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  3. Rabextin-O Tablet 10's

Rabextin-O Tablet 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Rabextin-O Tablet 10's is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. It contains Rabeprazole and Ondansetron which inhibit the production of acid in the stomach, protect the ulcers from acid, and block the action of serotonin (chemical messenger) that triggers nausea and vomiting. This medicine may sometimes cause side effects such as constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain.
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Composition :

ONDANSETRON-4Mg + RABEPRAZOLE-20Mg

Manufacturer/Marketer :

Metamorf Lifesciences

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rabextin-O Tablet 10's

Rabextin-O Tablet 10's is a gastrointestinal medication, primarily used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). Rabextin-O Tablet 10's is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.

Rabextin-O Tablet 10's contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Take Rabextin-O Tablet 10's as advised by the doctor. Your doctor will advise the appropriate dose that suits your medical condition. Common side effects of Rabextin-O Tablet 10's include nausea, vomiting, constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor’s advice.

Let your doctor know if you are sensitive or allergic to Rabextin-O Tablet 10's or any other medications. Before using Rabextin-O Tablet 10's, let your doctor know if you have any liver, kidney or heart diseases, and gastrointestinal problems. Pregnant and breastfeeding women should consult their doctor before using Rabextin-O Tablet 10's. Avoid alcohol intake while using Rabextin-O Tablet 10's since it can increase acid production in the stomach. Ondansetron in Rabextin-O Tablet 10's is not recommended for children below four years of age.

Uses of Rabextin-O Tablet 10's

Treatment of Nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis, and Zollinger-Ellison syndrome.

Directions for Use

• Rabextin-O Tablet 10's can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Rabextin-O Tablet 10's as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Rabextin-O Tablet 10's is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn and erosive oesophagitis. It contains Rabeprazole and Ondansetron. Rabeprazole is a proton pump inhibitor that blocks the action of the gastric proton pump that is responsible for acid production in the stomach. Ondansetron is an anti-emetic drug. It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting. Thus, collectively Rabextin-O Tablet 10's prevents nausea and vomiting, reduces the amount of acid produced, heals the ulcers, and prevents new ulcers. Rabextin-O Tablet 10's is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

How Rabextin-O Tablet 10's Works

Rabextin-O Tablet 10's contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.

Storage

Keep out of sight and reach of children.

What if I have taken an overdose of Rabextin-O Tablet 10's

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Let your doctor know if you are sensitive to Rabextin-O Tablet 10's or its components. Rabextin-O Tablet 10's should be used with caution and only under doctor’s supervision if you have stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures and autoimmune diseases like lupus. Long term treatment with Rabextin-O Tablet 10's may increase the risk of fractures of the hip, spine, and wrist. Hence, inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids before starting Rabextin-O Tablet 10's. Let your doctor know if you are pregnant or a nursing mother before starting Rabextin-O Tablet 10's. Avoid alcohol intake while using Rabextin-O Tablet 10's since it can increase acid production in the stomach.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
RabeprazoleErlotinib
Critical

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Rabextin-o Tab:
Taking Rabextin-o Tab with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Rabextin-o Tab with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
RabeprazoleErlotinib
Critical
How does the drug interact with Rabextin-o Tab:
When used in combination with erlotinib, Rabextin-o Tab may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Rabextin-o Tab with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Rabextin-o Tab:
Co-administration of Rabextin-o Tab can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Rabextin-o Tab with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
OndansetronEscitalopram
Severe
How does the drug interact with Rabextin-o Tab:
Taking Rabextin-o Tab with escitalopram may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Co-administration of Rabextin-o Tab along with escitalopram can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
OndansetronCrizotinib
Severe
How does the drug interact with Rabextin-o Tab:
Taking Rabextin-o Tab with crizotinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Rabextin-o Tab along with crizotinib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronHydroxychloroquine
Severe
How does the drug interact with Rabextin-o Tab:
Taking Rabextin-o Tab with hydroxychloroquine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Rabextin-o Tab along with hydroxychloroquine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronOlanzapine
Severe
How does the drug interact with Rabextin-o Tab:
The combined use of Rabextin-o Tab and Olanzapine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Rabextin-o Tab and Olanzapine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OndansetronNortriptyline
Severe
How does the drug interact with Rabextin-o Tab:
Using Nortriptyline together with Rabextin-o Tab can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Rabextin-o Tab along with nortriptyline can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, or diarrhea. while taking these medications. Do not discontinue any medications without a doctor's advice.
OndansetronZolmitriptan
Severe
How does the drug interact with Rabextin-o Tab:
When Rabextin-o Tab, is taken with zolmitriptan it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Rabextin-o Tab along with zolmitriptan can lead to interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronImipramine
Severe
How does the drug interact with Rabextin-o Tab:
Coadministration of Rabextin-o Tab along with imipramine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Taking Rabextin-o Tab along with imipramine together can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit taking high fibre foods, foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods. 
  • Do not have large meals at a time, instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
  • Practice yoga and recreation techniques to manage your emotional stress.
  • If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomforts.
  • If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
  • Drink plenty of fluids to prevent dehydration.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS
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Alcohol

Unsafe

Alcohol consumption may increase acid production in the stomach. It is advised to avoid alcohol intake to prevent any undesirable side effects of Rabextin-O Tablet 10's and further worsening of your disease. Please consult your doctor for more information before using Rabextin-O Tablet 10's.

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Pregnancy

Caution

Rabextin-O Tablet 10's is not recommended for use in pregnancy since Ondansetron may cause harmful effects on the developing baby. It is advised to consult your doctor if you plan to conceive or already pregnant before starting Rabextin-O Tablet 10's.

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Breast Feeding

Caution

It is not known if Rabextin-O Tablet 10's passes into breast milk. Please consult your doctor before taking Rabextin-O Tablet 10's if you are a nursing mother.

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Driving

Safe if prescribed

Rabextin-O Tablet 10's is probably safe to use and doesn’t affect driving. However, please do not drive or operate machines if you experience any side effects that affect your ability to drive.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Rabextin-O Tablet 10's.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Rabextin-O Tablet 10's.

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Children

Caution

Ondansetron in Rabextin-O Tablet 10's may not be suitable for children below four years of age. Please consult your doctor before giving Rabextin-O Tablet 10's to your child. Your doctor will decide the dose and duration based on your child’s age and medical condition.

Have a query?

FAQs

Rabextin-O Tablet 10's is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). It is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.

Rabextin-O Tablet 10's works by reducing the amount of acid produced in the stomach and blocks the action of certain chemical messengers that trigger nausea and vomiting. Thus, Rabextin-O Tablet 10's relieves stomach ulcers, heartburn, GERD, nausea, vomiting and other gastrointestinal discomforts.

Rabextin-O Tablet 10's should be used with caution and only under doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures and autoimmune diseases like lupus.

Talk to your doctor if you do not feel better even after taking Rabextin-O Tablet 10's for 14 days. Do not take Rabextin-O Tablet 10's for longer durations unless prescribed by the doctor. If Rabextin-O Tablet 10's is prescribed for longer durations, a regular check-up is advised.

Antacids do not interfere with the absorption of Rabextin-O Tablet 10's. However, it is advised to take antacid and Rabextin-O Tablet 10's at different times. Please seek medical advice on how to use other medicines like antacids while using Rabextin-O Tablet 10's.

Diarrhoea might be a side-effect of Rabextin-O Tablet 10's. Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Prolonged intake of Rabextin-O Tablet 10's is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.

On long term treatment, Rabeprazole in Rabextin-O Tablet 10's may increase the risk of fractures of the hip, spine, and wrist. Inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids. Your doctor may suggest supplements like Calcium citrate and Vitamin D.

Rabeprazole in Rabextin-O Tablet 10's may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of Rabextin-O Tablet 10's accordingly and may also suggest Vitamin B12 supplements.

Rabextin-O Tablet 10's weakens bones and can increase the risk of fractures in elderly patients if used for long term or if taken in high doses.

Long term usage of the Rabextin-O Tablet 10's causes disturbances in liver function, B12 deficiency and changes in electrolyte (magnesium, calcium and sodium) levels. Therefore, if you experience symptoms such as yellow skin and eyes, nausea, dizziness, loss of appetite, fits, headache, itching, tiredness, pale skin, or irritability, consult your doctor immediately. Your doctor may recommend frequent follow-ups and blood tests if Rabextin-O Tablet 10's is prescribed for long term use.

Yes, you can take Rabextin-O Tablet 10's on an empty stomach preferably in the morning for better acid regulation throughout the day or take it as advised by your doctor. But try to take it at the same time every day for best results.

Rabextin-O Tablet 10's starts working within 60 minutes of taking it and takes about 2 to 4 hours to show full benefit. Although it may take up to 4 weeks to relieve your symptoms considerably, you should begin to feel better within 2 to 3 days. If you have concerns, discuss with your doctor.

You are recommended not to stop taking Rabextin-O Tablet 10's on your own without first consulting your doctor as it may worsen your condition. If you experience any difficulty while using Rabextin-O Tablet 10's, please consult your doctor.

Rabextin-O Tablet 10's is used along with antibiotics for the treatment of H. Pylori infection. It reduces the stomach acid volume and decreases breakdown and washout of antibiotics resulting in increased antibiotic concentration and tissue penetration. Also, it helps in symptomatic relief by reducing associated heartburn, acidity, and reflux.

Yes, you can take Rabextin-O Tablet 10's with vitamin D. It is usually advised to take vitamin D as a supplement with Rabextin-O Tablet 10's as the long-term use of Rabextin-O Tablet 10's reduces calcium absorption and may result in calcium deficiency. This can further lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like wrist, spine and hip fractures. Please discuss with your doctor about ways to prevent this.

Long-term usage of Rabextin-O Tablet 10's can decrease magnesium levels in patients taking several daily doses for 3 months or longer. Check your magnesium levels at regular intervals. However, if you experience dizziness, seizures (fits), abnormal or fast heartbeat, jerking movements or shaking (tremors), jitteriness, muscle weakness, spasms of the hands and feet, cramps, or muscle pains, inform your doctor.

No, you are recommended not to take alcohol with Rabextin-O Tablet 10's as it may increase acid production in the stomach and worsening of your symptoms. If you still have any concerns, please discuss with your doctor.

It is advised to take Rabextin-O Tablet 10's 1 hour before a meal. Avoid spicy and fatty foods while taking Rabextin-O Tablet 10's. Also, cut down on caffeinated drinks such as coffee, tea, and cola. Alcohol consumption should also be avoided as it may worsen your symptoms.

Eat healthy and exercise regularly. You can consult a dietician to obtain a diet plan that works best for you. Eat at least 3 hours before going to bed to reduce the chances of worsening of your symptoms at night. Avoid spicy and fatty foods and caffeinated drinks such as coffee, tea, and cola. Also, avoid smoking and alcohol consumption as they may worsen your symptoms.

The side effects of Rabextin-O Tablet 10's include headache, nausea, vomiting, constipation, diarrhoea, fatigue, sore throat and stomach pain. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Scf- 495 2nd Floor, Motor Market Manimajra, Chandigarh
Other Info - RAB2179

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:49 AM IST

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Reference

  1. https://www.drugs.com/ondansetron.html
  2. https://www.drugs.com/mtm/rabeprazole.html
  3. https://www.webmd.com/drugs/2/drug-17504/rabeprazole-oral/details
  4. https://www.webmd.com/drugs/2/drug-16910-1345/ondansetron-oral/ondansetron-soluble-film-oral/details

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