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  3. Natclovir 250 Capsule 10's

Natclovir 250 Capsule 10's, Pack of 10 CapsuleS
Natclovir 250 Capsule 10's, Pack of 10 CapsuleS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Natclovir 250 Capsule is an antiviral drug used to treat viral infections. It plays a vital role in treating Cytomegalovirus infection in immunosuppressed people (having HIV/AIDS) or those who have undergone bone marrow or organ transplantation. It contains Ganciclovir, which prevents the multiplication of the virus in human cells, decreases viral overload and stops the production of new viruses. In some cases, you may experience nausea, headache, dizziness, fever, vomiting, diarrhoea, increased liver enzymes, and stomach pain. Most of these side effects of Natclovir 250 Capsule are temporary, do not require medical attention, and gradually subside over time. However, if the side effects persist, contact your doctor immediately.

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Composition :

GANCICLOVIR-250MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Natclovir 250 Capsule

Natclovir 250 Capsule belongs to a class of drugs known as antivirals, which are used to treat viral infections. It plays a vital role in treating Cytomegalovirus infection in immunosuppressed people (having HIV/AIDS) or those who have undergone bone marrow or organ transplantation. Cytomegalovirus infection is a common herpes virus infection that often presents with no symptoms or mild symptoms, such as fever and fatigue. Severe infection may affect the eyes, brain, or other internal organs.

Natclovir 250 Capsule contains Ganciclovir, an antiviral medication. It works by preventing the multiplication of viruses in human cells by acting on their DNA, resulting in a decrease in viral overload and the production of new viruses. Hence, this helps in clearing up the infection.

Take Natclovir 250 Capsule as prescribed by your doctor. It can be taken with or without food. You are advised to take Natclovir 250 Capsule for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, headache, dizziness, fever, vomiting, diarrhoea, increased liver enzymes, and stomach pain. Most of these side effects of Natclovir 250 Capsule are temporary, do not require medical attention, and gradually subside over time. However, if the side effects persist, contact your doctor immediately.

Do not take Natclovir 250 Capsule if you are allergic to it, aciclovir or any of its ingredients. Never encourage self-medication or suggest your medicine to someone else, even if the symptoms occur similarly. Check with your doctor if you're pregnant, currently breastfeeding or taking any other prescribed or non-prescribed medicines. Use protection while having sexual intercourse to avoid the transfer of infection to your partner. If you have a weak immune system, please inform your doctor before taking Natclovir 250 Capsule , as a dose adjustment may be required.

Uses of Natclovir 250 Capsule

Natclovir 250 Capsule is used in the treatment of cytomegalovirus (CMV) infection. The detailed uses of Natclovir 250 Capsule are as follows:<br/> • Treats CMV infection in immunocompromised individuals: Natclovir 250 Capsule is effective in managing CMV infections in people with weakened immune systems, such as those with HIV/AIDS.<br/> • Prevents CMV disease in transplant patients: Natclovir 250 Capsule is used prophylactically to reduce the risk of CMV reactivation or infection after bone marrow or organ transplantation.<br/> • Inhibits viral replication: Natclovir 250 Capsule , an antiviral drug, works by blocking the multiplication of CMV, helping to control and limit the spread of the virus in the body.<br/>

Directions for Use

  • Natclovir 250 Capsule can be taken with or without food, as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Natclovir 250 Capsule contains Ganciclovir, which belongs to a class of drugs known as antiviral medicines. It is used to treat viral infections. It plays a vital role in treating Cytomegalovirus Infection in Immunosuppressed people who have undergone bone marrow or organ transplantation. In addition to this, it also reduces the risk of blindness in people with serious eye infections (CMV retinitis). It works by preventing the multiplication of viruses in human cells by acting on their DNA, resulting in decreased viral overload and new virus production. Hence, this helps in clearing up the infection.

How Natclovir 250 Capsule Works

Natclovir 250 Capsule contains Ganciclovir, an antiviral medication. It works by preventing the multiplication of viruses in human cells by acting on their DNA, resulting in a decrease in viral overload and the production of new viruses. Hence, this helps in clearing up the infection.

Storage

Keep Natclovir 250 Capsule out of the sight and reach of children.
Side effects of Natclovir 250 Capsule
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.

What if I have taken an overdose of Natclovir 250 Capsule

Do not take more than the prescribed dose of Natclovir 250 Capsule as it may cause an overdose. The symptoms of overdose include fits or shaking, blood in urine, diarrhoea, stomach pain, nausea, liver or kidney problems and changes in blood cell counts. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Natclovir 250 Capsule if you are allergic to Natclovir 250 Capsule  or any of its ingredients. 
  • Inform your doctor if you have or have ever had anaemia (red blood cells do not bring enough oxygen to all parts of the body), neutropenia (less than a normal number of white blood cells), thrombocytopenia (less than a normal number of platelets) or other blood or bleeding problems as Natclovir 250 Capsule may lower the blood cell count or if you have received or are receiving radiation (X-ray) therapy. 
  • If you experience any of the following symptoms, call your doctor immediately: excessive tiredness, pale skin, headache, dizziness, confusion, fast heartbeat, difficulty falling asleep or staying asleep, weakness, shortness of breath, unusual bleeding or bruising or sore throat, fever, chills, cough or other signs of infection.

Drug-Drug Interactions

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GanciclovirCidofovir
Critical
GanciclovirZidovudine
Severe

Drug-Drug Interactions

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GanciclovirCidofovir
Critical
How does the drug interact with Natclovir 250 Capsule:
Coadministration of cidofovir with Natclovir 250 Capsule can increase the risk of kidney problems.

How to manage the interaction:
Although there is a interaction between Natclovir 250 Capsule and Cidofovir hence it is not recommended to be taken together, but it can be taken only if advised by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
GanciclovirZidovudine
Severe
How does the drug interact with Natclovir 250 Capsule:
Using zidovudine together with Natclovir 250 Capsule may increase the risk of side effects affecting the blood leading to decreased levels of blood cells.

How to manage the interaction:
Taking Natclovir 250 Capsule with zidovudine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, sore throat, rashes, tiredness, headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GanciclovirCladribine
Severe
How does the drug interact with Natclovir 250 Capsule:
Taking cladribine together with Natclovir 250 Capsule may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Cladribine with Natclovir 250 Capsule can result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GanciclovirTenofovir alafenamide
Severe
How does the drug interact with Natclovir 250 Capsule:
When Tenofovir alafenamide is taken with Natclovir 250 Capsule, the amount of Tenofovir alafenamide in the blood can go up. This can increase the risk or severity of side effects like kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Tenofovir alafenamide and Natclovir 250 Capsule, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
GanciclovirClozapine
Severe
How does the drug interact with Natclovir 250 Capsule:
Clozapine can cause higher levels of Natclovir 250 Capsule in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Natclovir 250 Capsule and Clozapine, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, weight loss, or pain, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GanciclovirTenofovir disoproxil
Severe
How does the drug interact with Natclovir 250 Capsule:
coadministration of Tenofovir disoproxil with Natclovir 250 Capsule can increase the risk or severity of side effects like kidney damage.

How to manage the interaction:
Although taking Natclovir 250 Capsule and Tenofovir disoproxil together can cause an interaction, it can be taken if your doctor has suggested it. If you have symptoms like feeling sick, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, swelling, trouble breathing, bone or muscle pain, feeling weak or dizzy, feeling confused, or having an irregular heartbeat -contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
GanciclovirMaribavir
Severe
How does the drug interact with Natclovir 250 Capsule:
Coadministration of Natclovir 250 Capsule with Maribavir may alter the effectiveness of both these medications. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Maribavir and Natclovir 250 Capsule together can possibly result in an interaction; it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
GanciclovirDeferiprone
Severe
How does the drug interact with Natclovir 250 Capsule:
Natclovir 250 Capsule can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Natclovir 250 Capsule and Deferiprone together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms - like a sore throat, fever, or muscle aches - it's important to let a doctor know right away. Do not stop using any medications without a doctor's advice.
GanciclovirGolimumab
Severe
How does the drug interact with Natclovir 250 Capsule:
Using Natclovir 250 Capsule together with golimumab may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Natclovir 250 Capsule and Golimumab, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like fever, chills, diarrhea, a sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee contact a doctor immediately. Do not stop using any medications without a doctor's advice.
GanciclovirInfliximab
Severe
How does the drug interact with Natclovir 250 Capsule:
Combining Infliximab with Natclovir 250 Capsule can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Natclovir 250 Capsule and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate contact your doctor immediately. Don't hesitate to reach out to a doctor if you experience any of these. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid alcoholic beverages with Natclovir 250 Capsule as it can make you dehydrated and may affect your sleep.
  • Try to include heart-healthy omega-3 fatty acid-containing foods and drinks in your daily diet. You can also use low-fat cooking oils, such as olive oil, soybean oil, canola oil, and coconut oil.
  • Include turmeric or yellow mustard in your diet to avoid constipation caused by antiviral drugs, and increase the intake of fluids to stay hydrated.
  • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
  • Eat a healthy and balanced diet, and ensure you get at least 8 hours of sleep a day for a speedy recovery.
  • If you are going out in strong sunlight, please wear a lip balm with SPF 15 or higher, as Natclovir 250 Capsule may be sensitive to UV and sunlight.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

Natclovir 250 Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol is not known to cause any unpleasant side effects if taken along with Natclovir 250 Capsule . But intake of alcohol with Natclovir 250 Capsule may damage your liver. So intake of alcohol should be avoided with Natclovir 250 Capsule .

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Pregnancy

Caution

Natclovir 250 Capsule is a pregnancy Category C medicine. It is not known whether Natclovir 250 Capsule will affect pregnant women or fetus or not. Hence, the intake of Natclovir 250 Capsule should be only if prescribed and under medical supervision.

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Breast Feeding

Caution

Natclovir 250 Capsule is a pregnancy Category C medicine. It is not known whether Natclovir 250 Capsule will pass through the milk in breastfeeding women or not. Hence, Natclovir 250 Capsule should only be taken if prescribed by a doctor and under medical supervision.

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Driving

Unsafe

Natclovir 250 Capsule can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

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Liver

Consult your doctor

Natclovir 250 Capsule to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

Natclovir 250 Capsule to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Natclovir 250 Capsule is not recommended for children below 12 years as its safety and efficacy are not established.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Caution

Because elderly people may have diminished renal function and Natclovir 250 Capsule is known to be largely eliminated by the kidney, the risk of adverse responses to this medicine is higher in patients with impaired renal function.

Have a query?

FAQs

Natclovir 250 Capsule is used to treat viral infections. It plays a vital role in treating Cytomegalovirus infection in immunosuppressed people (having HIV/AIDS) or those who have undergone bone marrow or organ transplantation.

It contains Ganciclovir, an antiviral agent that is specifically effective against certain viral infections such as cytomegalovirus (CMV). Ganciclovir works by entering virus-infected cells and interfering with the replication of viral DNA, which is essential for the virus to multiply. By inhibiting DNA synthesis, it prevents the virus from spreading further in the body. As a result, it helps control the infection, reduce viral load, and support recovery.

The most common side effects of Natclovir 250 Capsule are headaches, dizziness, nausea, fever, vomiting, diarrhoea, and stomach pain. Most of these side effects of Natclovir 250 Capsule are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

No, you should not stop taking Natclovir 250 Capsule without consulting the doctor, even if you feel better. The symptoms may improve, but the infection may not be completely cured. Therefore, it is advisable to continue the treatment at the prescribed dose and duration for optimal results.

Natclovir 250 Capsule may affect fertility. It may temporarily or permanently stop men from producing sperm and reduce fertility in women. So, if you are planning a baby, inform your doctor before taking Natclovir 250 Capsule . Also, wear a condom during sexual intercourse to avoid the transfer of infection to the female counterpart.

No, Natclovir 250 Capsule should be taken as advised by the doctor in terms of dose and duration. If you take it in a dose greater than the recommended amount, it may cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - NAT0052

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 12:05 PM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a605011.html
  2. https://www.medicines.org.uk/emc/files/pil.10242.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209347lbl.pdf
  4. https://www.drugs.com/pro/ganciclovir.html

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