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compositionComposition:GIMERACIL-5.8MG+OTERACIL-15.8MG+TEGAFUR-20MG
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Prescription Medicine
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Tegonat 20 Capsule contains Tegafur, Gimeracil and Oteracil, a group of anti-cancer medicines used to treat stomach/gastric cancer. Together, these medications work by inhibiting the genetic material and preventing the growth of cancer cells. Thereby, it helps treat stomach cancer. Sometimes, Tegonat 20 Capsule may cause side effects, such as nausea, vomiting, diarrhoea, and constipation. Discuss with your doctor if any of the side effects persist or worsen.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GIMERACIL-5.8MG+OTERACIL-15.8MG+TEGAFUR-20MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tegonat 20 Capsule

Tegonat 20 Capsule is an oral chemotherapy medication prescribed to treat advanced stomach (gastric) cancer, colorectal cancer, and other specific solid tumors. Its primary medical purpose is to slow down or stop the growth and spread of cancer cells in the body. By targetting rapidly dividing cells, it helps manage advanced stages of cancer when surgical options may not be fully sufficient.

To achieve the best results, you must take Tegonat 20 Capsule consistently at the exact times prescribed by your doctor, typically twice a day. You should take your capsules within one hour after completing your morning and evening meals. Making specific lifestyle adjustments, such as eating small, frequent meals and staying well-hydrated, can significantly support your digestive tract during your treatment cycle.

While taking Tegonat 20 Capsule, you may experience common side effects, including mild nausea, diarrhea, skin changes, or temporary fatigue. However, you must contact your doctor or go to the nearest emergency room immediately if you experience serious side effects, such as a high fever, severe watery diarrhea, or unusual bleeding.

Do not take Tegonat 20 Capsule if you have severe kidney damage, severely low blood cell counts, or if you are allergic to any of its components. Before starting, you must tell your doctor if you have a history of liver damage, heart conditions, or severe dehydration, as these issues can increase your risk of severe complications.

Tegonat 20 Capsule has a highly dangerous, potentially fatal interaction with certain antiviral drugs, such as sorivudine and brivudine. You must also avoid alcohol and smoking, as they can worsen stomach irritation and strain your liver. Always consult your healthcare team if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly patient who may require a lower dose.

Uses of Tegonat 20 Capsule

Tegonat 20 Capsule is used in the treatment of gastric (stomach) cancer. The detailed uses of Tegonat 20 Capsule are as follows:

  • Advanced Gastric (Stomach) Cancer: Tegonat 20 Capsule helps treat stomach cancer that has spread or cannot be completely removed by surgery.
  • Colorectal Cancer: It is used as part of chemotherapy to help control the growth and spread of cancer cells in the colon or rectum.
  • Pancreatic Cancer: It may be used in selected patients, often in combination with other anticancer medicines, to help slow the progression of advanced pancreatic cancer.
  • Non-Small Cell Lung Cancer (NSCLC): It may be used as part of specific chemotherapy regimens for selected patients with advanced non-small cell lung cancer.

Key Benefits

Tegonat 20 Capsule helps treat certain types of cancer by slowing or stopping the growth of cancer cells. Its combination of active ingredients improves the effectiveness of treatment while helping reduce certain treatment-related side effects.

Benefits may include:

  • Helps slow or stop the growth of cancer cells, supporting tumor control.
  • May help shrink tumors and relieve symptoms caused by cancer.
  • Provides the convenience of oral chemotherapy, allowing treatment at home under medical supervision.
  • Contains ingredients that help improve the effectiveness of the anticancer medicine.
  • Includes a protective component that helps reduce certain gastrointestinal side effects compared with some older fluoropyrimidine treatments.
  • Supports improved quality of life as part of a comprehensive cancer treatment plan when used as prescribed.

Directions for Use

  • Tegonat 20 Capsule can be taken 1 hour before or after a meal.
  • It is usually taken 2 times a day, in the morning and evening, for the duration prescribed by your doctor.
  • Swallow Tegonat 20 Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Tegonat 20 Capsule Works

Tegonat 20 Capsule contains Tegafur, Gimeracil, and Oteracil. Tegafur: It is an anticancer medicine that is gradually converted in the body into 5-fluorouracil (5-FU), a chemotherapy drug. It works by interfering with the DNA and RNA of cancer cells, preventing them from growing, multiplying, and spreading. Gimeracil: It helps block the enzyme that normally breaks down 5-FU. This keeps the active chemotherapy medicine in the body for longer, allowing it to work more effectively at lower doses. Oteracil: It acts mainly in the stomach and intestines, where it helps reduce the effects of 5-FU on healthy digestive tissues. This helps lower the risk of gastrointestinal side effects such as nausea, abdominal pain, and diarrhea.
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Alcohol

Consult your doctor

It is not known if alcohol affects Tegonat 20 Capsule. Please consult your doctor. 

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Pregnancy

Unsafe

Tegonat 20 Capsule is not recommended during pregnancy as it may cause foetal harm. Consult the doctor immediately if you become pregnant during treatment with Tegonat 20 Capsule.

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Breast Feeding

Unsafe

It is not known if this medicine passes into breast milk. Therefore, breastfeeding is not recommended during treatment with Tegonat 20 Capsule.

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Driving

Caution

Tegonat 20 Capsule may cause fatigue, dizziness and blurred vision. Drive or operate heavy machinery only if you are alert.

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Liver

Consult your doctor

Consult the doctor if you have a history of liver problems.

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Kidney

Caution

Tegonat 20 Capsule is not recommended in patients with end-stage renal disease requiring dialysis. Consult the doctor if you have kidney problems.

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Children

Unsafe

Tegonat 20 Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Tegonat 20 Capsule should be avoided in individuals with heart problems unless strictly advised by a doctor. Tegonat 20 Capsule has been linked to rare but serious cardiac side effects like myocardial dysfunction and heart failure.

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Geriatrics

Caution

Tegonat 20 Capsule can be used in geriatric patients, but with caution due to increased sensitivity to side effects like bone marrow suppression, kidney strain, and gastrointestinal issues. Close medical supervision and regular monitoring are essential to ensure safe and effective treatment.

What if I have taken an overdose of Tegonat 20 Capsule

If you accidentally take more than your prescribed dose, seek emergency medical care immediately or contact your local poison control center. An overdose can cause severe stomach damage and drop your blood counts to dangerous levels.

Diet & Lifestyle Advise

  • Stay Hydrated: Drink at least 8 to 10 glasses of water or clear fluids daily to prevent dehydration, especially if you experience loose stools or mild nausea.
  • Eat Small, Bland Meals: To manage changes in appetite and nausea, eat five or six small meals throughout the day instead of three large ones. Stick to bland foods like toast, rice, oatmeal, and crackers.
  • Practice Strict Hygiene: Wash your hands frequently with soap and water, avoid close contact with anyone who is sick, and avoid crowded public areas, as Tegonat 20 Capsule lowers your body's ability to fight infections.
  • Use Sun Protection: Wear high-SPF sunscreen, a wide-brimmed hat, and protective clothing when outdoors, as Tegonat 20 Capsule can make your skin highly sensitive to sunlight.
health query

Have a query?

How Soon It Starts Working

The time required for Tegonat 20 Capsule to start to work: The time required for Tegonat 20 Capsule to show its action is unknown. The time for which the effects of Tegonat 20 Capsule last: The duration of action for Tegonat 20 Capsule is unknown.

What if you forget to take Tegonat 20 Capsule

If you miss a dose, do not take the missed dose. Skip it entirely and take your next dose at your regular scheduled time. Do not take a double dose to make up for a forgotten capsule. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Tegonat 20 Capsule capsules at room temperature, below 25°C.

Drug Warnings

  • Caregiver Safety: Caregivers should wear disposable gloves when handling the capsules to avoid direct contact with the chemotherapy drug.
  • Inspect Your medicine: Check your blister pack before taking your dose; never take a Tegonat 20 Capsule that is cracked, broken, or leaking powder.
  • Track Your Temperature: Use a thermometer to check your temperature daily. Call your cancer clinic immediately if you develop a fever of 38°C (100.4°F) or higher.
  • Avoid Live Vaccines: Do not receive any live vaccines (such as the nasal spray flu vaccine, shingles vaccine, or yellow fever vaccine) while on this treatment, as your immune system may be too weak to handle them safely.
  • Mouth Care: Rinse your mouth with water or a mild baking soda solution after meals to prevent painful mouth sores, and report any red patches or ulcers to your doctor.

Drug-Drug Interactions

verifiedApollotooltip
  • Antiviral medicines (e.g., sorivudine, brivudine): Do not take these medicines with Tegonat 20 Capsule or within 4 weeks of stopping them, as they can cause a dangerous and potentially fatal increase in chemotherapy levels.
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Tegonat 20 Capsule may increase the risk of serious bleeding. Your doctor may monitor your blood clotting tests more closely.
  • Anti-seizure medicines (e.g., phenytoin): Tegonat 20 Capsule may increase phenytoin levels in the body and raise the risk of toxicity. Your doctor may monitor phenytoin levels during treatment.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Food: Take Tegonat 20 Capsule within 1 hour after a meal. Taking it on an empty stomach may alter its absorption and increase the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Tegonat 20 Capsule is used to treat gastric/stomach cancer.
Tegonat 20 Capsule works by preventing the growth of cancer cells. Thereby, it helps treat stomach cancer.
Tegonat 20 Capsule may have anti-fertility effects, which may be irreversible. Talk to the doctor regarding fertility preservation prior to the start of the treatment or if you have any concerns.
Diarrhoea could be a side effect of Tegonat 20 Capsule. Consult the doctor if you experience diarrhoea. The doctor may monitor you carefully and give fluid/electrolyte replacement if you are dehydrated.
No, you must swallow Tegonat 20 Capsule capsules completely whole. Opening or crushing them is dangerous because the powder inside is a chemotherapy drug that can harm anyone who touches or inhales it. If you have difficulty swallowing capsules, talk to your doctor.
Do not take an additional capsule to replace the vomited dose. Wait until your next scheduled dose and take it at the regular time. Contact your doctor immediately to let them know, as they may need to provide anti-nausea support.
Taking Tegonat 20 Capsule within 1 hour after a meal ensures that the active ingredients are absorbed correctly and helps protect your stomach lining, reducing the risk of severe nausea and diarrhea. Consult your doctor if you struggle to eat before your dose.
It is best to avoid invasive dental work during treatment because Tegonat 20 Capsule lowers your white blood cells and platelets, increasing your risk of infections and bleeding.
It is highly recommended to avoid alcohol while taking Tegonat 20 Capsule. Alcohol can worsen stomach irritation, increase the risk of dehydration from diarrhea, and put extra stress on your liver.
Tegonat 20 Capsule can cause fatigue, dizziness, or mild vision changes in some patients. Do not drive or operate heavy machinery until you know how Tegonat 20 Capsule affects you. Consult your doctor if you experience these symptoms.
No, Tegonat 20 Capsule can cause severe harm to an unborn baby. Both men and women must use highly effective birth control during treatment and for a specified time after the last dose. If you suspect a pregnancy, inform your doctor immediately.
Your medical team will perform regular scans, blood tests, and physical examinations to monitor the tumor's size and check your body's response. Do not change your treatment plan based on how you feel; always talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - TEG0116
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