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compositionComposition:BIVALIRUDIN-250MG
prescription
Prescription Medicine
info
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Ngmine 250 Injection is used to prevent the formation of blood clots. It works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack) or stroke, especially in people who have had heart surgery, known as angioplasty.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BIVALIRUDIN-250MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ngmine 250 Injection

Because this medicine is injected directly into a vein during a medical procedure, it is typically given as a single, continuous dose for the duration of your procedure. You do not need to worry about daily scheduling or taking it with food, as a healthcare professional will handle the entire process. Following any heart-healthy lifestyle recommendations from your doctor, such as eating a low-salt diet and avoiding sudden physical strain, will support your recovery.

While receiving this medicine, you may experience mild side effects like minor bleeding, bruising, or nausea. It is vital to tell your healthcare team immediately if you notice serious signs such as severe, uncontrollable bleeding, blood in your urine or stool, or sudden weakness.

Before your procedure, tell your doctor if you have kidney disease, a history of bleeding disorders, or if you have recently had surgery. Before your procedure, tell your doctor if you have kidney disease, a history of bleeding disorders, have recently had surgery, or have recently had brain or spinal surgery, as these conditions may increase your risk of bleeding. Do not receive this medicine if you have active, severe bleeding or a known severe allergy to Ngmine 250 Injection.

This medicine can interact with other blood thinners, certain pain relief medicines, and some herbal supplements, which can increase your risk of bleeding. If you are pregnant, breastfeeding, or over the age of 65, talk to your doctor about the risks and benefits of receiving this medication during your procedure.

Uses of Ngmine 250 Injection

Your doctor may prescribe Ngmine 250 Injection to help manage the following conditions:

  • Blood clots during coronary procedures: Ngmine 250 Injection helps prevent dangerous blood clots from forming in the heart's blood vessels during angioplasty or other procedures to open blocked arteries.
    Unstable angina: It is used to reduce the risk of clot formation in patients experiencing severe chest pain who are undergoing heart procedures.
  • Heparin-induced thrombocytopenia (HIT) support: It serves as a safe alternative blood thinner for patients undergoing heart procedures who have a history of a specific severe immune reaction to heparin.
  • Heart attack (STEMI) during emergency angioplasty: Ngmine 250 Injection is also used in people having an emergency procedure (primary PCI) to open a blocked heart artery during a serious heart attack (STEMI). It helps reduce the risk of blood clots while the procedure is being performed. 

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Heart Protection During Procedures: This medicine helps protect your heart during delicate medical procedures by keeping your blood thin and flowing. By preventing blood clots, it reduces the risk of serious complications like heart attacks or strokes while your doctor is working on your blood vessels.
  • Fast and Predictable Action: Another significant benefit of Ngmine 250 Injection is its predictable action and quick clearance from the body. Once the injection is stopped, its blood-thinning effects wear off relatively quickly, which helps your body return to its normal clotting ability sooner after your procedure is complete.
Side effects of Ngmine 250 Injection

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Ngmine 250 Injection will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Ngmine 250 Injection Works

Ngmine 250 Injection contains bivalirudin, which is a direct thrombin inhibitor. Thrombin is a key protein in your blood that acts like a chemical switch to trigger clot formation during injury. While clot formation is normally helpful, it can be dangerous during heart procedures. By binding directly to thrombin, this medicine temporarily blocks its action. This prevents platelets from sticking together and stops the chain reaction that builds blood clots. Because it works directly on this specific protein, it provides reliable, immediate protection against clotting during your procedure.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Ngmine 250 Injection to prevent unpleasant side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Ngmine 250 Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Ngmine 250 Injection does not affect your ability to drive.

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Liver

Caution

Ngmine 250 Injection should be used with caution in patients with liver impairment. Please inform your doctor if you have liver disease or any concerns regarding this.

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Kidney

Caution

Ngmine 250 Injection should be used with caution in patients with kidney impairment. Please inform your doctor if you have kidney disease or any concerns regarding this.

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Children

Unsafe

Ngmine 250 Injection is not recommended for use in children, as efficacy and safety have not been established.

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Heart

Caution

Ngmine 250 Injection should be avoided in heart patients unless specifically prescribed. It affects blood clotting and demands strict medical supervision during cardiac procedures.

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Geriatrics

Caution

Ngmine 250 Injection should be avoided in geriatric patients unless specifically prescribed. Older adults may have reduced kidney function and higher bleeding risk, requiring strict medical supervision.

What if I have taken an overdose of Ngmine 250 Injection

Since this medication is carefully measured and injected by healthcare professionals in a controlled clinical environment, an overdose is extremely rare. However, if an overdose occurs, your medical team is equipped to manage it immediately by stopping the injection and monitoring you closely for any signs of bleeding.

Diet & Lifestyle Advise

  • Activity Precautions: Avoid sudden, rough physical activities or contact sports for a few days after your procedure to prevent bruising or bleeding.
  • Bleeding Precautions: Use a soft-bristled toothbrush and an electric razor to minimise the risk of minor cuts and bleeding while the medicine is still clearing from your system.
  • Dietary Advice: There are no specific food restrictions while receiving Ngmine 250 Injection. Eat a balanced diet and follow any dietary instructions provided by your healthcare team after your procedure.
  • Hydration Advice: Stay hydrated as directed by your doctor to help your kidneys naturally clear the medicine from your body after your procedure.
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How Soon It Starts Working

The time required for Ngmine 250 Injection to start to work: Ngmine 250 Injection ideally shows its action within 15 to 20 minutes after administration. The time for which the effects of Ngmine 250 Injection last: The effect of Ngmine 250 Injection lasts for 1 hour.

What if you forget to take Ngmine 250 Injection

Because this medicine is injected by a healthcare professional in a hospital setting during a specific medical procedure, it is highly unlikely that you will miss a dose. If your procedure is delayed or rescheduled, your medical team will adjust your treatment plan accordingly.

Storage

•Medical History: Ensure your medical team knows if you have a history of heparin-induced thrombocytopenia before they inject this medicine.

Drug Warnings

  • Medical History: Ensure your medical team knows if you have a history of heparin-induced thrombocytopenia before they inject this medicine.
  • Injection Site Care: Keep the injection site clean and dry after your procedure, and monitor it closely for any swelling, warmth, or active bleeding.
  • Medical Procedures: Do not receive any dental work or other minor surgical procedures immediately after receiving this medicine without consulting your doctor.
  • Inform Healthcare Provider: Inform any healthcare professional treating you in an emergency that you have recently received Ngmine 250 Injection, as this affects how they manage any bleeding risks.
  • Injection Safety: Verify that the injection solution is clear and free of visible particles before it is injected by your healthcare team.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinner Interaction: Combining this medicine with other blood thinners (like warfarin, heparin, or clopidogrel) can significantly increase your risk of bleeding.
  • NSAID Bleeding Risk: Taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or high-dose aspirin can increase the risk of stomach ulcers and bleeding.
  • Herbal Supplement Warning: Certain herbal supplements, such as ginkgo biloba, garlic, or ginger, may enhance the blood-thinning effect and should be avoided close to your procedure.
BivalirudinEstradiol
Critical
BivalirudinMifepristone
Critical

Drug-Drug Interactions

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BivalirudinEstradiol
Critical
How does the drug interact with Ngmine 250 Injection:
When Etodolac is taken with Ngmine 250 Injection, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Ngmine 250 Injection with Estradiol can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
BivalirudinMifepristone
Critical
How does the drug interact with Ngmine 250 Injection:
Co-administration of Mifepristone with Ngmine 250 Injection can increase the risk of negative side effects.

How to manage the interaction:
Taking Ngmine 250 Injection with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
BivalirudinDeferasirox
Severe
How does the drug interact with Ngmine 250 Injection:
Using Deferasirox together with Ngmine 250 Injection may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
BivalirudinFondaparinux
Severe
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Ngmine 250 Injection and Fondaparinux, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
BivalirudinWarfarin
Severe
How does the drug interact with Ngmine 250 Injection:
Coadministration of Warfarin with Ngmine 250 Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Ngmine 250 Injection and warfarin, you can take these medicines together if prescribed by a doctor. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
BivalirudinApixaban
Severe
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ngmine 250 Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
BivalirudinIbrutinib
Severe
How does the drug interact with Ngmine 250 Injection:
Co-administration of Ibrutinib with Ngmine 250 Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Ngmine 250 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
BivalirudinDabigatran etexilate
Severe
How does the drug interact with Ngmine 250 Injection:
Taking Dabigatran etexilate with Ngmine 250 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Ngmine 250 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
BivalirudinDasatinib
Severe
How does the drug interact with Ngmine 250 Injection:
Using Dasatinib together with Ngmine 250 Injection may increase the risk of bleeding.

How to manage the interaction:
Although taking Ngmine 250 Injection and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs: bruising, feeling dizzy or lightheaded, dark stools, headache, weakness, contact a doctor right away. Do not stop using any medications without a doctor's advice.
BivalirudinHeparin
Severe
How does the drug interact with Ngmine 250 Injection:
Taking Ngmine 250 Injection with Heparin may increase the risk of bleeding.

How to manage the interaction:
Although taking Ngmine 250 Injection and Heparin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Ngmine 250 Injection when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS]

FAQs

Ngmine 250 Injection is an injectable blood thinner used to prevent blood clots, especially during heart procedures such as angioplasty. It works by preventing clot formation and helps keep blood flowing smoothly while the procedure is being performed. Your doctor will determine whether it is appropriate for your condition.
Ngmine 250 Injection works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack).
Ngmine 250 Injection may cause anaemia (low haemoglobin and low red blood cell count). So it would be best if you include iron-rich food in your diet to prevent anaemia.
Ngmine 250 Injection does not affect the functioning of the liver. However, long-term use of Ngmine 250 Injection may slightly increase the risk of mild liver damage, particularly in those with increased liver enzyme levels. Therefore, if you have any liver problem, please inform your doctor before starting Ngmine 250 Injection.
It is best to avoid drinking alcohol while taking Ngmine 250 Injection. Intake of alcohol might increase the risk of stomach or intestinal bleeding.
Store Ngmine 250 Injection at controlled room temperature (15-25°C) in a cool and dry place. Do not freeze. Keep out of reach of children.
You might not feel any difference after taking Ngmine 250 Injection, but you should continue taking it as prescribed by your doctor. Even though you don't notice any difference, you will still receive all benefits of Ngmine 250 Injection.
Ngmine 250 Injection should not be taken by individuals with allergies, bleeding issues, strokes, liver disease, or taking any blood thinners. It is important to inform your doctor if you develop thrombotic thrombocytopenic purpura while on treatment with Ngmine 250 Injection. Pregnant or breastfeeding mothers should inform your doctor before receiving Ngmine 250 Injection. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.
No, Ngmine 250 Injection does not usually cause hair loss. However if you notice hair loss while on treatment with Ngmine 250 Injection, please consult your doctor.
The common side effects of Ngmine 250 Injection are nose bleeds, skin rash, bruising, bleeding in the bowels, blood in urine, low haemoglobin, and thrombocytopenia (low platelets). If any of these side effects persist or worsen, please consult your doctor.
This medicine is injected directly into a vein (intravenously) by a trained healthcare professional in a hospital or clinic setting. You will not need to inject this medicine yourself. Talk to your doctor about what to expect during the injection.
Yes, Ngmine 250 Injection is often used as a safe alternative blood thinner for patients who have had a serious allergic or immune reaction to heparin (such as heparin-induced thrombocytopenia). Talk to your doctor to ensure this is the right alternative for you.
Both medicines help prevent blood clots during heart procedures. Your doctor may choose Ngmine 250 Injection for some patients because it has a predictable effect, wears off relatively quickly after the procedure, and can be used in people with a history of heparin-induced thrombocytopenia (HIT). The best choice depends on your medical condition, bleeding risk, and the type of procedure you are having. Talk to your doctor about why this medicine was selected for you.
You should watch for unusual or severe bruising, blood in your urine or stool, frequent nosebleeds, or prolonged bleeding from the injection site. If you notice any of these signs, notify your medical team immediately. Talk to your doctor if you experience any unusual symptoms after your procedure.
There is limited research on the safety of using Ngmine 250 Injection during pregnancy. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor if you are pregnant or planning to become pregnant before undergoing your procedure.
No. You should avoid taking ibuprofen or other NSAIDs (such as naproxen) while receiving or shortly after receiving Ngmine 250 Injection unless specifically advised by your doctor, as these medicines can significantly increase the risk of bleeding. Consult your doctor or pharmacist before taking any pain reliever or over-the-counter medicine.
If you experience minor bleeding or oozing at the injection site after going home, apply firm, continuous pressure to the area with a clean cloth. If the bleeding does not stop after several minutes, or if it is flowing heavily, seek emergency medical care immediately. Talk to your doctor about proper post-procedure wound care.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - NGM0004
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