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Mbvorin 50 mg Injection 5 ml is used in cancer treatment as an antidote to reduce the toxic effects of certain cancer drugs, such as methotrexate. It contains calcium folinate, also known as Leucovorin, which is a form of vitamin B. It is folic acid in its active form. It works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.
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About Mbvorin 50 mg Injection 5 ml
Mbvorin 50 mg Injection 5 ml is used in cancer treatment as an antidote to reduce the toxic effects of certain cancer drugs, such as methotrexate. It can also be used in combination with 5-fluorouracil in cancer treatment (cytotoxic therapy).
Mbvorin 50 mg Injection 5 ml contains calcium folinate, also known as Leucovorin, which is a form of vitamin B. It is folic acid in its active form. Mbvorin 50 mg Injection 5 ml works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.
Mbvorin 50 mg Injection 5 ml will be administered by a qualified healthcare professional. You may experience nausea, diarrhoea, rash, vomiting, itching, urticaria or hives and stomatitis (oral mucositis). Most of these side effects of Mbvorin 50 mg Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Before taking the Mbvorin 50 mg Injection 5 ml, let your doctor know if you are allergic to any ingredient in it. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have pernicious anaemia or other forms of megaloblastic anaemia caused by vitamin B12 deficiency, GI toxicity, renal impairment and seizures.
Uses of Mbvorin 50 mg Injection 5 ml
Mbvorin 50 mg Injection 5 ml is used to prevent the harmful effects of methotrexate. The detailed uses of Mbvorin 50 mg Injection 5 ml are as follows:

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Directions for Use
Medicinal Benefits
Mbvorin 50 mg Injection 5 ml belongs to the class of medicines known as detoxifying agents or folic acid analogues used in cytotoxic therapy as an antidote to reduce the toxicity and effect of certain cancer drugs such as methotrexate. Mbvorin 50 mg Injection 5 ml works by preventing healthy cells from the toxic effects of methotrexate (or other cancer medicines) while accepting it to enter and kill the cancer cells. Besides this, it can also be used in combination with the drug 5-fluorouracil in cancer treatment (cytotoxic therapy).
How Mbvorin 50 mg Injection 5 ml Works
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What if I have taken an overdose of Mbvorin 50 mg Injection 5 ml
Drug Warnings
Before taking the Mbvorin 50 mg Injection 5 ml, inform your doctor if you are allergic to any of its ingredients. Also, if you are pregnant, planning to become pregnant, or breastfeeding, or if you have pernicious anaemia or other kinds of megaloblastic anaemia caused by vitamin B12 deficiency, GI toxicity, renal impairment, or seizures, please notify your doctor. Also, inform your doctor about your medical history and current drugs to rule out potential side effects.
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Alcohol
Caution
Avoid the consumption of alcohol as it may cause some side effects and make the impact of Mbvorin 50 mg Injection 5 ml less effective.
Pregnancy
Caution
Mbvorin 50 mg Injection 5 ml should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Mbvorin 50 mg Injection 5 ml.
Breast Feeding
Caution
Mbvorin 50 mg Injection 5 ml should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Mbvorin 50 mg Injection 5 ml.
Driving
Safe
Mbvorin 50 mg Injection 5 ml does not affect the ability to drive or operate machinery.
Liver
Caution
Inform your doctor before receiving the Mbvorin 50 mg Injection 5 ml if you have had a liver impairment/disorder history. Your doctor may adjust the dose of this medicine based on your condition.
Kidney
Caution
Inform your doctor before receiving the Mbvorin 50 mg Injection 5 ml if you have had a kidney impairment/disorder history. Your doctor may adjust the dose of this medicine based on your condition.
Children
Safe if prescribed
Your doctor will weigh the benefits and potential risks before prescribing Mbvorin 50 mg Injection 5 ml.
Heart
If you have a heart disease or any related concerns, Please consult your doctor before using Mbvorin 50 mg Injection 5 ml.
Geriatrics
Consult your doctor
Mbvorin 50 mg Injection 5 ml should be given to geriatrics only when prescribed by a doctor. If you have any concerns about using Mbvorin 50 mg Injection 5 ml for geriatrics, please consult a doctor.
Mbvorin 50 mg Injection 5 ml is used to prevent the harmful effects of methotrexate.
Mbvorin 50 mg Injection 5 ml contains calcium folinate, also known as Leucovorin. This compound prevents healthy cells from the toxic effects of methotrexate (cancer medicine) while accepting it to enter and kill cancer cells.
Mbvorin 50 mg Injection 5 ml is an antidote to the side effects of various chemotherapy medications, such as methotrexate.
Mbvorin 50 mg Injection 5 ml is contraindicated to use in populations with pernicious anaemia or other forms of megaloblastic anaemia caused by vitamin B12 deficiency.
It is contraindicated to use if you are known for hypersensitivity to any components present in Mbvorin 50 mg Injection 5 ml or if you have Pernicious anaemia or other anaemias due to vitamin B12 deficiency.
Megaloblastic anemia is a condition where abnormal, oversized red blood cells form due to defective DNA production, typically from a lack of vitamin B12 or folate (folic acid). Symptoms include fatigue, pale skin, and sometimes neurological issues.
Mbvorin 50 mg Injection 5 ml starts to act on the body within a few minutes of administration. It is not the same for everyone. It differs based on your health conditions, the dosage received, and the treatment recommended by your doctor.
Your doctor may recommend specific blood tests during your treatment with Mbvorin 50 mg Injection 5 ml to check methotrexate levels especially if you are undergoing chemotherapy or in cases of overdose. A complete blood count (CBC) will also be done to check red blood cell levels if you are being treated for anemia and also calcium levels (to avoid hypercalcemia due to calcium in Mbvorin 50 mg Injection 5 ml). These tests are essential for ensuring the treatment is both safe and effective.
To promote the excretion of methotrexate during treatment with Mbvorin 50 mg Injection 5 ml, increase fluid intake to maintain urine output above 2,500 mL/day for 12 hours before and 36 hours after methotrexate infusion. Ensure urine pH is above 7.0 before the infusion and avoid acidic substances. Measure blood methotrexate levels at 24, 48 and 72 hours after infusion.
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