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compositionComposition:METOCLOPRAMIDE-5MG
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Prescription Medicine
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Perinorm Injection is an anti-emetic medication used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, migraine, and post-operative conditions. It contains metoclopramide which increases the motility of the upper gastrointestinal tract and thus helps in gastric emptying. Some of the common side effects include fatigue, dizziness, headache, and bowel disturbances.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METOCLOPRAMIDE-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Perinorm Injection

Perinorm Injection is a prescription injection used to treat severe nausea and vomiting, especially when caused by chemotherapy, radiation therapy, or after surgical procedures. It is also used to help patients with diabetic gastroparesis, a condition where the stomach takes too long to empty its contents. This medicine helps speed up the movement of food through the digestive tract to provide relief from discomfort.

Because Perinorm Injection is given as an injection, it is typically used for short-term treatment. It is important to receive or use this medicine consistently as scheduled by your healthcare provider to get the best results. Making simple lifestyle adjustments, such as eating smaller meals and avoiding fatty foods, can further support your recovery while on this treatment.

While using Perinorm Injection, you might experience mild side effects like drowsiness, restlessness, or low energy. However, you must contact your doctor immediately if you experience serious side effects, such as unusual muscle movements, muscle stiffness, or sudden mood changes.

Talk to your doctor before starting this medicine if you have a history of depression, high blood pressure, heart failure, or kidney problems. Do not take this if you have a history of bleeding, tears, or blockages in your stomach or intestines, epilepsy, or a tumour of the adrenal gland.

Avoid drinking alcohol while using Perinorm Injection, as it can significantly increase drowsiness and slow down your reaction times. Tell your doctor about all other medicines you are taking, especially sleep medicines, strong pain relievers, or antidepressants, as they can interact and worsen side effects. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Perinorm Injection

Perinorm Injection may be used to help manage the following conditions:

  • Severe nausea and vomiting: Perinorm Injection helps control severe nausea and vomiting, particularly after surgery or during chemotherapy and radiation treatments.
  • Diabetic gastroparesis: This medicine helps relieve symptoms like bloating, heartburn, and feeling too full by speeding up how quickly the stomach empties in people with diabetes.
  • Small bowel intubation: It is used to help pass tubes into the small intestine during medical procedures by increasing muscle movement in the upper digestive tract.

Key Benefits

Perinorm Injection injection is used to treat nausea and vomiting and to improve stomach emptying in certain conditions. It works by increasing the movement of the stomach and intestines, helping food pass more easily through the digestive tract.

  • Provides Rapid Relief from Nausea and Vomiting: As an injectable medicine, it acts quickly to control severe nausea and vomiting, especially when oral medicines cannot be taken.
  • Improves Stomach Emptying: Helps move food from the stomach into the intestines more efficiently, reducing symptoms of delayed stomach emptying.
  • Relieves Digestive Discomfort: Helps reduce bloating, fullness, acid reflux, and discomfort associated with slow stomach movement.
  • Supports Medical Procedures: May be used before certain diagnostic procedures or to facilitate the placement of feeding tubes by improving stomach emptying.
  • Promotes Recovery: By controlling nausea and improving digestion, it helps maintain hydration, nutrition, and overall comfort during recovery.
Side effects of Perinorm Injection 20 ml
  • Stretching and walking are examples of mild exercises that can improve mobility and reduce muscle stiffness.
  • Improving posture, mobility, and muscle coordination through physical therapy can help manage slowness or stiffness.
  • Maintain healthy weight and advance general health depend on eating a balanced diet.
  • Reducing symptoms like tremors or muscle spasms requires adequate sleep and rest.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Perinorm Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Perinorm Injection Works

Perinorm Injection contains metoclopramide. works mainly by blocking dopamine D2 receptors in the brain and digestive tract. In the brain, this helps prevent nausea and vomiting by blocking signals in the vomiting centre. In the stomach and intestines, it increases the movement of food through the digestive tract by enhancing the action of natural nerve signals that stimulate gut muscles. At higher doses, it may also stimulate 5-HT4 (serotonin) receptors, further improving stomach emptying and intestinal movement.
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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Perinorm Injection as it may cause increased sleepiness and drowsiness.

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Pregnancy

Caution

Consult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Perinorm Injection may be excreted in human milk. Consult your doctor if you are breastfeeding.

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Driving

Caution

Perinorm Injection may cause dizziness and drowsiness. Do not drive or operate machinery until you know how Perinorm Injection affects you.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Perinorm Injection is not recommended for children below one year.

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Heart

Caution

Perinorm Injection should be used with caution in patients with heart problems, especially those with arrhythmias, heart failure, or coronary artery disease. It may cause QT prolongation, bradycardia, or other cardiac side effects, so close monitoring and dose adjustment are essential.

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Geriatrics

Caution

Geriatric patients can receive Perinorm Injection, but it is more prone to side effects like drowsiness or movement disorders. Close monitoring and dose adjustments are recommended to ensure safety.

What if I have taken an overdose of Perinorm Injection

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include extreme drowsiness, confusion, or muscle spasms.

Diet & Lifestyle Advise

  • Eat smaller, more frequent meals: Instead of three large meals, eat five or six small meals daily to help your stomach process food more easily.
  • Avoid high-fat and high-fibre foods: Fatty, greasy, or highly fibrous foods take longer to digest and can worsen stomach delays.
  • Stay upright after eating: Sit or stand for at least two hours after a meal to help gravity assist your digestion and reduce reflux.
  • Limit liquids during meals: Drink fluids between meals rather than with your food to avoid making your stomach feel overly full.

Health Queries

Are Aciloc and Perinorm injections safe to receive during the fifth month of pregnancy?

Veda Maddala

Veda Maddala

M Pharmacy

Aciloc (ranitidine) and Perinorm (metoclopramide) injections are generally considered safe to use during the second trimester of pregnancy when prescribed by your doctor. They are typically used to treat severe acidity and nausea if oral medications aren't working. Please rest assured that these are commonly used and well-tolerated. However, always ensure they are administered under the direct supervision of your obstetrician to ensure the best care for you and your baby.
health query

Have a query?

How Soon It Starts Working

The time required for Perinorm Injection to start to work: Perinorm Injection ideally shows its action within 1 to 3 minutes for intravenous administration and 10 to 15 minutes for iintramuscular administration. The time for which the effects of Perinorm Injection last: The effect of Perinorm Injection lasts for 1 to 2 hours.

What if you forget to take Perinorm Injection

If you miss a scheduled injection, contact your doctor or healthcare provider right away for instructions. Do not double the dose to make up for a missed one.

Storage

• Store Perinorm Injection at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the Injection Before Use: Do not use the medicine if the solution appears cloudy, discoloured, contains visible particles, or if the vial or syringe is damaged.
  • Avoid Long-Term Use: Do not use Perinorm Injection for longer than 12 weeks unless specifically advised by your doctor, as prolonged use may increase the risk of involuntary muscle movement disorders.
  • Avoid Driving Until You Know Its Effects: This medicine may cause drowsiness, dizziness, or reduced alertness. Do not drive or operate machinery until you know how it affects you.
  • Use Sterile Injection Equipment: If self-administering, always use a new sterile needle and syringe for each injection and dispose of used sharps safely in an approved sharps container.
  • Report Unusual Muscle Movements Immediately: Contact your doctor promptly if you develop stiffness, muscle spasms, twitching, or unusual movements of your face, tongue, or limbs.

Drug-Drug Interactions

verifiedApollotooltip

  • Strong pain medicines (opioids) and sleep aids: May increase drowsiness and reduce the effectiveness of Perinorm Injection on stomach movement.
  • MAO inhibitors (antidepressants): Combining these can cause a dangerous spike in blood pressure.
  • Parkinson’s disease medications: May reduce the effectiveness of both medicines and increase muscle-related side effects.
MetoclopramideTrazodone
Critical
MetoclopramidePromethazine
Critical

Drug-Drug Interactions

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MetoclopramideTrazodone
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Perinorm Injection 20 ml with Trazodone can rarely increase serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Perinorm Injection 20 ml with Trazodone is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience any symptoms like dizziness, fever, excessive sweating, shivering, blurred vision, muscle stiffness, stomach cramps, nausea, vomiting, or diarrhoea contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
MetoclopramidePromethazine
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Perinorm Injection 20 ml with Promethazine can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Promethazine with Perinorm Injection 20 ml is generally avoided as it can possibly result in an interaction. They can be taken together However, consult a doctor if you experience puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
MetoclopramideClozapine
Critical
How does the drug interact with Perinorm Injection 20 ml:
Co-administration of Perinorm Injection 20 ml with Clozapine can increase the risk of side effects.

How to manage the interaction:
Taking Perinorm Injection 20 ml with Clozapine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MetoclopramideNefazodone
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Perinorm Injection 20 ml with Nefazodone can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Perinorm Injection 20 ml with Nefazodone is generally avoided as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without consulting a doctor.
MetoclopramideMethyldopa
Critical
How does the drug interact with Perinorm Injection 20 ml:
Taking Methyldopa and Perinorm Injection 20 ml together can decrease the levels and effects of Methyldopa.

How to manage the interaction:
Taking Perinorm Injection 20 ml with Methyldopa is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MetoclopramideProchlorperazine
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Perinorm Injection 20 ml and prochlorperazine can increase the risk of side effects.

How to manage the interaction:
Taking Perinorm Injection 20 ml with Prochlorperazine together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
MetoclopramideLurasidone
Critical
How does the drug interact with Perinorm Injection 20 ml:
The combination of Lurasidone and Perinorm Injection 20 ml may result in significantly increased Lurasidone blood levels. This may raise the possibility of undesirable consequences such as Parkinson's disease. (It is a neurological condition that causes uncontrollable movements)and Tardive dyskinesia (uncontrollable movements, particularly of the lower face).

How to manage the interaction:
Lurasidone and Perinorm Injection 20 ml is not recommended, as they may interact, but can be used if a doctor prescribes them. Consult a doctor if you have muscle spasms, or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning, tongue thrusting, teeth clenching, jaw twitching, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without visiting a doctor.
MetoclopramideRisperidone
Critical
How does the drug interact with Perinorm Injection 20 ml:
Co-administration of Perinorm Injection 20 ml with Risperidone can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Risperidone with Perinorm Injection 20 ml is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking, jitteriness, restlessness, pacing, and foot tapping contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
MetoclopramideTetrabenazine
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Tetrabenazine and Perinorm Injection 20 ml can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Tetrabenazine and Perinorm Injection 20 ml together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetoclopramideDuloxetine
Critical
How does the drug interact with Perinorm Injection 20 ml:
Coadministration of Perinorm Injection 20 ml with duloxetine increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Perinorm Injection 20 ml with Duloxetine is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol, as it can significantly increase drowsiness and dizziness caused by this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS, GASTROPROKINETIC AGENTS]

FAQs

Perinorm Injection belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, migraine, and in post-operative conditions. Additionally, Perinorm Injection is also used to treat delayed gastric emptying.
Perinorm Injection works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and treats gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.
Perinorm Injection may cause tardive dyskinesia (movement disorder) that is often irreversible. The risk increases with the duration of treatment and dosage. Perinorm Injection therapy should be discontinued in patients who develop the symptoms of tardive dyskinesia. Consult your doctor immediately if you notice symptoms such as involuntary movements of the face, tongue, mouth, jaw, trunk and/or extremities.
Perinorm Injection may be used to facilitate small bowel intubation (the process of passing a small, flexible plastic tube through the nose/mouth into the stomach/small intestine) in adults and pediatric patients in whom the tube does not pass the pylorus (the opening from the stomach into the duodenum) with conventional manoeuvres.
Treatment with Perinorm Injection should be avoided for longer than 12 weeks except in rare cases where benefits outweigh the risks of developing tardive dyskinesia.
Perinorm Injection may cause depression in people with or without a medical history of depression. Consult your doctor immediately if you have any suicidal thoughts, such as killing or harming yourself.
Perinorm Injection may be used to facilitate gastric emptying and intestinal transit of barium in patients where delayed emptying interrupts radiological examination of the stomach and/or small intestine.
Yes, if your doctor determines it is safe, you or a caregiver can be trained to inject this medicine at home. Make sure you fully understand the injection technique and safety steps. Talk to your doctor or pharmacist if you have any questions.
Yes, drowsiness is a common side effect of this medicine. Avoid driving or performing tasks that require concentration until you know how it affects you. Talk to your doctor if the sleepiness becomes severe.
This medicine should only be used during pregnancy if your doctor decides the benefits outweigh the risks. Talk to your doctor to discuss your options safely.
Tell your healthcare provider or seek medical attention immediately if you develop muscle twitching, unusual muscle movements, stiffness, or uncontrollable movements. These symptoms may indicate a serious side effect that requires prompt medical evaluation.
No, you should avoid alcohol while using this medicine. Alcohol can worsen side effects like extreme drowsiness, dizziness, and slow reactions. Talk to your doctor or pharmacist if you have questions about alcohol use.
Used needles and syringes must be placed in a puncture-resistant sharps disposal container immediately after use. Never throw them in your regular household trash. Talk to your pharmacist or local waste authority for disposal guidelines.
Perinorm Injection may be used in children only when prescribed by a doctor. Children and adolescents have a higher risk of developing involuntary muscle movements and other nervous system side effects, so they require careful monitoring during treatment.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - PER0370

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