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Ocrevus 300 mg Injection 10 ml is a monoclonal antibody used in the treatment of relapsing forms of multiple sclerosis and primary progressive multiple sclerosis (PPMS) in adults. It works by targeting and destroying certain types of immune cells called B cells. In multiple sclerosis, these B cells attack the myelin sheath, a protective covering that envelops nerve fibres in the brain and spinal cord. By destroying these B cells, Ocrevus 300 mg Injection 10 ml helps to reduce inflammation and slow down the progression of multiple sclerosis. The common side effects of Ocrevus 300 mg Injection 10 ml include swelling or pain in hands, legs, arms, or feet; upper respiratory tract infections; cough; itchy skin; rash; nausea; headache; and dizziness.

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Written By ,
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

OCRELIZUMAB-300MG

Manufacturer/Marketer :

Roche Diagnostics India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Ocrevus 300 mg Injection 10 ml

Ocrevus 300 mg Injection 10 ml is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS) and primary progressive MS. It works by targeting specific immune cells to help reduce the frequency of flare-ups and slow down the worsening of physical disability. This specialised treatment aims to protect the nervous system from ongoing damage.

This medicine is not a daily treatment; instead, it is taken as an intravenous infusion every six months. Because it is delivered directly into a vein by a healthcare provider, you do not need to worry about taking it with food. Incorporating a balanced, anti-inflammatory diet and regular, gentle physical activity can also support your overall health while receiving this therapy.

Some people may experience common side effects, such as nose or throat infections, skin infections, or temporary reactions during the infusion, like itching and redness. It is crucial to consult your doctor immediately if you notice serious symptoms, including severe breathing difficulties, persistent cough, yellowing of your skin or eyes, or unusual skin changes. Early reporting of these issues helps your healthcare team manage them safely.

Do not take this if you have an active hepatitis B infection or have had life-threatening allergic reactions to this medicine in the past. Before starting, talk to your doctor if you have any active infections, a history of hepatitis B, or a history of cancer, as this treatment can affect your immune system. Your doctor will perform key health checks before your first dose.

This medicine may interact with other treatments that weaken your immune system or with live vaccines, which should be avoided before and during therapy. If you are pregnant, planning a pregnancy, breastfeeding, or are an older adult, talk to your doctor or pharmacist to carefully weigh the safety of this treatment for your specific situation. They will help you make a safe, informed choice.

Uses of Ocrevus 300 mg Injection 10 ml

Ocrevus 300 mg Injection 10 ml is used to treat multiple sclerosis and help reduce disease progression. The detailed uses of Ocrevus 300 mg Injection 10 ml are as follows:

  • Relapsing forms of multiple sclerosis (MS): Ocrevus 300 mg Injection 10 ml helps reduce the number of relapses (flare-ups) and slows the progression of physical disability in adults with active disease.
  • Primary progressive multiple sclerosis (MS): Ocrevus 300 mg Injection 10 ml is used to delay the steady worsening of symptoms and physical disability in people diagnosed with this progressive form of the condition.
     

Key Benefits

Ocrevus 300 mg Injection 10 ml offers meaningful, real-world support for individuals living with multiple sclerosis by protecting the nervous system from immune system attacks.

  • Fewer disease relapses: It helps keep your symptoms stable for longer periods, reducing the frequency of painful or disruptive flare-ups that interrupt daily life.
  • Slower disability progression: It helps preserve your physical mobility, allowing you to maintain your independence and continue daily activities for a longer time.
  • Fewer brain lesions: It reduces the formation of new areas of damage in the brain and spinal cord, as observed on periodic MRI scans.
  • Convenient schedule: Because it is taken only twice a year after the initial starter doses, it frees you from the burden of daily pills or frequent self-injections.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Ocrevus 300 mg Injection 10 ml will be administered by the doctor or healthcare professional through the intravenous route.
  • Do not self-administer.

How Ocrevus 300 mg Injection 10 ml Works

Ocrevus 300 mg Injection 10 ml contains ocrelizumab. In multiple sclerosis, your body's own immune system mistakenly attacks the protective covering around your nerves. This medicine is designed as a monoclonal antibody, which is a type of protein engineered to identify and target specific cells in the body. It works by specifically binding to a protein called CD20 found on the surface of B-cells, which are a type of white blood cell involved in the immune attack on your nerves. By targeting and reducing these specific B-cells, Ocrevus 300 mg Injection 10 ml helps quiet down the overactive immune response. This action reduces inflammation in the brain and spinal cord, helping to prevent damage to the nerves and slowing down the overall progression of MS.
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Alcohol

Consult your doctor

The interaction of alcohol with Ocrevus 300 mg Injection 10 ml is unknown. If you have any concerns, please discuss them with your doctor.

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Pregnancy

Caution

It is unknown if Ocrevus 300 mg Injection 10 ml will harm your foetus. Women of childbearing potential should use effective contraception while receiving Ocrevus 300 mg Injection 10 ml and for 6 months after the last dose of Ocrevus 300 mg Injection 10 ml.

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Breast Feeding

Consult your doctor

It is unknown if Ocrevus 300 mg Injection 10 ml is excreted in breast milk. Therefore, take your doctor's advice if you are a breastfeeding mother.

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Driving

Caution

Avoid driving or operating machinery if you feel uncomfortable after receiving Ocrevus 300 mg Injection 10 ml.

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Liver

Caution

For patients with liver disease, it is crucial to undergo hepatitis B screening before initiating treatment with Ocrevus 300 mg Injection 10 ml, as those with active HBV infection may be at risk of severe and potentially life-threatening complications.

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Kidney

Caution

Ocrevus 300 mg Injection 10 ml can be administered to patients with mild kidney problems. Still, it is unknown for those with moderate or severe kidney problems as its safety and efficacy were not fully established.

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Children

Unsafe

Ocrevus 300 mg Injection 10 ml is not recommended for children below 18 years of age, as its safety and efficacy were not established.

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Heart

Safe if prescribed

Ocrevus 300 mg Injection 10 ml can generally be taken even if you have heart problems. Consult your doctor if you have any concerns regarding it.

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Geriatrics

Safe if prescribed

Ocrevus 300 mg Injection 10 ml is generally safe for geriatric individuals. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Ocrevus 300 mg Injection 10 ml

Because this medicine is prepared and administered by trained healthcare professionals in a medical clinic, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe symptoms after an infusion, seek immediate medical attention or contact emergency services right away.

Diet & Lifestyle Advise

  • Prioritise food safety: Because this medicine lowers your immune response, you are more prone to infections. Wash all fruits and vegetables thoroughly, cook meats to safe temperatures, and avoid unpasteurised dairy products.
  • Stay active with low-impact exercise: Engage in regular, moderate physical activities like swimming, walking, or stationary cycling. This helps maintain muscle strength, flexibility, and balance without overheating your body.
  • Manage body temperature: Multiple sclerosis symptoms can flare up when you get too warm. Take cool showers, use cooling vests during hot weather, and avoid hot tubs or saunas.
  • Focus on an anti-inflammatory diet: Incorporate foods rich in omega-3 fatty acids (like salmon, walnuts, and flaxseeds) and plenty of leafy greens to support brain and nerve health.
  • Get adequate vitamin D: Ask your doctor to check your vitamin D levels, as maintaining healthy levels of this vitamin is highly beneficial for people managing multiple sclerosis.
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Have a query?

How Soon It Starts Working

The time required for Ocrevus 300 mg Injection 10 ml to start to work: The time required for Ocrevus 300 mg Injection 10 ml to show its action is unknown. The time for which the effects of Ocrevus 300 mg Injection 10 ml last: The duration of action for Ocrevus 300 mg Injection 10 ml is unknown.

What if you forget to take Ocrevus 300 mg Injection 10 ml

If you miss an appointment for your infusion, contact your doctor or infusion clinic immediately to reschedule. It is important to receive your doses as close to the scheduled time as possible to keep the medicine working effectively in your body.

Storage

• Store the medicine in a refrigerator between 2°C and 8°C.

Drug Warnings

  • Check the solution: Before your infusion begins, make sure the solution is clear to slightly cloudy and colourless to pale brown. It should not be used if it is discoloured or contains distinct particles.
  • Complete vaccinations early: Ensure you receive all necessary vaccines (especially live vaccines) at least 4 to 6 weeks before starting this treatment, as live vaccines should not be taken during therapy.
  • Monitor the injection site: After your infusion, monitor the area where the needle was inserted for signs of infection, such as redness, warmth, swelling, or leaking fluid.
  • Tell all your doctors: Inform any dentist, surgeon, or specialist you visit that you are receiving Ocrevus 300 mg Injection 10 ml, as it affects your immune system for several months after a dose.
  • Track your symptoms: Keep a daily journal of any new or worsening symptoms, especially neurological changes, and share them with your care team before your next scheduled infusion.

Drug-Drug Interactions

verifiedApollotooltip
  • Immunosuppressants or chemotherapy: Combining Ocrevus 300 mg Injection 10 ml with other medicines that weaken the immune system can significantly increase your risk of severe infections.
  • Vaccines (especially live vaccines): Receiving live vaccines while on this treatment can lead to vaccine-related infections, as your immune system is less active.
     
OcrelizumabCladribine
Severe
OcrelizumabBaricitinib
Severe

Drug-Drug Interactions

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OcrelizumabCladribine
Severe
How does the drug interact with Ocrevus 300 mg Injection 10 ml:
Taking Ocrevus 300 mg Injection 10 ml with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Ocrevus 300 mg Injection 10 ml, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
OcrelizumabBaricitinib
Severe
How does the drug interact with Ocrevus 300 mg Injection 10 ml:
Coadministration of Baricitinib with Ocrevus 300 mg Injection 10 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Ocrevus 300 mg Injection 10 ml and Baricitinib, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
OcrelizumabInfliximab
Severe
How does the drug interact with Ocrevus 300 mg Injection 10 ml:
Taking Ocrevus 300 mg Injection 10 ml and Infliximab together can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Ocrevus 300 mg Injection 10 ml and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Ocrevus 300 mg Injection 10 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MONOCLONAL ANTIBODIES]

FAQs

Ocrevus 300 mg Injection 10 ml belongs to the group of medications called monoclonal antibodies used in the treatment of relapsing forms of multiple sclerosis and primary progressive multiple sclerosis (PPMS) in adults.
Ocrevus 300 mg Injection 10 ml contains ocrelizumab. It works by targeting and destroying certain types of immune cells called B cells. In multiple sclerosis, these B cells attack the myelin sheath, the protective covering that envelops nerve fibres in the brain and spinal cord. By destroying these B cells, Ocrevus 300 mg Injection 10 ml reduces inflammation and slows down the progression of multiple sclerosis.
The side effects of Ocrevus 300 mg Injection 10 ml include swelling or pain in hands, legs, arms, or feet; upper respiratory tract infections; cough; itchy skin; rash; nausea; headache; and dizziness. Most of these side effects gradually resolve on their own over time. However, please consult your doctor if these symptoms persist or worsen.
Please inform your doctor before taking other medicines while being treated with Ocrevus 300 mg Injection 10 ml. Your doctor will determine which medicines should not be taken along with Ocrevus 300 mg Injection 10 ml.
Ocrevus 300 mg Injection 10 ml is contraindicated in patients with active Hepatitis B virus (HBV) infection and those with a history of life-threatening infusion reactions to the medication. Patients with these conditions should not receive Ocrevus 300 mg Injection 10 ml due to the risk of serious and potentially life-threatening complications.
After your first two starter doses (given two weeks apart), you will receive Ocrevus 300 mg Injection 10 ml as a single infusion once every six months. Talk to your doctor to establish your exact treatment schedule.
You should avoid receiving live vaccines while using this medicine and for several months after your last dose. Non-live (inactivated) vaccines may be given, but they might not work as well. Talk to your doctor or pharmacist before getting any vaccination.
Hair loss is not a commonly reported side effect of this medicine. If you notice unusual hair thinning or loss, it could be related to other factors, stress, or other medicines. Talk to your doctor for guidance.
There is no direct interaction between alcohol and this medicine, but alcohol can sometimes worsen MS symptoms like balance issues and fatigue. Talk to your doctor or pharmacist about safe alcohol limits.
This medicine is generally not recommended during pregnancy as it can affect the immune system of the unborn baby. It is advised to use effective birth control during treatment and for at least six months after your last infusion. Talk to your doctor if you are planning a family.
Some patients experience mild infusion reactions like itching, headache, or a scratchy throat during or shortly after the infusion. These are usually managed easily with pre-treatment medicines. Talk to your doctor if you feel unwell after your appointment.
This medicine can cause the hepatitis B virus to become active again in people who carry it, which can lead to severe liver damage. A simple blood test before starting ensures it is safe for you to take. Talk to your doctor to learn more.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Roche Diagnostics India Pvt Ltd, 501 B, Silver Utopia, Cardinal Gracious Road, Chakala Road, Andheri East, Mumbai 400069
Other Info - OCR0001
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