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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Mecobion-Np 75mg Tablet is a combination medicine used to manage diabetic neuropathy, neuropathic pain, and nutritional deficiencies. This medicine works by altering the nerve signals that cause pain and thereby protects nerve fibres. It helps provide a protective effect on the nerve tissues and the brain. You may experience common side effects like nausea, vomiting, diarrhoea, stomach upset, dizziness, and rash.
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Manufacturer/Marketer :

Medley Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mecobion-Np 75mg Tablet

Mecobion-Np 75mg Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Mecobion-Np 75mg Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Mecobion-Np 75mg Tablet helps to treat neuropathic pain.

Take Mecobion-Np 75mg Tablet as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Mecobion-Np 75mg Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.

Please do not take Mecobion-Np 75mg Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Mecobion-Np 75mg Tablet if you are pregnant or breastfeeding. Mecobion-Np 75mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Mecobion-Np 75mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Mecobion-Np 75mg Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Mecobion-Np 75mg Tablet

Mecobion-Np 75mg Tablet is used in the treatment of Neuropathic pain. The detailed uses of Mecobion-Np 75mg Tablet are as follows:<br/>• Neuropathic Pain: Mecobion-Np 75mg Tablet is used to treat diabetic neuropathy, post-herpetic neuralgia (shingles), sciatica, and spinal cord injuries.<br/>• Fibromyalgia: Mecobion-Np 75mg Tablet helps manage widespread pain and fatigue.<br/>• Peripheral Neuropathy: Mecobion-Np 75mg Tablet supports nerve repair and reduces tingling, numbness, and burning sensations.<br/>• Chronic Pain Syndromes: Mecobion-Np 75mg Tablet is used to treat pain including lower back pain and migraine prevention.<br/>

Directions for Use

• Take Mecobion-Np 75mg Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Mecobion-Np 75mg Tablet is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Mecobion-Np 75mg Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Mecobion-Np 75mg Tablet helps to treat neuropathic pain.

How Mecobion-Np 75mg Tablet Works

Mecobion-Np 75mg Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Mecobion-Np 75mg Tablet helps to treat neuropathic pain.

Storage

Keep Mecobion-Np 75mg Tablet out of the sight and reach of children.

What if I have taken an overdose of Mecobion-Np 75mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Mecobion-Np 75mg Tablet may include irregular heartbeats, severe drowsiness, vision problems, confusion, hallucinations, agitation, stiff muscles, overactive reflexes, vomiting, feeling hot or cold, feeling like you might pass out, seizures, or coma. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to any of the ingredients in Mecobion-Np 75mg Tablet , do not consume it. Please do not stop taking Mecobion-Np 75mg Tablet without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Mecobion-Np 75mg Tablet unless your doctor has prescribed it. Mecobion-Np 75mg Tablet may cause drowsiness and dizziness, therefore drive only if you are alert. Mecobion-Np 75mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Mecobion-Np 75mg Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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NortriptylinePotassium citrate
Critical
NortriptylineIsocarboxazid
Critical

Drug-Drug Interactions

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NortriptylinePotassium citrate
Critical
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Coadministration of Mecobion-Np 75mg Tablet 10s with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Using Mecobion-Np 75mg Tablet 10s together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Mecobion-Np 75mg Tablet 10s is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Coadministration of Mecobion-Np 75mg Tablet 10s with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Coadministration of Mecobion-Np 75mg Tablet 10s with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Coadministration of Mecobion-Np 75mg Tablet 10s with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Co-administration of Mecobion-Np 75mg Tablet 10s with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Coadministration of Mecobion-Np 75mg Tablet 10s with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Mecobion-Np 75mg Tablet 10s with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PregabalinSodium oxybate
Severe
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Using Sodium oxybate together with Mecobion-Np 75mg Tablet 10s may increase the risk of side effects.

How to manage the interaction:
Although taking Mecobion-Np 75mg Tablet 10s with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult the doctor. For at least six hours after taking sodium oxybate, avoid operating machinery or engaging in potentially dangerous activities. Also, be careful when getting up from a sitting or lying down posture. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Using Mecobion-Np 75mg Tablet 10s together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Mecobion-Np 75mg Tablet 10s together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinHydrocodone
Severe
How does the drug interact with Mecobion-Np 75mg Tablet 10s:
Using Mecobion-Np 75mg Tablet 10s together with Hydrocodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and Mecobion-Np 75mg Tablet 10s together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.

  • Cayenne pepper should be included in your diet because it can help with neuropathic pain.

  • Exercising regularly helps to improve overall health and combat pain.

  • Rest well and get plenty of rest.

  • Taking a warm bath can be very relaxing.

  • Avoid smoking and drinking alcohol.

  • Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.

  • Acupuncture, by stimulating pressure points, can be beneficial.

  • Massages with essential oils can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Mecobion-Np 75mg Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take Mecobion-Np 75mg Tablet unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Mecobion-Np 75mg Tablet in breastfeeding/nursing mothers.

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Driving

Unsafe

Mecobion-Np 75mg Tablet causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Mecobion-Np 75mg Tablet should not be given to children as the safety and efficacy have not been established.

Have a query?

FAQs

Mecobion-Np 75mg Tablet is used to treat neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.

Mecobion-Np 75mg Tablet contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Mecobion-Np 75mg Tablet helps to treat neuropathic pain.

Dry mouth could be a side-effect of Mecobion-Np 75mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Do not stop taking Mecobion-Np 75mg Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Mecobion-Np 75mg Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Mecobion-Np 75mg Tablet , do not be afraid to speak with your doctor.

Mecobion-Np 75mg Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.

Mecobion-Np 75mg Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.

Mecobion-Np 75mg Tablet is not a painkiller. However, it is a combination medicine used to manage neuropathic pain, particularly in conditions like diabetic peripheral neuropathy and postherpetic neuralgia.

The common side effects of Mecobion-Np 75mg Tablet include sleepiness, dizziness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult the doctor if these symptoms persist or worsen.

Mecobion-Np 75mg Tablet is a medication combination consisting of Methylcobalamin (Vitamin B12), Nortriptyline (Tricyclic Antidepressant), and Pregabalin (Anticonvulsant), commonly prescribed for managing neuropathic pain and nerve damage.

To manage weight gain associated with Mecobion-Np 75mg Tablet , maintain a balanced diet rich in fibre and protein while avoiding processed and sugary foods. Engage in regular physical activity, including cardio and strength training, to boost your metabolism. Monitor your weight and consult your doctor if you notice any significant changes.

Yes, Mecobion-Np 75mg Tablet may cause sleepiness or dizziness as a common side effect. Therefore, avoid driving or operating heavy machinery unless you are fully alert.

Mecobion-Np 75mg Tablet may affect sexual health in some individuals. It may cause side effects such as reduced libido, erectile dysfunction, or difficulty achieving orgasm, mainly due to Nortriptyline and Pregabalin affecting neurotransmitters and nerve function. Please consult the doctor for guidance or alternative treatment options if you experience any changes in your sexual health.

Mecobion-Np 75mg Tablet is generally well tolerated, but in very rare cases, it may cause allergic reactions, such as rash, itching, or swelling, and breathing difficulties, especially in individuals with pre-existing lung conditions or when combined with CNS depressants.

Mecobion-Np 75mg Tablet starts working as soon as you begin taking it. However, it may take a few weeks to show its complete effects. Therefore, continue taking it as prescribed by the doctor, and please consult your doctor if you have any concerns.

If you forget a dose of Mecobion-Np 75mg Tablet , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose.

If you accidentally overdose on Mecobion-Np 75mg Tablet , seek immediate medical attention. Overdose symptoms can be severe and include drowsiness, confusion, vision problems, dizziness, irregular heartbeat, low blood pressure, convulsions, and breathing difficulties. In extreme cases, an overdose can lead to coma or even life-threatening complications. Call your doctor or emergency services right away for urgent treatment.

No, taking a higher dose of Mecobion-Np 75mg Tablet than recommended will not necessarily be more effective and may increase the risk of serious side effects. Always follow the dosage instructions provided by your doctor or pharmacist.

Avoid consuming alcohol while taking Mecobion-Np 75mg Tablet as it may increase drowsiness or sleepiness. Avoid driving or operating heavy machinery until you know how the medication affects you. Avoid taking other medicines, including herbal supplements and OTC medications, without a doctor’s advice.

While taking Mecobion-Np 75mg Tablet , your doctor may recommend regular check-ups based on your medical condition to monitor your response, adjust dosages, and manage potential side effects. Please consult your doctor immediately if you experience any changes in your condition.

Mecobion-Np 75mg Tablet should be stored in a cool and dry place, away from sunlight. Keep it out of sight and reach of children.

Country of origin

INDIA

Manufacturer/Marketer address

Medley House, D2, M.I.D.C. Area, Andheri (East), Mumbai-400 093, INDIA
Other Info - MEC0545

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