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compositionComposition:MEPOLIZUMAB-100MG
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Nucala 100 mg Injection 1 ml is used to treat asthma. Its active ingredient is mepolizumab, which works by preventing the body's natural production of certain chemicals that increase asthma symptoms, such as coughing, wheezing, chest pain, and breathing difficulties. Sometimes, Nucala 100 mg Injection 1 ml may cause side effects such as fever, back pain, itching, headache, sore throat, and breathing difficulty. This medicine is not recommended in cases of bronchospasm or status asthmaticus.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MEPOLIZUMAB-100MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nucala 100 mg Injection 1 ml

Nucala 100 mg Injection 1 ml is a prescription injection used to treat severe eosinophilic asthma, which is a type of asthma caused by too many inflammatory white blood cells. It is also used to treat chronic swelling of the sinuses with nasal polyps, and certain rare blood vessel diseases. This medicine helps manage long-term inflammation to keep your airways open and reduce severe breathing attacks.

This medicine must be injected regularly, usually once every 4 weeks, to keep your symptoms under control. Because it is given as an injection under the skin, you can take it with or without food. Combining this treatment with healthy habits, like avoiding smoke and managing daily stress, will help you get the best results from your therapy.

Many people tolerate this medication well, but you may experience mild side effects like headaches or injection site pain. However, you should contact your doctor immediately if you experience signs of a severe allergic reaction, such as difficulty breathing or sudden facial swelling.

Talk to your doctor before starting this medicine if you have a history of parasitic infections or shingles, as Nucala 100 mg Injection 1 ml can affect how your body fights these conditions. Do not take this if you have ever had a severe allergic reaction to this medication or any of its ingredients.

Tell your doctor about all other medicines you take, especially steroids, as stopping them suddenly can cause withdrawal symptoms. Additionally, consult your healthcare provider if you are pregnant, breastfeeding, or an older adult, as they will help decide if this treatment is safe for your specific situation.

Uses of Nucala 100 mg Injection 1 ml

Your doctor may prescribe Nucala 100 mg Injection 1 ml for the following conditions:

  • Severe eosinophilic asthma: Nucala 100 mg Injection 1 ml targets and reduces specific inflammatory cells in the lungs to prevent sudden, severe asthma attacks.
  • Chronic rhinosinusitis with nasal polyps: This medicine helps shrink polyps in the nasal passages to improve nasal congestion and restore your sense of smell.
  • Eosinophilic granulomatosis with polyangiitis (EGPA): It helps reduce widespread blood vessel inflammation caused by an excess of certain white blood cells.
  • Hypereosinophilic syndrome (HES): It works to lower the abnormally high levels of inflammatory cells that can cause organ damage and severe flare-ups.

Key Benefits

Using Nucala 100 mg Injection 1 ml as prescribed helps reduce inflammation caused by eosinophils, improve symptom control, and support long-term disease management. Here are the key benefits you can expect:

  • Reduces severe flare-ups: Helps prevent asthma attacks and disease flare-ups, allowing you to breathe more comfortably and carry out daily activities with greater confidence.
  • Reduces the need for oral steroids: Helps lower the reliance on long-term oral steroid treatment, reducing the risk of steroid-related side effects such as bone thinning and high blood sugar.
  • Improves long-term symptom control: Helps relieve nasal congestion and sinus pressure caused by nasal polyps while providing consistent disease control, reducing emergency hospital visits and the need for nasal surgery.
Side effects of Nucala 100 mg Injection 1 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep. This helps the body fight infection.
  • Keep yourself hydrated by drinking enough water and other fluids.
  • Wash your hands often and avoid touching your eyes, mouth or nose.
  • Wear a mask whilst going out.
  • Warm steam or a hot shower may help with nose secretions.
  • Avoid contact with others to prevent contamination.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

Directions for Use

  • Follow your doctor’s recommendations for the correct dosage and timing of this medication.
  • The first dose of Nucala 100 mg Injection 1 ml may be administered by the doctor. After that, your doctor may allow you or a caregiver to administer it at home. Check the label for directions and use it as advised by the doctor. Choose an injection site such as the thigh or abdomen; pinch the skin and inject the advised dose slowly and steadily.
  • Rotate the injection site each time. Do not inject into skin that is red, bruised, or hard.

How Nucala 100 mg Injection 1 ml Works

Nucala 100 mg Injection 1 ml contains mepolizumab, a monoclonal antibody that targets a protein called interleukin-5 (IL-5). IL-5 plays an important role in the growth, activation, and survival of eosinophils, a type of white blood cell. Although eosinophils normally help protect the body, excessive numbers can cause inflammation in the lungs, airways, blood vessels, and nasal passages. Nucala 100 mg Injection 1 ml works by binding to IL-5 and blocking its activity, preventing it from signalling the body to produce and maintain eosinophils. As a result, the number of these inflammatory cells decreases in the blood and tissues. This helps reduce inflammation, improves breathing, and lowers the risk of severe asthma attacks and inflammatory flare-ups associated with eosinophilic conditions.
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Alcohol

Consult your doctor

It is unknown whether Nucala 100 mg Injection 1 ml interacts with alcohol or not. Consult your doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Nucala 100 mg Injection 1 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if Nucala 100 mg Injection 1 ml passes into the breastmilk when used by a breastfeeding mother. Your doctor will prescribe Nucala 100 mg Injection 1 ml only if the benefit outweighs the risk.

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Driving

Safe

Nucala 100 mg Injection 1 ml does not affect your driving ability.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney problems, tell your doctor before receiving this medicine.

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Children

Caution

Nucala 100 mg Injection 1 ml is not recommended in children below six years of age as the safety and efficacy are not established.

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Heart

Caution

If you have a pre-existing or a history of heart problems, tell your doctor before receiving this medicine.

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Geriatrics

Caution

Nucala 100 mg Injection 1 ml should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Nucala 100 mg Injection 1 ml

If you suspect that you have received more than the prescribed dose of Nucala 100 mg Injection 1 ml, seek immediate medical attention right away, even if you do not notice any symptoms. Prompt medical evaluation is important to help prevent or manage any potential complications.

Diet & Lifestyle Advise

  • Identify and avoid environmental triggers: Keep your living space free from common irritants such as dust, pet dander, mold, and strong perfumes.
  • Avoid all exposure to tobacco smoke: Quit smoking and stay away from secondhand smoke, as it directly damages sensitive airway linings and reduces the effectiveness of your medications.
  • Monitor your breathing daily: Use a peak flow meter or keep a daily symptom log to track how well your lungs are functioning.
  • Maintain a lung-healthy diet: Focus on eating anti-inflammatory foods like fresh berries, leafy greens, and fatty fish containing omega-3 fatty acids.
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Have a query?

How Soon It Starts Working

The time required for Nucala 100 mg Injection 1 ml to start to work: The time required for Nucala 100 mg Injection 1 ml to show its action is unknown. The time for which the effects of Nucala 100 mg Injection 1 ml last: The duration of action for Nucala 100 mg Injection 1 ml is unknown.

What if you forget to take Nucala 100 mg Injection 1 ml

If you miss a dose, inject your missed dose as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and resume your regular schedule. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure about what to do.

Storage

•Store Nucala 100 mg Injection 1 ml in the refrigerator between 2°C and 8°C (36°F and 46°F).• Keep the medicine in its original carton to protect it from light.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect the medicine before use: Check the solution inside the syringe or auto-injector before injecting. It should be clear to pale yellow or pale brown. Do not use it if it appears cloudy, discoloured, or contains visible particles.
  • Rotate injection sites: Use a different injection site with each dose to help reduce the risk of skin irritation, bruising, or tissue damage.
  • Do not share injection devices: Never share your injection device or reuse needles, as this can increase the risk of serious skin and blood infections.
  • Continue other prescribed medicines: Do not stop or reduce the dose of your other asthma controller medicines, especially oral steroids, unless your doctor advises you to do so.
  • Watch for allergic reactions: Be alert for delayed allergic reactions, which may occur several hours or even days after your injection.

Drug-Drug Interactions

verifiedApollotooltip
  • Corticosteroids (oral or inhaled): Do not stop taking or reduce your steroid dose suddenly when starting Nucala 100 mg Injection 1 ml. Your doctor will help you gradually decrease dose levels to prevent steroid withdrawal symptoms.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with Nucala 100 mg Injection 1 ml when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Nucala 100 mg Injection 1 ml is used to treat Asthma.
Nucala 100 mg Injection 1 ml contains Mepolizumab, which reduces the synthesis of pro-inflammatory markers called cytokines. Thus, it helps in decreasing inflammation.
Yes, once you or your caregiver receive proper training from a healthcare professional, you can self-inject Nucala 100 mg Injection 1 ml at home. Do not try to inject it until you feel confident in the technique. Talk to your doctor to see if home injection is right for you.
Take the missed dose as soon as you remember. If your next scheduled injection is very close, skip the missed dose and return to your regular monthly schedule. Talk to your doctor or pharmacist if you are confused about timing.
No, Nucala 100 mg Injection 1 ml is a long-term controller medicine and will not stop a sudden asthma attack. You must always keep your fast-acting rescue inhaler with you for quick relief during sudden breathing emergencies.
No, you should not stop or change any of your other asthma medicines unless your doctor explicitly tells you to do so. Nucala 100 mg Injection 1 ml works alongside your regular controller treatments. Talk to your doctor before making any adjustments.
Because Nucala 100 mg Injection 1 ml affects your immune system, you should discuss your vaccination history with your doctor before starting treatment. Some vaccines, such as those for shingles, are recommended before starting this medicine. Talk to your doctor about your immunization schedule.
The safety of Nucala 100 mg Injection 1 ml during pregnancy or breastfeeding is not fully established. Your doctor will help you balance the risks of uncontrolled asthma against any potential risks to your baby. Talk to your doctor if you are pregnant or planning to become pregnant.
You should experience fewer asthma flare-ups, reduced sinus congestion, and a decreased need for your rescue inhaler or oral steroids. Keep a daily log of your symptoms and talk to your doctor during your regular follow-ups to evaluate your progress.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

24-25 Floor, One Horizon Center Golf Course Road, Dlf Phase 5 Gurgaon 122002, India.
Other Info - NUC0169
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