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compositionComposition:CYCLOSPORINE-50MG
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Prescription Medicine
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Sandimmun 50 mg Injection 1 ml is used to prevent rejection of transplanted organs. It contains cyclosporine, which works by suppressing the body’s immune system. This medicine may cause side effects like nausea, vomiting, headache, and abdominal pain. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml is a prescription immunosuppressant medicine available as an injectable formulation. It is usually given in hospitals or specialised healthcare settings when a person cannot temporarily take cyclosporine by mouth, such as around the time of an organ transplant or after surgery. It helps prevent organ rejection in people who have received a kidney, liver, or heart transplant by reducing the activity of the immune system. It may also be used in selected patients with severe rheumatoid arthritis when other disease-modifying antirheumatic drugs (DMARDs), such as methotrexate, have not worked well enough or are not suitable, and in severe plaque psoriasis when other treatments are ineffective or unsuitable. This medicine should only be started and managed by specialists experienced in treating these conditions.

This medicine is given by injection or intravenous infusion according to the schedule determined by your healthcare team. Keeping a consistent treatment schedule is important because changes in cyclosporine levels may increase the risk of organ rejection or side effects. The injectable form is generally used only until you are able to switch safely to oral cyclosporine. Eat a balanced diet, practise good food hygiene, and avoid raw or undercooked foods that may increase your risk of infection while your immune system is suppressed.

While receiving Sandimmun 50 mg Injection 1 ml, you may experience mild side effects such as tremors (shaky hands), high blood pressure, nausea, or headache. These effects are often manageable, but you should consult your doctor if they persist or become troublesome. Seek medical attention immediately if you develop signs of kidney problems, severe infections, seizures, confusion, or signs of an allergic reaction.

Do not receive this medicine if you are allergic to cyclosporine or any ingredient in the formulation. Before starting treatment, tell your doctor if you have kidney disease, liver disease, uncontrolled high blood pressure, a history of cancer, or any active infection. Long-term treatment with immunosuppressants such as cyclosporine may increase the risk of certain cancers, particularly skin cancer and lymphoma, so regular medical follow-up is essential.

Cyclosporine can interact with many medicines, including certain antibiotics, antifungal medicines, blood pressure medicines, cholesterol-lowering medicines, and herbal products. If you are pregnant, planning a pregnancy, breastfeeding, or an older adult, discuss your treatment with your specialist before receiving this medicine. Do not switch between different cyclosporine formulations unless your specialist specifically instructs you to do so, as different formulations are not always directly interchangeable.

Uses of Sandimmun 50 mg Injection 1 ml

Your doctor may prescribe Sandimmun 50 mg Injection 1 ml for the following conditions:

  • Prevention of organ transplant rejection: Helps prevent your immune system from attacking a transplanted kidney, liver, or heart.
  • Severe rheumatoid arthritis: Helps reduce joint pain, swelling, and stiffness in people whose disease has not responded adequately to other disease-modifying antirheumatic drugs (DMARDs) or when those treatments are not suitable.
  • Severe plaque psoriasis: Helps control severe skin inflammation and plaque formation in people whose psoriasis has not responded adequately to other treatments or when other treatments are unsuitable.Continuous treatment for psoriasis is generally limited, and your specialist will decide the most appropriate treatment duration.

Key Benefits

Sandimmun 50 mg Injection 1 ml helps control an overactive immune system in conditions where it would otherwise damage transplanted organs or healthy body tissues.

  • Helps protect transplanted organs: Reduces the risk of organ rejection and supports long-term transplant success.
  • Controls autoimmune inflammation: Helps reduce joint pain, swelling, and stiffness in rheumatoid arthritis.
    Improves severe psoriasis: Helps reduce redness, scaling, itching, and thickened skin plaques.
  • Provides reliable treatment when oral medicines cannot be used: The injectable form ensures treatment can continue when patients are temporarily unable to take medicines by mouth.
Side effects of Sandimmun 50 mg Injection 1 ml
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Sandimmun 50 mg Injection 1 ml will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Sandimmun 50 mg Injection 1 ml Works

Sandimmun 50 mg Injection 1 ml contains cyclosporine, an immunosuppressant medicine that reduces the activity of your immune system. Cyclosporine works by blocking a protein called calcineurin inside certain white blood cells known as T-lymphocytes. This prevents these immune cells from becoming overactive and producing substances that trigger inflammation and immune attacks. After an organ transplant, this action helps prevent your immune system from attacking the transplanted organ. In autoimmune diseases such as rheumatoid arthritis and psoriasis, it helps reduce inflammation by preventing the immune system from mistakenly attacking your own healthy tissues.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sandimmun 50 mg Injection 1 ml. It could lead to an increase in adverse events.

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Pregnancy

Caution

In general, Sandimmun 50 mg Injection 1 ml should not be taken during pregnancy. If it is necessary for you to use this medicine, your doctor will discuss with you the benefits and potential risks of taking it during pregnancy.

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Breast Feeding

Unsafe

Breastfeeding is not recommended while taking Sandimmun 50 mg Injection 1 ml.

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Driving

Caution

Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert.

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Liver

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of liver disease. Your doctor will prescribe it only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of kidney disease. Your doctor will prescribe it only if the benefits outweigh the risks.

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Children

Unsafe

Sandimmun 50 mg Injection 1 ml is not recommended for children as efficacy and safety have not been established.

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Heart

Caution

Sandimmun 50 mg Injection 1 ml should be used with caution in patients with heart problems. Therefore, please inform your doctor if your have any heart problems before prescribing Sandimmun 50 mg Injection 1 ml.

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Geriatrics

Caution

Sandimmun 50 mg Injection 1 ml should be used under medical supervision in geriatric patients due to increased risk of side effects. Therefore, please consult your doctor before using Sandimmun 50 mg Injection 1 ml.

What if I have taken an overdose of Sandimmun 50 mg Injection 1 ml

Because this medicine is usually administered by healthcare professionals, an overdose is uncommon. If an overdose is suspected, seek immediate medical attention or go to the nearest emergency department. Symptoms may include severe kidney problems, severe high blood pressure, tremors, drowsiness, confusion, or signs of liver damage.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: They can greatly increase cyclosporine levels in your blood and raise the risk of serious side effects.
  • Maintain good oral hygiene: Brush and floss regularly and attend routine dental check-ups because cyclosporine may cause swollen gums.
  • Discuss potassium intake with your doctor or dietitian: Cyclosporine can increase potassium levels in some people. Do not restrict or increase foods rich in potassium unless your healthcare team specifically advises you to do so.
  • Protect yourself from the sun: Use a broad-spectrum sunscreen, wear protective clothing, and avoid excessive sun exposure because long-term treatment may increase the risk of skin cancer.
  • Reduce your risk of infection: Wash your hands regularly, avoid close contact with people who have contagious illnesses, and follow safe food-handling practices.
  • Check with your doctor before receiving any vaccines: Some vaccines, particularly live vaccines, may not be suitable while you are receiving cyclosporine.
health query

Have a query?

How Soon It Starts Working

The time required for Sandimmun 50 mg Injection 1 ml to start to work: The time required for Sandimmun 50 mg Injection 1 ml to show its action is unknown. The time for which the effects of Sandimmun 50 mg Injection 1 ml last: The duration of action for Sandimmun 50 mg Injection 1 ml is unknown.

What if you forget to take Sandimmun 50 mg Injection 1 ml

Because this medicine is usually given in a hospital or clinic, missed doses are uncommon. If you miss a scheduled dose or appointment, contact your healthcare provider immediately for instructions. Do not receive an extra dose unless your doctor tells you to do so.

Storage

• Store Sandimmun 50 mg Injection 1 ml at room temperature between 15°C and 30°C, or according to the product label.

Drug Warnings

  • Receive this medicine only under specialist supervision: Do not change your dose or treatment schedule unless instructed by your transplant specialist, rheumatologist, or dermatologist.
  • Do not switch between cyclosporine formulations: Injectable cyclosporine, Sandimmune, Neoral, and other formulations are not always directly interchangeable. Only switch formulations if your specialist specifically instructs you to do so.
  • Attend all blood test appointments: Regular monitoring of cyclosporine blood levels, kidney function, liver function, and blood pressure helps ensure your treatment remains both safe and effective.
  • Protect your skin from sunlight: Long-term treatment may increase the risk of skin cancer. Wear protective clothing, use sunscreen daily, and report any new or changing skin lesions to your doctor.
  • Report signs of infection promptly: Contact your doctor immediately if you develop fever, chills, persistent sore throat, or other signs of infection.
  • People with rheumatoid arthritis or psoriasis may use this medicine for a limited period: Your specialist will regularly review whether treatment should be continued, adjusted, or changed to another medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Macrolide antibiotics (i.e. erythromycin, clarithromycin) and azole antifungals (i.e. ketoconazole, itraconazole): May increase cyclosporine levels in the blood, increasing the risk of kidney damage and other side effects.
  • Rifamycin antibiotics (i.e. rifampicin): May reduce cyclosporine levels, increasing the risk of organ rejection or reduced treatment effectiveness.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. ibuprofen, diclofenac, naproxen): May increase the risk of kidney damage.
  • Statins (i.e. simvastatin, atorvastatin, rosuvastatin): May increase the risk of muscle injury, muscle pain, or rhabdomyolysis.
  • Potassium-sparing diuretics (i.e. spironolactone, amiloride): May increase the risk of high potassium levels in the blood.
  • Other immunosuppressants (i.e. tacrolimus): Using these medicines together may increase the risk of kidney damage and other serious side effects unless carefully supervised by a specialist.
  • Herbal products (i.e. St John's wort): May lower cyclosporine levels, increasing the risk of transplant rejection or treatment failure.
CiclosporinPitavastatin
Critical
CiclosporinCidofovir
Critical

Drug-Drug Interactions

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CiclosporinPitavastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of pitavastatin with Sandimmun 50 mg Injection 1 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Sandimmun 50 mg Injection 1 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinSimvastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Combining Sandimmun 50 mg Injection 1 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBaricitinib
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinAdefovir dipivoxil
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of adefovir dipivoxil with Sandimmun 50 mg Injection 1 ml may significantly increase the negative effect of kidneys.

How to manage the interaction:
Although there is a possible interaction between adefovir dipivoxil and Sandimmun 50 mg Injection 1 ml, they can be taken together if your doctor has prescribed them. However, contact your doctor if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinGolimumab
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Using Sandimmun 50 mg Injection 1 ml together with golimumab may increase the risk of serious infections.

How to manage the interaction:
Although taking golimumab and Sandimmun 50 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinIndinavir
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking indinavir with ciclosporine may increase the blood levels and effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
Co-administration of cyclosporine and indinavir can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, diarrhea, abdominal pain, dizziness, weakness, headache, shaking, fits, and increased or decreased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CiclosporinOrlistat
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of Sandimmun 50 mg Injection 1 ml with Orlistat can reduce the levels and effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Orlistat and Sandimmun 50 mg Injection 1 ml, you can take these medicines together when prescribed by your doctor. Do not stop using any medications without talking to a doctor.
CiclosporinCisapride
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of cisapride with cyclosporine may significantly increase the blood levels of cisapride which may increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between cisapride and Sandimmun 50 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Can greatly increase cyclosporine levels in the blood and increase the risk of serious side effects.
  • Potassium-rich foods: Do not change your intake of potassium-rich foods unless your doctor or dietitian specifically advises you to do so, as your potassium levels may need individual monitoring.
CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml can increase the effects of Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Sandimmun 50 mg Injection 1 ml belongs to the class of medicines called immunosuppressants, used to prevent organ rejection after a transplant.
Sandimmun 50 mg Injection 1 ml works by suppressing the body's immune system, preventing it from attacking the transplanted organ. It does this by blocking the production of certain cells that usually attack the transplanted tissue.
The side effects of Sandimmun 50 mg Injection 1 ml include kidney problems, high blood pressure, headaches, tremors, excessive hair growth, and elevated lipid levels.
Sandimmun 50 mg Injection 1 ml may cause high blood pressure. If you experience this side effect, monitoring your blood pressure regularly and following a healthy lifestyle are essential. This includes eating a balanced diet low in sodium and fat, exercising regularly, reducing stress, and taking any prescribed medication as directed. Working closely with your healthcare provider is crucial to managing high blood pressure and adjusting your treatment plan as needed.
If you're already taking blood pressure medication, consult your doctor before starting Cyclosporine Injection, as it may increase blood pressure. Your doctor will advise on safe usage.
Yes, grapefruit and grapefruit juice can interact with Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit or grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.
Yes, in rare cases, Sandimmun 50 mg Injection 1 ml may cause allergic reactions. Seek medical attention immediately if you experience hives, itching, or difficulty breathing.
No. Live vaccines are generally not recommended because cyclosporine suppresses your immune system. Always discuss vaccinations with your specialist before receiving any vaccine.
Regular blood tests measure the amount of cyclosporine in your blood, often just before your next dose (trough level), and check your kidney function, liver function, and other important health markers. These tests help your doctor adjust your treatment safely.
No. Never stop cyclosporine without your specialist's advice. Stopping treatment suddenly may cause transplant rejection or allow your underlying disease to become active again.
Yellowing of the skin or eyes may be a sign of liver problems. Contact your doctor immediately so you can be assessed promptly.
Alcohol may increase the risk of liver problems and worsen certain side effects. Ask your specialist whether alcohol is appropriate for your individual medical condition.
Cyclosporine may sometimes be continued during pregnancy in certain situations, such as after an organ transplant, when the benefits outweigh the potential risks. If you are pregnant, planning a pregnancy, or become pregnant during treatment, your specialist will carefully assess your treatment and advise you on the safest approach.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.1036 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% [Internet]. [Accessed on 27 Feb 2025]Check here
  3. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 27 Feb 2025]Check here
  4. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 5280754, Cyclosporine. Retrieved February 27, 2025Check here
  5. DrugBank. Cyclosporine. DrugBank.[Accessed on 27 Feb 2025]Check here
  6. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC) [Revised in May 2022] [ Accessed on 21st November 2022]Check here
  7. Sandimmunneoral Jul2020.Sin App091120. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SAN0075
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