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compositionComposition:PRIMIDONE-12.5MG
prescription
Prescription Medicine
info
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Prolet 12.5 Tablet is used to control seizures. It contains Primidone which works by decreasing abnormal electrical activity in the brain. In some cases, this medicine may cause side effects such as nausea, headache, vomiting, drowsiness, vertigo, visual impairment, low energy, and impaired coordination. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRIMIDONE-12.5MG

Manufacturer/Marketer :

Alteus Biogenics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prolet 12.5 Tablet

Prolet 12.5 Tablet is an oral prescription medication primarily used to control and prevent various types of seizures, including grand mal and psychomotor seizures. It is also commonly prescribed to help manage essential tremors, which cause involuntary shaking of the hands, head, or other parts of the body. By helping to calm abnormal electrical activity in the brain, Prolet 12.5 Tablet supports steadier movement and daily physical control.

To get the best results, you must take Prolet 12.5 Tablet consistently every day, exactly as prescribed by your doctor. You can take this medication either with or without food, but taking it with meals may help if you experience a mild upset stomach. Alongside your medicine, maintaining a regular sleep schedule and avoiding excessive stress can significantly support your overall seizure or tremor control.

While taking Prolet 12.5 Tablet , you may experience mild, temporary side effects such as drowsiness, dizziness, or a temporary loss of coordination. Most of these symptoms improve as your body adjusts to the medicine, but you should contact your doctor immediately if you notice severe skin rashes, extreme mood shifts, or unusual bruising.

Before starting Prolet 12.5 Tablet , it is crucial to discuss your complete medical history with your healthcare provider. Do not take this if you have a rare genetic metabolic disorder called porphyria, or if you have a known allergy to similar seizure medications. Your doctor will carefully evaluate your health history to ensure this treatment is safe for you.

Prolet 12.5 Tablet can interact with alcohol, smoking, and other drugs, potentially increasing drowsiness or reducing the medication's effectiveness. Speak to your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an elderly individual, as you may require special monitoring or adjustments.

Uses of Prolet 12.5 Tablet

Prolet 12.5 Tablet is used to treat Epilepsy (fits), Bipolar disorder, and Migraine. The detailed use of Prolet 12.5 Tablet is as follows:

  • Control of epilepsy and seizures: Prolet 12.5 Tablet helps reduce the frequency and intensity of generalized tonic-clonic (grand mal), focal, and psychomotor seizures by calming overactive nerve pathways in the brain.
  • Management of essential tremor: Prolet 12.5 Tablet helps control involuntary shaking of the hands, head, or voice, making daily activities like writing, eating, and drinking much easier.

Key Benefits

Prolet 12.5 Tablet helps control seizures and certain types of tremors, improving daily functioning and overall quality of life. Reducing abnormal nerve activity helps promote greater independence and confidence in everyday activities. Benefits may include:

  • Helps reduce the frequency and severity of seizures.
  • Supports long-term control of epilepsy and seizure disorders.
  • Helps reduce essential tremors and improves hand steadiness.
  • Makes everyday activities such as writing, eating, and dressing easier to perform.
  • Promotes greater independence and confidence in daily life.
  • Supports improved overall quality of life through effective symptom management.
Side effects of Prolet 12.5 Tablet
  • Regular eye exams can detect conditions causing Involuntary Eye Movement.
  • Alcohol and drugs should be avoided as they can increase the symptoms of nystagmus.
  • Wearing corrective lenses for refractive errors can reduce eye strain and symptoms.
  • Stress management and getting proper sleep can help to reduce symptoms.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Prolet 12.5 Tablet can be taken with or without food, as advised by your doctor.
  • It is usually taken twice daily or as prescribed by your doctor.
  • Swallow Prolet 12.5 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Prolet 12.5 Tablet Works

Prolet 12.5 Tablet contains Primidone, which belongs to a class of medications known as anticonvulsants. Inside your body, the active medicine is slowly processed by your liver into other active components, including phenobarbital. These substances work together to calm hyperactive nerve cells in the central nervous system. By boosting the activity of a natural calming chemical in the brain called GABA, and by limiting rapid electrical firing in the nerve pathways, Prolet 12.5 Tablet prevents abnormal electrical signals from spreading. This dual action stabilizes brain activity, preventing the onset of seizures and dampening the physical signals that cause involuntary muscle shaking.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Prolet 12.5 Tablet to prevent unpleasant side effects.

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Pregnancy

Caution

Do not take Prolet 12.5 Tablet if you are pregnant unless prescribed by the doctor. If you become pregnant while taking Prolet 12.5 Tablet , then do not stop taking Prolet 12.5 Tablet without consulting your doctor. Your doctor will prescribe Prolet 12.5 Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will decide whether Prolet 12.5 Tablet can be given to breastfeeding mothers.

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Driving

Caution

Prolet 12.5 Tablet may cause dizziness and drowsiness, drive and operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Prolet 12.5 Tablet can be given to children if prescribed by the doctor.

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Heart

Caution

Prolet 12.5 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Prolet 12.5 Tablet .

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Geriatrics

Caution

Prolet 12.5 Tablet can be given in elderly patients with extreme caution, if prescribed by the physician. Careful monitoring of the patient is required.

What if I have taken an overdose of Prolet 12.5 Tablet

If you suspect an overdose, seek immediate medical attention or call your local poison control center. Symptoms of an overdose may include extreme drowsiness, severe clumsiness, rapid eye movements, or shallow breathing.

Diet & Lifestyle Advise

  • Avoid alcohol entirely: Alcohol can dangerously increase the sedative effects of Prolet 12.5 Tablet , causing extreme drowsiness, and can also trigger seizures or worsen tremors.
  • Maintain a consistent sleep routine: Lack of sleep is a well-known trigger for seizures. Aim for 7 to 9 hours of quality sleep every night.
  • Manage physical and emotional stress: High stress levels can worsen both tremors and seizure activity. Practicing deep breathing, meditation, or gentle yoga can help keep your nervous system calm.
  • Limit caffeine intake: Excessive caffeine from coffee, energy drinks, or soda can stimulate the nervous system and directly worsen hand shakes and tremors.
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How Soon It Starts Working

  • The time required for Prolet 12.5 Tablet to start to work: Prolet 12.5 Tablet ideally shows its action within 3 hours after administration.
  • The time for which the effects of Prolet 12.5 Tablet last: The duration of action for Prolet 12.5 Tablet is clinically unknown.

What if you forget to take Prolet 12.5 Tablet

If you miss a dose of Prolet 12.5 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Prolet 12.5 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop treatment abruptly: Never stop taking Prolet 12.5 Tablet suddenly, as this may trigger severe, prolonged seizures that can be life-threatening. Your doctor will advise you on how to reduce the dose safely if treatment needs to be stopped.
  • Use caution during activities requiring alertness: Prolet 12.5 Tablet may cause drowsiness, dizziness, or impaired coordination. Avoid driving, operating heavy machinery, or performing hazardous tasks until you know how the medicine affects you.
  • Monitor for serious skin reactions: Contact your healthcare provider immediately if you develop an unexplained skin rash, blistering, peeling, or other signs of a severe allergic skin reaction.
  • Carry medical identification: Consider carrying a medical ID card or wearing a medical alert bracelet stating that you take Prolet 12.5 Tablet so emergency healthcare providers are aware of your treatment.
  • Inform healthcare providers before procedures: Tell your dentist, surgeon, or other healthcare professionals that you are taking Prolet 12.5 Tablet before undergoing any medical or dental procedure.

Drug-Drug Interactions

verifiedApollotooltip
  • Hormonal contraceptives (e.g., birth control pills, patches, implants): Prolet 12.5 Tablet may reduce the effectiveness of hormonal birth control, increasing the risk of unintended pregnancy. Your doctor may recommend using a non-hormonal method of contraception.
  • Medicines that cause drowsiness (e.g., sleeping pills, muscle relaxants, opioid pain relievers, certain allergy medicines): Taking these alongside Prolet 12.5 Tablet may cause excessive drowsiness, dizziness, slow breathing, and impaired coordination.
  • Other anti-seizure medicines (e.g., phenytoin, sodium valproate): Combining these with Prolet 12.5 Tablet may alter the levels of both medicines in the body and require closer monitoring or dose adjustments.
  • Blood thinners (e.g., warfarin): Prolet 12.5 Tablet may reduce the effectiveness of blood thinners, increasing the risk of blood clots.
PrimidonePraziquantel
Critical
PrimidoneDaclatasvir
Critical

Drug-Drug Interactions

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PrimidonePraziquantel
Critical
How does the drug interact with Prolet 12.5 Tablet:
Taking praziquantel with Prolet 12.5 Tablet can lower the levels of praziquantel in your blood, which leads to a decreased therapeutic effect.

How to manage the interaction:
Taking Prolet 12.5 Tablet with Praziquantel is not recommended. Please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PrimidoneDaclatasvir
Critical
How does the drug interact with Prolet 12.5 Tablet:
Coadministration of daclatasvir with Prolet 12.5 Tablet may decrease the blood levels of daclatasvir, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between Prolet 12.5 Tablet and Daclatasvir, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneLurasidone
Critical
How does the drug interact with Prolet 12.5 Tablet:
Co-administration of lurasidone with Prolet 12.5 Tablet may result in significantly lower blood levels of lurasidone, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
There is an interaction between Lurasidone and Prolet 12.5 Tablet, so it is not recommended; it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneRanolazine
Critical
How does the drug interact with Prolet 12.5 Tablet:
Coadministration of ranolazine with Prolet 12.5 Tablet can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between Prolet 12.5 Tablet and Ranolazine, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneVoriconazole
Critical
How does the drug interact with Prolet 12.5 Tablet:
Taking voriconazole together with Prolet 12.5 Tablet may reduce the blood levels of voriconazole, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Voriconazole and Prolet 12.5 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PrimidoneRitonavir
Critical
How does the drug interact with Prolet 12.5 Tablet:
Taking ritonavir and Prolet 12.5 Tablet may decrease the blood levels of ritonavir.

How to manage the interaction:
Taking Prolet 12.5 Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneBoceprevir
Critical
How does the drug interact with Prolet 12.5 Tablet:
Coadministration of boceprevir with Prolet 12.5 Tablet may decrease the blood levels of boceprevir, which may make it less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between Prolet 12.5 Tablet and boceprevir, they can be taken together if your doctor advises. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PrimidonePirfenidone
Critical
How does the drug interact with Prolet 12.5 Tablet:
Coadministration of pirfenidone with Prolet 12.5 Tablet can reduce levels and the effects of pirfenidone.

How to manage the interaction:
Although there is an interaction between pirfenidone and Prolet 12.5 Tablet, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneIsavuconazole
Critical
How does the drug interact with Prolet 12.5 Tablet:
Taking isavuconazole with Prolet 12.5 Tablet may decrease the blood levels of isavuconazole and reduce its effectiveness.

How to manage the interaction:
Taking isavuconazole with Prolet 12.5 Tablet is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PrimidoneEthinylestradiol
Severe
How does the drug interact with Prolet 12.5 Tablet:
Coadministration of ethinylestradiol with Prolet 12.5 Tablet may decrease the blood levels of ethinylestradiol and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between Prolet 12.5 Tablet with ethinylestradiol, it can be taken if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol while taking Prolet 12.5 Tablet , as it may increase drowsiness, dizziness, coordination problems, and the risk of seizures.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Prolet 12.5 Tablet is used for the treatment of Epilepsy (fits), Bipolar disorder, and Migraine.
Prolet 12.5 Tablet works by controlling overactivity of the brain that causes seizures (fits). Thereby, Prolet 12.5 Tablet helps in controlling epileptic fits involving spasms of the muscles and jerking.
Prolet 12.5 Tablet can make birth control pills less effective. Talk to your doctor about using non-hormonal contraceptives like condoms and diaphragm with spermicide to prevent pregnancy.
Please do not stop taking Prolet 12.5 Tablet without consulting your doctor as it may cause increased seizures. Continue taking Prolet 12.5 Tablet for as long as your doctor prescribes it. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Prolet 12.5 Tablet .
Yes, Prolet 12.5 Tablet may cause swelling in the gums. Brush and floss your teeth daily; visit your dentist if you experience this problem regularly.
You should not take Prolet 12.5 Tablet if you have liver disease, kidney disease, porphyria (an inherited disease that affects haemoglobin biosynthesis), alcohol dependence and suicidal thoughts.
Primidone may affect the breakdown of blood sugar/glucose and may prevent the release of insulin, thereby leading to high blood sugar. This is important if you have diabetes. So, contact a doctor before using Prolet 12.5 Tablet in this condition.
A partial seizure, also known as a focal seizure, occurs when there is abnormal electrical activity in just one part of the brain. These seizures can cause a variety of symptoms depending on the area of the brain affected.
It is essential to inform your doctor if are allergic to Prolet 12.5 Tablet , if you are taking vitamins, supplements, herbal products and other medicines. Let your know doctor if you have or have ever had porphyria (condition in which certain natural substances accumulate in the body and may cause changes in thinking and behaviour, stomach pain, or other symptoms). It is crucial to inform your doctor if you are pregnant or planning to become pregnant.
No, Prolet 12.5 Tablet is not habit forming. However, with the long-term use, Prolet 12.5 Tablet can be habit forming. So it's important to take it exactly as prescribed by your doctor. If you have any concerns regarding this, please discuss with your doctor.
If Prolet 12.5 Tablet makes you feel sleepy, avoid driving or operating heavy machinery. Avoid taking Prolet 12.5 Tablet if you are pregnant or breastfeeding unless prescribed by your doctor. Avoid alcohol consumption while taking Prolet 12.5 Tablet as it may cause unpleasant side effects.
The serious side effects of Prolet 12.5 Tablet are painful joints, yellowing of the skin and/or eyes, fever, bleeding or bruising under the skin, suicidal thoughts or behaviour, unusual changes in moods, worsening of depression and swelling of the face, lips, tongue or throat. To check for these side effects, it's important to, monitor for symptoms, and inform your doctor immediately if you notice any of these symptoms.
Yes, Prolet 12.5 Tablet can cause headache as a mild and temporary side effect. However, if you experience persistent or severe headaches, please consult your doctor.
No, Prolet 12.5 Tablet does not have any effect on blood pressure. However consult your doctor, if you notice any changes in the blood pressure.
You are recommended to consult your doctor before taking Prolet 12.5 Tablet with propranolol or any other medicines to avoid possible interactions.
Store Prolet 12.5 Tablet at room temperature in a cool and dry place away from sunlight. Keep it out of reach of children.
No, you should never stop taking Prolet 12.5 Tablet suddenly. Doing so can cause your seizures to return more frequently or severely, or cause your tremors to worsen. If you need to stop, your doctor will guide you on gradually decreasing your dose. Talk to your doctor before making any changes.
Taking Prolet 12.5 Tablet during pregnancy or breastfeeding requires careful medical consideration, as it can affect the baby. However, stopping your seizure medication suddenly can also be dangerous. Talk to your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.
Yes, you can take Prolet 12.5 Tablet either with or without food. If the medication causes you to have a mild upset stomach, taking it with a meal or a snack can help reduce this side effect. Talk to your doctor or pharmacist if stomach upset continues.

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Country of origin

India

Manufacturer/Marketer address

Alteus Biogenics Pvt. Ltd., 14-B Dover Lane, Kolkata - 700029, Wb, India.
Other Info - PRO2505

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