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Pantocid HP Combipack is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). It kills bacteria or prevents their growth. Also, it reduces the amount of acid produced in the stomach. It may cause common side effects, such as nausea, diarrhoea, vomiting, stomach pain, taste change, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMOXYCILLIN-750MG+CLARITHROMYCIN-500MG+PANTOPRAZOLE-40MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pantocid HP Combipack

Pantocid HP Combipack is an oral combination medicine prescribed to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach and digestive tract. By clearing this infection, it helps heal peptic ulcers and reduces the risk of ulcers returning. This combination works by lowering stomach acid and eliminating the bacteria responsible for ongoing stomach irritation and ulcer formation.

To get the best results, take Pantocid HP Combipack exactly as prescribed by your doctor, usually twice daily. It is generally taken before meals, commonly before breakfast and the evening meal, so the acid-reducing component can work effectively. Most treatment courses last about 7–14 days, depending on your doctor's recommendation and your individual condition.

Some people may experience mild side effects such as a temporary change in taste, mild diarrhea, nausea, or headache. These effects are often temporary and improve after treatment is completed. However, if you develop severe watery diarrhea, persistent stomach cramps, severe skin reactions, or yellowing of the skin or eyes, contact your doctor promptly.

Before starting Pantocid HP Combipack, tell your doctor if you have liver disease, kidney problems, heart rhythm disorders, or a history of allergies to penicillin antibiotics, macrolide antibiotics, or proton pump inhibitors. Your doctor will review your medical history to make sure this treatment is appropriate for you.

Avoid alcohol during treatment, as it may worsen stomach irritation and increase side effects such as nausea or dizziness. If you are pregnant, breastfeeding, elderly, or taking multiple medicines, consult your doctor before starting treatment. Because antibiotic resistance can affect treatment success, your doctor may select this therapy based on local resistance patterns and current treatment guidelines.

Uses of Pantocid HP Combipack

Pantocid HP Combipack is used in the treatment of Peptic ulcer disease. The detailed uses of Pantocid HP Combipack are as follows:

  • Helicobacter pylori (H. pylori) Infection: Pantocid HP Combipack eliminates the specific bacteria responsible for stomach irritation and ulcers, stopping the infection from spreading.
  • Peptic Ulcer Disease: By lowering stomach acid and clearing bacteria, Pantocid HP Combipack allows painful sores in the stomach lining or upper small intestine to heal completely.
  • Chronic Gastritis: It relieves severe inflammation of the stomach lining caused by bacterial overgrowth, reducing persistent stomach pain and bloating.

Key Benefits

Pantocid HP Combipack helps treat H. pylori infection and promote healing of stomach and duodenal ulcers by addressing the underlying cause of the condition. By reducing stomach acid and eliminating the infection, it helps relieve digestive discomfort and supports long-term recovery. Benefits may include:

  • Helps eliminate H. pylori bacteria from the digestive tract.
  • Supports healing of stomach and duodenal ulcers.
  • Reduces stomach acid and helps relieve burning pain and discomfort.
  • Improves symptoms such as indigestion, bloating, and stomach irritation.
  • Helps reduce the risk of ulcer recurrence when the full treatment course is completed.
  • Supports long-term digestive health and recovery.
Side effects of Pantocid HP Combipack
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth or herbal tea to soothe sore throat.
  • Gargle with warm salt water to decrease inflammation.
  • Suck on hard candies or lozenges to increase the production of saliva and soothe your throat.
  • Avoid smoking, spicy foods, and extremely hot fluids.
  • Rest your voice and get enough sleep.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Bitter or bad taste can be managed by taking Vitamin B12 supplements only after your doctor's consultation.
  • Maintain good oral hygiene by using mouthwash frequently and cleaning your tongue while brushing.
  • Avoid eating foods that cause heartburn or stomach pain, as they can lead to a bitter taste in your mouth.
  • Do not smoke or drink alcohol, as it can worsen your condition.

Directions for Use

  • Take Pantocid HP Combipack 30-60 minutes before food as advised by your doctor.
  • It is advised to take Pantocid HP Combipack as directed by your doctor, at the same time each day for best results.
  • Swallow Pantocid HP Combipack as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Pantocid HP Combipack Works

Pantocid HP Combipack contains Pantoprazole, Amoxycillin, and Clarithromycin. • Pantoprazole: It helps reduce the amount of acid produced in the stomach. This relieves symptoms such as heartburn and stomach pain and helps the stomach lining heal. • Amoxycillin: It is an antibiotic that helps kill the bacteria responsible for the infection, helping clear it from the body. • Clarithromycin: It is an antibiotic that helps stop the growth and multiplication of bacteria, supporting the treatment of the infection.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pantocid HP Combipack. Alcohol intake leads to increased production of stomach acid.

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Pregnancy

Consult your doctor

Consult your doctor before taking Pantocid HP Combipack if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Pantocid HP Combipack. Your doctor will decide whether Pantocid HP Combipack can be taken by breastfeeding mothers or not.

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Driving

Caution

Pantocid HP Combipack causes dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantocid HP Combipack if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantocid HP Combipack if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pantocid HP Combipack should not be given to children as the safety and effectiveness were not established.

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Heart

Caution

Pantocid HP Combipack should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Pantocid HP Combipack.

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Geriatrics

Safe if prescribed

Pantocid HP Combipack is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Pantocid HP Combipack

If you accidentally take more than your prescribed dose, seek medical attention immediately or contact your local poison control center. Symptoms of an overdose may include severe stomach upset, vomiting, or confusion.

Diet & Lifestyle Advise

  • Eat smaller, frequent meals: Choose smaller meals throughout the day to reduce strain on your stomach and help prevent excess acid production.
  • Avoid stomach-irritating foods and drinks: Limit spicy foods, citrus fruits, tomatoes, caffeine, and carbonated beverages, as they can irritate the stomach lining and worsen symptoms.
  • Limit fried and high-fat foods: Avoid greasy, fried, and high-fat meals, as they take longer to digest and may increase acid reflux and stomach discomfort.
  • Avoid smoking: Do not smoke, as nicotine can weaken the valve between the esophagus and stomach and slow the healing of ulcers.
  • Manage stress effectively: Practice stress-relieving activities such as deep breathing, meditation, or walking, as stress can increase stomach acid production and aggravate symptoms.

Health Queries

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What should I do if I was prescribed Pantocid HP KIT for stomach inflammation and a bacterial infection, but after only two doses, I am experiencing extreme stomach fullness and a loss of appetite?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

I understand how uncomfortable this fullness and loss of appetite can be. The Pantocid HP kit contains strong antibiotics (amoxicillin and clarithromycin) and an acid reducer (pantoprazole). These medications can temporarily disrupt your digestion and cause these exact symptoms as your body adjusts. It is very important not to stop this treatment early, as finishing the course is crucial to completely cure the bacterial infection. To help, try eating smaller, light meals throughout the day and stay hydrated. Please contact your prescribing doctor to share what you are experiencing; they can reassure you and provide specific guidance to make the treatment more comfortable.

Is there a cheaper generic alternative to the Pantocid HP kit, is it safe to start this 15-day treatment three months after being diagnosed with a stomach bacterial infection (H. pylori) and stomach inflammation, and should I still take it if I am currently experiencing bloating, stomach burning after eating, headaches, bowel movements right after eating, and burning when I pee?

Vikas Singh

Vikas Singh

M Pharmacy

I understand you are feeling uncomfortable, and I am here to help. Yes, cheaper generic alternatives to the Pantocid HP kit exist; your pharmacist can provide the individual generic medications: pantoprazole, amoxicillin, and clarithromycin. It is safe and highly recommended to treat the H. pylori infection now, as your stomach symptoms are likely related to it. However, because you are experiencing burning when you urinate, please consult your doctor before starting this kit. This urinary symptom needs a quick evaluation to rule out a urinary tract infection. Once cleared, starting your stomach treatment will help you feel much better. Wishing you a very speedy recovery.

Should I consult a general medicine doctor, a gastroenterologist (stomach specialist), a nephrologist (kidney specialist), or a psychiatrist for my ongoing stomach burning, sour taste, and burning in my mouth, given that I have redness and inflammation in my stomach and upper small intestine, a mild fatty liver, a small kidney stone, and bladder inflammation, and my symptoms did not improve after taking Pantocid HP kit, Levoflax, bacillus, Urisol, antacid syrup, or psychiatric medications?

Vikas Singh

Vikas Singh

M Pharmacy

Given your ongoing stomach burning, sour taste, and upper digestive tract inflammation, consulting a gastroenterologist is your best next step. They can investigate why the previous therapies did not provide relief and help manage your mild fatty liver. Additionally, since you have a kidney stone and bladder inflammation, a brief follow-up with a urologist or nephrologist is advisable to ensure your urinary tract heals completely. Please coordinate with these specialists will help target the root causes safely and effectively.

After stopping my 14-day Pantocid HP kit after only 8 days because of diarrhea, my H. pylori stomach infection symptoms have returned; should I follow another doctor's advice and start a new 14-day course of Pentop HP kit?

Veda Maddala

Veda Maddala

M Pharmacy

Stopping your Pantocid HP kit early can unfortunately allow the H. pylori bacteria to survive and become resistant to those antibiotics. Before starting a new 14-day course of Pentop HP, it is very important to consult your doctor again. They may want to test if the bacteria are still active or consider a different combination of medications to ensure the infection is completely cleared. Please don't worry?this is a highly manageable situation, but we want to make sure your next treatment is both safe and effective for you.

Is it safe and effective to restart the Pantocid HP kit three months after stopping the treatment unfinished, will it resolve my constant stomach gas, and can an H. pylori infection be completely cured?

Veda Maddala

Veda Maddala

M Pharmacy

Please do not restart the Pantocid HP kit on your own. Stopping antibiotic treatment early can cause the bacteria to become resistant, making it harder to treat. The good news is that H. pylori can be completely cured with the correct, full course of medication. Please consult your doctor. They will likely recommend a simple test to see if the infection is still active and prescribe a fresh, effective treatment plan to safely clear the bacteria and relieve your gas.

How should I take PANTOcid hp for my ulcer, how many days should I use it, and do I need to take all six tablets in the strip in a single day?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Hello. I understand managing ulcer treatments can be confusing, but I am here to help. Yes, you do need to take all six tablets in the Pantocid HP strip in a single day. The strip contains a one-day dose: take three tablets (one pantoprazole, one amoxicillin, and one clarithromycin) in the morning before breakfast, and the remaining three in the evening before dinner. This combination of an acid-reducer and antibiotics is highly effective when taken this way. Typically, this therapy is prescribed for 10 to 14 days. Please complete the full course exactly as your doctor recommended for complete healing. Wishing you a very speedy recovery.

How should I take the six tablets in the Pantocid HP kit, and do all of them need to be taken on an empty stomach?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

The Pantocid HP kit contains three medicines to be taken twice daily, usually split into morning and evening doses. For each dose, you should take the pantoprazole tablet on an empty stomach, about 30 to 60 minutes before your meal. The other two tablets?amoxicillin and clarithromycin?should be taken after your meal to help prevent stomach upset. So, only the pantoprazole needs to be taken on an empty stomach. Please be sure to complete the entire course.

Why do I still feel constantly full even after taking my prescribed Pantocid HP and Librax to treat an H. pylori stomach infection?

Veda Maddala

Veda Maddala

M Pharmacy

Hello. It is very common to still feel bloated or full while treating an H. pylori infection. The infection itself causes stomach inflammation, which slows down digestion. Additionally, medications like Pantocid HP (which contains pantoprazole and antibiotics) can temporarily alter your gut bacteria, and Librax can slow down stomach movement. This combination often leads to a persistent feeling of fullness. Please rest assured that your stomach lining needs time to heal, which continues even after completing your treatment. Try eating smaller, more frequent meals and stay well-hydrated. Be sure to complete your full medication course, and keep your doctor updated on your progress. Wishing you a speedy recovery!

Could taking Pantocid-HP for three days cause someone to faint, after they had been suffering from stomach inflammation for a couple of weeks?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

I am so sorry to hear you are dealing with this. While Pantocid-HP (which contains pantoprazole, amoxicillin, and clarithromycin) rarely causes fainting directly, your ongoing stomach inflammation can lead to dehydration, low blood sugar, or decreased blood pressure, making you feel lightheaded. Sometimes, antibiotics can also cause side effects like diarrhea or electrolyte changes that contribute to this. Because fainting can occasionally point to a more significant issue, like severe dehydration or heart rhythm changes, it is very important that you contact your healthcare provider or seek medical care right away to be safely evaluated. Please rest and stay well-hydrated in the meantime.

I am on day seven of a 14-day treatment with the Pantocid HP kit for a stomach infection, but I still have a burning sensation in my chest; how many days will it take to get relief, and should I take the kit before or after meals for the best results?

Vikas Singh

Vikas Singh

M Pharmacy

It can be frustrating to still feel a burning sensation on day seven, but please be reassured that healing takes time. The Pantocid HP kit?which contains an acid reducer (pantoprazole) and antibiotics?works best when taken 30 to 60 minutes before your morning and evening meals. This allows the acid reducer to work most effectively. While the treatment is actively fighting the infection, it may take a few more days, or even a week after completing the full 14-day course, for your stomach lining to fully heal and the burning to completely subside. Please finish the entire course as prescribed, and reach out to your doctor if symptoms persist.
health query

Have a query?

How Soon It Starts Working

  • The time required for Pantocid HP Combipack to start to work: The time required for Pantocid HP Combipack to show its action is unknown.
  • The time for which the effects of Pantocid HP Combipack last: The duration of action for Pantocid HP Combipack is unknown.

What if you forget to take Pantocid HP Combipack

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inspect the medicine before use: Check the blister pack before taking the medicine and do not use it if the packaging is damaged.
  • Complete the full course of treatment: Continue taking the medicine for the entire prescribed duration, even if your symptoms improve before finishing the pack. Completing the full course helps improve treatment success and reduces the risk of the infection returning.
  • Do not share your medication: Pantocid HP Combipack has been prescribed specifically for you and should not be given to anyone else.
  • Watch for severe diarrhoea: Contact your doctor if you develop severe watery diarrhoea during treatment or within several weeks after completing treatment. Avoid self treating with antidiarrheal medicines until you have received medical advice, as this may occasionally indicate a serious intestinal infection.
  • Inform healthcare providers before tests or procedures: Tell your doctor, dentist, or other healthcare professionals that you are taking Pantocid HP Combipack before undergoing medical tests or procedures.
  • Attend recommended follow-up testing: Your doctor may recommend a follow-up H. pylori test, usually at least 4 weeks after treatment, to confirm that the infection has been successfully cleared.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Blood thinners (e.g., warfarin): Taking these medicines alongside Pantocid HP Combipack may increase the risk of bleeding and may require closer monitoring.
  • Heart medicines (e.g., digoxin): Pantocid HP Combipack may increase digoxin levels in the body, raising the risk of side effects and toxicity.
  • Certain HIV medicines (e.g., atazanavir): The pantoprazole component may reduce the absorption and effectiveness of these medicines.
  • Gout medicines (e.g., colchicine): Combining these with Pantocid HP Combipack may increase the risk of colchicine toxicity, particularly in older adults and those with kidney problems.

Drug-Food Interactions

  • Grapefruit and grapefruit juice: Consuming grapefruit products while taking Pantocid HP Combipack may increase the levels of certain components in the bloodstream and raise the risk of side effects.
  • Alcohol: Avoid consuming alcohol while taking Pantocid HP Combipack, as it may irritate the stomach lining and worsen side effects such as nausea, dizziness, and stomach discomfort.

Drug-Disease Interactions

  • Myasthenia gravis: Pantocid HP Combipack may worsen muscle weakness and breathing difficulties in patients with this condition.
  • Liver disease: Patients with liver impairment may require closer monitoring or dose adjustments, as the medicine may accumulate in the body.
  • Kidney disease: Reduced kidney function may affect the removal of some components of Pantocid HP Combipack and increase the risk of side effects.
  • Heart rhythm disorders (e.g., QT prolongation): Pantocid HP Combipack may increase the risk of irregular heartbeats in patients with existing heart rhythm abnormalities.
Amoxicillin + Pantoprazole + ClarithromycinQuinidine
Critical
Amoxicillin + Pantoprazole + ClarithromycinNimodipine
Critical

Drug-Drug Interactions

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Amoxicillin + Pantoprazole + ClarithromycinQuinidine
Critical
How does the drug interact with Pantocid HP Combipack:
Taking Amoxicillin, Pantoprazole and Clarithromycin with Quinidine, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin and Quinidine can lead to an interaction, it can be taken if advised by a doctor. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats, headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinNimodipine
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration with Amoxicillin, Pantoprazole and Clarithromycin, it can increase the blood levels and effects of nimodipine.

How to manage the interaction:
Co-administration of Clarithromycin and Nimodipine is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heart rhythm, swelling, and low blood pressure, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinIsavuconazole
Critical
How does the drug interact with Pantocid HP Combipack:
Taking Amoxicillin, Pantoprazole and Clarithromycin with Isavuconazole, can increase the risk of side effects.

How to manage the interaction:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin with Isavuconazole is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinPimozide
Critical
How does the drug interact with Pantocid HP Combipack:
Combining Amoxicillin, Pantoprazole and Clarithromycin with Pimozide can increase the risk of heart rhythm problems.

How to manage the interaction:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin and Pimozide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heartbeat, chest tightness, blurred vision or nausea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinLovastatin
Critical
How does the drug interact with Pantocid HP Combipack:
Taking Amoxicillin, Pantoprazole and Clarithromycin with Lovastatin can increase the risk of muscle problems.

How to manage the interaction:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin with Lovastatin is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinEplerenone
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin with Eplerenone may significantly increase the blood levels and effects of eplerenone. This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Amoxicillin, Pantoprazole and Clarithromycin with Eplerenone is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinTolvaptan
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin together with Tolvaptan may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Amoxicillin, Pantoprazole, Clarithromycin and Tolvaptan, but it can be taken if prescribed by a doctor. If you notice any of these signs- difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
Amoxicillin + Pantoprazole + ClarithromycinAlprazolam
Critical
How does the drug interact with Pantocid HP Combipack:
The combination of Alprazolam with Amoxicillin, Pantoprazole, Clarithromycin may increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam Amoxicillin, Pantoprazole, Clarithromycin, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.
Amoxicillin + Pantoprazole + ClarithromycinSimvastatin
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin with Simvastatin can increase the blood levels and effects of Simvastatin.

How to manage the interaction:
Taking Amoxicillin, Pantoprazole and Clarithromycin together with Simvastatin is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Amoxicillin + Pantoprazole + ClarithromycinRegorafenib
Critical
How does the drug interact with Pantocid HP Combipack:
Co-adminstration of Amoxicillin, Pantoprazole and Clarithromycin with Regorafenib, may alter the blood levels and effects of Regorafenib.

How to manage the interaction:
Co-administration of Amoxicillin, Pantoprazole and Clarithromycin with Regorafenib can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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AMOXYCILLIN-750MG+CLARITHROMYCIN-500MG+PANTOPRAZOLE-40MGFruit juices
Mild

Drug-Food Interactions

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AMOXYCILLIN-750MG+CLARITHROMYCIN-500MG+PANTOPRAZOLE-40MGFruit juices
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice with Pantocid HP Combipack may delay the gastrointestinal absorption of Pantocid HP Combipack. Avoid Grapefruit juice while being treated with Pantocid HP Combipack.

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[ANTIULCERS, GASTROINTESTINAL AGENTS]

FAQs

Pantocid HP Combipack is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). It works by inhibiting the action of the gastric proton pump and preventing the growth of microorganisms.
Speak to your doctor if you do not feel better even after taking Pantocid HP Combipack for 14 days. Do not take Pantocid HP Combipack for longer durations unless prescribed by the doctor.
Pantocid HP Combipack may cause dizziness. Drive only if you are alert, and do not operate machinery if you feel dizzy after taking Pantocid HP Combipack.
Avoid or limit the consumption of alcohol while on Pantocid HP Combipack as it may lead to increased dizziness. Alcohol intake may also lead to excess production of stomach acid, thereby increasing acidity and heartburn.
Diarrhoea might be a side-effect of Pantocid HP Combipack. Drink enough fluids and eat fibre-rich food if you experience diarrhoea after taking Pantocid HP Combipack. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Pantocid HP Combipack contains pantoprazole, which may increase the risk of bone fracture in the hip, spine, or wrist. Recent clinical studies indicated that pantoprazole may affect the absorption of certain nutrients and minerals required for maintaining good bone health, leading to fractures. This mainly occurs in people taking higher doses of Pantocid HP Combipack for longer durations. Inform your doctor before taking Pantocid HP Combipack if you have osteoporosis or if you are already taking corticosteroids.
Dry mouth could be a side effect of Pantocid HP Combipack. Limiting caffeine intake, avoiding smoking, drinking enough water, and chewing sugar-free gum or candy might help stimulate saliva production and thereby prevent dry mouth.
Inform your doctor if you don’t get better after finishing the full course of treatment. Also, let your doctor know if your symptoms are getting worse while using Pantocid HP Combipack. Your doctor may need to reassess your condition, possibly perform additional tests, and prescribe a different treatment if necessary.
A peptic ulcer is a sore that develops on the lining of your stomach, lower esophagus, or small intestine. It's usually caused by an infection with Helicobacter pylori (H. pylori) bacteria or prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Do not use Pantocid HP Combipack if you have a known hypersensitivity to Pantocid HP Combipack. Use Pantocid HP Combipack with caution if you have liver disease, as the antibiotics in Pantocid HP Combipack can affect liver function. Inform your doctor if you have or ever had gastrointestinal bleeding, diabetes, myasthenia gravis (neuromuscular disease), bone fractures, or hypomagnesemia (low levels of magnesium). Also, let your doctor know if you are breastfeeding, pregnant or planning pregnancy.
Take Pantocid HP Combipack 30-60 minutes before food or as advised by your doctor. Swallow it as a whole with a glass of water. But try to take it at the same time each day for better efficacy. Do not crush or chew it.
No, do not stop using Pantocid HP Combipack even if you feel better, as stopping Pantocid HP Combipack early can leave the infection untreated, which could lead to side effects. Therefore, complete the full course of treatment as prescribed by your doctor.
Common side effects of Pantocid HP Combipack include nausea, diarrhoea, vomiting, stomach pain, altered taste, and headache. If any of these side effects persist or worsen, please consult your doctor.
Yes. Most people can continue consuming dairy products while taking Pantocid HP Combipack. Dairy products do not usually interfere significantly with the effectiveness of this treatment. Follow your doctor's instructions regarding meal timing.
Medicines such as ibuprofen or aspirin may irritate the stomach lining and slow ulcer healing. Speak with your doctor before taking additional pain relievers while being treated for an ulcer.
Pantocid HP Combipack is generally used during pregnancy only when your doctor believes the benefits outweigh the potential risks. If you are pregnant, planning a pregnancy, or breastfeeding, discuss your treatment options with your doctor before starting Pantocid HP Combipack.
Yes. Many doctors recommend a follow-up H. pylori test, such as a stool antigen test or urea breath test, usually at least 4 weeks after completing treatment. This helps confirm that the infection has been successfully cleared.

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Reference

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  2. Electronic Medicines Compendium (EMC). Pil.526 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.7072 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Amoxicillin Clarithromycin And Omeprazole Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. National Center for Biotechnology Information (NCBI). Pmc2974811 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  6. Amoxicillin Amoxicillin. 1974. [Accessed on 01 Feb. 2019]Check here
  7. Pantoprazole sodium sesquihydrate. 2009. [Accessed on 12 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - PAN0090

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