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compositionComposition:MIDAZOLAM-1.25%W/V
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Midazom Plus 1.25% Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures). It contains Midazolam, which increases GABA activity (a chemical messenger in the brain). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls Seizures. Common side effects of Midazom Plus 1.25% Nasal Spray 4 MDI are headache, drowsiness, runny nose, throat irritation, and nasal discomfort.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDAZOLAM-1.25%W/V

Manufacturer/Marketer :

Mindneuro Pharma

Consume Type :

Nasal

Return Policy :

Not Returnable

About Midazom Plus 1.25% Nasal Spray 4 MDI

Midazom Plus 1.25% Nasal Spray 4 MDI belongs to a class of drugs called benzodiazepines used for the short-term treatment of seizure clusters. Seizure clusters are episodes of elevated seizure activity, defined as two or more seizures occurring within 24 hours. They are upsetting situations that can make you anxious, frustrated, or helpless.

Midazom Plus 1.25% Nasal Spray 4 MDI contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Midazom Plus 1.25% Nasal Spray 4 MDI suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Use Midazom Plus 1.25% Nasal Spray 4 MDI as prescribed and for the duration as your doctor has prescribed it for you based on your medical condition. Sometimes, it may cause side effects such as headache, drowsiness, runny nose, throat irritation, and nasal discomfort. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Midazolam or other medicines. If you are pregnant, planning for pregnancy or are breastfeeding, please inform your doctor before taking Midazom Plus 1.25% Nasal Spray 4 MDI. Midazom Plus 1.25% Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness have not been established. Avoid consumption of alcohol with Midazom Plus 1.25% Nasal Spray 4 MDI as it may cause increased drowsiness. Avoid driving or operating machinery until you know how Midazom Plus 1.25% Nasal Spray 4 MDI affects you. Avoid using Midazom Plus 1.25% Nasal Spray 4 MDI if you have acute narrow-angle glaucoma (eye problem). Do not take Midazom Plus 1.25% Nasal Spray 4 MDI with opioids unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma.

Uses of Midazom Plus 1.25% Nasal Spray 4 MDI

Midazom Plus 1.25% Nasal Spray 4 MDI is used in the treatment of seizure clusters (acute repetitive seizures). The detailed uses of Midazom Plus 1.25% Nasal Spray 4 MDI are as follows:

  • Conscious Sedation: Midazom Plus 1.25% Nasal Spray 4 MDI is used before diagnostic or therapeutic procedures to help patients feel relaxed and comfortable, and helps relieve anxiety and muscle tension before minor surgeries or dental procedures.
  • Treatment of Seizure Clusters: Midazom Plus 1.25% Nasal Spray 4 MDI helps manage acute repetitive seizures, which involve multiple seizures within a short period and works by increasing GABA activity, a brain chemical that calms nerve cells and controls seizures.
  • Pre-Surgical Sedation: Midazom Plus 1.25% Nasal Spray 4 MDI is administered before medical procedures to induce drowsiness and reduce discomfort, and helps patients remain calm without the need for general anaesthesia.

Key Benefits

Midazom Plus 1.25% Nasal Spray 4 MDI contains Midazolam used to treat acute (sudden) repetitive fits. Midazom Plus 1.25% Nasal Spray 4 MDI increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration.
  • Blow your nose to clear the nostrils before use. Insert the nozzle into one nostril while closing the other nostril. Spray the medicine while breathing in. Repeat for the other nostril if required.
  • Shake the nasal spray well before each use.

How Midazom Plus 1.25% Nasal Spray 4 MDI Works

Midazom Plus 1.25% Nasal Spray 4 MDI contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Midazom Plus 1.25% Nasal Spray 4 MDI suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.
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Alcohol

Unsafe

Avoid consumption of alcohol with Midazom Plus 1.25% Nasal Spray 4 MDI as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before using Midazom Plus 1.25% Nasal Spray 4 MDI. Babies born to mothers receiving Midazom Plus 1.25% Nasal Spray 4 MDI late in pregnancy may be at risk of feeding or breathing problems, withdrawal symptoms or dangerously low body temperature.

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Breast Feeding

Caution

Midazom Plus 1.25% Nasal Spray 4 MDI may be excreted in breast milk and may harm your baby. Therefore, discuss with your doctor the best way to feed your baby if you use Midazom Plus 1.25% Nasal Spray 4 MDI.

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Driving

Caution

Avoid driving or operating machinery until you know how Midazom Plus 1.25% Nasal Spray 4 MDI affects you.

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Liver

Consult your doctor

If you have liver problems, consult your doctor before using Midazom Plus 1.25% Nasal Spray 4 MDI.

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Kidney

Consult your doctor

If you have kidney diseases/conditions, consult your doctor before using Midazom Plus 1.25% Nasal Spray 4 MDI.

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Children

Unsafe

Midazom Plus 1.25% Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness were not established.

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Heart

Caution

Midazom Plus 1.25% Nasal Spray 4 MDI is generally safe for heart patients due to its rapid, localized action and low systemic absorption. However, it may cause sedation or breathing issues, so medical supervision is essential.

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Geriatrics

Caution

Geriatric patients can use Midazom Plus 1.25% Nasal Spray 4 MDI, but with caution. Older adults are more sensitive to sedative effects, which may increase the risk of drowsiness, confusion, or slowed breathing. It's important that a healthcare provider supervises its use, especially if there are other medications or health conditions involved.

What if I have taken an overdose of Midazom Plus 1.25% Nasal Spray 4 MDI

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Midazom Plus 1.25% Nasal Spray 4 MDI may include agitation, changes in patterns and rhythms of speech, confusion, drowsiness, dullness, feeling of sluggishness, irritability, lack of coordination, loss of consciousness, loss of strength or energy, nervousness, nightmares, problems with muscle control or coordination, relaxed and calm feeling, restlessness, shakiness and unsteady walk, sleepiness, slurred speech, talkativeness, tiredness, trouble speaking, unsteadiness, unusual excitement, unusual weak feeling, and weakness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • Do regular exercise and maintain a healthy body weight.
  • Maintain a diet rich in fruits, vegetables and whole grains. Avoid fried foods, high-fat dairy products, pastries and processed foods, as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during the daytime.
  • Avoid watching tv and using mobiles or laptops just before bedtime.
  • Avoid the consumption of alcohol as it may increase drowsiness.

Have a query?

How Soon It Starts Working

The time required for Midazom Plus 1.25% Nasal Spray 4 MDI to start to work: Midazom Plus 1.25% Nasal Spray 4 MDI shows its action rapidly, its complete effect can be achieved within 10 minutes of administration. The time for which the effects of Midazom Plus 1.25% Nasal Spray 4 MDI last: The duration of Midazom Plus 1.25% Nasal Spray 4 MDI’s effect is clinically not established.

What if you forget to take Midazom Plus 1.25% Nasal Spray 4 MDI

If you miss a dose, use it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not use two doses at once to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Midazom Plus 1.25% Nasal Spray 4 MDI out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy, or breastfeeding, please inform your doctor before using Midazom Plus 1.25% Nasal Spray 4 MDI. Midazom Plus 1.25% Nasal Spray 4 MDI is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Midazom Plus 1.25% Nasal Spray 4 MDI as it may cause drowsiness. Avoid driving or operating machinery until you know how Midazom Plus 1.25% Nasal Spray 4 MDI affects you. Avoid using Midazom Plus 1.25% Nasal Spray 4 MDI if you have acute narrow-angle glaucoma (eye problem). Do not take Midazom Plus 1.25% Nasal Spray 4 MDI with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma. Get medical help immediately if you experience unusually excessive sleepiness or shallow or slowed breathing while using Midazom Plus 1.25% Nasal Spray 4 MDI.

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Drug-Drug Interaction: Inform your doctor about all the other medicines you are taking, including prescription and over-the-counter medicines and herbal and vitamin supplements.

Drug-Food Interaction: Avoid alcohol consumption with Midazom Plus 1.25% Nasal Spray 4 MDI as it may increase drowsiness or dizziness.

Drug-Disease Interaction: Avoid using Midazom Plus 1.25% Nasal Spray 4 MDI if you have acute narrow-angle glaucoma (eye problem). If you have a history of drug abuse, mood problems, depression, suicidal thoughts or behaviour, asthma, bronchitis, chronic obstructive pulmonary disease or other breathing problems, kidney, liver or heart problems, inform your doctor before taking Midazom Plus 1.25% Nasal Spray 4 MDI.

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Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Midazom Plus 1.25% Nasal Spray 4 MDI is used to treat Seizure clusters (acute repetitive seizures).

Midazom Plus 1.25% Nasal Spray 4 MDI contains Midazolam, which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thereby preventing fits by stabilizing the electrical activity of nerve cells in the brain.

If the seizure cluster continues after 10 minutes of the first dose, you can use the second dose of Midazom Plus 1.25% Nasal Spray 4 MDI if advised by your doctor. However, the second dose should be given in the other nostril. Do not use more than two doses to treat a seizure cluster.

You are not recommended to take Midazom Plus 1.25% Nasal Spray 4 MDI with opioids, alcohol or other central nervous system depressants as it may cause breathing problems, severe drowsiness or coma. Therefore, please consult your doctor before taking Midazom Plus 1.25% Nasal Spray 4 MDI with any other medicines.

You are not recommended to stop using Midazom Plus 1.25% Nasal Spray 4 MDI suddenly without consulting your doctor as it may cause withdrawal symptoms such as hallucinations, nervousness, shaking, muscle pain or cramps. Therefore, use Midazom Plus 1.25% Nasal Spray 4 MDI for as long as your doctor has prescribed it, and if you experience any difficulty while using Midazom Plus 1.25% Nasal Spray 4 MDI, please consult your doctor so that the dose may be reduced gradually.

Yes, Midazom Plus 1.25% Nasal Spray 4 MDI may cause physical dependence if used for prolonged periods. Therefore, use Midazom Plus 1.25% Nasal Spray 4 MDI only in the dose and for the duration as advised by your doctor.

Disclaimer

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Country of origin

India
Other Info - MID0134
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