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Topolive 1 mg Capsule 10's is used to treat ovarian and small-cell lung cancer. It contains Topotecan which works by killing the cancer cells. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), and electrolyte disturbances. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOPOTECAN-1MG

Manufacturer/Marketer :

Oncobiotek Drugs Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Topolive 1 mg Capsule 10's

Topolive 1 mg Capsule 10's is a prescription medicine used to treat relapsed small-cell lung cancer. It is prescribed for patients whose cancer has returned or progressed after receiving their first chemotherapy treatment. This medicine works by targeting and slowing the growth of rapidly dividing cancer cells in the body.

You will typically take this medicine once daily for several consecutive days, followed by a rest period, as part of a treatment cycle planned by your oncologist. It is important to take it consistently at the same time each day, and you may take it with or without food. To support your body during treatment, try to eat small, frequent meals and drink plenty of fluids to help manage common side effects.

Common side effects of Topolive 1 mg Capsule 10's include a temporary drop in blood cell counts, feeling very tired, nausea, and diarrhoea. You must consult your doctor immediately if you experience serious side effects, such as a fever, signs of infection, unusual bruising, or persistent bleeding. Your doctor will arrange regular blood tests before and during treatment to monitor your white blood cells, red blood cells, and platelets. These tests help ensure it is safe for you to continue each treatment cycle.

Talk to your doctor before starting this medicine if you have kidney disease, a weakened immune system, or existing low blood cell counts. Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine can cause serious harm to an unborn baby or nursing infant.

This medicine can interact with other treatments, live vaccines, and certain over-the-counter products, which may increase your risk of severe side effects. Pregnant individuals, breastfeeding mothers, and elderly patients must consult their healthcare team to discuss the specific risks and benefits before starting treatment.

Uses of Topolive 1 mg Capsule 10's

Topolive 1 mg Capsule 10's is used to treat certain types of cancer by slowing or stopping the growth of cancer cells. It is mainly used for:

  • Relapsed small cell lung cancer: Topolive 1 mg Capsule 10's is used to treat small cell lung cancer that has returned or progressed after at least one prior course of chemotherapy.
  • Relapsed ovarian cancer: It may be used to treat ovarian cancer that has returned after previous chemotherapy.
  • Advanced cervical cancer: It may be used in combination with cisplatin to treat advanced or recurrent cervical cancer when recommended by your oncologist. 

Key Benefits

Topolive 1 mg Capsule 10's helps slow the growth and spread of cancer cells, which may help manage your condition and improve your quality of life during treatment. Key benefits of using Topolive 1 mg Capsule 10's include:

  • Convenient treatment option: Allowing patients to take their cancer treatment at home rather than spending hours in a hospital or clinic for intravenous infusions.
  • Helps control disease progression:  by slowing down and stopping the division of cancer cells, helping control the spread of the disease.
  • Relieves distressing symptoms: Helping relieve symptoms such as coughing, breathing difficulties, or chest discomfort, making you feel more comfortable during your treatment. 
Side effects of Topolive 1 mg Capsule
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.

Directions for Use

  • Topolive 1 mg Capsule 10's can be taken with or without food as prescribed by your doctor.
  • It is typically taken once daily for 5 consecutive days every 21 days. Your doctor will determine how many treatment cycles you need. Follow your doctor's advice regarding the dosage and timing.
  • Swallow Topolive 1 mg Capsule 10's as a whole with a glass of water.
  • Do not chew, crush or break it.

How Topolive 1 mg Capsule 10's Works

Topolive 1 mg Capsule 10's works by blocking a specific protein in the body called topoisomerase I, which cancer cells rely on to repair and copy their DNA so they can divide and multiply. By attaching to this protein, Topotecan prevents cancer cells from repairing their genetic material. This causes severe damage inside the cancer cells, leading to their death and helping to prevent the tumour from growing larger.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Topolive 1 mg Capsule 10's. It could lead to avoiding unpleasant side-effects.

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Pregnancy

Unsafe

Topolive 1 mg Capsule 10's should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Topolive 1 mg Capsule 10's and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Topolive 1 mg Capsule 10's should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Topolive 1 mg Capsule 10's may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Topolive 1 mg Capsule 10's may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please inform the doctor before taking the Topolive 1 mg Capsule 10's. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please inform the doctor before taking the Topolive 1 mg Capsule 10's. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Safety and effectiveness in pediatric patients have not been established. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Heart

Caution

Limited information is available. Please consult your doctor if you have any concerns regarding the usage of Topolive 1 mg Capsule 10's in patients with heart problems.

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Geriatrics

Caution

Topolive 1 mg Capsule 10's should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Topolive 1 mg Capsule 10's in geriatrics, please consult your doctor.

What if I have taken an overdose of Topolive 1 mg Capsule 10's

If you take more than your prescribed dose, contact your doctor immediately or seek urgent medical attention by calling emergency services (112) or visiting the nearest hospital emergency department.

Diet & Lifestyle Advise

  • Practice strict food safety: Because this medicine lowers your white blood cell count, your risk of infection is higher. Avoid raw or undercooked meats, unpasteurized dairy, and unwashed raw fruits and vegetables.
  • Stay well-hydrated: Drink plenty of fluids like water, clear broths, or electrolyte solutions throughout the day, especially if you experience diarrhoea or vomiting.
  • Eat small, frequent meals: If you feel nauseous, eating five to six small portions a day instead of three large meals can help settle your stomach.
  • Avoid crowds and sick people: Wash your hands frequently with soap and water, and try to stay away from individuals who have colds, flu, or other contagious infections.
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Have a query?

How Soon It Starts Working

The time required for Topolive 1 mg Capsule 10's to start to work: The time required for Topolive 1 mg Capsule 10's to show its action is unknown. The time for which the effects of Topolive 1 mg Capsule 10's last: The duration of action for Topolive 1 mg Capsule 10's is clinically unknown.

What if you forget to take Topolive 1 mg Capsule 10's

If you miss a dose, do not take an extra dose to make up for the missed one. Skip the missed dose and take your next scheduled dose at your regular time. Inform your doctor or pharmacist about the missed dose.

Storage

• Store the capsules in a refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze them.

Drug Warnings

  • Inspect the capsules before use: Always inspect the capsules before taking them; do not take any capsule that is cracked, leaking, or damaged.
  • Handle capsules carefully: Wear disposable gloves if a caregiver needs to handle the capsules for you. Avoid touching your face while handling the capsules, and wash your hands thoroughly with soap and water after removing gloves. Dispose of used gloves safely after handling the medicine.
  • Use effective birth control: Use highly effective birth control during treatment and for at least 6 months after the last dose for women and 3 months after the last dose for men, as this medicine can cause severe birth defects. Discuss contraception and fertility preservation options, such as sperm or egg banking, with your doctor before starting treatment if you may want to have children in the future.
  • Avoid live vaccines: Avoid getting live vaccines (such as the shingles or MMR vaccine) while taking this medicine, as your weakened immune system may not handle them safely. Inform your oncologist about any upcoming vaccination appointments and share your complete vaccination schedule before starting treatment.
  • Monitor your body temperature: Monitor your body temperature daily and contact your healthcare team immediately if it rises above 38°C (100.4°F).

Drug-Drug Interactions

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Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Bone marrow-suppressing treatments: Combining Topolive 1 mg Capsule 10's with other chemotherapy medicines or therapies that suppress bone marrow can severely increase the risk of dangerously low blood cell counts.
  • Live vaccines: Avoid receiving live vaccines while on this treatment, as your weakened immune system increases the risk of contracting the infection from the vaccine.
  • Medicines that stimulate white blood cell production (such as G-CSF): These medicines may need to be given at specific times during treatment. Your doctor will decide the safest schedule.
  • P-glycoprotein (P-gp) inhibitors or inducers: Some medicines that affect P-gp may change the levels of Topolive 1 mg Capsule 10's in your body. Inform your doctor about all medicines you are taking before starting treatment.
  • ABCG2/BCRP transporter interactions: Medicines that affect this transporter may change how Topolive 1 mg Capsule 10's is absorbed in your body. Your doctor will review your medicines to reduce the risk of interactions. 

Drug-Drug Interactions

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How does the drug interact with Topolive 1 mg Capsule:
Taking Tofacitinib with Topolive 1 mg Capsule may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Topolive 1 mg Capsule, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Topolive 1 mg Capsule:
When Etanercept is used with Topolive 1 mg Capsule, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Topolive 1 mg Capsule and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Topolive 1 mg Capsule:
Coadministration of baricitinib and Topolive 1 mg Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Topolive 1 mg Capsule if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Topolive 1 mg Capsule:
When carboplatin is used with Topolive 1 mg Capsule, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of carboplatin with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Topolive 1 mg Capsule:
When Clozapine is taken with Topolive 1 mg Capsule, the effect of Clozapine in the blood can go up.

How to manage the interaction:
Although there is a possible interaction between Topolive 1 mg Capsule and Clozapine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, weight loss, pain or burning during urination - it's important to contact your doctor right away. They may be able to recommend other options that won't cause any problems with your current medications. Do not stop using any medications without a doctor's advice.
How does the drug interact with Topolive 1 mg Capsule:
Combining Infliximab with Topolive 1 mg Capsule can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Topolive 1 mg Capsule with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Topolive 1 mg Capsule:
Taking thalidomide together with Topolive 1 mg Capsule may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Topolive 1 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Avoid drinking alcohol while taking this medicine, as it can worsen common side effects like nausea, vomiting, and fatigue, and increase your risk of dehydration.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Topolive 1 mg Capsule 10's is used to treat ovarian and small-cell lung cancer.
Topolive 1 mg Capsule 10's contains 'Topotecan'. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
You should not receive Topolive 1 mg Capsule 10's if you are allergic to Topolive 1 mg Capsule 10's or other medicines or suffer from severe lung problems, Infections, renal dysfunction, and thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), hepatic disorders. Topolive 1 mg Capsule 10's should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Topolive 1 mg Capsule 10's if you are pregnant or breastfeeding because this Topolive 1 mg Capsule 10's can cause harmful effects on the unborn baby.
Yes, Topolive 1 mg Capsule 10's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
The live vaccine may not work while on treatment with Topolive 1 mg Capsule 10's. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
For the treatment of ovarian or lung cancer, Topolive 1 mg Capsule 10's is typically given once a day for five consecutive days, with the treatment cycle often repeated every 3 weeks. However, your doctor will tailor the exact dose and schedule based on your specific condition and how well you tolerate the medication. Always follow your doctor’s instructions precisely, and do not change the dosage or schedule without consulting them.
Yes, hair loss is a common side effect of Topolive 1 mg Capsule 10's, though not everyone will experience it. The severity can range from mild thinning to more noticeable shedding. In many cases, hair may begin to grow back once the treatment is finished. If you are concerned about hair loss, please talk to your doctor. They can recommend strategies or treatments to help manage this side effect.
Topolive 1 mg Capsule 10's does not cause a flare reaction. Flare reactions typically occur when a drug is infused into blood vessels. Since Topolive 1 mg Capsule 10's is taken orally, it does not trigger this response.
Topolive 1 mg Capsule 10's usually starts to work within a few hours after taking it, but the full effects may take a few days to weeks to become noticeable, depending on your specific condition. Your doctor will monitor your progress and adjust your treatment as needed.
No, Topolive 1 mg Capsule 10's is not a vesicant. It is an irritant. Vesicants are substances that can cause severe tissue damage or blistering if they leak from blood vessels into surrounding tissues, which is common with some chemotherapy drugs given through an IV. Since Topolive 1 mg Capsule 10's is taken orally, it does not have the same harmful effects as vesicants.
Yes, Topolive 1 mg Capsule 10's is effective in treating cancer. It works by inhibiting the growth of cancer cells. As a healthcare provider determines, it is particularly effective for ovarian cancer, small cell lung cancer, and other cancers.
Your doctor will give you instructions on how to take Topolive 1 mg Capsule 10's. It is typically taken orally once a day. For optimal results, swallow the medication whole with a glass of water and take it at the same time each day. Do not crush, break, or chew the tablet.
Common side effects of Topolive 1 mg Capsule 10's include nausea, diarrhoea, vomiting, low platelet count, nerve malfunction, kidney damage (at high doses), and electrolyte disturbances. Most of these side effects typically resolve on their own over time after stopping treatment. However, if the side effects persist, consult your doctor for further guidance.
No, you must swallow the capsule whole. Opening, crushing, or chewing the capsule can expose you to the active cancer medicine, which can be harmful if it touches your skin or is breathed in. If you have trouble swallowing, talk to your doctor or pharmacist.
You can take Topolive 1 mg Capsule 10's either with or without food. However, it is best to take it at the same time each day to keep a steady amount of the medicine in your system. Talk to your doctor or pharmacist for personalised advice.
Topolive 1 mg Capsule 10's temporarily lowers your white blood cell count, which makes it much harder for your body to fight off infections. You should avoid contact with sick individuals and contact your doctor immediately if you develop a fever. Talk to your doctor or pharmacist for more safety measures.
Do not touch the powder or liquid from a broken capsule. If it touches your skin, wash the area thoroughly with soap and water immediately. If it gets in your eyes, rinse them with water right away and contact your doctor.
It is highly recommended to limit or avoid alcohol during your treatment. Alcohol can worsen common side effects like nausea, vomiting, and fatigue, and it can increase your risk of dehydration. Talk to your doctor or pharmacist for guidance.
No, you should not take Topolive 1 mg Capsule 10's if you are pregnant or planning a pregnancy, as it can cause serious harm to an unborn baby. Both male and female patients must use reliable birth control during treatment and for a specified time after stopping. Talk to your doctor for details.
Topolive 1 mg Capsule 10's capsules must be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). Keep them in their original box to protect them from light, and do not freeze them. Talk to your doctor or pharmacist if you have questions about safe storage.

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Country of origin

India

Manufacturer/Marketer address

204, Siddhivinayak Plaza, Nirant Cross Road, Roads, Vastral, Ahmedabad, Gujarat 382418
Other Info - TOP0645
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