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  3. Rabopep O Tablet 10's

Rabopep O Tablet 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Rabopep O Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. It contains Rabeprazole and Ondansetron which inhibit the production of acid in the stomach, protect the ulcers from acid, and block the action of serotonin (chemical messenger) that triggers nausea and vomiting. This medicine may sometimes cause side effects such as constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain.
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Composition :

ONDANSETRON-4MG + RABEPRAZOLE-20MG

Manufacturer/Marketer :

Seagull Pharmaceutical Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Rabopep O Tablet

Rabopep O Tablet is a gastrointestinal medication, primarily used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). Rabopep O Tablet is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.

Rabopep O Tablet contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Take Rabopep O Tablet as advised by the doctor. Your doctor will advise the appropriate dose that suits your medical condition. Common side effects of Rabopep O Tablet include nausea, vomiting, constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor’s advice.

Let your doctor know if you are sensitive or allergic to Rabopep O Tablet or any other medications. Before using Rabopep O Tablet , let your doctor know if you have any liver, kidney or heart diseases, and gastrointestinal problems. Pregnant and breastfeeding women should consult their doctor before using Rabopep O Tablet . Avoid alcohol intake while using Rabopep O Tablet since it can increase acid production in the stomach. Ondansetron in Rabopep O Tablet is not recommended for children below four years of age.

Uses of Rabopep O Tablet

Treatment of Nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis, and Zollinger-Ellison syndrome.

Directions for Use

• Rabopep O Tablet can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Rabopep O Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Rabopep O Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn and erosive oesophagitis. It contains Rabeprazole and Ondansetron. Rabeprazole is a proton pump inhibitor that blocks the action of the gastric proton pump that is responsible for acid production in the stomach. Ondansetron is an anti-emetic drug. It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting. Thus, collectively Rabopep O Tablet prevents nausea and vomiting, reduces the amount of acid produced, heals the ulcers, and prevents new ulcers. Rabopep O Tablet is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

How Rabopep O Tablet Works

Rabopep O Tablet contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Storage

Keep out of sight and reach of children.

What if I have taken an overdose of Rabopep O Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Let your doctor know if you are sensitive to Rabopep O Tablet or its components. Rabopep O Tablet should be used with caution and only under doctor’s supervision if you have stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures and autoimmune diseases like lupus. Long term treatment with Rabopep O Tablet may increase the risk of fractures of the hip, spine, and wrist. Hence, inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids before starting Rabopep O Tablet . Let your doctor know if you are pregnant or a nursing mother before starting Rabopep O Tablet . Avoid alcohol intake while using Rabopep O Tablet since it can increase acid production in the stomach.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
RabeprazoleErlotinib
Critical

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Rabopep O Tablet:
Taking Rabopep O Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Rabopep O Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
RabeprazoleErlotinib
Critical
How does the drug interact with Rabopep O Tablet:
When used in combination with erlotinib, Rabopep O Tablet may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Rabopep O Tablet with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Rabopep O Tablet:
Co-administration of Rabopep O Tablet can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Rabopep O Tablet with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
OndansetronEfavirenz
Severe
How does the drug interact with Rabopep O Tablet:
Taking Rabopep O Tablet with efavirenz increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Rabopep O Tablet along with efavirenz can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronNilotinib
Severe
How does the drug interact with Rabopep O Tablet:
Taking Rabopep O Tablet with nilotinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Rabopep O Tablet along with nilotinib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronBedaquiline
Severe
How does the drug interact with Rabopep O Tablet:
Taking Rabopep O Tablet with bedaquiline increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Rabopep O Tablet along with bedaquiline can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.
OndansetronClozapine
Severe
How does the drug interact with Rabopep O Tablet:
Although it is a very rare adverse effect, taking Rabopep O Tablet with clozapine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Rabopep O Tablet along with clozapine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronDoxepin
Severe
How does the drug interact with Rabopep O Tablet:
When Rabopep O Tablet is taken with doxepin, it can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Rabopep O Tablet along with doxepin can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronTramadol
Severe
How does the drug interact with Rabopep O Tablet:
Co-administration of tramadol with Rabopep O Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Taking Rabopep O Tablet with tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OndansetronAlfuzosin
Severe
How does the drug interact with Rabopep O Tablet:
Taking Rabopep O Tablet along with alfuzosin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking Rabopep O Tablet along with alfuzosin can lead to interaction, they can be taken if prescribed by a doctor. Contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit taking high fibre foods, foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods. 
  • Do not have large meals at a time, instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
  • Practice yoga and recreation techniques to manage your emotional stress.
  • If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomforts.
  • If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
  • Drink plenty of fluids to prevent dehydration.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Rabopep O Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol consumption may increase acid production in the stomach. It is advised to avoid alcohol intake to prevent any undesirable side effects of Rabopep O Tablet and further worsening of your disease. Please consult your doctor for more information before using Rabopep O Tablet .

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Pregnancy

Caution

Rabopep O Tablet is not recommended for use in pregnancy since Ondansetron may cause harmful effects on the developing baby. It is advised to consult your doctor if you plan to conceive or already pregnant before starting Rabopep O Tablet .

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Breast Feeding

Caution

It is not known if Rabopep O Tablet passes into breast milk. Please consult your doctor before taking Rabopep O Tablet if you are a nursing mother.

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Driving

Safe if prescribed

Rabopep O Tablet is probably safe to use and doesn’t affect driving. However, please do not drive or operate machines if you experience any side effects that affect your ability to drive.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Rabopep O Tablet .

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Rabopep O Tablet .

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Children

Caution

Ondansetron in Rabopep O Tablet may not be suitable for children below four years of age. Please consult your doctor before giving Rabopep O Tablet to your child. Your doctor will decide the dose and duration based on your child’s age and medical condition.

Have a query?

FAQs

Rabopep O Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). It is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

Rabopep O Tablet works by reducing the amount of acid produced in the stomach and blocks the action of certain chemical messengers that trigger nausea and vomiting. Thus, Rabopep O Tablet relieves stomach ulcers, heartburn, GERD, nausea, vomiting and other gastrointestinal discomforts.

Rabopep O Tablet should be used with caution and only under doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures and autoimmune diseases like lupus.

Talk to your doctor if you do not feel better even after taking Rabopep O Tablet for 14 days. Do not take Rabopep O Tablet for longer durations unless prescribed by the doctor. If Rabopep O Tablet is prescribed for longer durations, a regular check-up is advised.

Antacids do not interfere with the absorption of Rabopep O Tablet . However, it is advised to take antacid and Rabopep O Tablet at different times. Please seek medical advice on how to use other medicines like antacids while using Rabopep O Tablet .

Diarrhoea might be a side-effect of Rabopep O Tablet . Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Prolonged intake of Rabopep O Tablet is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.

On long term treatment, Rabeprazole in Rabopep O Tablet may increase the risk of fractures of the hip, spine, and wrist. Inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids. Your doctor may suggest supplements like Calcium citrate and Vitamin D.

Rabeprazole in Rabopep O Tablet may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of Rabopep O Tablet accordingly and may also suggest Vitamin B12 supplements.

Rabopep O Tablet weakens bones and can increase the risk of fractures in elderly patients if used for long term or if taken in high doses.

Long term usage of the Rabopep O Tablet causes disturbances in liver function, B12 deficiency and changes in electrolyte (magnesium, calcium and sodium) levels. Therefore, if you experience symptoms such as yellow skin and eyes, nausea, dizziness, loss of appetite, fits, headache, itching, tiredness, pale skin, or irritability, consult your doctor immediately. Your doctor may recommend frequent follow-ups and blood tests if Rabopep O Tablet is prescribed for long term use.

Yes, you can take Rabopep O Tablet on an empty stomach preferably in the morning for better acid regulation throughout the day or take it as advised by your doctor. But try to take it at the same time every day for best results.

Rabopep O Tablet starts working within 60 minutes of taking it and takes about 2 to 4 hours to show full benefit. Although it may take up to 4 weeks to relieve your symptoms considerably, you should begin to feel better within 2 to 3 days. If you have concerns, discuss with your doctor.

You are recommended not to stop taking Rabopep O Tablet on your own without first consulting your doctor as it may worsen your condition. If you experience any difficulty while using Rabopep O Tablet , please consult your doctor.

Rabopep O Tablet is used along with antibiotics for the treatment of H. Pylori infection. It reduces the stomach acid volume and decreases breakdown and washout of antibiotics resulting in increased antibiotic concentration and tissue penetration. Also, it helps in symptomatic relief by reducing associated heartburn, acidity, and reflux.

Yes, you can take Rabopep O Tablet with vitamin D. It is usually advised to take vitamin D as a supplement with Rabopep O Tablet as the long-term use of Rabopep O Tablet reduces calcium absorption and may result in calcium deficiency. This can further lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like wrist, spine and hip fractures. Please discuss with your doctor about ways to prevent this.

Long-term usage of Rabopep O Tablet can decrease magnesium levels in patients taking several daily doses for 3 months or longer. Check your magnesium levels at regular intervals. However, if you experience dizziness, seizures (fits), abnormal or fast heartbeat, jerking movements or shaking (tremors), jitteriness, muscle weakness, spasms of the hands and feet, cramps, or muscle pains, inform your doctor.

No, you are recommended not to take alcohol with Rabopep O Tablet as it may increase acid production in the stomach and worsening of your symptoms. If you still have any concerns, please discuss with your doctor.

It is advised to take Rabopep O Tablet 1 hour before a meal. Avoid spicy and fatty foods while taking Rabopep O Tablet . Also, cut down on caffeinated drinks such as coffee, tea, and cola. Alcohol consumption should also be avoided as it may worsen your symptoms.

Eat healthy and exercise regularly. You can consult a dietician to obtain a diet plan that works best for you. Eat at least 3 hours before going to bed to reduce the chances of worsening of your symptoms at night. Avoid spicy and fatty foods and caffeinated drinks such as coffee, tea, and cola. Also, avoid smoking and alcohol consumption as they may worsen your symptoms.

The side effects of Rabopep O Tablet include headache, nausea, vomiting, constipation, diarrhoea, fatigue, sore throat and stomach pain. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

305-307, Ansal Imperial Tower, C Block Community Centre, Naraina Vihar, New Delhi-110028, India
Other Info - RAB1490

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:49 AM IST

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Reference

  1. https://www.drugs.com/ondansetron.html
  2. https://www.drugs.com/mtm/rabeprazole.html
  3. https://www.webmd.com/drugs/2/drug-17504/rabeprazole-oral/details
  4. https://www.webmd.com/drugs/2/drug-16910-1345/ondansetron-oral/ondansetron-soluble-film-oral/details

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