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compositionComposition:SELEXIPAG-400MCG
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Prescription Medicine
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Selepeg 400 Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs), slow down the worsening of symptoms, and reduce the chance of hospitalisation. It contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries, lowering the pressure in them.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SELEXIPAG-400MCG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Selepeg 400 Tablet

Selepeg 400 Tablet is a prescription medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the blood vessels that carry blood from the heart to your lungs. By targeting this condition, the medicine helps to slow down the progression of this serious heart and lung disease and reduces the risk of needing hospital treatment. It is designed to help you maintain your physical abilities and improve long-term outcomes.

You will typically take this medicine twice daily, and it is highly important to take it consistently at the exact same times every day to keep a steady amount of the medicine in your bloodstream. You can take this medication with or without food; however, taking your doses with meals can make some common stomach-related side effects much easier to tolerate. Combining this medical treatment with doctor-approved lifestyle adjustments, such as adopting a low-sodium diet and engaging in light physical activity, can significantly support your treatment results.

While taking Selepeg 400 Tablet , you may experience common, manageable side effects such as headaches, jaw pain, flushing, or nausea as your body adjusts to the therapy. However, you must contact your doctor immediately if you experience severe symptoms, such as sudden and severe worsening of shortness of breath, rapid swelling of your feet or legs, or signs of an allergic reaction. Monitoring how you feel and maintaining open communication with your healthcare team is key to a safe treatment experience.

Before starting Selepeg 400 Tablet , it is essential to discuss your medical history with your doctor, especially if you have a history of liver disease, kidney issues, or thyroid problems. Do not take this medicine if you have severe liver damage, as your body will not be able to process the medication safely. Your doctor will weigh the risks and benefits to ensure this medicine is appropriate for your specific health profile.

This medicine can interact with other substances, which may alter how it works or increase your risk of severe side effects. For example, taking certain medicines used to treat high cholesterol or other blood conditions can cause Selepeg 400 Tablet to build up to dangerous levels in your body. It is also important to talk to your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly patient who may require extra monitoring during treatment.

Uses of Selepeg 400 Tablet

Selepeg 400 Tablet is used to treat pulmonary arterial hypertension (PAH). The detailed uses of Selepeg 400 Tablet are as follows:

  • Pulmonary Arterial Hypertension (PAH): Selepeg 400 Tablet is prescribed to treat high blood pressure in the vessels of the lungs. It works to relax these blood vessels, which improves blood flow, delays the worsening of your condition, and lowers your risk of being hospitalised due to PAH.

Key Benefits

Selepeg 400 Tablet helps manage pulmonary arterial hypertension by relaxing the blood vessels in the lungs and improving blood flow. With regular use as prescribed, it helps reduce symptoms, improve exercise capacity, and slow the progression of the disease.

  • Improves Breathing and Physical Activity: By lowering the pressure in the blood vessels of the lungs, this medicine reduces the workload on the heart, helping relieve shortness of breath and allowing you to perform daily activities more comfortably.
  • Slows Disease Progression: Regular treatment helps delay the progression of pulmonary arterial hypertension, preserving physical function and supporting better long-term heart and lung health.
  • Reduces the Risk of Hospitalisation: By helping keep the condition stable and improving overall cardiovascular function, this medicine lowers the risk of complications that may require emergency hospital admission and supports a better quality of life.
Side effects of Selepeg 400 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Consult your doctor to discuss which medicine could be contributing to your jaw pain and whether you need to change the dose or switch to a different medicine.
  • Try taking pain relievers like paracetamol, ibuprofen or naproxen.
  • Apply cold or warm compresses to your jaw for pain relief.
  • Do gentle jaw stretching exercises to enhance muscle flexibility and reduce pain.
  • Eat soft foods that need little jaw movement to reduce strain.
  • Avoid habits like nail biting, clenching your jaw, and gum chewing.
  • Maintain good posture of your jaw to reduce strain.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
  • Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
  • Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
  • Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
  • Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
  • Rest and take a break from usual activities.
  • Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
  • Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
  • Avoid strenuous activities and rest the affected area.
  • Try light stretching with gentle exercises to maintain flexibility.
  • Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.

Directions for Use

  • Take Selepeg 400 Tablet with food to reduce stomach upset.
  • Recommended to take twice a day or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Selepeg 400 Tablet Works

Selepeg 400 Tablet contains selexipag, which helps to understand how the body naturally controls blood pressure in the lungs. In a healthy body, a natural substance called prostacyclin binds to specific receptors on the walls of blood vessels. This action signals the blood vessels to relax, widen, and allow blood to flow smoothly. People with pulmonary arterial hypertension often do not produce enough natural prostacyclin, causing their lung blood vessels to become narrow, stiff, and tight. Selepeg 400 Tablet works by mimicking the helpful actions of your body's natural prostacyclin. Once taken, it acts directly on the prostacyclin receptors in your blood vessels, signalling the tight muscles in the vessel walls to relax and widen. This opening of the vessels immediately lowers the high blood pressure in your lungs, reducing the workload on your heart and making it easier for blood to circulate and pick up oxygen.
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Alcohol

Consult your doctor

It is not known whether Selepeg 400 Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Selepeg 400 Tablet is not recommended during pregnancy. Consult the doctor if you become pregnant during treatment with Selepeg 400 Tablet .

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Breast Feeding

Unsafe

It is not known if Selexipag passes into breast milk. Selepeg 400 Tablet is not recommended during lactation.

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Driving

Caution

Selepeg 400 Tablet may cause headaches and low blood pressure, affecting your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Selepeg 400 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in people with moderate hepatic impairment. Consult the doctor if you have liver problems.

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Kidney

Caution

Please consult the doctor if you have any concerns regarding the usage of Selepeg 400 Tablet in patients with kidney impairment.

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Children

Unsafe

Selepeg 400 Tablet is not recommended for use in children below 18 years as the safety and effectiveness have not been established.

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Heart

Safe if prescribed

Selepeg 400 Tablet is often used in heart-related conditions like PAH and may benefit certain cardiac patients. However, it must be taken under medical supervision to manage potential side effects and drug interactions.

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Geriatrics

Caution

Selepeg 400 Tablet may be used in geriatric patients, but with caution due to increased sensitivity to its effects. While studies haven’t shown major age-related issues, doctors monitor elderly patients closely and may adjust the dose to ensure safe and effective treatment.

What if I have taken an overdose of Selepeg 400 Tablet

If you accidentally take more than your prescribed dose of Selepeg 400 Tablet , seek emergency medical assistance immediately. An overdose can cause a dangerous drop in blood pressure, leading to severe dizziness, lightheadedness, or a rapid heart rate. Keep the medication packaging with you so the medical staff knows exactly what you have taken.

Diet & Lifestyle Advise

  • Reduce your salt intake: Consuming too much sodium causes your body to hold onto extra water, which puts additional strain on your heart and lungs. Avoid processed foods and do not add salt to your meals.
  • Monitor your fluids: Ask your doctor if you need to limit your daily fluid intake. Restricting liquids can help prevent fluid accumulation in your lungs and limbs.
  • Weigh yourself daily: Stand on the scale at the same time every morning. A sudden weight gain of 2 to 3 pounds in a single day, or 5 pounds in a week, can indicate dangerous fluid buildup and should be reported to your doctor immediately.
  • Engage in safe, light exercise: Gentle physical activities like walking can improve your cardiovascular health. Always consult your doctor to determine what level of exercise is safe for you, and avoid heavy lifting or high-intensity workouts.
  • Avoid smoking and secondhand smoke: Nicotine constricts blood vessels and decreases the amount of oxygen in your blood, which directly worsens pulmonary arterial hypertension.

Health Queries

Can selexipag (Skepxipag) be used with Pulmokit, which contains ambrisentan 5 mg and tadalafil 20 mg?

Bayyarapu Mahesh Kumar

Bayyarapu Mahesh Kumar

M Pharmacy

Selexipag may be used along with Pulmokit, which contains Ambrisentan and Tadalafil, in some patients with pulmonary arterial hypertension as part of combination or triple therapy, but this is strictly not for self use and must only be decided by a specialist because the treatment is highly individualised based on factors like disease severity, blood pressure, heart function, oxygen levels, response to current therapy, and side effect risk; using these medicines together can increase the chance of side effects such as low blood pressure, dizziness, headache, flushing, and fluid retention, so careful monitoring and dose adjustment under a cardiologist or pulmonologist is essential.
health query

Have a query?

How Soon It Starts Working

The time required for Selepeg 400 Tablet to start to work: The time required for Selepeg 400 Tablet to show its action is unknown. The time for which the effects of Selepeg 400 Tablet last: The duration of action for Selepeg 400 Tablet is unknown.

What if you forget to take Selepeg 400 Tablet

If you miss a dose of Selepeg 400 Tablet and remember it within 6 hours of your scheduled time, take the missed dose immediately. If your next scheduled dose is less than 6 hours away, skip the missed dose entirely and resume your regular dosing schedule. Do not take two doses at once to make up for a missed tablet. If you miss your medication for three or more days in a row, do not restart it on your own; call your doctor for specific instructions on how to safely resume taking it.

Storage

•Store Selepeg 400 Tablet at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not stop taking Selepeg 400 Tablet abruptly: Stopping this medicine suddenly can cause your pulmonary arterial hypertension to worsen very quickly, which can be life-threatening. Always consult your doctor before making any changes.
  • Expect a gradual dose adjustment: Your dose will be increased slowly over several weeks. If you experience bothersome side effects like jaw pain or headaches during this period, contact your doctor for advice rather than stopping the medication.
  • Watch for signs of low blood pressure: Because this medicine widens blood vessels, it can cause dizziness or lightheadedness, especially when you stand up. Rise slowly from sitting or lying positions to prevent falls.
  • Keep a complete medicine list: Always share a full list of your prescription drugs, over-the-counter medicines, vitamins, and herbal supplements with your doctor and pharmacist to check for potential drug interactions.
  • Regularly inspect your limbs: Visually check your feet, ankles, and calves daily for any signs of new or worsening swelling, as fluid retention is a common issue that requires medical evaluation.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP2C8 Inhibitors (such as gemfibrozil): Taking these medicines alongside Selepeg 400 Tablet can significantly slow down how your body clears this medication. This can cause the drug to build up to unsafe levels in your blood, greatly increasing the risk and severity of side effects.
  • CYP2C8 Inducers (such as rifampin): These medications can speed up how quickly your body breaks down Selepeg 400 Tablet , which can make your treatment much less effective at managing your lung blood pressure.
SelexipagClopidogrel
Critical
SelexipagGemfibrozil
Critical

Drug-Drug Interactions

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SelexipagClopidogrel
Critical
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet and Clopidogrel are taken together, the body's ability to break down Selepeg 400 Tablet may be reduced.

How to manage the interaction:
Taking Clopidogrel with Selepeg 400 Tablet is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
SelexipagGemfibrozil
Critical
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet is taken with Gemfibrozil, the amount of Selepeg 400 Tablet in the blood can go up. This can increase the risk or severity of side effects like anemia, muscle and joint pain, or electrolyte imbalance.

How to manage the interaction:
Taking Selepeg 400 Tablet with Gemfibrozil can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle and joint pain, diarrhea, sudden dizziness, lightheadedness, fainting, shortness of breath, nausea, vomiting, flushing, and decreased appetite, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SelexipagEfavirenz
Severe
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet is taken with Efavirenz, the levels and efficacy of Selepeg 400 Tablet increases. This results in an increased risk of side effects.

How to manage the interaction:
Taking Selepeg 400 Tablet with Efavirenz together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
SelexipagCarbamazepine
Severe
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet is taken with Carbamazepine, it can decrease the levels of Selepeg 400 Tablet which may lead to reduced action.

How to manage the interaction:
Co-administration of Selepeg 400 Tablet with Carbamazepine can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
SelexipagDeferasirox
Severe
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet and Deferasirox are taken together Deferasirox may significantly increase the blood levels of Selepeg 400 Tablet.

How to manage the interaction:
Although taking Selepeg 400 Tablet and Deferasirox together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience any sife effects like anemia (paleness), reduced hunger, diarrhea, nausea, and vomiting, consult a doctor. Do not stop using any medications without a doctor's advice.
SelexipagCelecoxib
Severe
How does the drug interact with Selepeg 400 Tablet:
When Selepeg 400 Tablet is taken with Celecoxib, therapeutic efficacy of Selepeg 400 Tablet can be decreased.

How to manage the interaction:
Taking Selepeg 400 Tablet with Celecoxib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience any unusual symptoms. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking this medicine. Alcohol dilates blood vessels and can interact with Selepeg 400 Tablet to cause a sudden drop in blood pressure, leading to severe dizziness, flushing, or fainting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Selepeg 400 Tablet is used to treat Pulmonary arterial hypertension (PAH).
Selepeg 400 Tablet relaxes the blood vessels in the lungs and allows the blood to flow easily. Thereby, it relieves the symptoms of pulmonary arterial hypertension and slows down its progression.
Selepeg 400 Tablet should not be stopped on your own, even if you feel well. It helps control the symptoms of pulmonary arterial hypertension (PAH) and slows its progression, but it does not cure the condition. Continue taking Selepeg 400 Tablet for as long as prescribed by your doctor. If you wish to stop treatment or have concerns about long-term use, consult your doctor for guidance.
Selepeg 400 Tablet should be used with caution in patients older than 75 years as there is limited experience in this age group. Consult the doctor if you have any concerns.
Let the doctor know if you are taking gemfibrozil, a medicine used to lower fat levels in the blood. If you are taking gemfibrozil, your doctor may tell you not to take Selepeg 400 Tablet .
No, you must always swallow Selepeg 400 Tablet tablets whole with a glass of water. Crushing, chewing, or splitting the tablets can alter how the medicine is absorbed into your bloodstream and may increase your risk of experiencing side effects. If you have difficulty swallowing pills, talk to your doctor or pharmacist for guidance.
Jaw pain and headaches are common side effects as your body adjusts to the blood vessels widening. Taking your dose with food can often help reduce these symptoms. If the discomfort is severe or does not go away, talk to your doctor or pharmacist about safe over-the-counter pain relievers you can use.
It is highly recommended to avoid or limit alcohol while taking Selepeg 400 Tablet . Alcohol can relax your blood vessels further, which may cause your blood pressure to drop too low and worsen side effects like dizziness, lightheadedness, and flushing. Talk to your doctor for personalised advice.
There is limited clinical information on the safety of Selepeg 400 Tablet during pregnancy and breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss the potential risks and benefits in detail with your doctor before taking this medicine. Talk to your doctor to explore the safest options for you and your baby.
If you miss taking Selepeg 400 Tablet for three or more consecutive days, do not simply resume taking your usual dose. Stopping the medication for this long can cause your condition to worsen. You must contact your doctor or pharmacist immediately to receive safe, step-by-step instructions on how to restart your medication.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.2163 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 207947S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A616031 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Selexipag [Prescribing Information]. 2017. [Accessed on 25th Nov. 2022]Check here
  5. CiplaMed CiplaMed. [Accessed on 25 Jul. 2024]Check here
  6. Uptravi Ppi. [Accessed on 02 Jun. 2026]Check here
  7. Onur yazici, hasan gungor. Selexipag: a new treatment agent for pulmonary hypertension. Meandros medical & dental journal 2029-2020. [Accessed on 12th August 2022] 27391/MMDJ-20-1-En.pdfCheck here

Country of origin

India

Manufacturer/Marketer address

Msn Laboratories Pvt.Ltd., Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - SEL0135
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