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Trespin Respules 5 ml is an aminoglycoside antibiotic used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis. It helps by inhibiting the protein synthesis of the bacterial cell and therby helps fight infection in the lungs. Sometimes, you may experience certain common side effects, such as discolouration of the substance you cough up (sputum), worsening of lung function test results, runny or stuffy nose, sneezing, hoarseness,feeling unwell, muscle pain, etc

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOBRAMYCIN-300MG

Manufacturer/Marketer :

Fusion Health Care Pvt Ltd

Consume Type :

Inhalation

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trespin Respules 5 ml

Trespin Respules 5 ml is a prescription inhalation medicine used to manage and treat chronic lung infections in patients with cystic fibrosis. It specifically targets a type of bacteria that commonly infects the airways of individuals with this condition. By clearing these bacteria, the medicine helps maintain and improve lung function so patients can breathe more comfortably.

For the medicine to work effectively, you must take it with strict consistency as directed by your doctor, usually in alternating treatment cycles. To support your lung health and get the best results, combine this treatment with daily airway clearance techniques and stay well-hydrated to help loosen thick mucus. Because this is an inhaled medication, there are no specific food requirements, so you can take it regardless of your meal times.

While taking Trespin Respules 5 ml, some people may experience mild side effects like a temporary change in their voice, throat soreness, or a mild cough. However, you must contact your doctor immediately if you experience serious symptoms such as ringing in your ears, hearing changes, severe dizziness, or difficulty breathing right after inhalation.

Before starting Trespin Respules 5 ml, talk to your doctor if you have a history of kidney problems, hearing impairment, or muscle weakness disorders. Do not take this if you have had a severe allergic reaction to similar inhaled antibiotics in the past.

This medicine can interact with other drugs that cause kidney damage or hearing loss, so your doctor should know all the medications you are taking. You should also consult your healthcare provider if you are pregnant, breastfeeding, or an older adult, as special monitoring may be required.

Uses of Trespin Respules 5 ml

Trespin Respules 5 ml is used to manage and treat chronic lung infections in patients with cystic fibrosis. The detailed uses of Trespin Respules 5 ml are as follows:

  • Cystic Fibrosis Lung Infections: Trespin Respules 5 ml helps clear and control the growth of bacteria in the lungs, reducing the severity of ongoing infections.
  • Worsening Lung Function: By keeping bacterial growth in check, this medicine helps prevent the decline in lung health and supports easier breathing.

Key Benefits

Trespin Respules 5 ml helps manage chronic airway infections, improving respiratory health and supporting better lung function. With regular use as prescribed, it helps reduce respiratory flare-ups, preserve lung capacity, and improve overall quality of life.

  • Supports Easier Breathing: By helping control airway infections, this medicine reduces respiratory symptoms and makes breathing more comfortable.
  • Helps Prevent Severe Lung Flare-Ups: Regular use helps reduce the frequency and severity of respiratory infections, lowering the need for hospitalisation and intravenous antibiotic treatment.
  • Promotes Better Lung Function: By preserving lung capacity and reducing chronic respiratory symptoms, this medicine helps you stay active and perform daily activities with greater ease and comfort.
Side effects of Trespin Respules 5 ml
  • Drink plenty of water to promote filtration and elimination.
  • Eat protein-rich foods like seeds, nuts, beans, and lean meats.
  • Include fruits, vegetables and whole foods into your diet.
  • Limit salt, sugar, and saturated fats.
  • Choose healthy fats and oils like olive oil and flaxseed oil.
  • Exercise regularly to promote circulation and lymph vessel activity.
  • Practice compression therapy and wear compression garments.
  • Massage therapy can help move fluid through the lymphatic system.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Check the label for directions before using it. Twist off the top of the respule (a small plastic container containing a solution) and pour the solution into the nebuliser chamber. This solution is made into a fine mist to breathe in. Inhale the medicine slowly and deeply through the nebuliser’s mouthpiece.
  • Clean the nebulizer pieces (cup, mouthpiece, mask, and tubing) after each use.

How Trespin Respules 5 ml Works

Trespin Respules 5 ml contains tobramycin, which is an antibiotic that goes directly to the source of the infection in your lungs when inhaled. It works by binding to the components inside the bacteria that make vital proteins. By disrupting this protein production, the medicine stops the bacteria from growing and multiplying, eventually causing them to die. Since the treatment is inhaled, it delivers a high concentration of the active medicine directly to your airways while keeping the level of medicine in the rest of your body very low.
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Alcohol

Caution

It is unknown if alcohol affects Trespin Respules 5 ml. However, it is advisable to limit or avoid alcohol as a precautionary measure.

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Pregnancy

Caution

Trespin Respules 5 ml may not be recommended to be used in pregnancy. If you are pregnant, please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on using Trespin Respules 5 ml in breastfeeding/nursing mothers.

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Driving

Safe if prescribed

Trespin Respules 5 ml may not affect your ability to drive, use, or operate machines.

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Liver

Caution

Limited information about the usage of Trespin Respules 5 ml in patients with liver disease is available. Please consult your physician. Your doctor will weigh the benefits and potential risks before prescribing Trespin Respules 5 ml.

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Kidney

Caution

Limited information about the usage of Trespin Respules 5 ml in patients with kidney disease is available. Please consult your physician. Your doctor will weigh the benefits and potential risks before prescribing Trespin Respules 5 ml.

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Children

Caution

Children and adolescents aged six and up are eligible to use Trespin Respules 5 ml. Trespin Respules 5 ml should not be given to children under the age of six.

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Heart

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Trespin Respules 5 ml in heart patients.

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Geriatrics

Caution

Trespin Respules 5 ml should be used with caution in elderly patients due to an increased risk of side effects. It is important to consult a healthcare professional before use.

What if I have taken an overdose of Trespin Respules 5 ml

If you inhale too much of this medicine or accidentally swallow it, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Perform your chest physical therapy or airway clearance techniques before using your Trespin Respules 5 ml treatment to ensure the medicine reaches deep into your lungs.
  • Drink plenty of water throughout the day to help thin and loosen the sticky mucus in your airways.
  • Follow a high-calorie, nutritious diet recommended by your healthcare provider to help your body maintain the energy needed to fight off infections.
  • Avoid smoking, secondhand smoke, and other lung irritants like strong chemical fumes or heavy dust.
     
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How Soon It Starts Working

The time required for Trespin Respules 5 ml to start to work: The onset time of Trespin Respules 5 ml has not been clinically established. The time for which the effects of Trespin Respules 5 ml last: The duration of Trespin Respules 5 ml’s effect is clinically not established.

What if you forget to take Trespin Respules 5 ml

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 6 hours away, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

.•Store the medicine in the refrigerator between 2°C and 8°C (36°F and 46°F) to keep it stable.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Always check the liquid in the vial before use; it should be clear or pale yellow. If it is cloudy, dark, or contains particles, do not use it.
  • Do not mix Trespin Respules 5 ml with any other medications in your nebuliser cup.
  • Always use the exact nebuliser and compressor model recommended by your healthcare team to ensure you receive the correct dose.
  • If you use multiple inhaled medications, follow the specific sequence advised by your doctor (usually bronchodilators first, then airway clearance, and Trespin Respules 5 ml last).
  • Clean, disinfect, and air-dry your nebuliser parts thoroughly after every use to prevent the growth of harmful bacteria.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Certain water pills (diuretics): Taking strong diuretics alongside Trespin Respules 5 ml may increase the risk of hearing damage or kidney problems.
  • Other antibiotics: Combining this medicine with other injectable antibiotics that can affect the kidneys or hearing may increase the risk of side effects.

Drug-Drug Interactions

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How does the drug interact with Trespin Respules 5 ml:
Coadministration of cidofovir with Trespin Respules 5 ml can cause kidney problems.

How to manage the interaction:
Taking Trespin Respules 5 ml with Cidofovir is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Trespin Respules 5 ml:
Coadministration of Trespin Respules 5 ml with Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Trespin Respules 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TobramycinBumetanide
Severe
How does the drug interact with Trespin Respules 5 ml:
When Trespin Respules 5 ml is taken with Bumetanide, the amount of Trespin Respules 5 ml in the blood can go up.

How to manage the interaction:
Although there is a possible interaction between Trespin Respules 5 ml and Bumetanide, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Trespin Respules 5 ml:
Taking Furosemide with Trespin Respules 5 ml can increase the risk of hearing loss and kidney problems.

How to manage the interaction:
Although there is a possible interaction between Trespin Respules 5 ml and Furosemide, you can take these medicines together if prescribed by your doctor. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Trespin Respules 5 ml:
Using pancuronium with Trespin Respules 5 ml can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
Although taking Pancuronium and Trespin Respules 5 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Trespin Respules 5 ml:
Co-administration of Trespin Respules 5 ml with torasemide increases the risk of toxicity.

How to manage the interaction:
Although taking Trespin Respules 5 ml and torasemide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as blurred vision, dry mouth, dry skin, frequent urination, nausea, and stomach pain, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
TobramycinTubocurarine
Severe
How does the drug interact with Trespin Respules 5 ml:
Using Trespin Respules 5 ml with tubocurarine can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
There may be a possibility of interaction between Trespin Respules 5 ml and Tubocurarine, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
TobramycinDoxacurium chloride
Severe
How does the drug interact with Trespin Respules 5 ml:
Taking Trespin Respules 5 ml with doxacurium chloride can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
Although there is a possible interaction between Trespin Respules 5 ml and Doxacurium chloride, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Trespin Respules 5 ml:
Taking tacrolimus with Trespin Respules 5 ml may increase risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Trespin Respules 5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trespin Respules 5 ml:
Taking tenofovir alafenamide with Trespin Respules 5 ml can increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Trespin Respules 5 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Trespin Respules 5 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Trespin Respules 5 ml belongs to the class of aminoglycoside antibiotics. Trespin Respules 5 ml is used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis patients aged six years and older.
Trespin Respules 5 ml contains Tobramycin, an aminoglycoside antibiotic that fights pulmonary infection by interfering with protein synthesis in Pseudomonas bacterial cells and allows you to breathe easier.
Please do not stop using Trespin Respules 5 ml until the course prescribed by your doctor has been completed. If you stop taking Trespin Respules 5 ml too soon, your symptoms may recur.
Trespin Respules 5 ml is recommended not to use it for more than the prescribed duration. Please reach out to your doctor if your symptoms do not improve or if it becomes worse.
Trespin Respules 5 ml is only used to treat chest infections caused by the bacteria Pseudomonas aeruginosa in cystic fibrosis patients.
Yes, you should typically continue using your medicine even if you have a cold, as it helps manage your underlying lung infection. However, talk to your doctor if your breathing symptoms worsen significantly.
Hoarseness or changes in your voice are common temporary side effects because the inhaled mist directly contacts your vocal cords. Rinsing your mouth and gargling with water after each use can help prevent this. Talk to your doctor if it persists.
No, you should never mix Trespin Respules 5 ml with any other medications in the nebuliser cup. Each medicine must be taken separately to ensure they work correctly and safely. Talk to your doctor for the correct schedule.
If you need to cough, you can pause your nebuliser, cough, and then resume your treatment. Try to complete the entire dose as prescribed. Talk to your doctor if coughing prevents you from completing your treatment.
This medicine may cause harm to an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to weigh the benefits and risks.
Yes, the vials can be kept at room temperature for up to 28 days if a refrigerator is not available. Ensure they are kept in their original foil pouch and protected from intense light. Talk to your pharmacist if you are unsure.
Generally, you should use your bronchodilator first to open your airways, followed by chest physical therapy to loosen mucus, and use Trespin Respules 5 ml last to target the bacteria directly. Talk to your doctor to confirm your specific sequence.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034
Other Info - TRE0372
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