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  3. Septran Oral Suspension 60 ml

Prescription drug
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Septran Oral Suspension 60 ml, Pack of 1
Septran Oral Suspension 60 ml, Pack of 1
Septran Oral Suspension 60 ml, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Septran Oral Suspension is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). It contains Trimethoprim and Sulfamethoxazole, which stop the growth of bacteria and kill them. Therefore, it helps treat bacterial infections. In some cases, you may experience specific common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SULFAMETHOXAZOLE-200MG + TRIMETHOPRIM-40MG

Manufacturer/Marketer :

Koye Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Septran Oral Suspension

Septran Oral Suspension is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. Septran Oral Suspension does not work against infections caused by the virus, including cold and flu. 

Septran Oral Suspension combines two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for forming proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Septran Oral Suspension stops the growth of bacteria and kills them. Therefore, it helps treat bacterial infections.

Your doctor will decide the dose and duration of Septran Oral Suspension based on your condition and the severity of the infection. In some cases, you may experience specific common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Septran Oral Suspension, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Septran Oral Suspension on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Septran Oral Suspension if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Septran Oral Suspension is not recommended for children below 12 years.

Uses of Septran Oral Suspension

Septran Oral Suspension is used to treat bacterial infections. The detailed uses of Septran Oral Suspension are as follows:

  • Urinary Tract Infections (UTIs): Septran Oral Suspension is often utilised to treat urinary tract infections caused by susceptible bacteria. It prevents bacterial growth and allows the immune system to eliminate the disease.
  • Respiratory Tract Infection: Septran Oral Suspension can be used to treat specific respiratory infections, including bronchitis and pneumonia, and prevent breathing difficulties caused by bacterial infection.
  • Gastrointestinal infections: Septran Oral Suspension is often helpful against gastrointestinal infections, especially those caused by Shigella or Salmonella strains. It reduces symptoms like diarrhoea and abdominal pain.
  • Skin and Soft Tissue Infections: Septran Oral Suspension effectively treats bacterial skin infections such as infected cuts, burns, or surgical wounds.
  • Pneumocystis Pneumonia (PCP): Septran Oral Suspension prevents a potentially life-threatening condition in those with weakened immune systems.

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Directions for Use

  • Septran Oral Suspension can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Septran Oral Suspension as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Septran Oral Suspension belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Septran Oral Suspension is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Septran Oral Suspension kills the bacteria and stops their growth. Therefore, it helps treat bacterial infections. Septran Oral Suspension is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

How Septran Oral Suspension Works

Septran Oral Suspension is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Septran Oral Suspension stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Septran Oral Suspension 60 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

What if I have taken an overdose of Septran Oral Suspension

Do not take more than the prescribed dose of Septran Oral Suspension as it may cause overdose. The symptoms of overdose include headache, dizziness, nausea, vomiting, confusion, loss of appetite, drowsiness, or mental depression. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Septran Oral Suspension if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Septran Oral Suspension if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Septran Oral Suspension to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

verifiedApollotooltip
TrimipramineTranylcypromine
Critical
TrimipramineZiprasidone
Critical

Drug-Drug Interactions

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TrimipramineTranylcypromine
Critical
How does the drug interact with Septran Oral Suspension 60 ml:
Taking Tranylcypromine with Septran Oral Suspension 60 ml can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Septran Oral Suspension 60 ml is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
TrimipramineZiprasidone
Critical
How does the drug interact with Septran Oral Suspension 60 ml:
Co-administration of Septran Oral Suspension 60 ml with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Septran Oral Suspension 60 ml with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrimipramineSafinamide
Critical
How does the drug interact with Septran Oral Suspension 60 ml:
Taking Safinamide with Septran Oral Suspension 60 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Septran Oral Suspension 60 ml is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
sulfamethoxazoleClozapine
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
The combined use of Septran Oral Suspension 60 ml and clozapine may increase the risk or severity of toxicity.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Septran Oral Suspension 60 ml, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
TrimipramineParoxetine
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
Taking Paroxetine with Septran Oral Suspension 60 ml can cause sedation, dry mouth, blurred vision, constipation.

How to manage the interaction:
Although there is a possible interaction between Paroxetine and Septran Oral Suspension 60 ml, you can take these medicines together if prescribed by your doctor. However, if you experience dry mouth, blurred vision, constipation contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimipramineVilazodone
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
When Vilazodone is taken with Septran Oral Suspension 60 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Septran Oral Suspension 60 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
TrimipramineVenlafaxine
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
Using Venlafaxine together with Septran Oral Suspension 60 ml can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Taking Venlafaxine with Septran Oral Suspension 60 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, seek immediate medical attention. Do not discontinue any medications without first consulting a doctor.
TrimipramineEphedrine
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
Co-administration of Ephedrine and Septran Oral Suspension 60 ml together may increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Ephedrine and Septran Oral Suspension 60 ml, but it can be taken if prescribed by a doctor. It's important to maintain your blood pressure. Do not stop using any medications without talking to a doctor.
TrimipramineFlumazenil
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
Combining flumazenil together with Septran Oral Suspension 60 ml can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although taking Flumazenil and Septran Oral Suspension 60 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience irregular heartbeat, chest tightness, blurred vision, nausea and seizures contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrimipramineHaloperidol
Severe
How does the drug interact with Septran Oral Suspension 60 ml:
Using haloperidol together with Septran Oral Suspension 60 ml can affect the rhythm of your heart.

How to manage the interaction:
Co-administration of Septran Oral Suspension 60 ml and Haloperidol can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like tiredness, dizziness, fainting, confusion, tremor, difficulty breathing, an irregular heartbeat, dry mouth, visual disturbances, urinary retention, dizziness, constipation, and seizures, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Avoid alcohol consumption while taking Septran Oral Suspension to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

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Pregnancy

Caution

Please consult your doctor before taking Septran Oral Suspension if you are pregnant. Your doctor will prescribe Septran Oral Suspension only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding, your doctor will prescribe Septran Oral Suspension only if the benefits outweigh the risks.

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Driving

Caution

It is unknown whether Septran Oral Suspension affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed.

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Liver

Caution

Please consult your doctor before taking Septran Oral Suspension if you have liver impairment/liver disease. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

Septran Oral Suspension to be taken with caution, especially if you have a history of kidney impairment/kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Septran Oral Suspension is not recommended for children below 12 years.

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Heart

Caution

Septran Oral Suspension should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Septran Oral Suspension.

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Geriatrics

Unsafe

Septran Oral Suspension should be avoided in geriatric patients, as it can cause adverse effects like dizziness or drowsiness.

FAQs

Septran Oral Suspension is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).

Septran Oral Suspension is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Septran Oral Suspension kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.

Septran Oral Suspension causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Septran Oral Suspension. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Septran Oral Suspension and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of Septran Oral Suspension even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking Septran Oral Suspension for as long as your doctor has prescribed to treat your condition effectually.

Country of origin

India

Manufacturer/Marketer address

24-25 Floor, One Horizon Center Golf Course Road, DLF Phase 5 Gurgaon 122002, India.
Other Info - SEP0013

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 21, 2025 | 11:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6997.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018374s025lbl.pdf
  3. https://www.drugs.com/mtm/sulfamethoxazole-and-trimethoprim.html
  4. https://medlineplus.gov/druginfo/meds/a684026.html#:~:text=Co%2Dtrimoxazole%20is%20a%20combination,flu%2C%20or%20other%20viral%20infections

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