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  3. Nicoduce 48mg Injection

Nicoduce 48mg Injection, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nicoduce 48mg Injection prevents or treats angina pectoris (heart-related chest pain). It contains Nicorandil, a potassium-channel activator that opens potassium channels present on the muscle cells within the walls of blood vessels, relaxes these muscle cells, and widens blood vessels. Thus, it reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, it helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.

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Composition :

NICORANDIL-48MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Nicoduce 48mg Injection

Nicoduce 48mg Injection is mainly used to prevent or treat angina pectoris in adults who cannot take beta-blockers (blood pressure-lowering pills). Angina pectoris is a kind of chest pain due to decreased blood flow to the heart. It is a symptom of coronary artery disease.

Nicoduce 48mg Injection contains Nicorandil, that opens potassium channels present on the muscle cells within the walls of blood vessels and relaxes these muscle cells and widens blood vessels.

Some people may experience side effects such as headache, nausea, vomiting, dizziness, injection site reactions, weakness or flushing (reddening of the skin). Most of these side effects of Nicoduce 48mg Injection do not require medical attention and resolve over time. However, if the side effects persist, please consult your doctor.

Nicoduce 48mg Injection will be administered by a healthcare professional; do not self-administer. The dose of the medicine will be decided by the physician based on the severity of the disease.

If you are allergic to Nicoduce 48mg Injection or any other medicines, please tell your doctor. Inform your doctor if you are pregnant or breastfeeding. Nicoduce 48mg Injection is not recommended for children as the safety and effectiveness were not been established. It is advised to drive only if you are alert as Nicoduce 48mg Injection may cause dizziness or weakness. Avoid alcohol consumption with Nicoduce 48mg Injection as it may cause severely low blood pressure.

Uses of Nicoduce 48mg Injection

Nicoduce 48mg Injection is used in the treatment of angina pectoris (heart-related chest pain). The detailed use of Nicoduce 48mg Injection is as follows:<br/>

  • Treatment of Angina Pectoris: Nicoduce 48mg Injection manages angina effectively by reducing chest pain frequency and severity, enhancing exercise capacity, and improving quality of life through potassium channel-mediated vasodilation.<br/>

Directions for Use

• Nicoduce 48mg Injection is given only in clinical settings by healthcare professionals, usually through slow intravenous injection. • The dose and duration are decided by the doctor, based on the patient's condition and response to treatment. • Do not self-administer this injection, as incorrect use can lead to serious side effects. • Patients are carefully monitored during and after administration to ensure safety and manage any side effects promptly.

Medicinal Benefits

  • Nicoduce 48mg Injection contains Nicorandil, a potassium-channel activator used to prevent or treat angina pectoris (chest pain).
  • Nicoduce 48mg Injection helps reduce the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen.
  • Also, Nicoduce 48mg Injection helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.
  • Nicoduce 48mg Injection is given to adults who cannot tolerate other heart medicines such as calcium antagonists or beta-blockers. 

How Nicoduce 48mg Injection Works

Nicoduce 48mg Injection contains Nicorandil, a potassium-channel activator that opens potassium channels present on the muscle cells within the walls of blood vessels and relaxes these muscle cells and widens blood vessels. Thereby, Nicoduce 48mg Injection reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicoduce 48mg Injection helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.

Storage

• Store in a cool and dry place away from sunlight.• Keep Nicoduce 48mg Injection out of reach and sight of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

What if I have taken an overdose of Nicoduce 48mg Injection

As Nicoduce 48mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

  • Inform your doctor if you are allergic to Nicoduce 48mg Injection or any other components present in it.
  • Avoid receiving Nicoduce 48mg Injection if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (accumulation of fluid in the lungs) or any heart problems.
  • Do not take Nicoduce 48mg Injection if you are pregnant or breastfeeding, and consult a doctor.
  • Nicoduce 48mg Injection is not recommended for children as the safety and effectiveness have not been established.
  • Avoid alcohol consumption with Nicoduce 48mg Injection as it may cause severely low blood pressure.
  • Avoid taking vardenafil, sildenafil, tadalafil and riociguat with Nicoduce 48mg Injection as it may affect blood pressure.
  • If you notice in blood in stools while administration with Nicoduce 48mg Injection, inform your doctor immediately, as it may be due to ulcers in the stomach, intestines or back passage. 

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Consume low-salt and a low-fat diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption.
  • Choose healthy fats and cut down on trans fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

VASODILATORS

Nicoduce 48mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Nicoduce 48mg Injection as it may cause severely low blood pressure.

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Pregnancy

Unsafe

There is limited information on the use of Nicoduce 48mg Injection in pregnant women. Usually, it is not recommended for pregnant women. Therefore, if you are pregnant or planning pregnancy, please inform your doctor.

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Breast Feeding

Consult your doctor

There is limited information on the use of Nicoduce 48mg Injection in breastfeeding mothers. Therefore, please inform your doctor if you are a breastfeeding mother.

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Driving

Unsafe

Nicoduce 48mg Injection may cause dizziness or weakness in some people. Therefore, avoid driving if you feel dizzy or weak after receiving Nicoduce 48mg Injection.

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Liver

Caution

Take Nicoduce 48mg Injection with caution, especially if you have a history of liver disease.

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Kidney

Caution

Take Nicoduce 48mg Injection with caution, especially if you have a history of kidney disease.

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Children

Unsafe

Nicoduce 48mg Injection is not recommended for children as safety and effectiveness were not established.

Have a query?

FAQs

Nicoduce 48mg Injection is used to treat Angina pectoris (heart-related chest pain).

Nicoduce 48mg Injection contains Nicorandil which works by relaxing and widening blood vessels. Thereby, Nicoduce 48mg Injection reduces the workload of the heart by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicoduce 48mg Injection helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.

Nicoduce 48mg Injection may cause headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor so that the dose may be reduced initially.

Nicoduce 48mg Injection is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Nicoduce 48mg Injection.

You are not recommended to take aspirin (pain reliever) with Nicoduce 48mg Injection as co-administration of these two medicines may increase the risk of ulcers or other adverse effects. However, please consult a doctor before taking other medicines with Nicoduce 48mg Injection.

You are recommended to avoid receiving Nicoduce 48mg Injection if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (accumulation of fluid in the lungs) or any heart problems such as left ventricular failure with low filling pressure, cardiac decompensation or cardiogenic shock.

You are not recommended to take more than the prescribed dose of Nicoduce 48mg Injection as it may cause Nicoduce 48mg Injection overdose resulting in symptoms such as weakness, dizziness (signs of low blood pressure), and fast or irregular heartbeat. However, if you experience any of these symptoms while receiving Nicoduce 48mg Injection, please consult a doctor immediately.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - NIC0209

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 25, 2025 | 8:17 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.652.pdf
  2. https://www.nhs.uk/medicines/nicorandil/

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