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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Ostigard 200mg/50mg Capsule is used to relieve pain, tenderness, swelling and stiffness caused by various medical conditions. It contains Celecoxib and Diacerein. Celecoxib works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.

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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

About Ostigard 200mg/50mg Capsule

Ostigard 200mg/50mg Capsule belongs to the class of nonsteroidal anti-inflammatory drugs. It is used to relieve pain, tenderness, swelling and stiffness caused by various medical conditions such as rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and ankylosing spondylitis (arthritis primarily affecting the spine). It is also used in the treatment of juvenile rheumatoid arthritis (a kind of arthritis that affects children) in children aged two and up.

Ostigard 200mg/50mg Capsule contains Celecoxib and Diacerein. Celecoxib works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.

Your doctor will advise you on how often you take this medicine based on your medical condition. In some cases, you may experience nausea, headache, indigestion, stomach pain, diarrhoea, oedema, and flatulence. Most of these side effects of Ostigard 200mg/50mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to any foods or medicines. Do not take Ostigard 200mg/50mg Capsule during and after 20 weeks of pregnancy unless you are told to do so by your doctor. If you become pregnant while taking celecoxib, consult your doctor right away. Celecoxib users may be more likely to suffer a heart attack or stroke than nonusers. Tell your doctor if you or anyone in your family has or has ever had heart disease, a stroke or a heart attack if you smoke, and if you have or have ever had high blood pressure, high cholesterol or diabetes. If you have recently had a heart attack, do not take an NSAID like Ostigard 200mg/50mg Capsule unless your doctor tells you to.

Uses of Ostigard 200mg/50mg Capsule

Ostigard 200mg/50mg Capsule is used in the management of osteoarthritis, especially of the knee, by alleviating pain and improving joint function. The detailed combined uses of Ostigard 200mg/50mg Capsule are as follows:<br/>• Reduces pain and improves mobility: Ostigard 200mg/50mg Capsule provides rapid relief from pain and inflammation, while diacerein supports long-term joint function.<br/>• Provides both symptomatic relief and structural support in osteoarthritis: It helps reduce inflammation and pain quickly, while also protecting cartilage and slowing the progression of joint damage, making it effective for long-term management.<br/>

Directions for Use

• Take Ostigard 200mg/50mg Capsule with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Ostigard 200mg/50mg Capsule contains Celecoxib and Diacerein. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID). It acts as an analgesic (reduces pain) and an anti-inflammatory (reduces inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes convert arachidonic acid to prostaglandins, which are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation. Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.

How Ostigard 200mg/50mg Capsule Works

Ostigard 200mg/50mg Capsule contains Celecoxib and Diacerein. Celecoxib works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.

Storage

• Store in a cool and dry place away from sunlight.• Keep Ostigard 200mg/50mg Capsule out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Ostigard 200mg/50mg Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Ostigard 200mg/50mg Capsule may include lack of energy, drowsiness, nausea, vomiting, stomach pain, vomiting, bloody or black, tarry stools, loss of consciousness, hives, rashes, swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs, and difficulty breathing or swallowing. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are scheduled to have a coronary artery bypass graft (CABG, a form of heart surgery), you should not take celecoxib before or after the procedure. Before taking Ostigard 200mg/50mg Capsule, inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are pregnant or breastfeeding, do not consume Ostigard 200mg/50mg Capsule unless recommended by the doctor. Keep your doctor informed about your health condition and all the medicines you take before taking Ostigard 200mg/50mg Capsule to rule out any side effects. Consumption of alcohol should be avoided while on medication. If you have any symptoms like chest pain, shortness of breath, weakness in one area or side of the body, or slurred speech, seek emergency medical attention immediately.

Drug-Drug Interactions

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CelecoxibEliglustat
Critical

Drug-Drug Interactions

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CelecoxibEliglustat
Critical
How does the drug interact with Ostigard 200mg/50mg Capsule:
Taking eliglustat with Ostigard 200mg/50mg Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of serious side effects.

How to manage the interaction:
Taking Ostigard 200mg/50mg Capsule with Eliglustat is not recommended, but can be taken together if prescribed by a doctor. However, consult the doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate and weak pulse. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Co-administration of Cidofovir with Ostigard 200mg/50mg Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Ostigard 200mg/50mg Capsule with Cidofovir is not recommended, please consult your doctor before taking it. However, consult the doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Taking thioridazine and Ostigard 200mg/50mg Capsule may increases the blood levels of thioridazine which may cause irregular heart rhythm.

How to manage the interaction:
Taking Ostigard 200mg/50mg Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Taking Ketorolac with Ostigard 200mg/50mg Capsule can increase the risk of gastrointestinal bleeding and ulcers,

How to manage the interaction:
Taking Ketorolac tromethamine with Ostigard 200mg/50mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Taking Ketorolac with Ostigard 200mg/50mg Capsule can increase the risk of side effects such as gastrointestinal bleeding and ulcers.

How to manage the interaction:
Taking Ostigard 200mg/50mg Capsule with Ketorolac is not recommended, but can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Co-administration of Ostigard 200mg/50mg Capsule with Meloxicam can increase the risk or severity of bleeding and ulcers of the stomach lining leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Ostigard 200mg/50mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a dcovct
How does the drug interact with Ostigard 200mg/50mg Capsule:
Co-administration of Diclofenac with Ostigard 200mg/50mg Capsule may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between diclofenac and Ostigard 200mg/50mg Capsule, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Coadministration of Sirolimus with Ostigard 200mg/50mg Capsule together may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Sirolimus and Ostigard 200mg/50mg Capsule together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Taking Ostigard 200mg/50mg Capsule with Etodolac can increase the risk of stomach inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is a interaction between Etodolac and Ostigard 200mg/50mg Capsule, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ostigard 200mg/50mg Capsule:
Coadministration of Ostigard 200mg/50mg Capsule with Tenofovir Disoproxil may increase the risk of kidney problems.

How to manage the interaction:
Taking Ostigard 200mg/50mg Capsule with Tenofovir Disoproxil together can possibly result in an interaction, but it can be taken if your doctor has advised it. Consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, or dizziness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy body weight because obesity can lead to joint pain. Please avoid strenuous exercise as it may aggravate your arthritis-related joint pain. Instead, you can stretch and engage in low-impact aerobic exercises such as treadmill walking, biking, and swimming. Lifting light weights can also help to improve your muscle strength.
  • Increase your intake of glucosamine, chondroitin sulphate, vitamin D, and calcium-rich supplements. Aside from that, turmeric and fish oils can help to reduce tissue inflammation.
  • Include fish such as salmon, trout, tuna, and sardines in your diet if you have arthritis or joint pain. These fish are high in omega-3 fatty acids, which aid in the reduction of inflammation (redness and swelling) and the protection of the heart.
  • Your sitting posture is critical, especially if you suffer from pain or inflammation. Try to sit as little as possible and only for a short period of time (10-15 min). To alleviate pain, place a rolled-up towel at the back of your curve. In addition, if necessary, a footrest can be used.
  • Follow heat or cold therapy by applying a cold or hot compress to the joints on a regular basis for 15-20 minutes.
  • Relax by meditating, reading, taking a bubble bath, or listening to calming music.
  • Avoid drinking alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANALGESICS

Ostigard 200mg/50mg Capsule Substitute

Substitutes safety advice
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Alcohol

Caution

Consuming alcohol along with Ostigard 200mg/50mg Capsule is not advisable.

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Pregnancy

Caution

Ostigard 200mg/50mg Capsule should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Ostigard 200mg/50mg Capsule.

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Breast Feeding

Caution

Caution should be exercised. Ostigard 200mg/50mg Capsule should not be used in nursing mothers unless clearly necessary. So, inform the doctor if you are breastfeeding. A decision should be made whether to discontinue nursing or the medicine, considering the importance of the medicine to the mother.

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Driving

Caution

Ostigard 200mg/50mg Capsule may cause dizziness. So, you should not drive or operate heavy machinery after taking Ostigard 200mg/50mg Capsule.

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Liver

Caution

Ostigard 200mg/50mg Capsule should be used with caution if you have liver problems. Inform your doctor before receiving Ostigard 200mg/50mg Capsule if you have a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Ostigard 200mg/50mg Capsule should be used with caution if you have kidney problems. Inform your doctor before receiving Ostigard 200mg/50mg Capsule if you have a history of kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Ostigard 200mg/50mg Capsule is also used in treating juvenile rheumatoid arthritis (a kind of arthritis that affects children) in children aged 2 and up.

Have a query?

FAQs

Ostigard 200mg/50mg Capsule is used to treat pain.

Celecoxib and Diacerein are both present in Ostigard 200mg/50mg Capsule. Celecoxib acts by inhibiting the release of chemical messengers that induce pain and inflammation (redness and swelling). Diacerein acts by suppressing the action of a protein implicated in cartilage inflammation and degradation. As a result, it aids in the formation and repair of cartilage (the soft connective tissue that protects and covers the ends of long bones at joints) and lowers joint discomfort and swelling.

Ostigard 200mg/50mg Capsule is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.

Ostigard 200mg/50mg Capsule may increase blood pressure, especially in high doses. It should not be given to patients with uncontrolled blood pressure, heart problems or recent heart surgeries.

If you are going to take a vaccine, it is not recommended to take Ostigard 200mg/50mg Capsule without consulting a doctor. Please ask your doctor for clarification.

NSAIDs, such as Ostigard 200mg/50mg Capsule, can induce stomach ulcers, bleeding, or perforations in the intestine. These complications can arise at any point during therapy without warning symptoms and can result in death.

Country of origin

India
Other Info - OS88222

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