Indapamide+perindopril
About Indapamide+perindopril
Indapamide+perindopril is a prescription medicine used to treat high blood pressure (hypertension). It contains two active ingredients that work together to lower blood pressure, helping to reduce the risk of serious cardiovascular events. Doctors typically prescribe this oral tablet to patients whose blood pressure is not fully controlled by a single medicine.
To get the best results, you should take Indapamide+perindopril consistently once a day, preferably in the morning before breakfast. Taking it at the same time every day helps keep a steady amount of medicine in your body. Combining this medication with healthy lifestyle choices, like eating a low-salt diet and getting regular exercise, will help you manage your blood pressure more effectively.
While taking Indapamide+perindopril, you may experience some mild side effects such as dizziness, a dry cough, or feeling unusually tired. Most of these effects go away as your body gets used to the medicine. However, if you experience serious symptoms like swelling of the face, lips, or throat, or a sudden change in how much you urinate, contact your doctor immediately.
Do not take this if you are pregnant, planning to become pregnant, or have severe kidney or liver disease. It is also important to tell your healthcare provider if you have diabetes, heart rhythm problems, or gout before starting this medication. Your doctor will evaluate if Indapamide+perindopril is safe and appropriate for your specific health history.
Indapamide+perindopril can interact with other medications, such as potassium supplements, pain relievers like ibuprofen, and lithium, which can affect how your kidneys work or dangerously alter your potassium levels. Drinking alcohol while taking this medicine can cause your blood pressure to drop too low, making you feel extremely dizzy or faint. Breastfeeding individuals and elderly patients should consult their doctor before using Indapamide+perindopril to ensure safe monitoring.
Uses of Indapamide+perindopril
Medicinal Benefits
Indapamide+perindopril helps manage high blood pressure and supports long-term cardiovascular health. By combining two blood pressure-lowering medicines in a single tablet, it provides effective blood pressure control while helping protect vital organs from the effects of hypertension.
- Helps Maintain Healthy Blood Pressure Levels: By lowering and controlling elevated blood pressure, Indapamide+perindopril helps reduce strain on the heart and blood vessels, supporting stable blood pressure throughout the day.
- Supports Long-Term Heart, Brain, and Kidney Health: Effective blood pressure management with Indapamide+perindopril helps reduce the risk of complications such as heart attack, stroke, and kidney damage, promoting long-term cardiovascular and overall health.
- Offers Convenient Combination Therapy: By combining two antihypertensive medicines into a single daily tablet, Indapamide+perindopril simplifies your treatment routine, supports better medication adherence, and helps maintain consistent blood pressure control over the long term.
Directions for Use
- Indapamide+perindopril can be taken before a meal, preferably in the morning or as advised by your doctor.
- It should be taken once a day or as directed by the doctor.
- Swallow Indapamide+perindopril as a whole with a glass of water.
- Do not chew, crush, or break it.
Storage
Side Effects of Indapamide+perindopril
Common Side Effects (Usually mild)
- Dry, tickly cough
- Dizziness or lightheadedness, especially when standing up quickly
- Feeling weak or unusually tired
- Mild headache or nausea
Serious Side Effects (Call a doctor right away)
- Allergic reactions, such as swelling of the face, lips, tongue, or throat, or difficulty breathing or swallowing
- Severe dizziness or fainting
- Signs of high or low potassium levels, such as muscle weakness, muscle cramps, or an irregular heartbeat
- Yellowing of your skin or eyes (jaundice), which may indicate liver damage
- A severe skin rash with blistering or peeling
Medicines Containing this Salt
View AllDrug Warnings
- Always stand up slowly from a sitting or lying position to prevent dizziness and reduce the risk of falling.
- Check your blood pressure regularly at home as advised by your doctor, and keep a log of your readings to share during your check-ups.
- Avoid driving or operating heavy machinery until you know how Indapamide+perindopril affects you, as it can cause dizziness or fatigue, especially during the first few days of treatment.
- Inform any surgeon, dentist, or medical specialist that you are taking Indapamide+perindopril before undergoing any medical procedures or surgeries.
- Get your blood tested regularly; your doctor will need to monitor your kidney function and electrolyte levels (like potassium and sodium) while you are taking this medicine.
- Be cautious in hot weather or during intense exercise, as excessive sweating can lead to dehydration and a sharp drop in blood pressure.
Drug Interactions
- Blood pressure medicines, diuretics (water tablets), and lithium: Taking Indapamide+perindopril with other antihypertensive medicines or diuretics may cause blood pressure to fall too low, leading to dizziness or fainting. Indapamide+perindopril may also increase lithium levels in the blood, raising the risk of lithium toxicity. Your doctor may recommend closer monitoring if these medicines are used together.
- Potassium-sparing diuretics, potassium supplements, and potassium-containing salt substitutes: Combining these products with Indapamide+perindopril may significantly increase the risk of hyperkalaemia (high potassium levels), which can affect heart rhythm and muscle function. Regular monitoring of blood potassium levels may be required.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen): Regular use of NSAIDs may reduce the blood-pressure-lowering effect of Indapamide+perindopril and increase the risk of kidney problems, particularly in patients with existing kidney disease or dehydration.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeLimit or cut down alcohol consumption; alcohol consumption may enhance this drug's hypotensive (low blood pressure) effect
Pregnancy
cautionThe use of Indapamide+perindopril or any ACE inhibitors (pregnancy category D) is usually contraindicated during the second and third trimesters of pregnancy. It may cause harm to the developing fetus. Hence, you should always consult your doctor before using Indapamide+perindopril.
Breast Feeding
cautionUse of Indapamide+perindopril is not recommended during the breastfeeding stage.
Driving
cautionDrive with caution, Indapamide+perindopril may cause blurry vision, and dizziness or weariness may occur.
Liver
cautionIndapamide+perindopril to be taken with caution, especially in case of severe liver disease. The dose may have to be adjusted by your doctor.
Kidney
cautionIndapamide+perindopril to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. Indapamide+perindopril should be given with precaution in hemodialysis conditions.
Children
cautionIndapamide+perindopril is not recommended for children. The safety and effectiveness of Indapamide+perindopril have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Indapamide+perindopril or not.
Habit Forming
Diet & Lifestyle Advise
- Reduce salt (sodium) intake: High salt intake raises blood pressure and can reduce the effectiveness of Indapamide+perindopril. Try to limit processed foods and avoid adding extra salt to your meals.
- Monitor your potassium intake: Since this medicine can affect potassium levels in your body, check with your doctor before using salt substitutes or taking potassium supplements.
- Stay moderately active: Engaging in regular, low-impact exercise like walking, swimming, or cycling can naturally help lower your blood pressure and strengthen your heart.
- Limit alcohol consumption: Drinking alcohol can cause your blood pressure to drop dangerously low while taking this medicine, leading to severe dizziness or fainting.
- Stay hydrated: Drink plenty of fluids throughout the day, especially in hot weather or during exercise, as this medicine helps your body lose water.
Special Advise
- Monitor your blood pressure daily, and if there is too much fluctuation, then immediately contact your doctor.
Patients Concern
Disease/Condition Glossary
Hypertension: The blood exerts increased pressure on the walls of blood vessels, leading to hypertension. High blood pressure is expressed as systolic/diastolic pressure. Systolic pressure is the pressure in the arteries when the heart beats or pumps out blood. Diastolic pressure is the pressure in the arteries between the heartbeats. Blood pressure is measured in millimetres of mercury (mmHg) by a blood pressure monitor called a sphygmomanometer. Some of the symptoms are headache, dizziness, nosebleeds, altered vision, chest pain, weakness, and shortness of breath. However, most of the time, the signs and symptoms of hypertension are none.
FAQs
Indapamide+perindopril is used to treat hypertension (high blood pressure), a condition in which the blood exerts increased pressure on the walls of blood vessels.
Indapamide+perindopril contains two medicines: Perindopril (blood pressure-lowering agent) and Indapamide (diuretic or water pill). Perindopril is an angiotensin-converting enzyme or ACE inhibitor that lowers high blood pressure by blocking a naturally occurring substance known as angiotensin II (which tightens your blood vessels). Indapamide (diuretic) increases the amount of urine passed out from the kidneys. Thus, both help lower high blood pressure, reducing the chances of a heart attack or stroke.
It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.
Usually, Indapamide+perindopril is prescribed for a long-term treatment ranging from months to years for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor's consent can be fatal. Hence, only take it as long as your doctor prescribes it.
Before surgery, you should inform your doctor that you are taking Indapamide+perindopril to reduce your blood pressure when used along with anaesthesia, which is given before a major operation.
Indapamide+perindopril contains Indapamide, which gives a positive reaction to drug tests. If you are an athlete, be aware if you are taking Indapamide+perindopril and are undergoing a drug test.
No, you should not take Indapamide+perindopril if you are pregnant or planning to become pregnant. It can cause serious harm or death to an unborn baby. Talk to your doctor immediately about alternative blood pressure treatments if you become pregnant.
It is usually best to take Indapamide+perindopril once a day in the morning, preferably before breakfast. Taking it early in the day helps prevent you from having to wake up during the night to urinate.
You should avoid or significantly limit alcohol while taking Indapamide+perindopril. Alcohol can increase the blood pressure-lowering effect of the medicine, making you feel dizzy, lightheaded, or faint.
Yes, a dry, tickly cough is a common side effect of this medicine. If this cough becomes persistent or bothersome, do not stop taking the medicine on your own; talk to your doctor for advice.
Yes, your doctor will likely recommend regular blood tests to check your kidney function and the levels of electrolytes, such as potassium and sodium, in your blood.
You should avoid salt substitutes that contain potassium unless your doctor tells you otherwise. Combining these substitutes with Indapamide+perindopril can lead to dangerously high levels of potassium in your body.
If you feel dizzy, sit or lie down until the feeling passes. To prevent dizziness when standing up, try to get up slowly from sitting or lying down. If the dizziness persists or worsens, talk to your doctor.
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