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compositionComposition:INDAPAMIDE-1.25MG+PERINDOPRIL-4MG
prescription
Prescription Medicine
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Perigard D Tablet is used to treat Hypertension (High blood pressure). It contains Perindopril and Indapamide, which relax blood vessels and lower high blood pressure. Also, it increases the amount of urine passed out from the kidneys. Sometimes, it may cause headaches, tiredness, a slow heart rate, and nausea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

INDAPAMIDE-1.25MG+PERINDOPRIL-4MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Perigard D Tablet

Perigard D Tablet is a prescription medicine used to treat high blood pressure (hypertension). It contains two active ingredients that work together to lower blood pressure, helping to reduce the risk of serious cardiovascular events. Doctors typically prescribe this oral tablet to patients whose blood pressure is not fully controlled by a single medicine.

To get the best results, you should take Perigard D Tablet consistently once a day, preferably in the morning before breakfast. Taking it at the same time every day helps keep a steady amount of medicine in your body. Combining this medication with healthy lifestyle choices, like eating a low-salt diet and getting regular exercise, will help you manage your blood pressure more effectively.

While taking Perigard D Tablet , you may experience some mild side effects such as dizziness, a dry cough, or feeling unusually tired. Most of these effects go away as your body gets used to the medicine. However, if you experience serious symptoms like swelling of the face, lips, or throat, or a sudden change in how much you urinate, contact your doctor immediately.

Do not take this if you are pregnant, planning to become pregnant, or have severe kidney or liver disease. It is also important to tell your healthcare provider if you have diabetes, heart rhythm problems, or gout before starting this medication. Your doctor will evaluate if Perigard D Tablet is safe and appropriate for your specific health history.

Perigard D Tablet can interact with other medications, such as potassium supplements, pain relievers like ibuprofen, and lithium, which can affect how your kidneys work or dangerously alter your potassium levels. Drinking alcohol while taking this medicine can cause your blood pressure to drop too low, making you feel extremely dizzy or faint. Breastfeeding individuals and elderly patients should consult their doctor before using Perigard D Tablet to ensure safe monitoring.

Uses of Perigard D Tablet

Perigard D Tablet is used to treat high blood pressure (hypertension). The detailed uses of Perigard D Tablet are as follows:

  • High Blood Pressure (Hypertension): Perigard D Tablet is used to treat long-term high blood pressure when treatment with a single drug has not been effective. Lowering blood pressure helps reduce the strain on your heart and arteries.
     

Key Benefits

Perigard D Tablet helps manage high blood pressure and supports long-term cardiovascular health. By combining two blood pressure-lowering medicines in a single tablet, it provides effective blood pressure control while helping protect vital organs from the effects of hypertension.

  • Helps Maintain Healthy Blood Pressure Levels: By lowering and controlling elevated blood pressure, Perigard D Tablet helps reduce strain on the heart and blood vessels, supporting stable blood pressure throughout the day.
  • Supports Long-Term Heart, Brain, and Kidney Health: Effective blood pressure management with Perigard D Tablet helps reduce the risk of complications such as heart attack, stroke, and kidney damage, promoting long-term cardiovascular and overall health.
  • Offers Convenient Combination Therapy: By combining two antihypertensive medicines into a single daily tablet, Perigard D Tablet simplifies your treatment routine, supports better medication adherence, and helps maintain consistent blood pressure control over the long term.
     

Directions for Use

  • Perigard D Tablet can be taken before a meal, preferably in the morning or as advised by your doctor.
  • It should be taken once a day or as directed by the doctor.
  • Swallow Perigard D Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Perigard D Tablet Works

Perigard D Tablet works through a dual mechanism because it combines two active blood-pressure-lowering medicines in a single oral tablet. The first medicine, Perindopril, belongs to a class called ACE inhibitors. It relaxes and widens your blood vessels by blocking a natural substance in the body that causes them to tighten, allowing your blood to flow more easily. The second medicine, indapamide, is a diuretic, often referred to as a water pill. It works in your kidneys to help your body eliminate extra salt and water through your urine. Together, these two actions reduce the volume of fluid in your blood vessels and lower the resistance your heart faces when pumping blood, resulting in a steady, controlled decrease in blood pressure.
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Alcohol

Unsafe

Limit or cut down alcohol consumption; alcohol consumption may enhance this drug's hypotensive (low blood pressure) effect

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Pregnancy

Caution

The use of Perigard D Tablet or any ACE inhibitors (pregnancy category D) is usually contraindicated during the second and third trimesters of pregnancy. It may cause harm to the developing fetus. Hence, you should always consult your doctor before using Perigard D Tablet .

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Breast Feeding

Caution

Use of Perigard D Tablet is not recommended during the breastfeeding stage.

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Driving

Caution

Drive with caution, Perigard D Tablet may cause blurry vision, and dizziness or weariness may occur.

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Liver

Caution

Perigard D Tablet to be taken with caution, especially in case of severe liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Perigard D Tablet to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. Perigard D Tablet should be given with precaution in hemodialysis conditions.

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Children

Caution

Perigard D Tablet is not recommended for children. The safety and effectiveness of Perigard D Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Perigard D Tablet or not.

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Heart

Safe if prescribed

Perigard D Tablet is generally safe and beneficial for many heart patients, particularly those with high blood pressure. However, it must be used under a doctor's supervision.

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Geriatrics

Safe if prescribed

Perigard D Tablet is considered safe for use in elderly (geriatric) patients, but with careful monitoring and dose adjustment as needed.

What if I have taken an overdose of Perigard D Tablet

If you take too much, Perigard D Tablet , you may experience extreme dizziness, fainting, weakness, or nausea. Seek immediate medical attention or call emergency services if you suspect an overdose.

Diet & Lifestyle Advise

  • Reduce salt (sodium) intake: High salt intake raises blood pressure and can reduce the effectiveness of Perigard D Tablet . Try to limit processed foods and avoid adding extra salt to your meals.
  • Monitor your potassium intake: Since this medicine can affect potassium levels in your body, check with your doctor before using salt substitutes or taking potassium supplements.
  • Stay moderately active: Engaging in regular, low-impact exercise like walking, swimming, or cycling can naturally help lower your blood pressure and strengthen your heart.
  • Limit alcohol consumption: Drinking alcohol can cause your blood pressure to drop dangerously low while taking this medicine, leading to severe dizziness or fainting.
  • Stay hydrated: Drink plenty of fluids throughout the day, especially in hot weather or during exercise, as this medicine helps your body lose water.
     
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How Soon It Starts Working

The time required for Perigard D Tablet to start to work: The time required for Perigard D Tablet to show its action is unknown.

The time for which the effects of Perigard D Tablet last: The effect of Perigard D Tablet lasts for 24 hours.

What if you forget to take Perigard D Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your normal schedule. Do not take a double dose to make up for a forgotten one.

Storage

•Store Perigard D Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F), away from direct sunlight, moisture, and heat. • Do not store this medication in the bathroom, as humidity can damage the tablets.

Drug Warnings

  • Always stand up slowly from a sitting or lying position to prevent dizziness and reduce the risk of falling.
  • Check your blood pressure regularly at home as advised by your doctor, and keep a log of your readings to share during your check-ups.
  • Avoid driving or operating heavy machinery until you know how Perigard D Tablet affects you, as it can cause dizziness or fatigue, especially during the first few days of treatment.
  • Inform any surgeon, dentist, or medical specialist that you are taking Perigard D Tablet before undergoing any medical procedures or surgeries.
  • Get your blood tested regularly; your doctor will need to monitor your kidney function and electrolyte levels (like potassium and sodium) while you are taking this medicine.
  • Be cautious in hot weather or during intense exercise, as excessive sweating can lead to dehydration and a sharp drop in blood pressure.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Blood pressure medicines, diuretics (water tablets), and lithium: Taking Perigard D Tablet with other antihypertensive medicines or diuretics may cause blood pressure to fall too low, leading to dizziness or fainting. Perigard D Tablet may also increase lithium levels in the blood, raising the risk of lithium toxicity. Your doctor may recommend closer monitoring if these medicines are used together.
  • Potassium-sparing diuretics, potassium supplements, and potassium-containing salt substitutes: Combining these products with Perigard D Tablet may significantly increase the risk of hyperkalaemia (high potassium levels), which can affect heart rhythm and muscle function. Regular monitoring of blood potassium levels may be required.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen): Regular use of NSAIDs may reduce the blood-pressure-lowering effect of Perigard D Tablet and increase the risk of kidney problems, particularly in patients with existing kidney disease or dehydration.
     
Perindopril + IndapamideAliskiren
Critical
Perindopril + IndapamideThioridazine
Critical

Drug-Drug Interactions

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Perindopril + IndapamideAliskiren
Critical
How does the drug interact with Perigard D Tablet:
Co-administration of Aliskiren with Perindopril and Indapamide can increase the risk of kidney problems..

How to manage the interaction:
Taking Perindopril and Indapamide with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience tingling of the hands and feet, feelings of heaviness in the legs, irregular heartbeat contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Perindopril + IndapamideThioridazine
Critical
How does the drug interact with Perigard D Tablet:
Co-administration of Perindopril and Indapamide with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Thioridazine with Perindopril and Indapamide is not recommended, but can be taken if prescribed by the doctor.
Perindopril + IndapamideProtriptyline
Critical
How does the drug interact with Perigard D Tablet:
Taking Protriptyline along with Perindopril and Indapamide can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Protriptyline with Perindopril and Indapamide is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
Perindopril + IndapamideDroperidol
Critical
How does the drug interact with Perigard D Tablet:
Co-administration of Droperidol with Perindopril and Indapamide can lead to irregular heart rhythm.

How to manage the interaction:
Taking Droperidol with Perindopril and Indapamide is not recommended, but can be taken if prescribed by the doctor. However, contact a doctor if you experience any symptoms such as tiredness, drowsiness, confusion, muscle pain, cramps, dizziness. Do not discontinue the medication without consulting a doctor.
Perindopril + IndapamidePotassium gluconate
Severe
How does the drug interact with Perigard D Tablet:
Co-administration of Potassium gluconate with Perindopril and Indapamide can cause hyperkalaemia (high levels of potassium in blood) which increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Taking Perindopril and Indapamide with Potassium gluconate together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience tingling of the hands and feet, feelings of heaviness in the legs, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Perindopril + IndapamideLomitapide
Severe
How does the drug interact with Perigard D Tablet:
Taking Perindopril and Indapamide with Lomitapide can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Perindopril and Indapamide with Lomitapide, but it can be taken if prescribed by a doctor. However, if you experience itching, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Perindopril + IndapamideLithium
Severe
How does the drug interact with Perigard D Tablet:
Co-administration of Perindopril and Indapamide when taken together with Lithium may significantly increase the blood levels of Lithium.

How to manage the interaction:
Although there is drug interaction between Perindopril and Indapamide with Lithium, but can be taken together if advised by a doctor. if experience muscle weakness, tremor (shaking of hand & legs) ringing in the ear, increased urination consult a doctor immediately. Do not discontinue medications without consulting a doctor.
Perindopril + IndapamideTrimethoprim
Severe
How does the drug interact with Perigard D Tablet:
Taking Perindopril and Indapamide with Trimethoprim can cause hyperkalaemia (high levels of potassium in blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Co-administration of Perindopril and Indapamide with Trimethoprim can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience tingling of the hands and feet, feelings of heaviness in the legs, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Perindopril + IndapamidePiroxicam
Severe
How does the drug interact with Perigard D Tablet:
Co-administration of Perindopril and Indapamide together with Piroxicam may reduce the effects of Perindopril and Indapamide in lowering blood pressure, they may also increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Piroxicam with Perindopril and Indapamide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or weight loss, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Perindopril + IndapamideTelmisartan
Severe
How does the drug interact with Perigard D Tablet:
Taking Perindopril and Indapamide with Telmisartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and high blood potassium.

How to manage the interaction:
Although there is a possible interaction, Telmisartan can be taken with Perindopril and Indapamide if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as tingling of the hands and feet, feelings of heaviness in the legs. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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  • Potassium-containing salt substitutes: Avoid using salt substitutes that contain potassium unless advised by your doctor. Combining these products with Perigard D Tablet may increase the risk of excessively high potassium levels in the blood.
     
INDAPAMIDE-1.25MG+PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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INDAPAMIDE-1.25MG+PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Apricots, Avocado, Bananas, Beans, Beetroot, Broccoli, Coconut Water, Lentils, Orange Juice, Oranges, Potatoes, Raisins, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Yogurt

How to manage the interaction:
Consuming Potassium containing food with Perindopril and Indapamide can increase the risk of high levels of potassium in your blood. Avoid consuming Potassium-containing food with Perindopril and Indapamide.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Perigard D Tablet is used to treat hypertension (high blood pressure), a condition in which the blood exerts increased pressure on the walls of blood vessels.
Perigard D Tablet contains two medicines: Perindopril (blood pressure-lowering agent) and Indapamide (diuretic or water pill). Perindopril is an angiotensin-converting enzyme or ACE inhibitor that lowers high blood pressure by blocking a naturally occurring substance known as angiotensin II (which tightens your blood vessels). Indapamide (diuretic) increases the amount of urine passed out from the kidneys. Thus, both help lower high blood pressure, reducing the chances of a heart attack or stroke.
It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.
Usually, Perigard D Tablet is prescribed for a long-term treatment ranging from months to years for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor's consent can be fatal. Hence, only take it as long as your doctor prescribes it.
Before surgery, you should inform your doctor that you are taking Perigard D Tablet to reduce your blood pressure when used along with anaesthesia, which is given before a major operation.
Perigard D Tablet contains Indapamide, which gives a positive reaction to drug tests. If you are an athlete, be aware if you are taking Perigard D Tablet and are undergoing a drug test.
No, you should not take Perigard D Tablet if you are pregnant or planning to become pregnant. It can cause serious harm or death to an unborn baby. Talk to your doctor immediately about alternative blood pressure treatments if you become pregnant.
It is usually best to take Perigard D Tablet once a day in the morning, preferably before breakfast. Taking it early in the day helps prevent you from having to wake up during the night to urinate.
You should avoid or significantly limit alcohol while taking Perigard D Tablet . Alcohol can increase the blood pressure-lowering effect of the medicine, making you feel dizzy, lightheaded, or faint.
Yes, a dry, tickly cough is a common side effect of this medicine. If this cough becomes persistent or bothersome, do not stop taking the medicine on your own; talk to your doctor for advice.
Yes, your doctor will likely recommend regular blood tests to check your kidney function and the levels of electrolytes, such as potassium and sodium, in your blood.
You should avoid salt substitutes that contain potassium unless your doctor tells you otherwise. Combining these substitutes with Perigard D Tablet can lead to dangerously high levels of potassium in your body.
If you feel dizzy, sit or lie down until the feeling passes. To prevent dizziness when standing up, try to get up slowly from sitting or lying down. If the dizziness persists or worsens, talk to your doctor.

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Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - PER0013
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