ml:
Coadministration of Trespin Respules 5 ml with Sirolimus can cause an increased risk or severity of kidney problems.

How to manage the interaction:
Although taking Sirolimus and Trespin Respules 5 ml together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Trespin Respules 5 ml:
Taking Trespin Respules 5 ml with succinylcholine can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
There may be a possibility of interaction between Suxamethonium and Trespin Respules 5 ml, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Trespin Respules 5 ml:
Coadministration of Trespin Respules 5 ml with Colistin can increase the blood levels and risk of Colistin side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Trespin Respules 5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Trespin Respules 5 ml to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Trespin Respules 5 ml.
  • Avoid intake of alcoholic beverages with Trespin Respules 5 ml as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Trespin Respules 5 ml in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS
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Alcohol

Caution

It is unknown if alcohol affects Trespin Respules 5 ml. However, it is advisable to limit or avoid alcohol as a precautionary measure.

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Pregnancy

Caution

Trespin Respules 5 ml may not be recommended to be used in pregnancy. If you are pregnant, please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on using Trespin Respules 5 ml in breastfeeding/nursing mothers.

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Driving

Safe if prescribed

Trespin Respules 5 ml may not affect your ability to drive, use, or operate machines.

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Liver

Caution

Limited information about the usage of Trespin Respules 5 ml in patients with liver disease is available. Please consult your physician. Your doctor will weigh the benefits and potential risks before prescribing Trespin Respules 5 ml.

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Kidney

Caution

Limited information about the usage of Trespin Respules 5 ml in patients with kidney disease is available. Please consult your physician. Your doctor will weigh the benefits and potential risks before prescribing Trespin Respules 5 ml.

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Children

Caution

Children and adolescents aged six and up are eligible to use Trespin Respules 5 ml. Trespin Respules 5 ml should not be given to children under the age of six.

Have a query?

FAQs

Trespin Respules 5 ml belongs to the class of aminoglycoside antibiotics. Trespin Respules 5 ml is used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis patients aged six years and older.

Trespin Respules 5 ml contains Tobramycin, an aminoglycoside antibiotic that fights pulmonary infection by interfering with protein synthesis in Pseudomonas bacterial cells and allows you to breathe easier.

Please do not stop using Trespin Respules 5 ml until the course prescribed by your doctor has been completed. If you stop taking Trespin Respules 5 ml too soon, your symptoms may recur.

Voice alteration (hoarseness) is the most common side effect of Trespin Respules 5 ml. If you experience any major changes, immediately consult your doctor.

Trespin Respules 5 ml is recommended not to use it for more than the prescribed duration. Please reach out to your doctor if your symptoms do not improve or if it becomes worse.

Trespin Respules 5 ml is only used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis patients.

Country of origin

India

Manufacturer/Marketer address

Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034
Other Info - TRE0372

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Keep Refrigerated. Do not freeze.

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