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  3. RBO 20 mg/4 mg Tablet 10's

RBO 20 mg/4 mg Tablet 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
RBO 20 mg/4 mg Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. It contains Rabeprazole and Ondansetron which inhibit the production of acid in the stomach, protect the ulcers from acid, and block the action of serotonin (chemical messenger) that triggers nausea and vomiting. This medicine may sometimes cause side effects such as constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain.
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Composition :

ONDANSETRON-4MG + RABEPRAZOLE-20MG

Manufacturer/Marketer :

Silok Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About RBO 20 mg/4 mg Tablet

RBO 20 mg/4 mg Tablet is a gastrointestinal medication, primarily used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). RBO 20 mg/4 mg Tablet is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.

RBO 20 mg/4 mg Tablet contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Take RBO 20 mg/4 mg Tablet as advised by the doctor. Your doctor will advise the appropriate dose that suits your medical condition. Common side effects of RBO 20 mg/4 mg Tablet include nausea, vomiting, constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor’s advice.

Let your doctor know if you are sensitive or allergic to RBO 20 mg/4 mg Tablet or any other medications. Before using RBO 20 mg/4 mg Tablet , let your doctor know if you have any liver, kidney or heart diseases, and gastrointestinal problems. Pregnant and breastfeeding women should consult their doctor before using RBO 20 mg/4 mg Tablet . Avoid alcohol intake while using RBO 20 mg/4 mg Tablet since it can increase acid production in the stomach. Ondansetron in RBO 20 mg/4 mg Tablet is not recommended for children below four years of age.

Uses of RBO 20 mg/4 mg Tablet

Treatment of Nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis, and Zollinger-Ellison syndrome.

Directions for Use

• RBO 20 mg/4 mg Tablet can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow RBO 20 mg/4 mg Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

RBO 20 mg/4 mg Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn and erosive oesophagitis. It contains Rabeprazole and Ondansetron. Rabeprazole is a proton pump inhibitor that blocks the action of the gastric proton pump that is responsible for acid production in the stomach. Ondansetron is an anti-emetic drug. It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting. Thus, collectively RBO 20 mg/4 mg Tablet prevents nausea and vomiting, reduces the amount of acid produced, heals the ulcers, and prevents new ulcers. RBO 20 mg/4 mg Tablet is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

How RBO 20 mg/4 mg Tablet Works

RBO 20 mg/4 mg Tablet contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Storage

Keep out of sight and reach of children.

What if I have taken an overdose of RBO 20 mg/4 mg Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Let your doctor know if you are sensitive to RBO 20 mg/4 mg Tablet or its components. RBO 20 mg/4 mg Tablet should be used with caution and only under doctor’s supervision if you have stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures and autoimmune diseases like lupus. Long term treatment with RBO 20 mg/4 mg Tablet may increase the risk of fractures of the hip, spine, and wrist. Hence, inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids before starting RBO 20 mg/4 mg Tablet . Let your doctor know if you are pregnant or a nursing mother before starting RBO 20 mg/4 mg Tablet . Avoid alcohol intake while using RBO 20 mg/4 mg Tablet since it can increase acid production in the stomach.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
RabeprazoleErlotinib
Critical

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with RBO 20 mg/4 mg Tablet:
Taking RBO 20 mg/4 mg Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking RBO 20 mg/4 mg Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
RabeprazoleErlotinib
Critical
How does the drug interact with RBO 20 mg/4 mg Tablet:
When used in combination with erlotinib, RBO 20 mg/4 mg Tablet may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking RBO 20 mg/4 mg Tablet with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with RBO 20 mg/4 mg Tablet:
Co-administration of RBO 20 mg/4 mg Tablet can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking RBO 20 mg/4 mg Tablet with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
OndansetronEscitalopram
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
Taking RBO 20 mg/4 mg Tablet with escitalopram may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Co-administration of RBO 20 mg/4 mg Tablet along with escitalopram can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
OndansetronCrizotinib
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
Taking RBO 20 mg/4 mg Tablet with crizotinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking RBO 20 mg/4 mg Tablet along with crizotinib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronHydroxychloroquine
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
Taking RBO 20 mg/4 mg Tablet with hydroxychloroquine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of RBO 20 mg/4 mg Tablet along with hydroxychloroquine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronOlanzapine
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
The combined use of RBO 20 mg/4 mg Tablet and Olanzapine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of RBO 20 mg/4 mg Tablet and Olanzapine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OndansetronNortriptyline
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
Using Nortriptyline together with RBO 20 mg/4 mg Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of RBO 20 mg/4 mg Tablet along with nortriptyline can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, or diarrhea. while taking these medications. Do not discontinue any medications without a doctor's advice.
OndansetronZolmitriptan
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
When RBO 20 mg/4 mg Tablet, is taken with zolmitriptan it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking RBO 20 mg/4 mg Tablet along with zolmitriptan can lead to interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronImipramine
Severe
How does the drug interact with RBO 20 mg/4 mg Tablet:
Coadministration of RBO 20 mg/4 mg Tablet along with imipramine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Taking RBO 20 mg/4 mg Tablet along with imipramine together can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit taking high fibre foods, foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods. 
  • Do not have large meals at a time, instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
  • Practice yoga and recreation techniques to manage your emotional stress.
  • If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomforts.
  • If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
  • Drink plenty of fluids to prevent dehydration.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

RBO 20 mg/4 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol consumption may increase acid production in the stomach. It is advised to avoid alcohol intake to prevent any undesirable side effects of RBO 20 mg/4 mg Tablet and further worsening of your disease. Please consult your doctor for more information before using RBO 20 mg/4 mg Tablet .

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Pregnancy

Caution

RBO 20 mg/4 mg Tablet is not recommended for use in pregnancy since Ondansetron may cause harmful effects on the developing baby. It is advised to consult your doctor if you plan to conceive or already pregnant before starting RBO 20 mg/4 mg Tablet .

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Breast Feeding

Caution

It is not known if RBO 20 mg/4 mg Tablet passes into breast milk. Please consult your doctor before taking RBO 20 mg/4 mg Tablet if you are a nursing mother.

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Driving

Safe if prescribed

RBO 20 mg/4 mg Tablet is probably safe to use and doesn’t affect driving. However, please do not drive or operate machines if you experience any side effects that affect your ability to drive.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing RBO 20 mg/4 mg Tablet .

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing RBO 20 mg/4 mg Tablet .

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Children

Caution

Ondansetron in RBO 20 mg/4 mg Tablet may not be suitable for children below four years of age. Please consult your doctor before giving RBO 20 mg/4 mg Tablet to your child. Your doctor will decide the dose and duration based on your child’s age and medical condition.

Have a query?

FAQs

RBO 20 mg/4 mg Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). It is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

RBO 20 mg/4 mg Tablet works by reducing the amount of acid produced in the stomach and blocks the action of certain chemical messengers that trigger nausea and vomiting. Thus, RBO 20 mg/4 mg Tablet relieves stomach ulcers, heartburn, GERD, nausea, vomiting and other gastrointestinal discomforts.

RBO 20 mg/4 mg Tablet should be used with caution and only under doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures and autoimmune diseases like lupus.

Talk to your doctor if you do not feel better even after taking RBO 20 mg/4 mg Tablet for 14 days. Do not take RBO 20 mg/4 mg Tablet for longer durations unless prescribed by the doctor. If RBO 20 mg/4 mg Tablet is prescribed for longer durations, a regular check-up is advised.

Antacids do not interfere with the absorption of RBO 20 mg/4 mg Tablet . However, it is advised to take antacid and RBO 20 mg/4 mg Tablet at different times. Please seek medical advice on how to use other medicines like antacids while using RBO 20 mg/4 mg Tablet .

Diarrhoea might be a side-effect of RBO 20 mg/4 mg Tablet . Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Prolonged intake of RBO 20 mg/4 mg Tablet is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.

On long term treatment, Rabeprazole in RBO 20 mg/4 mg Tablet may increase the risk of fractures of the hip, spine, and wrist. Inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids. Your doctor may suggest supplements like Calcium citrate and Vitamin D.

Rabeprazole in RBO 20 mg/4 mg Tablet may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of RBO 20 mg/4 mg Tablet accordingly and may also suggest Vitamin B12 supplements.

RBO 20 mg/4 mg Tablet weakens bones and can increase the risk of fractures in elderly patients if used for long term or if taken in high doses.

Long term usage of the RBO 20 mg/4 mg Tablet causes disturbances in liver function, B12 deficiency and changes in electrolyte (magnesium, calcium and sodium) levels. Therefore, if you experience symptoms such as yellow skin and eyes, nausea, dizziness, loss of appetite, fits, headache, itching, tiredness, pale skin, or irritability, consult your doctor immediately. Your doctor may recommend frequent follow-ups and blood tests if RBO 20 mg/4 mg Tablet is prescribed for long term use.

Yes, you can take RBO 20 mg/4 mg Tablet on an empty stomach preferably in the morning for better acid regulation throughout the day or take it as advised by your doctor. But try to take it at the same time every day for best results.

RBO 20 mg/4 mg Tablet starts working within 60 minutes of taking it and takes about 2 to 4 hours to show full benefit. Although it may take up to 4 weeks to relieve your symptoms considerably, you should begin to feel better within 2 to 3 days. If you have concerns, discuss with your doctor.

You are recommended not to stop taking RBO 20 mg/4 mg Tablet on your own without first consulting your doctor as it may worsen your condition. If you experience any difficulty while using RBO 20 mg/4 mg Tablet , please consult your doctor.

RBO 20 mg/4 mg Tablet is used along with antibiotics for the treatment of H. Pylori infection. It reduces the stomach acid volume and decreases breakdown and washout of antibiotics resulting in increased antibiotic concentration and tissue penetration. Also, it helps in symptomatic relief by reducing associated heartburn, acidity, and reflux.

Yes, you can take RBO 20 mg/4 mg Tablet with vitamin D. It is usually advised to take vitamin D as a supplement with RBO 20 mg/4 mg Tablet as the long-term use of RBO 20 mg/4 mg Tablet reduces calcium absorption and may result in calcium deficiency. This can further lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like wrist, spine and hip fractures. Please discuss with your doctor about ways to prevent this.

Long-term usage of RBO 20 mg/4 mg Tablet can decrease magnesium levels in patients taking several daily doses for 3 months or longer. Check your magnesium levels at regular intervals. However, if you experience dizziness, seizures (fits), abnormal or fast heartbeat, jerking movements or shaking (tremors), jitteriness, muscle weakness, spasms of the hands and feet, cramps, or muscle pains, inform your doctor.

No, you are recommended not to take alcohol with RBO 20 mg/4 mg Tablet as it may increase acid production in the stomach and worsening of your symptoms. If you still have any concerns, please discuss with your doctor.

It is advised to take RBO 20 mg/4 mg Tablet 1 hour before a meal. Avoid spicy and fatty foods while taking RBO 20 mg/4 mg Tablet . Also, cut down on caffeinated drinks such as coffee, tea, and cola. Alcohol consumption should also be avoided as it may worsen your symptoms.

Eat healthy and exercise regularly. You can consult a dietician to obtain a diet plan that works best for you. Eat at least 3 hours before going to bed to reduce the chances of worsening of your symptoms at night. Avoid spicy and fatty foods and caffeinated drinks such as coffee, tea, and cola. Also, avoid smoking and alcohol consumption as they may worsen your symptoms.

The side effects of RBO 20 mg/4 mg Tablet include headache, nausea, vomiting, constipation, diarrhoea, fatigue, sore throat and stomach pain. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - RBO0002

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:49 AM IST

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Reference

  1. https://www.drugs.com/ondansetron.html
  2. https://www.drugs.com/mtm/rabeprazole.html
  3. https://www.webmd.com/drugs/2/drug-17504/rabeprazole-oral/details
  4. https://www.webmd.com/drugs/2/drug-16910-1345/ondansetron-oral/ondansetron-soluble-film-oral/details

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